Compile Data Set for Download or QSAR
maximum 50k data
Found 1223 for UniProtKB: Q16665
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296480(CHEMBL553249)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50537295(CHEMBL4524475)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of HIF-1alpha (786 to 826 residues) (unknown origin)/p300 (unknown origin) protein-protein interaction by ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296473(CHEMBL558940)
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296481(CHEMBL562618)
Affinity DataKi:  5.80E+3nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296477(CHEMBL563460)
Affinity DataKi:  1.30E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296478(CHEMBL557433)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296476(CHEMBL557420)
Affinity DataKi:  1.60E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296479(CHEMBL562806)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296475(CHEMBL557344)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296474(CHEMBL558009)
Affinity DataKi:  5.80E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296482(CHEMBL541769)
Affinity DataKi:  7.70E+4nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296483(CHEMBL538372)
Affinity DataKi:  1.09E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50296472(CHEMBL558824)
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of interaction between fluorescein-labeled proline hydroxylated human HIFalpha (556 to 575) and human VHL-human elongin B-human elongin C ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50179013(CHEMBL205924 | moracin O)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058752(CHEMBL3335630)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50480476((-)-Moracin P | Moracin P)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of hypoxia-induced HIF1alpha protein accumulation in human Hep3B cells treated for 30 mins measured after 12 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50179011(CHEMBL380456 | Moracin P)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of Staphylococcus aureus FabI-mediated trans-2-octenoyl N-acetylcysteamine (t-o-NAC thioester) substrate reduction assessed as decrease in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058757(CHEMBL3335423)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50346783(CHEMBL1795446)
Affinity DataIC50:  1nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50524833(CHEMBL283631 | NSC-628679)
Affinity DataIC50:  1nMAssay Description:Inhibition of HIF-1alpha in human U373 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058753(CHEMBL3335427)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058754(CHEMBL3335426)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50401029(CHEMBL2205734)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIF-1alpha in human HCT116 cells under hypoxia condition by HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50478400(CHEBI:66664 | MANASSANTIN B)
Affinity DataIC50:  3nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50511097(CHEMBL4538400)
Affinity DataIC50:  3nMAssay Description:Activation of HIF1 in human T47D cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058760(CHEMBL3335421)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058766(CHEMBL3335415)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50005781(ALVESPIMYCIN | CHEBI:65324)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human AGS cells by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50346783(CHEMBL1795446)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058755(CHEMBL3335425)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50346796(CHEMBL1795432)
Affinity DataIC50:  6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50179013(CHEMBL205924 | moracin O)
Affinity DataIC50:  6.76nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50346790(CHEMBL1795439)
Affinity DataIC50:  7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058762(CHEMBL3335419)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058770(CHEMBL3335411)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50478890((-)-Cryptopleurine | CHEBI:3932 | Cryptopleurine |...)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human AGS cells after 16 hrs by pGL3-HRE-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50346795(CHEMBL1795433)
Affinity DataIC50:  10nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50179011(CHEMBL380456 | Moracin P)
Affinity DataIC50:  10.7nMAssay Description:Inhibition of hypoxia-induced HIF1alpha activation in human Hep3B cells after 16 hrs by HRE-luciferase reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50498799(Manassantin A | Manassantin B1)
Affinity DataIC50:  11nMAssay Description:Inhibition of HIF1 in human HEK293T cells transfected with pGL3-5HRE-VEGF and pRL-SV40 after 24 hrs by dual luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482091(10-Hydroxyglaucanetin | CHEMBL1098017)
Affinity DataIC50:  12nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells in presence of 1% O2 by HRE3-TK-luc reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50482090(Annonacin | Annonacin A)
Affinity DataIC50:  13nMAssay Description:Inhibition of hypoxia-induced HIF1 activation in human T47D cells in presence of 1% O2 by HRE3-TK-luc reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058765(CHEMBL3335416)
Affinity DataIC50:  13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058771(CHEMBL3335410)
Affinity DataIC50:  13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058768(CHEMBL3335413)
Affinity DataIC50:  14nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50426548(CHEMBL2323956)
Affinity DataIC50:  14nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50498797(CHEMBL3105545)
Affinity DataIC50:  20nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058756(CHEMBL3335424)
Affinity DataIC50:  21nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50511099(CHEMBL4434875)
Affinity DataIC50:  23nMAssay Description:Activation of HIF1 in human T47D cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50593342(CHEMBL5184354)
Affinity DataIC50:  24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50593328(CHEMBL5205360)
Affinity DataIC50:  24nMAssay Description:Inhibition of HIF-1alpha (unknown origin) transcriptional activity expressed in HEK293T cells co-transfected with renilla and HRE-firelfly luciferase...More data for this Ligand-Target Pair
In DepthDetails PubMed
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