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Target
Nuclear receptor ROR-gamma
Ligand
BDBM491941
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
4.80±n/a nM
Citation
 Goldberg, S; McClure, K; Tanis, VM; Fennema, EG; Lebsack, AD; Martin, CL; Venkatesan, H; Xue, X; Woods, CR 6-aminopyridin-3-yl thiazoles as modulators of RORγT US Patent  US10975068 Publication Date 4/13/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM491941
Synonyms:
4-((1s,4s)-7-Azabicyclo[2.2.1]heptane-7-carbonyl)-N-(2-hydroxy-2-methylpropyl)-5-(4-(trifluoromethyl)-6-(((S)-1,1,1-trifluoropropan-2-yl)amino)pyridin-3-yl)thiazole-2-carboxamide | US10975068, Example 82
Type:
Small organic molecule
Emp. Form.:
C24H27F6N5O3S
Mol. Mass.:
579.558
SMILES:
C[C@H](Nc1cc(c(cn1)-c1sc(nc1C(=O)N1C2CCC1CC2)C(=O)NCC(C)(C)O)C(F)(F)F)C(F)(F)F |r|
Structure:
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