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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM302081
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
>19900±n/a nM
Citation
 Guillemont, JE; Lançois, DF; Motte, MM; Koul, A; Balemans, WM Antibacterial piperidinyl substituted 3,4-dihydro-1H-[1,8]naphthyridinones US Patent  US9598407 Publication Date 3/21/2017 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | Enoyl-acyl carrier protein reductase (FaBI) | FABI_STAA8 | NADPH-dependent enoyl-ACP reductase (FabI) | fabI
Type:
Enzyme
Mol. Mass.:
28019.03
Organism:
Staphylococcus aureus
Description:
Q2FZQ3
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISASPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM302081
Synonyms:
US9598407, Compound 38
Type:
Small organic molecule
Emp. Form.:
C19H22N6O2
Mol. Mass.:
366.417
SMILES:
O=C(\C=C\c1cnc2NC(=O)CCc2c1)N1CCC(Cn2cnnc2)CC1
Structure:
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