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Found 1710 of affinity data for UniProtKB/TrEMBL: O36608
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM103838(MK-5172)
Affinity DataKi:  0.0600nMAssay Description:NS3/4A protease was preincubated with increasing concentration of drugs in protease reaction buffer for 1 hour. Inhibition assays were performed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236563(US9365582, 3)
Affinity DataKi:  0.100nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236571(US9365582, 13)
Affinity DataKi:  0.100nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236566(US9365582, 7)
Affinity DataKi:  0.100nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236565(US9365582, 5)
Affinity DataKi:  0.100nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236573(US9365582, 15)
Affinity DataKi:  0.200nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27076((1R,2S,5S)-N-[(1R)-2-cyclobutyl-1-(dihydroxyborany...)
Affinity DataKi:  0.200nM ΔG°:  -56.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM103837(Dan-mcP2P4)
Affinity DataKi:  0.220nMAssay Description:NS3/4A protease was preincubated with increasing concentration of drugs in protease reaction buffer for 1 hour. Inhibition assays were performed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM103836(Vaniprevir)
Affinity DataKi:  0.460nMAssay Description:NS3/4A protease was preincubated with increasing concentration of drugs in protease reaction buffer for 1 hour. Inhibition assays were performed in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236569(US9365582, 11)
Affinity DataKi:  0.5nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27072((1R,2S,5S)-N-[(1R)-2-cyclobutyl-1-[(2S,6R)-2,9,9-t...)
Affinity DataKi:  0.5nM ΔG°:  -54.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236567(US9365582, 9)
Affinity DataKi:  0.800nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27048(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-2,3-...)
Affinity DataKi:  0.900nM ΔG°:  -52.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27031(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-(4,4-dimethyl-...)
Affinity DataKi:  2nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM9690(SCH446211 (SCH6) Analog 23 | tert-butyl N-[(2S)-1-...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27016(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-3,3-dimethyl-1-[...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27028(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-(4,4-dimethyl-...)
Affinity DataKi:  2nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27039(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-2,3-...)
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27043(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-2H,3...)
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27015(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-[methane(methy...)
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27023(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-[methane(methy...)
Affinity DataKi:  3nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27068(2-[(3S,4S,13S,16S,17R,19S)-3-({[(2S)-1-{2,4-dioxo-...)
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27064(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-{2,4-dioxo-3-a...)
Affinity DataKi:  3nM ΔG°:  -49.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27030(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-{2,4-dioxo-3-a...)
Affinity DataKi:  3nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM9691(SCH446211 (SCH6) | TERT-BUTYL [(1S)-1-({(1R,2S,5S)...)
Affinity DataKi:  3.80nM ΔG°:  -48.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27029(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-3,3-dimethyl-1-(...)
Affinity DataKi:  4nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27020(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-3,3-dimethyl-1-[...)
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27045(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-2,3-...)
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27000(ketoamide derived macrocyclic inhibitor, 24 | tert...)
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27049(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-2,3-...)
Affinity DataKi:  5nM ΔG°:  -48.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27001(ketoamide derived macrocyclic inhibitor, 25 | tert...)
Affinity DataKi:  6nM ΔG°:  -47.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27066(2-[(3S,4S,13S,16S,17R,19S)-3-({[(2S)-3,3-dimethyl-...)
Affinity DataKi:  6nM ΔG°:  -47.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27002(2-[(3S,14S,17S,18R,20S)-3-[(tert-butylcarbamoyl)am...)
Affinity DataKi:  6nM ΔG°:  -47.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM12493((2S)-({N-[3-({[(7R,9S,12S)-12-cyclohexyl-5,5-dimet...)
Affinity DataKi:  6nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27033(3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(1,1-dioxo-1,2-...)
Affinity DataKi:  6nM ΔG°:  -47.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27022(2-[(3S,13S,16S,17R,19S)-3-({[(1S)-1-cyclohexyl-2-c...)
Affinity DataKi:  6nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27025(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-(1,1-dioxo-2H,...)
Affinity DataKi:  7nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27067(2-[(3S,4S,13S,16S,17R,19S)-3-({[(2S)-1-(4,4-dimeth...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM12483((2S)-({N-[3-({[(5S,8S,10R)-5-cyclohexyl-3,6-dioxo-...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27024(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-3,3-dimethyl-1-[...)
Affinity DataKi:  7nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27044(3-{[(1R,2S,5S)-3-[(2S)-2-cyclohexyl-2-({[(2S)-1-(1...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27047(4-cyclopropyl-3-{[(1R,2S,5S)-3-[(2S)-2-({[(2S)-1-(...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27063(2-[(3S,13S,16S,17R,19S)-3-({[(2S)-1-(4,4-dimethyl-...)
Affinity DataKi:  7nM ΔG°:  -47.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1027-1711](Hepatitis C virus genotype 1a (strain H77) (HCV))
Janssen Ireland

US Patent
LigandPNGBDBM236568(US9365582, 10)
Affinity DataKi:  7.70nMpH: 7.5Assay Description:The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM12287(SCH 491762 | tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(...)
Affinity DataKi:  8nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM12476((2S)-({N-[(3S)-3-({[(7R,9S,12S)-12-cyclohexyl-11,1...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27065(2-[(3S,4S,13S,16S,17R,19S)-3-({[(2S)-1-(4,4-dimeth...)
Affinity DataKi:  8nM ΔG°:  -47.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM9689(SCH446211 (SCH6) Analog 22 | tert-butyl N-[(2S)-1-...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27070((1R,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
University Of Massachusetts Medical School

LigandPNGBDBM27074((1R,5S)-3-[(2S)-2-[(tert-butylcarbamoyl)amino]-3,3...)
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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