Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300846
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
22.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300846
Synonyms:
(3S)-3-(4-((3-(2-Methyl-6- (methylsulfonamido)phenyl) benzo[b]thiophen-5- yl)methoxy)phenyl) hex-4-ynoic acid | US10131648, Compound 44 | US10195178, Compound 44 | US9790198, Compound 44
Type:
Small organic molecule
Emp. Form.:
C29H27NO5S2
Mol. Mass.:
533.658
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4c(C)cccc4NS(C)(=O)=O)c3c2)cc1 |r,wD:3.7,$;;;;;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;$,(6.84,-5,;6.84,-3.47,;6.84,-1.93,;6.84,-.38,;8.18,.38,;9.51,-.38,;10.84,.38,;9.51,-1.93,;5.51,.38,;4.17,-.38,;2.84,.38,;2.84,1.93,;1.51,2.69,;.17,1.93,;-1.16,2.69,;-1.16,4.23,;-2.49,5,;-3.83,4.23,;-5.29,4.71,;-6.2,3.47,;-5.29,2.22,;-5.69,.73,;-4.6,-.36,;-3.11,.04,;-5,-1.84,;-6.49,-2.24,;-7.58,-1.15,;-7.18,.33,;-8.27,1.42,;-9.75,1.02,;-10.84,2.11,;-10.84,-.07,;-9.36,-.46,;-3.83,2.69,;-2.49,1.93,;4.17,2.69,;5.51,1.93,)|
Structure:
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