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Target
Serine hydroxymethyltransferase, cytosolic
Ligand
BDBM485174
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
>5000±n/a nM
Citation
 Rabinowitz, JD; Kim, H; Ducker, GS; Ghergurovich, JM SHMT inhibitors US Patent  US10934305 Publication Date 3/2/2021 
Target
Name:
Serine hydroxymethyltransferase, cytosolic
Synonyms:
GLYC_HUMAN | Glycine hydroxymethyltransferase | SHMT | SHMT1 | Serine methylase
Type:
PROTEIN
Mol. Mass.:
53091.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_745716
Residue:
483
Sequence:
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
  
Inhibitor
Name:
BDBM485174
Synonyms:
US10934305, Compound GD-07
Type:
Small organic molecule
Emp. Form.:
C15H13N5O3
Mol. Mass.:
311.2954
SMILES:
Cc1n[nH]c2OC(N)=C(C#N)C(C)(c12)c1cccc(c1)N(=O)=O |t:7|
Structure:
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