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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM480682
Substrate
n/a
Meas. Tech.
Transcreener-Fluorecescence Polarization Assay
Ki
1.10±n/a nM
Citation
 Bryan, MC; Do, S; Katsumoto, T; Liang, J; Rajapaksa, NS; Kiefer, Jr., JR; Fu, L IRAK4 modulators US Patent  US10899772 Publication Date 1/26/2021 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM480682
Synonyms:
N-[6-morpholino-1-oxo-2-[rac- (2R)-2-fluoro-3-hydroxy-3- methyl-butyl]isoindolin-5-yl]- 1H-benzimidazole-4- carboxamide | US10899772, Example 32
Type:
Small organic molecule
Emp. Form.:
C25H28FN5O4
Mol. Mass.:
481.5193
SMILES:
CC(C)(O)[C@H](F)CN1Cc2cc(NC(=O)c3cccc4[nH]cnc34)c(cc2C1=O)N1CCOCC1 |r|
Structure:
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