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Target
TGF-beta receptor type-1 [162-503]
Ligand
BDBM451789
Substrate
n/a
Meas. Tech.
Caliper Assay
IC50
900±n/a nM
Citation
 Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent  US10947218 Publication Date 3/16/2021 
Target
Name:
TGF-beta receptor type-1 [162-503]
Synonyms:
ALK5 | Activin receptor-like kinase 5 (ALK-5)(aa 162-503) | Activin receptor-like kinase 5 (ALK5)(162-503) | SKR4 | TGFBR1 | TGFR1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38872.23
Organism:
Homo sapiens (Human)
Description:
aa 162-503
Residue:
342
Sequence:
EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
  
Inhibitor
Name:
BDBM451789
Synonyms:
US10710980, Example 21 | US10947218, Example 21
Type:
Small organic molecule
Emp. Form.:
C28H35FN4O3
Mol. Mass.:
494.6009
SMILES:
Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r|
Structure:
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