Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300849
Substrate
n/a
Meas. Tech.
GPR40 Calcium Flux Assay
EC50
20.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US10131648 Publication Date 11/20/2018 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300849
Synonyms:
3-(6-((3-(4-(2-Methoxyethoxy)- 2-methylphenyl) benzo[b]thiophen-5- yl)methoxy)pyridin-3-yl) hex-4-ynoic acid | US10131648, Compound 47 | US10195178, Compound 47 | US9790198, Compound 47
Type:
Small organic molecule
Emp. Form.:
C30H29NO5S
Mol. Mass.:
515.62
SMILES:
COCCOc1ccc(-c2csc3ccc(COc4ccc(cn4)C(CC(O)=O)C#CC)cc23)c(C)c1
Structure:
Search PDB for entries with ligand similarity: