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Target
Bromodomain-containing protein 2 [348-455]
Ligand
BDBM205429
Substrate
n/a
Meas. Tech.
Isothermal Titration Calorimetry Analysis of Binding to Brd2-BD1 and Brd2-BD2
Kd
112±n/a nM
Citation
 Guy, RK; Slavish, PJ; Shadrick, WR; Young, BM; Boyd, VA; Bharatham, N; Price, JE; Shelat, A Tetrahydroquinoline-based bromodomain inhibitors US Patent  US11028051 Publication Date 6/8/2021 
Target
Name:
Bromodomain-containing protein 2 [348-455]
Synonyms:
BET bromodomain 2(2) (BRD2(2)) | BRD2 | BRD2-BD2 | BRD2_HUMAN | Bromodomain-containing protein 2 (aa 348-455) | KIAA9001 | RING3
Type:
n/a
Mol. Mass.:
12751.52
Organism:
Homo sapiens (Human)
Description:
P25440[348-455]
Residue:
108
Sequence:
EQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPD
  
Inhibitor
Name:
BDBM205429
Synonyms:
(R)-JQ1 (3) | US10407441, Compound (R)-JQ1 | US10925881, Name (R)-JQ1 | US11028051, Cmpd (+)-JQ1 | US11117865, Compound JQ1 | US11306105, Compound JQ1 | US11406645, Compound JQ1 | US11542273, Example (+)-JQ1 | US11890288, Compound (+)-JQ1 | US9320741, (R)-JQ1
Type:
Small organic molecule
Emp. Form.:
C23H25ClN4O2S
Mol. Mass.:
456.988
SMILES:
Cc1nnc2[C@@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1 |r,c:14|
Structure:
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