Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300848
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
18.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300848
Synonyms:
3-(6-((3-(2-Methyl-4- ((tetrahydro-2H-pyran-4- yl)oxy)phenyl)benzo[b]thiophen- 5-yl)methoxy)pyridin-3-yl) hex-4-ynoic acid | US10131648, Compound 46 | US10195178, Compound 46 | US9790198, Compound 46
Type:
Small organic molecule
Emp. Form.:
C32H31NO5S
Mol. Mass.:
541.657
SMILES:
CC#CC(CC(O)=O)c1ccc(OCc2ccc3scc(-c4ccc(OC5CCOCC5)cc4C)c3c2)nc1
Structure:
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