| Assay Method Information | |
| | Enzymatic Inhibition of UAWJ9-36-1 and UAWJ9-36-3 against the Mpro's from Seven Human Coronaviruses |
| Description: | Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progression curves of the following: SARS-CoV-2 Mpro in the presence of GC-376 (A), UAWJ9-36-1 (B), and UAWJ9-36-3 (C); SARS-CoV Mpro in the presence of GC-376 (D), UAWJ9-36-1 (E), and UAWJ9-36-3 (F); MERS-CoV Mpro in the presence of GC-376 (G), UAWJ9-36-1 (H), and UAWJ9-36-3 (I). Dose-response curves of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro from SARS-CoV-2 (J), SARS-CoV (K), MERS-CoV (L), HCoV-229E (M), HCoV-OC43 (N), HCoV-NL63 (O), and HCoV-HKU1 (P). Ratios of k2 (second rate constant) over KI (equilibrium dissociation constant) from kinetic studies and IC50 values from the dose-response curves are listed in the table at the bottom. Data are mean ± standard deviation of three replicates. |
| Affinity data for this assay | |
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