Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM492007
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
6.40±n/a nM
Citation
 Goldberg, S; McClure, K; Tanis, VM; Fennema, EG; Lebsack, AD; Martin, CL; Venkatesan, H; Xue, X; Woods, CR 6-aminopyridin-3-yl thiazoles as modulators of RORγT US Patent  US10975068 Publication Date 4/13/2021 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM492007
Synonyms:
5-(6-(tert-Butylamino)-4-(difluoromethyl)-3-pyridyl)-N-((1R)-2-hydroxy-1-methyl-ethyl)-4-((2S)-2-methylpyrrolidine-1-carbonyl)thiazole-2-carboxamide | US10975068, Example 148
Type:
Small organic molecule
Emp. Form.:
C23H31F2N5O3S
Mol. Mass.:
495.586
SMILES:
C[C@H](CO)NC(=O)c1nc(C(=O)N2CCC[C@@H]2C)c(s1)-c1cnc(NC(C)(C)C)cc1C(F)F |r|
Structure:
Search PDB for entries with ligand similarity: