Compile Data Set for Download or QSAR
maximum 50k data
Found 1104 of affinity data for UniProtKB/TrEMBL: F5H0Y0
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  0.390nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  0.390nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  0.470nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248946(CHEMBL1908392 | US10981896, Compound 16)
Affinity DataKi:  0.470nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  0.680nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248938(CHEMBL4089284 | US10981896, Compound 21)
Affinity DataKi:  0.680nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248936(CHEMBL4083922 | US10981896, Compound 25)
Affinity DataKi:  2.30nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248945(CHEMBL4081410 | US10981896, Compound 19)
Affinity DataKi:  3.10nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50026612(BIBF-1120 | Nintedanib | US10981896, Compound Nint...)
Affinity DataKi:  5.60nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248950(CHEMBL4070814)
Affinity DataKi:  8.80nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248947(CHEMBL4075402 | US10981896, Compound 18)
Affinity DataKi:  46nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248937(CHEMBL4062168 | US10981896, Compound 15)
Affinity DataKi:  84nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248924(CHEMBL4099431 | US10981896, Compound 20)
Affinity DataKi:  149nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248925(CHEMBL4061117 | US10981896, Compound 22)
Affinity DataKi:  358nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM492923(US10981896, Compound 6)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM492924(US10981896, Compound 8)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM492925(US10981896, Compound 14)
Affinity DataKi: >650nMMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50248935(CHEMBL4062202 | US10981896, Compound 23)
Affinity DataKi: >650nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50553103(CHEMBL4784866)
Affinity DataKi:  5.47E+3nMAssay Description:Displacement of kinase tracer 236 from human N-terminal His-tagged MELK (1 to 337 residues) expressed in Escherichia coli BL21 pLysS by microscale th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50235402(CHEMBL4077934)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of MELK (unknown origin) containing kinase domain and UBA domain using STK S1 as substrate after 20 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166100(US9067937, 44)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50185443(CHEMBL3824328)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MELK catalytic domain (unknown origin) preincubated for 20 mins followed by addition of KinEASE STK S1 peptide as substrate in presence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166059(US9067937, 2)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM60438(US9067937, 28)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166117(US9067937, 61)
Affinity DataIC50:  0.400nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166154(US9067937, 202)
Affinity DataIC50:  0.460nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166061(US9067937, 4)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166072(US9067937, 15)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166127(US9067937, 71)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166137(US9067937, 81)
Affinity DataIC50:  0.5nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.542nMAssay Description:Inhibition of human MELK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166136(US9067937, 80)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166145(US9067937, 89)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166104(US9067937, 48)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166150(US9067937, 94)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166126(US9067937, 70)
Affinity DataIC50:  0.600nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177519(US9120749, 886)
Affinity DataIC50:  0.660nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.687nMAssay Description:Inhibition of human MELK using KKLNRTLSFAEPG as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166066(US9067937, 9)
Affinity DataIC50:  0.700nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166084(US9067937, 27)
Affinity DataIC50:  0.700nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177234(US9120749, 600)
Affinity DataIC50:  0.730nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177269(US9120749, 635)
Affinity DataIC50:  0.740nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177285(US9120749, 651)
Affinity DataIC50:  0.760nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166062(US9067937, 5)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177268(US9120749, 634)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM176910(US9120749, 276)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166119(US9067937, 63)
Affinity DataIC50:  0.800nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM176958(US9120749, 324)
Affinity DataIC50:  0.850nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM177315(US9120749, 681)
Affinity DataIC50:  0.860nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University Of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM166118(US9067937, 62)
Affinity DataIC50:  0.900nMpH: 7.4 T: 2°CAssay Description:MELK activity was determined in the presence or absence of compounds using fluorescein isothiocyanate-labeled (FITC-labeled) histone H3 peptide as a ...More data for this Ligand-Target Pair
In DepthDetails US Patent
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