Reaction Details Report a problem with these data
Target
AP-4 complex subunit sigma-1
Ligand
BDBM484117
Substrate
n/a
Meas. Tech.
Human Sigma-1 Receptor Radioligand Assay
Ki
<100±n/a nM
Citation
 Virgili-Bernado, M; Almansa-Rosales, C; Alegret-Molina, C Oxadiazaspiro compounds for the treatment of drug abuse and addiction US Patent  US10927128 Publication Date 2/23/2021 
Target
Name:
AP-4 complex subunit sigma-1
Synonyms:
AP-4 complex subunit sigma-1 | AP4S1 | AP4S1_HUMAN | Sigma-1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17000.04
Organism:
Homo sapiens (Human)
Description:
Sigma-1 0 HUMAN::Q9Y587
Residue:
144
Sequence:
MIKFFLMVNKQGQTRLSKYYEHVDINKRTLLETEVIKSCLSRSNEQCSFIEYKDFKLIYRQYAALFIVVGVNDTENEMAIYEFIHNFVEVLDEYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKMSES
  
Inhibitor
Name:
BDBM484117
Synonyms:
(S)-9-(2-(3-fluoropyridin-2-yl)ethyl-4-isopropyl- 2-methyl-1-oxa-4,9-diazaspiro[5.5]undecane | US10927128, Example 38
Type:
Small organic molecule
Emp. Form.:
C19H30FN3O
Mol. Mass.:
335.4594
SMILES:
CC(C)N1C[C@H](C)OC2(CCN(CCc3ncccc3F)CC2)C1 |r|
Structure:
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