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Target
N-lysine methyltransferase SMYD2
Ligand
BDBM50095625
Substrate
n/a
Meas. Tech.
Binding Affinity Assay
IC50
12100±n/a nM
Citation
 Chiang, GG; Pappano, WN; Sweis, RF; Wang, Z SMYD2 inhibitors US Patent  US9598381 Publication Date 3/21/2017 
Target
Name:
N-lysine methyltransferase SMYD2
Synonyms:
HSKM-B | Histone methyltransferase SMYD2 | KMT3C | Lysine N-methyltransferase 3C | N-lysine methyltransferase SMYD2 | SET and MYND domain-containing protein 2 | SET and MYND domain-containing protein 2 (SMYD2) | SMYD2 | SMYD2_HUMAN
Type:
Enzyme
Mol. Mass.:
49689.57
Organism:
Homo sapiens (Human)
Description:
Q9NRG4
Residue:
433
Sequence:
MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKEGLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLGFPDNDSLVVLFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVRYARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDWEGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYMGLEHKAAGEKALKKAIAIMEVAHGKDHPYISEIKQEIESH
  
Inhibitor
Name:
BDBM50095625
Synonyms:
CHEMBL3590523 | US9598381, 6
Type:
Small organic molecule
Emp. Form.:
C25H40Cl2N4O
Mol. Mass.:
483.517
SMILES:
Clc1ccc(CCNCCC(=O)N(CCNCCN2CCCC2)C2CCCCC2)cc1Cl
Structure:
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