| Assay Method Information | |
| | Identification of Molecular Probes that Activate MRP-1 - Dose Response |
| Description: | Southern Research Molecular Libraries Screening Center (SRMLSC) Southern Research Institute (Birmingham, Alabama) NIH Molecular Libraries Screening Centers Network (MLSCN) Award 1X01-MH077620-01: Submitted by Dr. Gary A. Piazza (Southern Research Institute) in collaboration with Sharon Terry (Genetic Alliance) Pseudoxanthoma elasticum (PXE) is a rare genetic disorder (Bergen, 2007), which involves damage to connective tissues that result in multiple manifestations including skin abnormalities, blindness, and cardiovascular complications. Recently, PXE has been found to be caused by loss of function mutations in the MRP-6 (ABCC6) gene (Chassaing, 2005). MRP-6 mutations have also been reported to be associated with a strong increase in the prevalence of premature coronary artery disease (Trip, 2002) MRP-6 belongs to a family of ATP-dependent transmembrane proteins that function to transport solutes across plasma membranes. In addition to their role in protecting tissues from xenobi |
| Affinity data for this assay | |
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