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Target
Menin
Ligand
BDBM480195
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Competitive Binding Assay
IC50
3300±n/a nM
Citation
 Wang, S; Aguilar, A; Zheng, K; Xu, S; Xu, T; Bernard, D; Huang, L Piperidines as menin inhibitors US Patent  US10899738 Publication Date 1/26/2021 
Target
Name:
Menin
Synonyms:
MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2
Type:
Protein
Mol. Mass.:
68022.55
Organism:
Homo sapiens (Human)
Description:
O00255
Residue:
610
Sequence:
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRRRGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAPTASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
  
Inhibitor
Name:
BDBM480195
Synonyms:
US10899738, Cpd. No 256 | rac-2-((1R,2R)-2- ((methylsulfonyl)methyl) cyclopentyl)-2-phenyl-2-(1-((1- (4-(pyridin-4- ylsulfonyl)phenyl)azetidin-3- yl)methyl)piperidin-4- yl)acetonitrile
Type:
Small organic molecule
Emp. Form.:
C35H42N4O4S2
Mol. Mass.:
646.862
SMILES:
CS(=O)(=O)C[C@@H]1CCC[C@H]1C(C#N)(C1CCN(CC2CN(C2)c2ccc(cc2)S(=O)(=O)c2ccncc2)CC1)c1ccccc1 |r|
Structure:
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