Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM160855
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
38.5±n/a nM
Citation
 Brodney, MA; Davoren, JE; Dounay, AB; Efremov, IV; Gray, DL; Green, ME; Henderson, JL; Lee, C; Mente, SR; O''Neil, SV; Rogers, BN; Zhang, L Heteroaromatic compounds and their use as dopamine D1 ligands US Patent  US11014909 Publication Date 5/25/2021 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM160855
Synonyms:
US10093655, Example 25 | US11014909, Example 25 | US9107923, 25
Type:
Small organic molecule
Emp. Form.:
C19H17Cl2N3O3
Mol. Mass.:
406.263
SMILES:
Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C |(-.67,4.23,;-.67,2.69,;-2,1.92,;-2,.38,;-3.33,-.39,;-3.33,-1.93,;-2,-2.7,;-2,-4.24,;-3.33,-5.01,;-3.33,-6.54,;-4.67,-4.24,;-6,-5.01,;-4.67,-2.7,;-6,-1.93,;-.67,-.39,;.67,.38,;.67,1.92,;2,2.69,;2,4.23,;.67,5,;3.33,5,;3.33,6.54,;4.67,4.23,;4.67,2.69,;6,1.92,;3.33,1.92,;3.33,.38,)|
Structure:
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