Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM301957
Substrate
n/a
Meas. Tech.
Binding Affinity Human 5-HT1A Receptor Test
Ki
1.10±n/a nM
Citation
 Zhang, Y; Jin, C; Zhou, R Substituted heteroaryl compounds and methods of use thereof US Patent  US9598401 Publication Date 3/21/2017 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM301957
Synonyms:
3-(4-(4-(4,6-Dimethylpyrimidin-2-yl)piperazin-1-yl)butyl)-1H-indole | US9598401, Example 11
Type:
Small organic molecule
Emp. Form.:
C22H29N5
Mol. Mass.:
363.4992
SMILES:
Cc1cc(C)nc(n1)N1CCN(CCCCc2c[nH]c3ccccc23)CC1
Structure:
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