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Found 224 of affinity data for UniProtKB/TrEMBL: O00222
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50007548((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Affinity DataKi:  61nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataKi:  170nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50004881((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Affinity DataKi:  210nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50004051(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Affinity DataKi:  400nMMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50089890(4-Amino-2-oxa-bicyclo[3.1.0]hexane-4,6-dicarboxyli...)
Affinity DataKi:  1.70E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50034504((1S,2S)-2-((S)-Amino-carboxy-methyl)-cyclopropanec...)
Affinity DataKi:  3.40E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50089897(4-Amino-2-thia-bicyclo[3.1.0]hexane-4,6-dicarboxyl...)
Affinity DataKi:  7.30E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataKi:  9.50E+3nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50215552(3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethyny...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at mGluR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50336843(3-((2-Fluorothiazol-4-yl)ethynyl)-5-fluorobenzonit...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity to mGluR8 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM525279(US11173137, Compound FA26 | US11173137, Compound ...)
Affinity DataKi: >1.00E+4nMAssay Description:Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50056272((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...)
Affinity DataKi:  1.20E+4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50089895(2-Amino-3-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarbo...)
Affinity DataKi:  1.50E+4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM66976((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid;...)
Affinity DataKi:  4.50E+4nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM86717(CAS_5218788 | CHEMBL88553 | NSC_5218788 | SIB-1757)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50084141((E)-2-methyl-6-styrylpyridine | 2-Methyl-6-((E)-st...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50052398((2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid |...)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM86213(CAS_5126051 | CHEMBL327783 | CPCCOEt | NSC_5126051)
Affinity DataKi: >1.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50069111((2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50049748((2S,4S)-2-Amino-4-(4,4-diphenyl-butyl)-pentanedioi...)
Affinity DataKi: >3.00E+5nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50079183((2S)-amino(3,5-dihydroxyphenyl)ethanoic acid | (S)...)
Affinity DataKi: >1.00E+6nMAssay Description:Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50004051(2-Amino-4-phosphono-butyric acid | 2-Amino-4-phosp...)
Affinity DataIC50:  5.10nMAssay Description:Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM17657((2S)-2-aminopentanedioic acid | (S)-Glu | D-Glutam...)
Affinity DataIC50:  5.70nMAssay Description:Inhibitory concentration against [3H]1 binding to recombinant human Metabotropic glutamate receptor 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataIC50:  170nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072169((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  340nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072170((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  380nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072177((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  490nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072173((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  750nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072176((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  990nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072171((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  1.23E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50204257(CHEMBL3947221)
Affinity DataIC50:  1.90E+3nMAssay Description:Antagonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing human EAAT1/Galpha1s assessed as inhibition of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072168((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  2.25E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072172((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  2.52E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50072174((1S,2S,3S)-2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl...)
Affinity DataIC50:  5.18E+3nMAssay Description:Antagonistic activity against metabotropic glutamate receptor 8 (mGluR8) was evaluatedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50301804(5-(1-(2,4-difluorophenyl)-5-methyl-1H-1,2,3-triazo...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at human mGluR8 receptor expressed in CHO cell membranes assessed as inhibition of L-glutamate-induced calcium mobilization by FL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50301520(4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)th...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human mGluR8 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50278924(CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50523865(CHEMBL4476495)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50531687(CHEMBL4445682)
Affinity DataIC50: >1.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM212860(US9278960, 2-7 | US9663506, Example 2-7)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGluR8 (unknown origin) by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50278930(2-(m-tolylethynyl)pyrimidine | CHEMBL496882)
Affinity DataIC50: >1.00E+4nMAssay Description:Antagonist activity at mGlu8 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50244219(CHEMBL4081453)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at recombinant human mGlu8 receptor expressed in hamster AV12 cells co-expressing rat EAAT1/Galpha15 assessed as inhibition of gl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50121643(CHEMBL3616847)
Affinity DataIC50: >1.25E+4nMAssay Description:Antagonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50558766(CHEMBL4751065)
Affinity DataIC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu8 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as incr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50116512(CHEMBL3609741)
Affinity DataIC50: >3.00E+4nMAssay Description:Activity at mGlu8 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50553603(CHEMBL1349403)
Affinity DataIC50: >3.00E+4nMAssay Description:Negative allosteric modulation of mGlu8 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 8(Homo sapiens (Human))
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM50339075(Adamantan-1-yl-(4-pyridin-2-yl-piperazin-1-yl)-met...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of mGluR8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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