Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM373561
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
79.4±n/a nM
Citation
 Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H 4-aminoquinazolinyl compounds as prolyl hydroxylase inhibitors US Patent  US10975062 Publication Date 4/13/2021 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM373561
Synonyms:
1-(6-Cyclohexyl-4-methylamino-quinazolin-2-yl)-1H-pyrazole-4-carboxylicacid; | US10246442, Example 22 | US10975062, Example 22
Type:
Small organic molecule
Emp. Form.:
C19H21N5O2
Mol. Mass.:
351.4023
SMILES:
CNc1nc(nc2ccc(cc12)C1CCCCC1)-n1cc(cn1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: