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N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors.
Bioorg Med Chem Lett 23: 5641-5 (2013)
Mitsubishi Tanabe Pharma
Design and synthesis of MMP inhibitors with appended fluorescent tags for imaging and visualization of matrix metalloproteinase enzymes.
Bioorg Med Chem Lett 23: 5566-70 (2013)
Mallinckrodt Pharmaceuticals
Design, synthesis, and biological evaluation of novel 3-pyrrolo[b]cyclohexylene-2-dihydroindolinone derivatives as potent receptor tyrosine kinase inhibitors.
Bioorg Med Chem Lett 23: 5630-3 (2013)
Nanjing University Of Technology
Thienopyrimidine bisphosphonate (ThPBP) inhibitors of the human farnesyl pyrophosphate synthase: optimization and characterization of the mode of inhibition.
J Med Chem 56: 7939-50 (2013)
Mcgill University
Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from
Medchemcomm 3: 976-981 (2012)
University Of Wisconsin-Milwaukee
Chemopreventive and antioxidant activity of 6-substituted imidazo[2,1-b]thiazoles.
Eur J Med Chem 68: 412-21 (2013)
Universit£
Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3ß (GSK-3ß) inhibitors.
Eur J Med Chem 68: 361-71 (2013)
Zhejiang University
6-Cyclohexylmethoxy-5-(cyano-NNO-azoxy)pyrimidine-4-amine: a new scaffold endowed with potent CDK2 inhibitory activity.
Eur J Med Chem 68: 333-8 (2013)
Universit£
Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization.
Eur J Med Chem 68: 312-20 (2013)
First Affiliated Hospital Of Guangzhou Medical University
Discovery of ZAP70 inhibitors by high-throughput docking into a conformation of its kinase domain generated by molecular dynamics.
Bioorg Med Chem Lett 23: 5721-6 (2013)
University Of Zurich
Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.
Bioorg Med Chem 21: 6642-9 (2013)
Eutropics Pharmaceuticals
Novel BACE1 inhibitors with a non-acidic heterocycle at the P1' position.
Bioorg Med Chem 21: 6665-73 (2013)
Kyoto Pharmaceutical University
Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake.
Bioorg Med Chem 21: 6771-7 (2013)
University Of Kentucky
Preparation of imidazoles as potent calcitonin gene-related peptide (CGRP) antagonists.
Bioorg Med Chem Lett 23: 5684-8 (2013)
Bristol-Myers Squibb
3-Ylidenephthalides as a new class of transient receptor potential channel TRPA1 and TRPM8 modulators.
Bioorg Med Chem Lett 23: 5614-8 (2013)
Sapienza University Of Rome
Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg Med Chem Lett 23: 5674-9 (2013)
Northwestern University
Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer.
Bioorg Med Chem Lett 23: 5624-9 (2013)
Leo Pharma
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Bioorg Med Chem Lett 23: 5646-9 (2013)
University Of Florida
Synthesis and biological evaluation of 2-amino-5-aryl-3-benzylthiopyridine scaffold based potent c-Met inhibitors.
Bioorg Med Chem 21: 6804-20 (2013)
Chinese Academy Of Sciences
Emerging technologies for metabolite generation and structural diversification.
Bioorg Med Chem Lett 23: 5471-83 (2013)
Abbvie Bioresearch Center
Studies toward the development of new silicon-containing building blocks for the direct (18)F-labeling of peptides.
J Med Chem 56: 7552-63 (2013)
Institute Of Technology (Eth) Zurich
Synthesis and structure-activity relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic acid esters, a class of potent N-acylethanolamine acid amidase (NAAA) inhibitors.
J Med Chem 56: 6917-34 (2013)
Istituto Italiano Di Tecnologia
Synthesis and enzymatic evaluation of phosphoramidon and itsß anomer: Anomerization ofa-l-rhamnose triacetate upon phosphitylation.
Bioorg Med Chem 21: 6778-87 (2013)
Jiangxi Science And Technology Normal University
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.
Eur J Med Chem 68: 291-300 (2013)
Tehran University Of Medical Sciences
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.
Eur J Med Chem 68: 260-9 (2013)
Tehran University Of Medical Sciences
Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.
Bioorg Med Chem Lett 23: 5311-6 (2013)
Kyorin Pharmaceutical
Long-lasting inhibition of EGFR autophosphorylation in A549 tumor cells by intracellular accumulation of non-covalent inhibitors.
Bioorg Med Chem Lett 23: 5290-4 (2013)
Universit£
Systematic replacement of amides by 1,4-disubstituted[1,2,3]triazoles in Leu-enkephalin and the impact on the delta opioid receptor activity.
Bioorg Med Chem Lett 23: 5267-9 (2013)
Universit£
Modulation of aldose reductase inhibition by halogen bond tuning.
ACS Chem Biol 8: 2484-92 (2013)
Academy Of Sciences Of The Czech Republic
Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.
Bioorg Med Chem 21: 5963-72 (2013)
University Of Southern California
Divergent structure-activity relationships of structurally similar acetylcholinesterase inhibitors.
J Med Chem 56: 7615-24 (2013)
Ume£
N-substituted 8-aminopentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecanes ass receptor ligands with potential neuroprotective effects.
Bioorg Med Chem 21: 6038-52 (2013)
The University Of Sydney
Discovery of cyclic sulfoxide hydroxyethylamines as potent and selectiveß-site APP-cleaving enzyme 1 (BACE1) inhibitors: structure based design and in vivo reduction of amyloidß-peptides.
Bioorg Med Chem Lett 23: 5300-6 (2013)
Novartis Pharma
Synthesis and biological analysis of benzazol-2-yl piperazine sulfonamides as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.
Bioorg Med Chem Lett 23: 5397-400 (2013)
Leopold-Franzens-Universit£T
The carbonate analogues of 5'-halogenated resiniferatoxin as TRPV1 ligands.
Eur J Med Chem 68: 233-43 (2013)
Seoul National University
Synthesis, resolution, and biological evaluation of atropisomeric (aR)- and (aS)-16-methyllamellarins N: unique effects of the axial chirality on the selectivity of protein kinases inhibition.
J Med Chem 56: 7289-301 (2013)
Nagasaki University
Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure.
J Med Chem 56: 7110-9 (2013)
Pfizer
Investigation of an F-18 oxytocin receptor selective ligand via PET imaging.
Bioorg Med Chem Lett 23: 5415-20 (2013)
Emory University
Design and synthesis of novel 3-substituted-indole derivatives as selective H3 receptor antagonists and potent free radical scavengers.
Bioorg Med Chem 21: 5936-44 (2013)
Zhejiang University
N-Methylanilide and N-methylbenzamide derivatives as phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg Med Chem 21: 6053-62 (2013)
H. Lundbeck
Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.
ACS Chem Biol 8: 2501-8 (2013)
Rutgers University
Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses.
J Med Chem 56: 9369-402 (2014)
Janssen Research And Development
Optimization of Arylamides as Novel, Potent and Brain-penetrant Antiprion Lead Compounds.
ACS Med Chem Lett 4: 647-650 (2013)
University Of California
Synthesis, molecular docking and kinetic properties of ?-hydroxy-?-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors.
Eur J Med Chem 68: 212-21 (2013)
Jishou University
Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation.
Eur J Med Chem 68: 167-77 (2013)
Universit£
2,3,9- and 2,3,11-trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands.
Eur J Med Chem 68: 150-66 (2013)
Universidad De Valencia
Toward the design of new DNA G-quadruplex ligands through rational analysis of polymorphism and binding data.
Eur J Med Chem 68: 139-49 (2013)
Universit£
Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study.
Eur J Med Chem 68: 72-80 (2013)
Agency For Science, Technology And Research (A*Star)
Fragment-based discovery of focal adhesion kinase inhibitors.
Bioorg Med Chem Lett 23: 5401-9 (2013)
Merck
Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors.
Bioorg Med Chem Lett 23: 5385-8 (2013)
Fudan University
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23).
Bioorg Med Chem Lett 23: 5361-6 (2013)
Merck Research Laboratories
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg Med Chem Lett 23: 5437-41 (2013)
Glaxosmithkline
Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors.
Eur J Med Chem 68: 58-71 (2013)
Sun Yat-Sen University
New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.
J Med Chem 56: 7431-41 (2013)
Sapienza University Of Rome
Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma.
J Med Chem 56: 7190-200 (2013)
University Of Toronto Mississauga
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.
J Med Chem 56: 7396-415 (2013)
Actelion Pharmaceuticals
Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.
Bioorg Med Chem 21: 5973-82 (2013)
Birla Institute Of Technology
Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.
J Med Chem 56: 6803-18 (2013)
Memorial Sloan-Kettering Cancer Center
Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147.
J Med Chem 56: 7302-11 (2013)
Max Planck Research Unit For Enzymology Of Protein Folding
Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform.
J Med Chem 56: 7201-11 (2013)
Millennium Pharmaceuticals
Structure of thes1 receptor and its ligand binding site.
J Med Chem 56: 9809-19 (2013)
Institut F£R Pharmazeutische Und Medizinische Chemie Der Westf£Lischen Wilhelms-Universit£T M£Nster
Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia.
J Med Chem 56: 7590-607 (2013)
Novartis Institutes For Biomedical Research
Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity.
J Med Chem 56: 7222-31 (2013)
Kyoto Prefectural University Of Medicine
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).
J Med Chem 56: 7343-57 (2013)
Bristol-Myers Squibb
Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity.
Bioorg Med Chem 21: 6084-91 (2013)
Soochow University
Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.
J Med Chem 56: 7324-33 (2013)
Gilead Sciences
FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas.
J Biol Chem 288: 29105-14 (2013)
The Scripps Research Institute
Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.
Bioorg Med Chem 21: 5983-94 (2013)
Takeda Pharmaceutical
Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).
J Med Chem 56: 7212-21 (2013)
Case Western Reserve University
Discovery of HIV-1 integrase inhibitors: pharmacophore mapping, virtual screening, molecular docking, synthesis, and biological evaluation.
Chem Biol Drug Des 83: 154-66 (2014)
Nirma University
Antioxidant, a-glucosidase and xanthine oxidase inhibitory activity of bioactive compounds from maize (Zea mays L.).
Chem Biol Drug Des 83: 119-25 (2014)
Srtm University
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Toxicol Sci 136: 216-41 (2013)
Amgen
Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer.
J Biol Chem 288: 28641-55 (2013)
University Of Michigan Medical School
?2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.
Bioorg Med Chem Lett 23: 5376-81 (2013)
Medical University Of South Carolina
Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2.
Bioorg Med Chem 21: 6022-37 (2013)
Purdue University
Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.
Bioorg Med Chem 21: 6077-83 (2013)
University Of Delhi
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett 23: 5410-4 (2013)
Pfizer
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.
Bioorg Med Chem Lett 23: 5442-7 (2013)
Ironwood Pharmaceuticals
Testing the substrate-envelope hypothesis with designed pairs of compounds.
ACS Chem Biol 8: 2433-41 (2013)
Massachusetts Institute Of Technology
Structure activity relationship studies of 17-cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function.
Bioorg Med Chem Lett 23: 5045-8 (2013)
Virginia Commonwealth University
Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metabotropic glutamate 5 (mGlu5) receptor.
J Med Chem 56: 7243-59 (2013)
Janssen Pharmaceutica
Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J Med Chem 56: 6696-708 (2013)
California Nanosystems Institute
Highly potent HIV-1 protease inhibitors with novel tricyclic P2 ligands: design, synthesis, and protein-ligand X-ray studies.
J Med Chem 56: 6792-802 (2013)
Purdue University
Lessons from (S)-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)ethyl)quinoline (PF-04254644), an inhibitor of receptor tyrosine kinase c-Met with high protein kinase selectivity but broad phosphodiesterase family inhibition leading to myocardial degeneration in rats.
J Med Chem 56: 6651-65 (2013)
Pfizer
Discovery of selective small molecule type III phosphatidylinositol 4-kinase alpha (PI4KIIIa) inhibitors as anti hepatitis C (HCV) agents.
J Med Chem 57: 2091-106 (2014)
Glaxosmithkline
The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.
Bioorg Med Chem Lett 23: 5061-5 (2013)
Chinese Academy Of Sciences
KLIFS: a knowledge-based structural database to navigate kinase-ligand interaction space.
J Med Chem 57: 249-77 (2014)
Vu University Amsterdam
Casuarinines A-J, lycodine-type alkaloids from Lycopodiastrum casuarinoides.
J Nat Prod 76: 1475-84 (2013)
Fudan University
Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.
J Med Chem 56: 6901-16 (2013)
Research Triangle Institute
Nicotinamide adenine dinucleotide-induced multimerization of the co-repressor CtBP1 relies on a switching tryptophan.
J Biol Chem 288: 27836-48 (2013)
Oregon Health And Science University
Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors.
Bioorg Med Chem 21: 5679-87 (2013)
Zhejiang University
Synthesis, enzyme kinetics and computational evaluation of N-(ß-D-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors.
Bioorg Med Chem 21: 5738-47 (2013)
University Of Debrecen
Discovery of N-(2,3,5-triazoyl)mycophenolic amide and mycophenolic epoxyketone as novel inhibitors of human IMPDH.
Bioorg Med Chem Lett 23: 5140-4 (2013)
Hokkaido University
Selectivity data: assessment, predictions, concordance, and implications.
J Med Chem 56: 6991-7002 (2013)
Eli Lilly
Specialization among iron-sulfur cluster helicases to resolve G-quadruplex DNA structures that threaten genomic stability.
J Biol Chem 288: 28217-29 (2013)
National Institutes Of Health, National Institutes Of Health Biomedical Research Center
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
J Biol Chem 288: 28195-206 (2013)
Glaxosmithkline
Synthesis, biological evaluation and molecular docking studies of pyrazole derivatives coupling with a thiourea moiety as novel CDKs inhibitors.
Eur J Med Chem 68: 1-9 (2013)
Nanjing University
Octahydropyrrolo[3,4-c]pyrrole negative allosteric modulators of mGlu1.
Bioorg Med Chem Lett 23: 5091-6 (2013)
Vanderbilt University Medical Center
A hit to lead discovery of novel N-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors.
Bioorg Med Chem Lett 23: 5097-104 (2013)
Genentech
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile.
Bioorg Med Chem Lett 23: 5082-5 (2013)
Clinical Research Institute Of Montreal
Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aß aggregation and antioxidant activity.
Bioorg Med Chem 21: 5830-40 (2013)
Sun Yat-Sen University
Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.
Bioorg Med Chem 21: 5673-8 (2013)
National Institute Of Diabetes And Digestive And Kidney Diseases
Structure- and reactivity-based development of covalent inhibitors of the activating and gatekeeper mutant forms of the epidermal growth factor receptor (EGFR).
J Med Chem 56: 7025-48 (2013)
Astrazeneca
SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
ACS Med Chem Lett 4: 517-521 (2013)
University Of Texas Southwestern Medical Center
VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
J Biol Chem 288: 28733-42 (2013)
Institut National De Recherche Agronomique (Inra)-Vetagro Sup, Veterinary School Of Lyon
Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists.
Bioorg Med Chem 21: 5725-37 (2013)
Takeda Pharmaceutical
Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora.
Bioorg Med Chem Lett 23: 5150-4 (2013)
Kyung Hee University
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bioorg Med Chem Lett 23: 5239-43 (2013)
Bristol-Myers Squibb Research & Development
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.
Bioorg Med Chem Lett 23: 5128-30 (2013)
Universit£
Cell-based medicinal chemistry optimization of high-throughput screening (HTS) hits for orally active antimalarials. Part 1: challenges in potency and absorption, distribution, metabolism, excretion/pharmacokinetics (ADME/PK).
J Med Chem 56: 7741-9 (2013)
Calibr
Development of Mycobacterium tuberculosis whole cell screening hits as potential antituberculosis agents.
J Med Chem 56: 7755-60 (2013)
Global Alliance For Tb Drug Development (Tb Alliance)
Cell-based medicinal chemistry optimization of high throughput screening hits for orally active antimalarials. Part 2: hits from SoftFocus kinase and other libraries.
J Med Chem 56: 7750-4 (2013)
University Of Cape Town
Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells.
J Med Chem 56: 6681-95 (2013)
University Of Eastern Finland
Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.
Bioorg Med Chem 21: 5782-93 (2013)
National Institute Of Pharmaceutical Education And Research
Metallo-?-lactamase inhibitory activity of 3-alkyloxy and 3-amino phthalic acid derivatives and their combination effect with carbapenem.
Bioorg Med Chem 21: 5841-50 (2013)
Meiji Seika Pharma
Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases.
Bioorg Med Chem 21: 5707-24 (2013)
The Institute Of Cancer Research
Discovery of highly potent and selective D4 ligands by interactive SAR study.
Bioorg Med Chem Lett 23: 5077-81 (2013)
German University In Cairo
Identification of quinazolinyloxy biaryl urea as a new class of SUMO activating enzyme 1 inhibitors.
Bioorg Med Chem Lett 23: 5145-9 (2013)
Riken
Ligand-protein interactions of selective casein kinase 1d inhibitors.
J Med Chem 56: 6819-28 (2013)
Pfizer
Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.
J Med Chem 56: 6761-74 (2013)
Helmholtz-Institute For Pharmaceutical Research Saarland
Polypharmacology - foe or friend?
J Med Chem 56: 8955-71 (2013)
F. Hoffmann-La Roche
Novel 1H-pyrrolo[2,3-b]pyridine derivative nortopsentin analogues: synthesis and antitumor activity in peritoneal mesothelioma experimental models.
J Med Chem 56: 7060-72 (2013)
Universit£
Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH.
Chembiochem 14: 1611-9 (2013)
Fondazione Istituto Italiano Di Tecnologia
Inhibitors of switch kinase 'spleen tyrosine kinase' in inflammation and immune-mediated disorders: a review.
Eur J Med Chem 67: 434-46 (2013)
Punjabi University
Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.
Bioorg Med Chem Lett 23: 5448-51 (2013)
Bristol-Myers Squibb
Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors.
Bioorg Med Chem Lett 23: 5217-22 (2013)
Activx Biosciences
Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.
Bioorg Med Chem Lett 23: 5195-8 (2013)
Vanderbilt University
Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett 24: 1239-42 (2014)
Janssen Research And Development
The discovery of inhibitors of Fas-mediated cell death pathway using the combined computational method.
Bioorg Med Chem Lett 23: 5155-64 (2013)
Chungnam National University
Novel selective inhibitors of aminopeptidases that generate antigenic peptides.
Bioorg Med Chem Lett 23: 4832-6 (2013)
University Of California San Diego
Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.
Bioorg Med Chem 21: 5876-85 (2013)
University Of Dundee
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.
J Enzyme Inhib Med Chem 29: 469-75 (2014)
University Of Calgary
Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.
J Nat Prod 76: 1393-8 (2013)
National Institute Of Pharmaceutical Education And Research-Niper
Synthesis, structure, and antibiotic activity of aryl-substituted LpxC inhibitors.
J Med Chem 56: 6954-6966 (2013)
Duke University
Discovery and characterization of carbamothioylacrylamides as EP
ACS Med Chem Lett 4: 616-621 (2013)
Emory University
Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A.
ACS Med Chem Lett 4: 601-605 (2013)
Vanderbilt University School Of Medicine
Modular construction of quaternary hemiaminal-based inhibitor candidates and their in cellulo assessment with HIV-1 protease.
Bioorg Med Chem 21: 5407-13 (2013)
Universit£
PIF-pocket as a target for C. albicans Pkh selective inhibitors.
ACS Chem Biol 8: 2283-92 (2013)
Universit£Tsklinikum Frankfurt
Synthesis of novel acridine and bis acridine sulfonamides with effective inhibitory activity against the cytosolic carbonic anhydrase isoforms II and VII.
Bioorg Med Chem 21: 5799-805 (2013)
Dumlup?Nar University
Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells.
Bioorg Med Chem Lett 23: 4813-6 (2013)
Kyoto Pharmaceutical University
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.
Bioorg Med Chem Lett 23: 5170-3 (2013)
Institute Of Nuclear Medicine
Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists.
J Med Chem 56: 6434-56 (2013)
Emory University
Identification of novel HDAC inhibitors through cell based screening and their evaluation as potential anticancer agents.
Bioorg Med Chem Lett 23: 4790-3 (2013)
Translational Drug Development
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
J Med Chem 56: 6478-94 (2013)
Takeda Pharmaceutical
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
J Med Chem 56: 6775-91 (2013)
National Taiwan University
Peripherally restricted CB1 receptor blockers.
Bioorg Med Chem Lett 23: 4751-60 (2013)
Jenrin Discovery
6-methoxy-7-benzofuranoxy and 6-methoxy-7-indolyloxy analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 discovery of a potent and selective ?1D-adrenoceptor antagonist.
J Med Chem 56: 6402-12 (2013)
Universit£
Quinazoline-based multi-tyrosine kinase inhibitors: synthesis, modeling, antitumor and antiangiogenic properties.
Eur J Med Chem 67: 373-83 (2013)
University Of Padova
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
ACS Chem Biol 8: 2145-50 (2013)
Massachusetts General Hospital And Harvard Medical School
Binding of (5S)-penicilloic acid to penicillin binding protein 3.
ACS Chem Biol 8: 2112-6 (2013)
University Of Oxford
Antithrombotic effects of LB30870, a potent, orally active, selective and direct thrombin inhibitor, and pharmacokinetics of its prodrug.
Bioorg Med Chem Lett 23: 4779-84 (2013)
Lg Life Sciences
Truncation of the peptide sequence in bifunctional ligands with mu and delta opioid receptor agonist and neurokinin 1 receptor antagonist activities.
Bioorg Med Chem Lett 23: 4975-8 (2013)
University Of Arizona
Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg Med Chem Lett 23: 4875-85 (2013)
Genentech
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
J Med Chem 56: 7015-24 (2013)
Astrazeneca
Inverse 1,2,3-triazole-1-yl-ethyl substituted hydroxamates as highly potent matrix metalloproteinase inhibitors: (radio)synthesis, in vitro and first in vivo evaluation.
J Med Chem 56: 6858-70 (2013)
University Hospital M£Nster
Exquisite selectivity for human toll-like receptor 8 in substituted furo[2,3-c]quinolines.
J Med Chem 56: 6871-85 (2013)
University Of Kansas
Resistance by allostery: a novel perspective for eg5-targeted drug design.
J Med Chem 56: 6314-6 (2013)
Korea Institute Of Science And Technology
Histone deacetylase (HDAC) inhibitor kinetic rate constants correlate with cellular histone acetylation but not transcription and cell viability.
J Biol Chem 288: 26926-43 (2013)
Genentech
Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents.
Bioorg Med Chem 21: 4904-13 (2013)
University Of Cape Town
Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors.
Bioorg Med Chem 21: 4923-7 (2013)
University Of Maryland
Biochemical characterization of the chloroplastic ß-carbonic anhydrase from Flaveria bidentis (L.) "Kuntze".
J Enzyme Inhib Med Chem 29: 500-4 (2014)
Istituto Di Biostrutture E Bioimmagini-Cnr
Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C.
J Med Chem 56: 6583-92 (2013)
Wake Forest University
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.
J Med Chem 56: 6829-44 (2013)
Duquesne University
Toward drugs for protease-activated receptor 2 (PAR2).
J Med Chem 56: 7477-97 (2013)
The University Of Queensland
The adenosine A(2A) antagonistic properties of selected C8-substituted xanthines.
Bioorg Chem 49: 49-58 (2013)
North-West University, Private Bag X6001, Potchefstroom 2520, South Africa
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.
Bioorg Med Chem 21: 4928-37 (2013)
Ege University
Selective orexin receptor antagonists.
Bioorg Med Chem Lett 23: 4761-9 (2013)
Janssen Pharmaceutica
Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol.
Bioorg Med Chem Lett 23: 4886-91 (2013)
United Arab Emirates University
Psammaplysin F: a unique inhibitor of bacterial chromosomal partitioning.
Bioorg Med Chem Lett 23: 4862-6 (2013)
University Of New South Wales
Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.
Bioorg Med Chem Lett 23: 4774-8 (2013)
Okayama University
1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors.
Bioorg Med Chem 21: 4951-7 (2013)
Aristotle University Of Thessaloniki
Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition.
Bioorg Med Chem 21: 5188-97 (2013)
Mcphs University
Design and synthesis of bicyclic heterocycles as potent¿-secretase modulators.
Bioorg Med Chem Lett 23: 4794-800 (2013)
Janssen Pharmaceutica
Synthesis and characterization of time-resolved fluorescence probes for evaluation of competitive binding to melanocortin receptors.
Bioorg Med Chem 21: 5029-38 (2013)
University Of Arizona
6-Bromo-8-(4-[(3)H]methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic Acid: a powerful tool for studying orphan G protein-coupled receptor GPR35.
J Med Chem 56: 7084-99 (2013)
University Of Bonn
Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports.
Bioorg Med Chem 21: 4938-50 (2013)
Hokkaido University
Solid phase synthesis of Smac/DIABLO-derived peptides using a 'Safety-Catch' resin: identification of potent XIAP BIR3 antagonists.
Bioorg Med Chem 21: 5004-11 (2013)
Queen'S University Of Belfast
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Bioorg Med Chem 21: 5907-22 (2013)
Daiichi Sankyo
3,4-Dihydroxy- and 3,4-methylenedioxy- phenanthrene-type alkaloids with high selectivity for D2 dopamine receptor.
Bioorg Med Chem Lett 23: 4824-7 (2013)
Universidad De Valencia
A novel necroptosis inhibitor-necrostatin-21 and its SAR study.
Bioorg Med Chem Lett 23: 4903-6 (2013)
Chinese Academy Of Sciences
QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at thea4ß2 anda3ß4 nicotinic acetylcholine receptors (nAChRs).
Bioorg Med Chem Lett 23: 4842-7 (2013)
Targacept
Synthesis of quaternarya-amino acid-based arginase inhibitors via the Ugi reaction.
Bioorg Med Chem Lett 23: 4837-41 (2013)
Institutes For Pharmaceutical Discovery
The discovery of potent blockers of the canonical transient receptor channels, TRPC3 and TRPC6, based on an anilino-thiazole pharmacophore.
Bioorg Med Chem Lett 23: 4979-84 (2013)
Glaxosmithkline
Structure-activity relationships of benzimidazole-based glutaminyl cyclase inhibitors featuring a heteroaryl scaffold.
J Med Chem 56: 6613-25 (2013)
Probiodrug
Roles of phosphate recognition in inositol 1,3,4,5,6-pentakisphosphate 2-kinase (IPK1) substrate binding and activation.
J Biol Chem 288: 26908-13 (2013)
Mcgill University
Neuroactive diol and acyloin metabolites from cone snail-associated bacteria.
Bioorg Med Chem Lett 23: 4867-9 (2013)
University Of Utah
Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: wild type and mutant (L1196M) active compounds with unique binding mode.
Bioorg Med Chem Lett 23: 4911-8 (2013)
Aurigene Discovery Technologies
Access to 7?-analogs of codeine with mixed ?/? agonist activity via 6,7-?-epoxide opening.
Bioorg Med Chem Lett 23: 4870-4 (2013)
University Of Texas At Austin
3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors.
Eur J Med Chem 67: 344-51 (2013)
University Of Siena
Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation.
Eur J Med Chem 67: 335-43 (2013)
National Institute On Drug Abuse And The National Institute On Alcohol Abuse And Alcoholism
Rapid modifications of N-substitution in iminosugars: development of newß-glucocerebrosidase inhibitors and pharmacological chaperones for Gaucher disease.
Bioorg Med Chem 21: 5021-8 (2013)
Genomics Research Center
A medicinal chemistry perspective for targeting histone H3 lysine-79 methyltransferase DOT1L.
J Med Chem 56: 8972-83 (2013)
Baylor College Of Medicine
Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.
J Med Chem 56: 7049-59 (2013)
Novartis Institutes For Biomedical Research
Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis.
J Med Chem 56: 6457-66 (2013)
Karolinska Institutet
Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor.
J Med Chem 56: 6371-85 (2013)
Eisai
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.
Bioorg Med Chem Lett 23: 4857-61 (2013)
Abbvie
Absolute configuration of acremoxanthone C, a potent calmodulin inhibitor from Purpureocillium lilacinum.
J Nat Prod 76: 1454-60 (2013)
Universidad Nacional Aut£Noma De M£Xico
Mitotic kinesin Eg5 overcomes inhibition to the phase I/II clinical candidate SB743921 by an allosteric resistance mechanism.
J Med Chem 56: 6317-29 (2013)
The Beatson Institute For Cancer Research
A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities.
Eur J Med Chem 67: 325-34 (2013)
National University Of Singapore
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.
Eur J Med Chem 67: 269-79 (2013)
University Of Salerno
Microwave assisted synthesis of some hybrid molecules derived from norfloxacin and investigation of their biological activities.
Eur J Med Chem 67: 230-42 (2013)
Karadeniz Technical University
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.
Eur J Med Chem 67: 221-9 (2013)
Universiti Sains Malaysia
Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor.
Bioorg Med Chem 21: 5081-97 (2013)
Pfizer
2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors.
Bioorg Med Chem Lett 23: 5014-21 (2013)
Genentech
Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase.
Biochemistry 52: 5133-44 (2013)
The Scripps Research Institute
Cushing's syndrome: development of highly potent and selective CYP11B1 inhibitors of the (pyridylmethyl)pyridine type.
J Med Chem 56: 6022-32 (2013)
Saarland University
Lead identification of novel and selective TYK2 inhibitors.
Eur J Med Chem 67: 175-87 (2013)
Genentech
Evaluation of novel aryloxyalkyl derivatives of imidazole and 1,2,4-triazole as heme oxygenase-1 (HO-1) inhibitors and their antitumor properties.
Bioorg Med Chem 21: 5145-53 (2013)
University Of Catania
Carbonic anhydrase inhibitors: Synthesis and inhibition of the cytosolic mammalian carbonic anhydrase isoforms I, II and VII with benzene sulfonamides incorporating 4,5,6,7-tetrachlorophthalimide moiety.
Bioorg Med Chem 21: 5168-74 (2013)
Birla Institute Of Technology
Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.
Bioorg Med Chem 21: 5271-4 (2013)
University Of Groningen
In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg Med Chem 21: 5323-31 (2013)
Northwestern University
Structure activity relationship study of benzo[d]thiazol-2(3H)one baseds receptor ligands.
Bioorg Med Chem Lett 23: 5011-3 (2013)
University Of Mississippi
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg Med Chem Lett 23: 4944-7 (2013)
Chinese Academy Of Sciences
Identification of GNE-293, a potent and selective PI3Kd inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Bioorg Med Chem Lett 23: 4953-9 (2013)
Genentech
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
Cell Chem Biol 56: 8224-56 (2013)
Arena Pharmaceuticals
Total synthesis and full histone deacetylase inhibitory profiling of Azumamides A-E as well asß²- epi-Azumamide E andß³-epi-Azumamide E.
J Med Chem 56: 6512-20 (2013)
Technical University Of Denmark
Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation.
J Biol Chem 288: 26235-45 (2013)
Wageningen University
Novelß-dicarbonyl derivatives as inhibitors of aminopeptidase N (APN).
Bioorg Med Chem Lett 23: 4948-52 (2013)
Shandong University
Selected furanochalcones as inhibitors of monoamine oxidase.
Bioorg Med Chem Lett 23: 4985-9 (2013)
North-West University
Cembrane diterpenoids from the soft coral Sarcophyton trocheliophorum Marenzeller as a new class of PTP1B inhibitors.
Bioorg Med Chem 21: 5076-80 (2013)
Chinese Academy Of Sciences
2-Substituted 4-hydroxybutanamides as potential inhibitors of ?-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.
Bioorg Med Chem 21: 5154-67 (2013)
Jagiellonian University Medical College
Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors.
Bioorg Med Chem 21: 5118-29 (2013)
University Of Arizona
5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.
Bioorg Med Chem 21: 5130-8 (2013)
Latvian Association Of Human Genetics
Highly potent and selective nonsteroidal dual inhibitors of CYP17/CYP11B2 for the treatment of prostate cancer to reduce risks of cardiovascular diseases.
J Med Chem 56: 6101-7 (2013)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors.
J Med Chem 56: 6413-33 (2013)
Forma Therapeutics
Toxoflavins and deazaflavins as the first reported selective small molecule inhibitors of tyrosyl-DNA phosphodiesterase II.
J Med Chem 56: 6352-70 (2013)
University Of Manchester
Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Bioorg Med Chem Lett 23: 4674-9 (2013)
Elan Pharmaceuticals
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
Bioorg Med Chem Lett 23: 4511-6 (2013)
Osi Pharmaceuticals
Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
Bioorg Med Chem Lett 23: 4493-500 (2013)
Merz Pharmaceuticals
Exploring the orthosteric binding site of the ?-aminobutyric acid type A receptor using 4-(Piperidin-4-yl)-1-hydroxypyrazoles 3- or 5-imidazolyl substituted: design, synthesis, and pharmacological evaluation.
J Med Chem 56: 6536-40 (2013)
University Of Copenhagen
1-substituted (Dibenzo[b,d]thiophen-4-yl)-2-morpholino-4H-chromen-4-ones endowed with dual DNA-PK/PI3-K inhibitory activity.
J Med Chem 56: 6386-401 (2013)
Newcastle University
The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-carboxamide (SR144528).
J Med Chem 56: 6593-612 (2013)
University Of Texas-Pan American
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.
J Biol Chem 288: 25362-74 (2013)
University Of Queensland
Synthesis and biological evaluation of pyrazolo[4,3-d]pyrimidine analogues.
Eur J Med Chem 67: 152-7 (2013)
Sichuan University
Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.
Eur J Med Chem 67: 115-26 (2013)
University Of Bonn
The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.
Eur J Med Chem 67: 81-9 (2013)
Academy Of Sciences Of The Czech Republic
Molecular design, synthesis and biological evaluation of 1,4-dihydro-4-oxoquinoline ribonucleosides as TcGAPDH inhibitors with trypanocidal activity.
Bioorg Med Chem Lett 23: 4597-601 (2013)
Da Universidade De S£O Paulo
A novel series of metabotropic glutamate receptor 5 negative allosteric modulators based on a 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine core.
Bioorg Med Chem Lett 23: 4523-7 (2013)
Addex Therapeutics
Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-ribose)polymerase inhibitors.
Bioorg Med Chem Lett 23: 4501-5 (2013)
Takeda California
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
Bioorg Med Chem Lett 23: 4517-22 (2013)
Osi Pharmaceuticals
1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases.
Bioorg Med Chem Lett 23: 4547-51 (2013)
Universit£
One-pot tandem Hurtley-retro-Claisen-cyclisation reactions in the synthesis of 3-substituted analogues of 5-aminoisoquinolin-1-one (5-AIQ), a water-soluble inhibitor of PARPs.
Bioorg Med Chem 21: 5218-27 (2013)
University Of Bath
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.
Bioorg Med Chem 21: 5383-94 (2013)
Universit£
Design and synthesis of imidazolidine-2,4-dione derivatives as selective inhibitors by targeting protein tyrosine phosphatase-1B over T-cell protein tyrosine phosphatase.
Chem Biol Drug Des 82: 595-602 (2013)
Tianjin Medical University
Discovery of 2-methyl-1-{1-[(5-methyl-1H-indol-2-yl)carbonyl]piperidin-4-yl}propan-2-ol: a novel, potent and selective type 5 17ß-hydroxysteroid dehydrogenase inhibitor.
Bioorg Med Chem 21: 5261-70 (2013)
Astellas Pharma
Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors.
Bioorg Med Chem Lett 23: 5244-8 (2013)
Bristol-Myers Squibb R & D
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.
Bioorg Med Chem Lett 23: 4608-16 (2013)
Amgen
1,1-Dioxo-5,6-dihydro-[4,1,2]oxathiazines, a novel class of 11ß-HSD1 inhibitors for the treatment of diabetes.
Bioorg Med Chem Lett 23: 4685-91 (2013)
Sanofi Deutschland
Synthesis of novel diarylamino-1,3,5-triazine derivatives as FAK inhibitors with anti-angiogenic activity.
Bioorg Med Chem Lett 23: 4552-6 (2013)
University Of Paris
Carbamoyl pyridone HIV-1 integrase inhibitors 3. A diastereomeric approach to chiral nonracemic tricyclic ring systems and the discovery of dolutegravir (S/GSK1349572) and (S/GSK1265744).
J Med Chem 56: 5901-16 (2013)
Glaxosmithkline Research & Development
Optimization of N-benzoylindazole derivatives as inhibitors of human neutrophil elastase.
J Med Chem 56: 6259-72 (2013)
Universit£
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.
J Med Chem 56: 6495-511 (2013)
Novartis Institutes For Biomedical Research
Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.
Bioorg Med Chem 21: 5228-32 (2013)
Bezmialem Vakif University
Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.
Bioorg Med Chem Lett 23: 4591-6 (2013)
Astrazeneca
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1.
J Biol Chem 288: 23858-67 (2013)
University Of Iowa
Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.
J Biol Chem 288: 24656-65 (2013)
Université Montpellier 1
Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.
Eur J Med Chem 67: 64-74 (2013)
Instituto De Qu£Mica Org£Nica General (Csic)
Discovery and optimization of novel 4-phenoxy-6,7-disubstituted quinolines possessing semicarbazones as c-Met kinase inhibitors.
Bioorg Med Chem 21: 5246-60 (2013)
Shenyang Pharmaceutical University
Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors.
Bioorg Med Chem Lett 23: 4562-6 (2013)
Northwest Agriculture & Forestry University
LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor.
J Med Chem 56: 5673-4 (2014)
University Of Michigan Comprehensive Cancer Center
Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors.
J Med Chem 56: 5744-56 (2014)
Astellas Pharma
Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors.
Eur J Med Chem 66: 526-30 (2013)
Aston University
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
J Med Chem 56: 6054-68 (2013)
University Of Illinois College Of Pharmacy
Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.
Eur J Med Chem 66: 438-49 (2013)
Forman Christian College (A Chartered University)
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett 23: 4571-8 (2013)
Pfizer
Discovery and optimisation of 1-hydroxyimino-3,3-diphenylpropanes, a new class of orally active GPBAR1 (TGR5) agonists.
Bioorg Med Chem Lett 23: 4627-32 (2013)
F. Hoffmann-La Roche
Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain.
Bioorg Med Chem 21: 5316-22 (2013)
National Institute Of Radiological Sciences
Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.
Bioorg Med Chem 21: 5297-309 (2013)
The University Of Tokyo
Synthesis and in vitro cellular uptake of 11C-labeled 5-aminolevulinic acid derivative to estimate the induced cellular accumulation of protoporphyrin IX.
Bioorg Med Chem Lett 23: 4567-70 (2013)
National Institute Of Radiological Sciences
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.
J Med Chem 56: 6069-87 (2013)
Entremed
A novel series of highly potent 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitors.
J Med Chem 56: 6234-47 (2013)
Palack£
Discovery of potent, isoform-selective inhibitors of histone deacetylase containing chiral heterocyclic capping groups and a N-(2-aminophenyl)benzamide binding unit.
J Med Chem 56: 6156-74 (2013)
University College London
Key mutations alter the cytochrome P450 BM3 conformational landscape and remove inherent substrate bias.
J Biol Chem 288: 25387-99 (2013)
University Of Manchester
Design and synthesis of novel 4-(4-oxo-2-arylthiazolidin-3-yl)benzenesulfonamides as selective inhibitors of carbonic anhydrase IX over I and II with potential anticancer activity.
Eur J Med Chem 66: 372-9 (2013)
Manipal College Of Pharmaceutical Sciences
DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design.
Chembiochem 14: 1309-15 (2013)
The Johns Hopkins University
Cyclic enkephalins with a diversely substituted guanidine bridge or a thiourea bridge: synthesis, biological and structural evaluations.
J Med Chem 56: 5964-5973 (2013)
Universit£
Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors.
J Med Chem 56: 5917-30 (2014)
Fondazione Istituto Italiano Di Tecnologia
Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).
Bioorg Med Chem 21: 5339-54 (2013)
China Pharmaceutical University
Synthesis and the 5-HT6 receptor antagonistic effect of 3-arylsulfonylamino-5,6-dihydro-6-substituted pyrazolo[3,4]pyridinones for neuropathic pain treatment.
Bioorg Med Chem Lett 23: 4696-700 (2013)
Korea Institutes Of Science And Technology (Kist)
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Bioorg Med Chem Lett 23: 4652-6 (2013)
Novartis Institutes For Biomedical Research
DXR inhibition by potent mono- and disubstituted fosmidomycin analogues.
J Med Chem 56: 6190-9 (2013)
Uppsala University
Identification of N-substituted 8-azatetrahydroquinolone derivatives as selective and orally active M(1) and M(4) muscarinic acetylcholine receptors agonists.
Bioorg Med Chem Lett 23: 4644-7 (2013)
Dainippon Sumitomo Pharma
Synthesis and in vivo evaluation of [(18)F]2-(4-(4-(2-(2-fluoroethoxy)phenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione ([(18)F]FECUMI-101) as an imaging probe for 5-HT1A receptor agonist in nonhuman primates.
Bioorg Med Chem 21: 5598-604 (2013)
Columbia University Medical Center
Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds.
Bioorg Med Chem 21: 5548-60 (2013)
The University Of Memphis
Antiproliferative activity on human prostate carcinoma cell lines of new peptidomimetics containing the spiroazepinoindolinone scaffold.
Bioorg Med Chem 21: 5470-9 (2013)
Universit£
Synthetic studies of centromere-associated protein-E (CENP-E) inhibitors: 1.Exploration of fused bicyclic core scaffolds using electrostatic potential map.
Bioorg Med Chem 21: 5488-502 (2013)
Takeda Pharmaceutical
4-Amino-7-chloroquinolines: probing ligand efficiency provides botulinum neurotoxin serotype A light chain inhibitors with significant antiprotozoal activity.
J Med Chem 56: 5860-71 (2014)
University Of Belgrade
A class of sulfonamides with strong inhibitory action against the ?-carbonic anhydrase from Trypanosoma cruzi.
J Med Chem 56: 5773-81 (2013)
Istanbul University
3-substituted indole inhibitors against Francisella tularensis FabI identified by structure-based virtual screening.
J Med Chem 56: 5275-87 (2014)
Naval Research Laboratories
ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27.
ACS Med Chem Lett 4: 456-459 (2013)
University Of California
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Sci Rep 3: (2013)
Chantest
Quercitylcinnamates, a new series of antidiabetic bioconjugates possessinga-glucosidase inhibition and antioxidant.
Eur J Med Chem 66: 296-304 (2013)
Chulalongkorn University
Modulation ofavß3- anda5ß1-integrin-mediated adhesion by dehydro-ß-amino acids containing peptidomimetics.
Eur J Med Chem 66: 258-68 (2013)
University Of Bologna
Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Bioorg Med Chem 21: 5461-9 (2013)
University Of Montpellier
Oxazolopyridines and thiazolopyridines as monoamine oxidase B inhibitors for the treatment of Parkinson's disease.
Bioorg Med Chem 21: 5480-7 (2013)
Korea Institute Of Science And Technology
Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.
Bioorg Med Chem 21: 5451-60 (2013)
Banaras Hindu University
Investigations on synthesis and structure elucidation of novel [1,2,4]triazolo[1,2-a]pyridazine-1-thiones and their inhibitory activity against inducible nitric oxide synthase.
Bioorg Med Chem 21: 5518-31 (2013)
Ernst-Moritz-Arndt University Greifswald
Synthesis anda-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-ß-d-glucopyranosides.
Bioorg Med Chem 21: 5442-50 (2013)
Xi'An Jiaotong University
A 2,6,9-hetero-trisubstituted purine inhibitor exhibits potent biological effects against multiple myeloma cells.
Bioorg Med Chem 21: 5618-28 (2013)
University Of Toronto
Hydantoin based inhibitors of MMP13--discovery of AZD6605.
Bioorg Med Chem Lett 23: 4705-12 (2013)
Astrazeneca
Synthesis and biological evaluation of aminobenzimidazole derivatives with a phenylcyclohexyl acetic acid group as anti-obesity and anti-diabetic agents.
Bioorg Med Chem Lett 23: 4713-8 (2013)
Korea Research Institute Of Chemical Technology
Design and synthesis of novel series of 5-HT6 receptor ligands having indole, a central aromatic core and 1-amino-4 methyl piperazine as a positive ionizable group.
Bioorg Med Chem 21: 5573-82 (2013)
Ewha Womans University
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.
Bioorg Med Chem 21: 5629-46 (2013)
Industrial Research
C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors.
Bioorg Med Chem 21: 5561-72 (2013)
Mitsubishi Tanabe Pharma
Carbonic anhydrase inhibitors. Phenols incorporating 2- or 3-pyridyl-ethenylcarbonyl and tertiary amine moieties strongly inhibit Saccharomyces cerevisiae ß-carbonic anhydrase.
J Enzyme Inhib Med Chem 29: 495-9 (2014)
Ataturk University
Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development.
J Med Chem 56: 5979-83 (2014)
Roche Research Center
2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.
J Med Chem 56: 5940-8 (2014)
Merck Research Laboratories
Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.
J Med Chem 56: 5247-60 (2014)
National Health Research Institutes
Exploring 4-substituted-2-thiazolylhydrazones from 2-, 3-, and 4-acetylpyridine as selective and reversible hMAO-B inhibitors.
Eur J Med Chem 66: 221-7 (2013)
Sapienza University Of Rome
Discovery of novel tetrahydro-pyrazolo [4,3-c] pyridines for the treatment of neuropathic pain: synthesis and neuropharmacology.
Eur J Med Chem 66: 211-20 (2013)
Birla Institute Of Technology & Science - Pilani
Development of stapled short helical peptides capable of inhibiting vitamin D receptor (VDR)-coactivator interactions.
Bioorg Med Chem Lett 23: 4292-6 (2013)
National Institute Of Health Sciences
3-Aryl-3-arylmethoxyazetidines. A new class of high affinity ligands for monoamine transporters.
Bioorg Med Chem Lett 23: 4404-7 (2013)
University Of New Orleans
Discovery of triazines as potent, selective and orally active PDE4 inhibitors.
Bioorg Med Chem Lett 23: 4308-14 (2013)
Biocrea
Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target.
J Nat Prod 76: 1064-70 (2013)
University Of London
Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities.
Bioorg Med Chem Lett 23: 4319-23 (2013)
Kyoto University
3'-Oxo-, amino-, thio- and sulfone-acetic acid modified thymidines: effect of increased acidity on ribonuclease A inhibition.
Bioorg Med Chem 21: 4634-45 (2013)
Institute Of Technology Kharagpur
Heteroaromatic and aniline derivatives of piperidines as potent ligands for vesicular acetylcholine transporter.
J Med Chem 56: 6216-33 (2013)
Washington University
Mono-carbonyl curcumin analogues as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.
Bioorg Med Chem Lett 23: 4362-6 (2013)
Wenzhou Medical College
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.
J Med Chem 56: 5843-59 (2014)
Sun Yat-Sen University
Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists.
Eur J Med Chem 66: 193-203 (2013)
University Of Concepcion
Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide ?-neoendorphin.
Bioorg Med Chem Lett 23: 4347-50 (2013)
Memorial Sloan-Kettering Cancer Center
Pin1 inhibitors: Pitfalls, progress and cellular pharmacology.
Bioorg Med Chem Lett 23: 4283-91 (2013)
Horizon Discovery
11ß-HSD1 inhibitors from Walsura cochinchinensis.
J Nat Prod 76: 1319-27 (2013)
Chinese Academy Of Sciences
Selective cannabinoid receptor type 2 (CB2) agonists: optimization of a series of purines leading to the identification of a clinical candidate for the treatment of osteoarthritic pain.
J Med Chem 56: 5722-33 (2013)
Lilly Research Laboratories
Thiazolylaminomannosides as potent antiadhesives of type 1 piliated Escherichia coli isolated from Crohn's disease patients.
J Med Chem 56: 5395-406 (2014)
Lunam Universit£
Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.
Medchemcomm 4: 822-826 (2013)
Baylor College Of Medicine
Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase.
ACS Med Chem Lett 4: 542-546 (2013)
Baylor College Of Medicine
L-Aminoacyl-triazine derivatives are isoform-selective PI3K? inhibitors that target non-conserved Asp862 of PI3K?
ACS Med Chem Lett 4: 206-210 (2013)
Monash University (Parkville Campus)
Site-specific inhibitory mechanism for amyloid ß42 aggregation by catechol-type flavonoids targeting the Lys residues.
J Biol Chem 288: 23212-24 (2013)
Kyoto University
Nonclassical antifolates, part 4. 5-(2-aminothiazol-4-yl)-4-phenyl-4H-1,2,4-triazole-3-thiols as a new class of DHFR inhibitors: synthesis, biological evaluation and molecular modeling study.
Eur J Med Chem 66: 135-45 (2013)
King Saud University
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Eur J Med Chem 66: 122-34 (2013)
Universidade Federal Do Rio De Janeiro
Nitric oxide donating anilinopyrimidines: synthesis and biological evaluation as EGFR inhibitors.
Eur J Med Chem 66: 82-90 (2013)
China Pharmaceutical University
Design, synthesis and preliminary evaluation of a series of histone deacetylase inhibitors carrying a benzodiazepine ring.
Eur J Med Chem 66: 56-68 (2013)
University Of Florence
Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing.
Bioorg Med Chem 21: 4477-84 (2013)
Chungbuk National University
Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins.
Bioorg Med Chem Lett 23: 4441-6 (2013)
University Of California
Anticancer activity and SAR studies of substituted 1,4-naphthoquinones.
Bioorg Med Chem 21: 4662-9 (2013)
The Ohio State University
Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.
Bioorg Med Chem Lett 23: 4336-41 (2013)
University Of Waterloo
Vialinin A is a ubiquitin-specific peptidase inhibitor.
Bioorg Med Chem Lett 23: 4328-31 (2013)
Tokyo University Of Agriculture
Anion inhibition studies of the ?-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
Bioorg Med Chem 21: 4472-6 (2013)
University Of Tampere And Tampere University Hospital
Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase.
Bioorg Med Chem 21: 4530-40 (2013)
University Of Pennsylvania
Structure-based design of flavone-based inhibitors of wild-type and T315I mutant of ABL.
Bioorg Med Chem Lett 23: 4324-7 (2013)
Korea Advanced Institute Of Science And Technology
Design, synthesis and biological studies of novel tubulin inhibitors.
Bioorg Med Chem Lett 23: 4465-8 (2013)
The Ohio State University
Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.
J Med Chem 56: 5949-63 (2014)
National Institute Of Diabetes And Digestive And Kidney Diseases
Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.
J Med Chem 56: 5456-63 (2013)
Universit£
Synthesis of substituted diphenyl sulfones and their structure-activity relationship with the antagonism of 5-??6 receptors.
Bioorg Med Chem 21: 4614-27 (2013)
Chemical Diversity Research Institute (Cdri)
Determination of the binding mode and interacting amino-acids for dibasic H3 receptor antagonists.
Bioorg Med Chem 21: 4526-9 (2013)
Bioprojet-Biotech
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.
Bioorg Med Chem Lett 23: 4419-23 (2013)
Jagiellonian University Medical College
Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorg Med Chem Lett 23: 4398-403 (2013)
Frederick National Laboratory For Cancer Research
Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase.
Eur J Med Chem 66: 22-31 (2013)
Sun Yat-Sen University
Histone deacetylase inhibitors equipped with estrogen receptor modulation activity.
J Med Chem 56: 5782-96 (2013)
Georgia Institute Of Technology
A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice.
J Med Chem 56: 5553-61 (2014)
University Of Michigan
Sulfonamides containing coumarin moieties selectively and potently inhibit carbonic anhydrases II and IX: design, synthesis, inhibitory activity and 3D-QSAR analysis.
Eur J Med Chem 66: 1-11 (2013)
Nanjing University
Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.
Bioorg Med Chem 21: 4575-80 (2013)
Universit£
Design, synthesis and evaluation of novel 2-hydroxypyrrolobenzodiazepine-5,11-dione analogues as potent angiotensin converting enzyme (ACE) inhibitors.
Bioorg Med Chem 21: 4485-93 (2013)
Csir-Indian Institute Of Chemical Technology
Orally available and efficaciousa4ß1/a4ß7 integrin inhibitors.
Bioorg Med Chem Lett 23: 4370-3 (2013)
Elan Pharmaceuticals
Phosphinic acid-based inhibitors of tubulin polyglutamylases.
Bioorg Med Chem Lett 23: 4408-12 (2013)
University Of British Columbia
Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists.
Bioorg Med Chem Lett 23: 4388-92 (2013)
Merck Research Laboratories
Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India.
J Nat Prod 76: 1187-90 (2013)
Tel-Aviv University
New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease.
Chembiochem 14: 1239-47 (2013)
Nankai University
Functional selectivity of 6'-guanidinonaltrindole (6'-GNTI) at kappa-opioid receptors in striatal neurons.
J Biol Chem 288: 22387-98 (2013)
The Scripps Research Institute
Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.
Bioorg Med Chem Lett 23: 4381-7 (2013)
Osi Pharmaceuticals
Rationally designed sulfamides as glutamate carboxypeptidase II inhibitors.
Chem Biol Drug Des 82: 612-9 (2013)
Washington State University At Pullman
Targeting gain of function and resistance mutations in Abl and KIT by hybrid compound design.
J Med Chem 56: 5757-72 (2014)
Technical University Of Dortmund
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity.
Medchemcomm 3: 720-724 (2012)
Baylor University
Synthesis of N-substituted acyclicß-amino acids and their investigation as GABA uptake inhibitors.
Eur J Med Chem 65: 487-99 (2013)
Zentrum F£R Pharmaforschung
Naphthalimides exhibit in vitro antiproliferative and antiangiogenic activities by inhibiting both topoisomerase II (topo II) and receptor tyrosine kinases (RTKs).
Eur J Med Chem 65: 477-86 (2013)
East China University Of Science And Technology
Dimeric and trimeric triazole based molecules as a new class of Hsp90 molecular chaperone inhibitors.
Eur J Med Chem 65: 464-76 (2013)
University Of Salerno
Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
Bioorg Med Chem Lett 23: 4037-43 (2013)
Lundbeck Research Usa
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.
Bioorg Med Chem 21: 4581-90 (2013)
Kurukshetra University
Synthesis, characterization, and biological assessment of the four stereoisomers of the H(3) receptor antagonist 5-fluoro-2-methyl-N-[2-methyl-4-(2-methyl[1,3']bipyrrolidinyl-1'-yl)phenyl]benzamide.
Bioorg Med Chem Lett 23: 4044-7 (2013)
Sanofi Us
Design, synthesis and structure-activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists.
Bioorg Med Chem Lett 23: 4026-30 (2013)
Astrazeneca
A highly catalytically active¿-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.
Bioorg Med Chem Lett 23: 4067-71 (2013)
Istituto Di Biochimica Delle Proteine-Cnr
Hydroxyethylamine-based inhibitors of BACE1: P1-P3 macrocyclization can improve potency, selectivity, and cell activity.
Bioorg Med Chem Lett 23: 4459-64 (2013)
Amgen
Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes.
Bioorg Med Chem Lett 23: 4185-90 (2013)
Korea University
Novel triple reuptake inhibitors with low risk of CAD associated liabilities: design, synthesis and biological activities of 4-[(1S)-1-(3,4-dichlorophenyl)-2-methoxyethyl]piperidine and related compounds.
Bioorg Med Chem 21: 4600-13 (2013)
Takeda Pharmaceutical
7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
Bioorg Med Chem 21: 4502-10 (2013)
Universit£
Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.
Bioorg Med Chem Lett 23: 4091-5 (2013)
Menarini Ricerche
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2.
Bioorg Med Chem Lett 23: 4085-90 (2013)
Novartis Institutes For Biomedical Research
Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERa-selective antagonist.
Bioorg Med Chem Lett 23: 4031-6 (2013)
The University Of Tokyo
Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Bioorg Med Chem Lett 23: 4132-40 (2013)
Boehringer Ingelheim (Canada)
Synthesis and changes in affinity for NOP and opioid receptors of novel hexapeptides containing ?(2)-tryptophan analogues.
Bioorg Med Chem Lett 23: 4052-5 (2013)
Bulgarian Academy Of Sciences
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
Bioorg Med Chem 21: 4559-69 (2013)
Universidade T£Cnica De Lisboa
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
J Med Chem 56: 5514-40 (2014)
The Walter And Eliza Hall Institute Of Medical Research
Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.
J Med Chem 56: 5601-12 (2013)
Shanghai Institute Of Materia Medica
Synthesis, biological evaluation, X-ray molecular structure and molecular docking studies of RGD mimetics containing 6-amino-2,3-dihydroisoindolin-1-one fragment as ligands of integrinaIIbß3.
Bioorg Med Chem 21: 4646-61 (2013)
A.V. Bogatsky Physico-Chemical Institute Of The National Academy Of Sciences Of Ukraine
Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies.
Bioorg Med Chem 21: 4730-43 (2013)
The Ohio State University
Synthesis and structure-activity relationship of 2-arylamino-4-aryl-pyrimidines as potent PAK1 inhibitors.
Bioorg Med Chem Lett 23: 4072-5 (2013)
Astex Pharmaceuticals
The discovery of potent selective NPY Y(2) antagonists.
Bioorg Med Chem Lett 23: 4141-4 (2013)
Janssen Research And Development
Discovery of TD-8954, a clinical stage 5-HT(4) receptor agonist with gastrointestinal prokinetic properties.
Bioorg Med Chem Lett 23: 4210-5 (2013)
Theravance
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics.
Bioorg Med Chem 21: 4714-29 (2013)
Takeda Pharmaceutical
Siderocalin outwits the coordination chemistry of vibriobactin, a siderophore of Vibrio cholerae.
ACS Chem Biol 8: 1882-7 (2013)
University Of California
?-aminobutyric acid(C) (GABAC) selective antagonists derived from the bioisosteric modification of 4-aminocyclopent-1-enecarboxylic acid: amides and hydroxamates.
J Med Chem 56: 5626-30 (2013)
University Of Sydney
A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.
ACS Chem Biol 8: 1747-54 (2013)
The Scripps Research Institute
Highly efficient biocompatible neuroprotectants with dual activity as antioxidants and P2Y receptor agonists.
J Med Chem 56: 4938-52 (2013)
Bar-Ilan University
Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives.
J Med Chem 56: 5335-50 (2014)
Bar-Ilan University
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
J Med Chem 56: 5562-86 (2013)
Icahn School Of Medicine At Mount Sinai
Discovery and structure-activity relationships of ent-Kaurene diterpenoids as potent and selective 11ß-HSD1 inhibitors: potential impact in diabetes.
Eur J Med Chem 65: 403-14 (2013)
Chinese Academy Of Sciences
Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y12 receptor.
Eur J Med Chem 65: 360-75 (2013)
Astrazeneca
Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: observation of extensive dynamics in an enzyme/inhibitor complex.
Bioorg Med Chem Lett 23: 4107-11 (2013)
Bristol-Myers Squibb Research And Development
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.
Bioorg Med Chem Lett 23: 4099-101 (2013)
Seoul National University
New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire.
Bioorg Med Chem Lett 23: 4248-52 (2013)
University Of Monastir
Synthesis and evaluation of a conditionally-silent agonist for thea7 nicotinic acetylcholine receptor.
Bioorg Med Chem Lett 23: 4145-9 (2013)
University Of Florida
The identification of novel p38? isoform selective kinase inhibitors having an unprecedented p38? binding mode.
Bioorg Med Chem Lett 23: 4120-6 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Notable difference in anti-HIV activity of integrase inhibitors as a consequence of geometric and enantiomeric configurations.
Bioorg Med Chem Lett 23: 4112-6 (2013)
University Of Georgia
Synthesis and acrosin inhibitory activities of 5-phenyl-1H-pyrazole-3-carboxylic acid amide derivatives.
Bioorg Med Chem Lett 23: 4177-84 (2013)
Second Military Medical University
Dissecting cytochrome P450 3A4-ligand interactions using ritonavir analogues.
Biochemistry 52: 4474-81 (2013)
University Of California Irvine
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant.
J Med Chem 56: 5382-94 (2014)
Universit£
2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents.
Bioorg Med Chem Lett 23: 4206-9 (2013)
Bristol-Myers Squibb
De novo tyrosinase inhibitor: 4-(6,7-dihydro-5H-indeno[5,6-d]thiazol-2-yl)benzene-1,3-diol (MHY1556).
Bioorg Med Chem Lett 23: 4172-6 (2013)
Pusan National University
Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
Bioorg Med Chem Lett 23: 4253-7 (2013)
Sanford-Burnham Medical Research Institute
Potent MCH-1 receptor antagonists from cis-1,4-diaminocyclohexane-derived indane analogs.
Bioorg Med Chem Lett 23: 4216-20 (2013)
Hoffmann-La Roche
Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
J Nat Prod 76: 1105-12 (2013)
Universit£
PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3.
ACS Chem Biol 8: 1698-703 (2013)
Ume£
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase
J Med Chem 56: 5675-90 (2014)
Genomics Institute Of The Novartis Research Foundation
An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.
J Med Chem 56: 5464-72 (2013)
Novartis Institutes For Biomedical Research
The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype.
J Biol Chem 288: 23488-504 (2013)
University Of Notre Dame
Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group.
Bioorg Med Chem 21: 4132-42 (2013)
Universidad De Granada
Identification of 1,6-dihydropyrazolo[4,3-c]carbazoles and 3,6-dihydropyrazolo[3,4-c]carbazoles as new Pim kinase inhibitors.
Bioorg Med Chem 21: 4102-11 (2013)
Clermont Universit£
BACE1 inhibitors: a head group scan on a series of amides.
Bioorg Med Chem Lett 23: 4239-43 (2013)
F. Hoffmann-La Roche
Evaluation of thiazole containing biaryl analogs as diacylglycerol acyltransferase 1 (DGAT1) inhibitors.
Eur J Med Chem 65: 337-47 (2013)
Piramal Enterprises
Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3,4-diphenylfuran-2-ones.
Eur J Med Chem 65: 323-36 (2013)
Henan University Of Traditional Chinese Medicine
Constrained H-Phe-Phe-NH2 analogues with high affinity to the substance P 1-7 binding site and with improved metabolic stability and cell permeability.
J Med Chem 56: 4953-65 (2013)
Uppsala University
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selectivea4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
J Med Chem 56: 5495-504 (2014)
University Of Illinois At Chicago
Thes2 receptor: a novel protein for the imaging and treatment of cancer.
J Med Chem 56: 7137-60 (2013)
Washington University
Discovery of new PPAR? agonists based on arylopeptoids.
Bioorg Med Chem Lett 23: 4162-5 (2013)
University Of Copenhagen
Synthesis of mixed (E,Z)-, (E)-, and (Z)-norendoxifen with dual aromatase inhibitory and estrogen receptor modulatory activities.
J Med Chem 56: 4611-8 (2013)
Purdue University
Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety.
J Med Chem 56: 5130-41 (2013)
Friedrich-Alexander University
The development of a new class of inhibitors for betaine-homocysteine S-methyltransferase.
Eur J Med Chem 65: 256-75 (2013)
Academy Of Sciences Of The Czech Republic
1-substituted apomorphines as potent dopamine agonists.
Bioorg Med Chem 21: 4143-50 (2013)
University Of Tartu
N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats.
Bioorg Med Chem Lett 23: 3713-8 (2013)
Vanderbilt University Medical Center
Macrocyclic inhibitors of 3C and 3C-like proteases of picornavirus, norovirus, and coronavirus.
Bioorg Med Chem Lett 23: 3709-12 (2013)
Wichita State University
Discovery of non-LBD inhibitor for androgen receptor by structure-guide design.
Bioorg Med Chem Lett 23: 3887-90 (2013)
Korea Research Institute Of Chemical Technology
Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus.
Bioorg Med Chem Lett 23: 3841-7 (2013)
Boehringer Ingelheim (Canada)
Heterocyclic modification of a novel bicyclo[3.1.0]hexane NPY1 receptor antagonist.
Bioorg Med Chem Lett 23: 3814-7 (2013)
Bristol-Myers Squibb Research And Development
Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.
Bioorg Med Chem Lett 23: 3741-8 (2013)
Novartis Institutes For Biomedical Research
Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells.
Bioorg Med Chem Lett 23: 3769-74 (2013)
University Of Science And Technology
Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.
Bioorg Med Chem Lett 23: 3802-5 (2013)
Kyoto University
Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors.
Bioorg Med Chem Lett 23: 3732-7 (2013)
University Of California
Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments.
Bioorg Med Chem Lett 23: 3728-31 (2013)
Universit£
Characterization of maleimide-based glycogen synthase kinase-3 (GSK-3) inhibitors as stimulators of steroidogenesis.
J Med Chem 56: 5115-29 (2013)
University Of Illinois At Chicago
Quantitative analysis of histone demethylase probes using fluorescence polarization.
J Med Chem 56: 5198-202 (2013)
University Of Colorado
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.
Eur J Med Chem 65: 240-8 (2013)
Madurai Kamaraj University
The synthesis of neurotensin antagonist SR 48692 for prostate cancer research.
Bioorg Med Chem 21: 4378-87 (2013)
Durham University
Opioid receptor selectivity profile change via isosterism for 14-O-substituted naltrexone derivatives.
Bioorg Med Chem Lett 23: 3719-22 (2013)
Virginia Commonwealth University
The development of CNS-active LRRK2 inhibitors using property-directed optimisation.
Bioorg Med Chem Lett 23: 3690-6 (2013)
The University Of Sydney
Identification of 2-(2-(1-naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic acid (setipiprant/ACT-129968), a potent, selective, and orally bioavailable chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonist.
J Med Chem 56: 4899-911 (2013)
Actelion Pharmaceuticals
Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes.
ACS Chem Biol 8: 1775-84 (2013)
University Of Konstanz
Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design.
Bioorg Med Chem 21: 4233-49 (2013)
Asubio Pharma
Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.
Bioorg Med Chem 21: 4218-24 (2013)
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University)
Synthesis and biological evaluation of a targeted DNA-binding transcriptional activator with HDAC8 inhibitory activity.
Bioorg Med Chem 21: 4201-9 (2013)
Kyoto University
Structure-activity relationship studies and sleep-promoting activity of novel 1-chloro-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 2.
Bioorg Med Chem Lett 23: 3857-63 (2013)
Actelion Pharmaceuticals
Metabolites from Microcystis aeruginosa bloom material collected at a water reservoir near Kibbutz Hafetz Haim, Israel.
J Nat Prod 76: 1196-200 (2013)
Tel-Aviv University
Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid (BQCA) as allosteric modulators of the M1 muscarinic receptor.
J Med Chem 56: 5151-72 (2013)
Monash University
Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition.
J Med Chem 56: 5059-70 (2013)
Virginia Commonwealth University
Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).
J Med Chem 56: 5208-12 (2013)
Vanderbilt University Medical Center
8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.
J Med Chem 56: 5182-97 (2013)
University Of Bonn
A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.
J Med Chem 56: 4990-5008 (2013)
Indiana University School Of Medicine
Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.
J Med Chem 56: 4880-98 (2013)
University Of Maryland
Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase.
Bioorg Med Chem 21: 4351-7 (2013)
Centre For Addiction And Mental Health
The synergic modeling for the binding of fluoroquinolone antibiotics to the hERG potassium channel.
Bioorg Med Chem Lett 23: 3848-51 (2013)
Takeda Pharmaceutical
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.
Bioorg Med Chem Lett 23: 3798-801 (2013)
Kitasato University
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.
Eur J Med Chem 64: 629-37 (2013)
Drug Discovery Laboratory
Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein.
J Med Chem 56: 5033-47 (2013)
Ibitecs, Cea
Re-evolution of the 2-phenylquinolines: ligand-based design, synthesis, and biological evaluation of a potent new class of Staphylococcus aureus NorA efflux pump inhibitors to combat antimicrobial resistance.
J Med Chem 56: 4975-89 (2013)
Universit£
A thienopyrimidine derivative induces growth inhibition and apoptosis in human cancer cell lines via inhibiting Aurora B kinase activity.
Eur J Med Chem 65: 151-7 (2013)
Fudan University
Expanding chemical diversity of conotoxins: peptoid-peptide chimeras of the sodium channel blocker ?-KIIIA and its selenopeptide analogues.
Eur J Med Chem 65: 144-50 (2013)
University Of Gdansk
Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.
Eur J Med Chem 65: 134-43 (2013)
Fudan University
Discovery of a small molecular compound simultaneously targeting RXR and HADC: design, synthesis, molecular docking and bioassay.
Bioorg Med Chem Lett 23: 3891-5 (2013)
Shenyang Pharmaceutical University
The discovery of BMS-457, a potent and selective CCR1 antagonist.
Bioorg Med Chem Lett 23: 3833-40 (2013)
Bristol-Myers Squibb
Optimization of novel nipecotic bis(amide) inhibitors of the Rho/MKL1/SRF transcriptional pathway as potential anti-metastasis agents.
Bioorg Med Chem Lett 23: 3826-32 (2013)
College Of Pharmacy
Membrane anchoring¿-secretase modulators with terpene-derived moieties.
Bioorg Med Chem Lett 23: 3852-6 (2013)
Technische Universit£T Darmstadt
Selectivity of phenothiazine cholinesterase inhibitors for neurotransmitter systems.
Bioorg Med Chem Lett 23: 3822-5 (2013)
Dalhousie University
Hypoxia induced CA9 inhibitory targeting by two different sulfonamide derivatives including acetazolamide in human glioblastoma.
Bioorg Med Chem 21: 3949-57 (2013)
University Of W£Rzburg
1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies.
Bioorg Med Chem 21: 4288-95 (2013)
University Of Alberta
Indazoles as potential c-Met inhibitors: design, synthesis and molecular docking studies.
Eur J Med Chem 65: 112-8 (2013)
Guangdong Pharmaceutical University
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
J Med Chem 56: 4320-42 (2013)
Amgen
Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex.
Biochemistry 52: 4217-28 (2013)
Stony Brook University
Discovery of 7-oxopyrazolo[1,5-a]pyrimidine-6-carboxamides as potent and selective CB(2) cannabinoid receptor inverse agonists.
J Med Chem 56: 4482-96 (2013)
Universit£
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.
Eur J Med Chem 65: 51-9 (2013)
Jamia Hamdard (Hamdard University)
Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor.
Bioorg Med Chem Lett 23: 3927-34 (2013)
Targacept
In vitro and in vivo evaluation of polymethylene tetraamine derivatives as NMDA receptor channel blockers.
Bioorg Med Chem Lett 23: 3901-4 (2013)
Chiba University
Structural optimization, biological evaluation, and application of peptidomimetic prostate specific antigen inhibitors.
J Med Chem 56: 4224-35 (2013)
The Johns Hopkins University
Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.
Eur J Med Chem 65: 41-50 (2013)
University Of Camerino
Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A2 receptor antagonists.
Eur J Med Chem 65: 32-40 (2013)
University Of Liege
Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.
Eur J Med Chem 65: 1-11 (2013)
National University Of Singapore
Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery.
Bioorg Med Chem 21: 4266-78 (2013)
City Of Hope National Medical Center
Antagonism of L-type Ca2+ channels CaV1.3 and CaV1.2 by 1,4-dihydropyrimidines and 4H-pyrans as dihydropyridine mimics.
Bioorg Med Chem 21: 4365-73 (2013)
Northwestern University
Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
ACS Chem Biol 8: 1713-21 (2013)
The University Of Tokyo
Design, synthesis, and initial evaluation of a high affinity positron emission tomography probe for imaging matrix metalloproteinases 2 and 9.
J Med Chem 56: 4912-20 (2013)
Eth Zurich
The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.
ACS Med Chem Lett 4: 486-490 (2013)
Vanderbilt University
Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes.
ACS Med Chem Lett 4: 441-445 (2013)
University Of Southern Denmark
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region.
Eur J Med Chem 64: 589-602 (2013)
Seoul National University
Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.
Eur J Med Chem 64: 562-78 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
New insight into adenosine receptors selectivity derived from a novel series of [5-substituted-4-phenyl-1,3-thiazol-2-yl] benzamides and furamides.
Eur J Med Chem 63: 924-34 (2013)
B.V. Patel Pharmaceutical Education And Research Development
Further studies on bis-charged tetraazacyclophanes as potent inhibitors of small conductance Ca(2+)-activated K+ channels.
Eur J Med Chem 63: 907-23 (2013)
University College London
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
Eur J Med Chem 64: 540-53 (2013)
China Pharmaceutical University
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.
Eur J Med Chem 64: 512-28 (2013)
Universit£
Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures.
Bioorg Med Chem 21: 4342-50 (2013)
Research Foundation Itsuu Laboratory
Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator.
Bioorg Med Chem 21: 4420-5 (2013)
The University Of Queensland
Potent suppression of c-di-GMP synthesis via I-site allosteric inhibition of diguanylate cyclases with 2'-F-c-di-GMP.
Bioorg Med Chem 21: 4396-404 (2013)
University Of Maryland
Natural product hybrid and its superacid synthesized analogues: dodoneine and its derivatives show selective inhibition of carbonic anhydrase isoforms I, III, XIII and XIV.
Bioorg Med Chem 21: 3790-4 (2013)
Superacid Group In Organic Synthesis Team-Universit£
Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
Bioorg Med Chem Lett 23: 3818-21 (2013)
University Of California
Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor.
Bioorg Med Chem Lett 23: 3884-6 (2013)
Kumamoto University
Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity.
Bioorg Med Chem 21: 3780-9 (2013)
Universit£
Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors.
Bioorg Med Chem 21: 4301-10 (2013)
Xiangtan University
20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs.
Bioorg Med Chem 21: 4279-87 (2013)
Chinese Academy Of Sciences
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
Bioorg Med Chem Lett 23: 3914-9 (2013)
Bristol-Myers Squibb Research And Development
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors.
Bioorg Med Chem Lett 23: 3983-7 (2013)
Jeil Pharmaceutical
Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase.
Bioorg Med Chem Lett 23: 3910-3 (2013)
Johns Hopkins University
Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases.
ACS Chem Biol 8: 1488-96 (2013)
University Of Oxford
A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.
Medchemcomm 4: 847-851 (2013)
Virginia Commonwealth University
Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class ofs1 ligands.
Eur J Med Chem 64: 488-97 (2013)
Nstri
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity.
Bioorg Med Chem 21: 3695-701 (2013)
Universit£
Antagonists for the orphan G-protein-coupled receptor GPR55 based on a coumarin scaffold.
J Med Chem 56: 4798-810 (2013)
University Of Bonn
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitors.
J Med Chem 56: 6279-96 (2013)
Universit£
X-ray crystal structures of the Escherichia coli RNA polymerase in complex with benzoxazinorifamycins.
J Med Chem 56: 4758-63 (2013)
The Pennsylvania State University
Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
J Med Chem 56: 5094-114 (2013)
Glaxosmithkline
Identification of M. tuberculosis thioredoxin reductase inhibitors based on high-throughput docking using constraints.
J Med Chem 56: 4849-59 (2013)
Msd Animal Health Innovation
Synthesis and biological investigation of coumarin piperazine (piperidine) derivatives as potential multireceptor atypical antipsychotics.
J Med Chem 56: 4671-90 (2013)
Huazhong University Of Science And Technology
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
J Med Chem 56: 4442-55 (2013)
Eli Lilly
Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for ?-amyloid plaques.
Bioorg Med Chem 21: 3708-14 (2013)
Beijing Normal University
Synthesis, biological evaluation, and molecular docking studies of novel 1,3,4-oxadiazole derivatives possessing benzotriazole moiety as FAK inhibitors with anticancer activity.
Bioorg Med Chem 21: 3723-9 (2013)
Nanjing University
Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.
Bioorg Med Chem Lett 23: 3967-75 (2013)
Boehringer Ingelheim (Canada)
Contributions of academic laboratories to the discovery and development of chemical biology tools.
J Med Chem 56: 7161-76 (2013)
University Of Pittsburgh
Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase.
J Med Chem 57: 1902-13 (2014)
Glaxosmithkline
Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.
J Med Chem 57: 1753-69 (2014)
Array Biopharma
Fragment-based ligand design of novel potent inhibitors of tankyrases.
J Med Chem 56: 4497-508 (2013)
Nanyang Technological University
Discovery of the first histone deacetylase 6/8 dual inhibitors.
J Med Chem 56: 4816-20 (2013)
Broad Institute Of Mit And Harvard
New azole antagonists with high affinity for the P2Y(1) receptor.
Bioorg Med Chem Lett 23: 3519-22 (2013)
Bristol-Myers Squibb
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Bioorg Med Chem Lett 23: 3531-8 (2013)
Genentech
Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
J Med Chem 56: 4521-36 (2013)
Genentech
Novel hybrids of (phenylsulfonyl)furoxan and anilinopyrimidine as potent and selective epidermal growth factor receptor inhibitors for intervention of non-small-cell lung cancer.
J Med Chem 56: 4738-48 (2013)
China Pharmaceutical University
Bispyrimidines as potent histamine H(4) receptor ligands: delineation of structure-activity relationships and detailed H(4) receptor binding mode.
J Med Chem 56: 4264-76 (2013)
Boehringer Ingelheim Rcv
Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase.
J Med Chem 56: 4028-43 (2013)
Brandeis University
Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo.
Bioorg Med Chem 21: 3831-8 (2013)
Kumamoto University
Synthesis and antiproliferative activity of 4-substituted-piperazine-1-carbodithioate derivatives of 2,4-diaminoquinazoline.
Eur J Med Chem 64: 401-9 (2013)
Capital Normal University
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Bioorg Med Chem Lett 23: 3565-9 (2013)
Roche Palo Alto
Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Bioorg Med Chem Lett 23: 3584-8 (2013)
Glaxosmithkline
Solid phase synthesis and biological evaluation of probestin as an angiogenesis inhibitor.
Bioorg Med Chem Lett 23: 3561-4 (2013)
The University Of Oklahoma Health Sciences Center
Discovery of TAK-960: an orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
Bioorg Med Chem Lett 23: 3662-6 (2013)
Takeda California
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.
Bioorg Med Chem Lett 23: 3551-5 (2013)
University Of Leeds
Discovery of new potent inhibitors for carbonic anhydrase IX by structure-based virtual screening.
Bioorg Med Chem Lett 23: 3496-9 (2013)
East China University Of Science And Technology
Caffeic acid derivatives: a new type of influenza neuraminidase inhibitors.
Bioorg Med Chem Lett 23: 3556-60 (2013)
Shandong University
Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment.
Bioorg Med Chem 21: 3873-81 (2013)
Astellas Pharma
Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors.
Bioorg Med Chem Lett 23: 3523-30 (2013)
Xuzhou Medical College
In vitro study of isoflavones and isoflavans as potent inhibitors of human 12- and 15-lipoxygenases.
Chem Biol Drug Des 82: 317-25 (2013)
Universidad De Santiago De Chile
Design, synthesis and biological evaluation of novel inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.
J Enzyme Inhib Med Chem 29: 408-19 (2014)
Nycomed
Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): aß-sparing phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity.
J Med Chem 56: 4597-610 (2013)
Genentech
Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.
J Med Chem 56: 4300-19 (2013)
Peking University
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.
J Biol Chem 288: 18260-70 (2013)
Uppsala University
Functional consequences of retro-inverso isomerization of a miniature protein inhibitor of the p53-MDM2 interaction.
Bioorg Med Chem 21: 4045-50 (2013)
Southwest University
Evaluation of selective inhibitors of 11ß-HSD1 for the treatment of hypertension.
Bioorg Med Chem Lett 23: 3650-3 (2013)
Merck
Design, synthesis and structure activity relationships of spirocyclic compounds as potent CCR1 antagonists.
Bioorg Med Chem Lett 23: 3500-4 (2013)
Astrazeneca
Study of binding thermodynamics in the optimization of BH3 mimetics.
Chem Biol Drug Des 82: 394-400 (2013)
Dalian University Of Technology
Neocosmospora sp.-derived resorcylic acid lactones with in vitro binding affinity for human opioid and cannabinoid receptors.
J Nat Prod 76: 824-8 (2013)
The University Of Mississippi
Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF).
J Nat Prod 76: 817-23 (2013)
University Of California-San Diego
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
J Med Chem 56: 4764-85 (2013)
Genentech
Discovery of potent, selective chymase inhibitors via fragment linking strategies.
J Med Chem 56: 4465-81 (2013)
Boehringer Ingelheim Pharmaceuticals
Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy.
J Med Chem 56: 3959-68 (2013)
Yale University
1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptora.
J Med Chem 56: 4631-40 (2013)
Chinese Academy Of Sciences
Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.
J Med Chem 56: 4509-20 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.
J Med Chem 56: 4701-17 (2013)
Istituto Italiano Di Tecnologia
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor.
J Med Chem 56: 4413-21 (2013)
University Of Oxford
Optimized method of G-protein-coupled receptor homology modeling: its application to the discovery of novel CXCR7 ligands.
J Med Chem 56: 4236-51 (2013)
Pharmadesign
Optimized chemical probes for REV-ERBa.
J Med Chem 56: 4729-37 (2013)
Glaxosmithkline
A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain.
Bioorg Med Chem Lett 23: 3640-5 (2013)
Merck Research Laboratories
Synthesis and biological evaluation of C-glucosides with azulene rings as selective SGLT2 inhibitors for the treatment of type 2 diabetes mellitus: discovery of YM543.
Bioorg Med Chem 21: 3934-48 (2013)
Astellas Pharmaceutical
Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.
J Med Chem 56: 4568-79 (2013)
Pfizer
Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease.
J Med Chem 56: 4786-97 (2013)
Northwestern University
Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors.
J Med Chem 56: 4277-99 (2013)
Universit£
Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design.
J Med Chem 56: 4402-12 (2013)
The Ohio State University
A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.
J Med Chem 56: 3969-79 (2013)
University Of Michigan
The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1.
Bioorg Med Chem Lett 23: 3620-6 (2013)
Sanofi
Discovery and optimization of arylsulfonyl 3-(pyridin-2-yloxy)anilines as novel GPR119 agonists.
Bioorg Med Chem Lett 23: 3609-13 (2013)
Amgen
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.
Bioorg Med Chem 21: 3730-7 (2013)
Korea Research Institute Of Bioscience And Biotechnology
Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism.
Bioorg Med Chem 21: 4011-9 (2013)
Biogen Idec
Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.
J Med Chem 56: 4691-700 (2013)
Universit£
Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control.
J Med Chem 56: 3922-35 (2013)
Max Institute Of Psychiatry
Low molecular weight dual inhibitors of factor Xa and fibrinogen binding to GPIIb/IIIa with highly overlapped pharmacophores.
Eur J Med Chem 64: 302-13 (2013)
University Of Ljubljana
Synthesis and biological characterization of spiro[2H-(1,3)-benzoxazine-2,4'-piperidine] based histone deacetylase inhibitors.
Eur J Med Chem 64: 273-84 (2013)
Congenia
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
Eur J Med Chem 64: 252-9 (2013)
University Of Zanjan
Synthesis and biological evaluation of novel phosphatidylinositol 3-kinase inhibitors: Solubilized 4-substituted benzimidazole analogs of 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474).
Eur J Med Chem 64: 137-47 (2013)
University Of Auckland
Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice.
Eur J Med Chem 64: 129-36 (2013)
Chinese Academy Of Sciences
Design, synthesis and antitumour activity of bisquinoline derivatives connected by 4-oxy-3-fluoroaniline moiety.
Eur J Med Chem 64: 62-73 (2013)
Shenyang Pharmaceutical University
Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template.
Bioorg Med Chem 21: 3821-30 (2013)
Seoul National University
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett 23: 3592-8 (2013)
Argenta Discovery
Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315.
Bioorg Med Chem Lett 23: 3654-61 (2013)
University Of Kansas Specialized Chemistry Center
From a4ß2 Nicotinic Ligands to the Discovery of s1 Receptor Ligands: Pharmacophore Analysis and Rational Design.
ACS Med Chem Lett 3: 1054-1058 (2012)
TBA
Synthetic chalcones and sulfonamides as new classes of Yersinia enterocolitica YopH tyrosine phosphatase inhibitors.
Eur J Med Chem 64: 35-41 (2013)
Universidade Federal De Santa Catarina
Development of peptidomimetic boronates as proteasome inhibitors.
Eur J Med Chem 64: 23-34 (2013)
Universit£
Synthesis of proline analogues as potent and selective cathepsin S inhibitors.
Bioorg Med Chem Lett 23: 3140-4 (2013)
Hanmi Research Center
NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.
Bioorg Med Chem Lett 23: 3162-5 (2013)
China Pharmaceutical University
Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.
Bioorg Med Chem Lett 23: 3248-52 (2013)
Vanderbilt University Medical Center
Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors.
Bioorg Med Chem Lett 23: 3200-3 (2013)
Central South University
Modular, efficient synthesis of asymmetrically substituted piperazine scaffolds as potent calcium channel blockers.
Bioorg Med Chem Lett 23: 3257-61 (2013)
University Of British Columbia
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
J Med Chem 56: 4343-56 (2013)
Shionogi Pharmaceutical Research Center
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
J Med Chem 56: 3996-4016 (2013)
Johns Hopkins University School Of Medicine
Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.
Bioorg Med Chem 21: 2960-7 (2013)
Nankai University
Discovery of potent transient receptor potential vanilloid 1 antagonists: design and synthesis of phenoxyacetamide derivatives.
Bioorg Med Chem Lett 23: 3154-6 (2013)
Toray Industries
Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery.
Bioorg Med Chem Lett 23: 3157-61 (2013)
Bristol-Myers Squibb R & D
Structural, kinetic, and pharmacodynamic mechanisms of D-amino acid oxidase inhibition by small molecules.
J Med Chem 56: 3710-24 (2013)
Sunovion Pharmaceuticals
Design, synthesis, and biological evaluation of aminoalkylindole derivatives as cannabinoid receptor ligands with potential for treatment of alcohol abuse.
J Med Chem 56: 4537-50 (2013)
The University Of Kansas
Matrix metalloproteinase inhibitors based on the 3-mercaptopyrrolidine core.
J Med Chem 56: 4357-73 (2013)
Florida State University
Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones.
J Med Chem 56: 4580-96 (2013)
University Of Bonn
Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
J Med Chem 56: 5436-45 (2013)
National Cancer Institute
Discovery of novel 4-(2-fluorophenoxy)quinoline derivatives bearing 4-oxo-1,4-dihydrocinnoline-3-carboxamide moiety as c-Met kinase inhibitors.
Bioorg Med Chem 21: 2843-55 (2013)
Shenyang Pharmaceutical University
Conformational restriction in a series of GPR119 agonists: differences in pharmacology between mouse and human.
Bioorg Med Chem Lett 23: 3175-9 (2013)
Astrazeneca
Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett 23: 3186-94 (2013)
Genentech
Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.
J Med Chem 56: 4422-41 (2013)
Duquesne University
Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors.
J Med Chem 56: 5351-81 (2014)
Emory University
CROSS: an efficient workflow for reaction-driven rescaffolding and side-chain optimization using robust chemical reactions and available reagents.
J Med Chem 56: 4656-70 (2013)
Sanofi-Aventis Deutschland
Development and therapeutic implications of selective histone deacetylase 6 inhibitors.
J Med Chem 56: 6297-313 (2013)
University Of Illinois At Chicago
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.
Bioorg Med Chem 21: 3032-50 (2013)
Kitasato University
Modification of agonist binding moiety in hybrid derivative 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-1-ol/-2-amino versions: impact on functional activity and selectivity for dopamine D2/D3 receptors.
Bioorg Med Chem 21: 3164-74 (2013)
Wayne State University
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.
Bioorg Med Chem 21: 2975-87 (2013)
The City University Of New York
Synthetic approaches to the 2011 new drugs.
Bioorg Med Chem 21: 2795-825 (2013)
Shenogen Pharma Group
7-Phenyl-imidazoquinolin-4(5H)-one derivatives as selective and orally available mPGES-1 inhibitors.
Bioorg Med Chem 21: 2868-78 (2013)
Dainippon Sumitomo Pharma
Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design.
Bioorg Med Chem Lett 23: 3149-53 (2013)
Genentech
Effect of anchoring 4-anilidopiperidines to opioid peptides.
Bioorg Med Chem Lett 23: 3434-7 (2013)
University Of Arizona
Synthesis and antifungal evaluation of pentyloxyl-diphenylisoxazoloyl pneumocandins and echinocandins.
Bioorg Med Chem Lett 23: 3253-6 (2013)
Merck Research Laboratories
Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP receptor-selective scaffolds. Part I.
Bioorg Med Chem Lett 23: 3308-13 (2013)
Astraea Therapeutics
Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening.
Bioorg Med Chem 21: 3214-20 (2013)
Kitasato University
Selective CB2 agonists with anti-pruritic activity: discovery of potent and orally available bicyclic 2-pyridones.
Bioorg Med Chem 21: 3154-63 (2013)
Shionogi Pharmaceutical Research Center
Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors.
Bioorg Med Chem 21: 3245-55 (2013)
Central China Normal University
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.
Bioorg Med Chem 21: 2925-31 (2013)
Atat£Rk University
Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators.
Bioorg Med Chem Lett 23: 3358-63 (2013)
Pfizer
Dual-acting histone deacetylase-topoisomerase I inhibitors.
Bioorg Med Chem Lett 23: 3283-7 (2013)
Georgia Institute Of Technology
Novel adamantyl cannabinoids as CB1 receptor probes.
J Med Chem 56: 3904-21 (2013)
Northeastern University
Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.
Bioorg Med Chem 21: 3298-309 (2013)
National Institute On Drug Abuse And The National Institute On Alcohol Abuse And Alcoholism
Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Bioorg Med Chem 21: 2856-67 (2013)
National Health Research Institutes
Evaluation of N-phenyl homopiperazine analogs as potential dopamine D3 receptor selective ligands.
Bioorg Med Chem 21: 2988-98 (2013)
Washington University
Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors.
J Med Chem 56: 4921-37 (2013)
Forma Therapeutics
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
J Biol Chem 288: 15813-20 (2013)
The Ohio State University
Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists.
J Med Chem 56: 4071-81 (2013)
University Of Copenhagen
Synthesis and in vitro and in vivo characterization of highlyß1-selectiveß-adrenoceptor partial agonists.
J Med Chem 56: 3852-65 (2013)
University Of Nottingham
Identification and Characterization of a New Chemotype of Noncovalent SENP Inhibitors.
ACS Chem Biol 8: 1435-41 (2013)
Beckman Research Institute Of The City Of Hope
Structure-based fragment screening is demonstrated to be a practical lead discovery method for a representative G-protein-coupled receptor.
J Med Chem 56: 3444-5 (2013)
Pfizer
Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR).
J Med Chem 56: 3518-30 (2013)
Fondazione Istituto Italiano Di Tecnologia
The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.
Bioorg Med Chem 21: 3231-9 (2013)
Novartis Institutes For Biomedical Research
The systematic structure-activity relationship to predict how flavones bind to human androgen receptor for their antagonistic activity.
Bioorg Med Chem 21: 2968-74 (2013)
Meijo University
Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.
Bioorg Med Chem 21: 4803-12 (2013)
Universit£
Protein kinase inhibitor design by targeting the Asp-Phe-Gly (DFG) motif: the role of the DFG motif in the design of epidermal growth factor receptor inhibitors.
J Med Chem 56: 3889-903 (2013)
National Health Research Institutes
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
J Med Chem 56: 5637-58 (2014)
Universit£
Chemo-Immunotherapeutic Anti-Malarials Targeting Isoprenoid Biosynthesis.
ACS Med Chem Lett 4: 423-427 (2013)
Prenylx Research Institute
Discovery of natural estrogen receptor modulators with structure-based virtual screening.
Bioorg Med Chem Lett 23: 3329-33 (2013)
East China University Of Science And Technology
Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.
Bioorg Med Chem Lett 23: 3320-4 (2013)
Cha University
Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.
ACS Med Chem Lett 4: 254-258 (2013)
University Of Minnesota
3D-QSAR Assisted Design, Synthesis and Evaluation of Novobiocin Analogues.
ACS Med Chem Lett 4: 57-62 (2012)
The University Of Kansas
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol 9: 390-7 (2013)
Walter And Eliza Hall Institute Of Medical Research
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.
Eur J Med Chem 63: 854-68 (2013)
Quaid-I-Azam University
Design, synthesis and pharmacological characterization of analogs of 2-aminoethyl diphenylborinate (2-APB), a known store-operated calcium channel blocker, for inhibition of TRPV6-mediated calcium transport.
Bioorg Med Chem 21: 3202-13 (2013)
University Of Bern
Design, synthesis and biological evaluation of novel pyrimidine, 3-cyanopyridine and m-amino-N-phenylbenzamide based monocyclic EGFR tyrosine kinase inhibitors.
Bioorg Med Chem 21: 3090-104 (2013)
Chinese Academy Of Sciences
The discovery of colchicine-SAHA hybrids as a new class of antitumor agents.
Bioorg Med Chem 21: 3240-4 (2013)
East China Normal University
Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.
Bioorg Med Chem 21: 3022-31 (2013)
Universiti Sains Malaysia
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.
Bioorg Med Chem Lett 23: 3411-5 (2013)
Ucl School Of Pharmacy
Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors.
Bioorg Med Chem Lett 23: 3230-4 (2013)
University Of Rhode Island
Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.
Bioorg Med Chem Lett 23: 3239-43 (2013)
Bristol-Myers Squibb
Novel adenosine A(2A) receptor ligands: a synthetic, functional and computational investigation of selected literature adenosine A(2A) receptor antagonists for extending into extracellular space.
Bioorg Med Chem Lett 23: 3427-33 (2013)
Monash University (Parkville Campus)
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors.
Bioorg Med Chem Lett 23: 3325-8 (2013)
Daiichi Sankyo
Tri-substituted imidazole analogues of SB203580 as inducers for cardiomyogenesis of human embryonic stem cells.
Bioorg Med Chem Lett 23: 3300-3 (2013)
Institute Of Chemical And Engineering Sciences
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Bioorg Med Chem Lett 23: 3262-6 (2013)
Merck Research Laboratories
Synthesis and biological evaluation of Esaprazole analogues showings1 binding and neuroprotective properties in vitro.
Bioorg Med Chem 21: 3334-47 (2013)
Nensius Research
Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease.
Bioorg Med Chem 21: 3356-62 (2013)
Kyoto University
Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.
Bioorg Med Chem Lett 23: 3389-92 (2013)
Harvard Medical School
2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists.
Bioorg Med Chem Lett 23: 3349-53 (2013)
RhôNe-Poulenc Rorer
Therapeutic and pharmacokinetic characterizations of an anti-amyloidogenic bis-styrylbenzene derivative for Alzheimer's disease treatment.
Bioorg Med Chem Lett 23: 3467-9 (2013)
Korea Institute Of Science And Technology
Design, synthesis, and biological evaluation of novel histone deacetylase 1 inhibitors through click chemistry.
Bioorg Med Chem Lett 23: 3295-9 (2013)
Chinese Academy Of Sciences
Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.
J Med Chem 56: 4082-92 (2013)
Xavier University Of Louisiana
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
J Med Chem 56: 3768-82 (2013)
H. Lee Moffitt Cancer Center And Research Institute
Discovery of new benzothiazole-based inhibitors of breakpoint cluster region-Abelson kinase including the T315I mutant.
J Med Chem 56: 3531-45 (2013)
Korea Institute Of Science And Technology (Kaist)
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.
Bioorg Med Chem 21: 3363-78 (2013)
Ludwig-Maximilians-University Munich
Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem 21: 3262-71 (2013)
St. John'S University
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Bioorg Med Chem 21: 3175-96 (2013)
Daiichi Sankyo
Pyrrolidine analogs of GZ-793A: synthesis and evaluation as inhibitors of the vesicular monoamine transporter-2 (VMAT2).
Bioorg Med Chem Lett 23: 3342-5 (2013)
University Of Arkansas For Medical Sciences
1,1-Difluoroethyl-substituted triazolothienopyrimidines as inhibitors of a human urea transport protein (UT-B): new analogs and binding model.
Bioorg Med Chem Lett 23: 3338-41 (2013)
San Francisco State University
Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.
Bioorg Med Chem Lett 23: 3443-7 (2013)
Pfizer
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.
Biochemistry 52: 2955-66 (2013)
Indiana University School Of Medicine
Rational design and binding mode duality of MDM2-p53 inhibitors.
J Med Chem 56: 4053-70 (2013)
Amgen
Structure-based approaches to ligands for G-protein-coupled adenosine and P2Y receptors, from small molecules to nanoconjugates.
J Med Chem 56: 3749-67 (2013)
National Institute Of Diabetes And Digestive And Kidney Diseases
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase.
J Med Chem 56: 3467-77 (2013)
Tufts University Sackler School Of Biomedical Sciences
Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer.
ACS Chem Biol 8: 1423-8 (2013)
Chinese Academy Of Sciences
Evaluating the Role of Macrocycles in the Susceptibility of Hepatitis C Virus NS3/4A Protease Inhibitors to Drug Resistance.
ACS Chem Biol 8: 1469-78 (2013)
University Of Massachusetts Medical School
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part II).
Bioorg Med Chem Lett 23: 3421-6 (2013)
Sanofi Us
A cyclodextrin-capped histone deacetylase inhibitor.
Bioorg Med Chem Lett 23: 3346-8 (2013)
University Of Sussex
Discovery of aryl ureas and aryl amides as potent and selective histamine H3 receptor antagonists for the treatment of obesity (part I).
Bioorg Med Chem Lett 23: 3416-20 (2013)
Sanofi Us
ß-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.
J Med Chem 56: 3980-95 (2013)
F. Hoffmann-La Roche
Potency switch between CHK1 and MK2: discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors.
Bioorg Med Chem Lett 23: 2863-7 (2013)
Merck Research Laboratories
Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.
Bioorg Med Chem Lett 23: 2860-2 (2013)
University Of Mississippi
A small molecule inhibitor of fungal histone acetyltransferase Rtt109.
Bioorg Med Chem Lett 23: 2853-9 (2013)
University Of Massachusetts Medical School
Recent advances in malaria drug discovery.
Bioorg Med Chem Lett 23: 2829-43 (2013)
Drug Discovery For Tropical Diseases
Development of a selective peptide macrocycle inhibitor of coagulation factor XII toward the generation of a safe antithrombotic therapy.
J Med Chem 56: 3742-6 (2013)
Ecole Polytechnique F�D�Rale De Lausanne Epfl
Pyridine-substituted desoxyritonavir is a more potent inhibitor of cytochrome P450 3A4 than ritonavir.
J Med Chem 56: 3733-41 (2013)
University Of California
Thiophene-core estrogen receptor ligands having superagonist activity.
J Med Chem 56: 3346-66 (2013)
Key Laboratory Of Combinatorial Biosynthesis And Drug Discovery (Wuhan University)
Synthesis and
Medchemcomm 4: 443-449 (2013)
Washington University School Of Medicine
Inhibition of Ras-Effector Interaction by Cyclic Peptides.
Medchemcomm 4: 378-382 (2013)
The Ohio State University
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers.
ACS Med Chem Lett 3: 640-644 (2012)
TBA
Antibacterial oxazolidinone analogues having a N-hydroxyacetyl-substituted seven-membered [1,2,5]triazepane or [1,2,5]oxadiazepane C-ring unit.
Eur J Med Chem 63: 811-25 (2013)
Research Foundation Itsuu Laboratory
Synthesis and evaluation of novel marine bromopyrrole alkaloid-based hybrids as anticancer agents.
Eur J Med Chem 63: 793-9 (2013)
Nmims University
Design, synthesis and biological evaluation of new classes of thieno[3,2-d]pyrimidinone and thieno[1,2,3]triazine as inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2).
Eur J Med Chem 63: 765-81 (2013)
Universit£
Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors.
Eur J Med Chem 63: 758-64 (2013)
Ludwig-Maximilians-Universit£T M£Nchen
Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.
Bioorg Med Chem Lett 23: 3396-400 (2013)
Boehringer Ingelheim (Canada)
Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.
Bioorg Med Chem Lett 23: 2880-2 (2013)
Ramkhamhaeng University
Discovery of novel orally bioavailable GPR40 agonists.
Bioorg Med Chem Lett 23: 2920-4 (2013)
Shanghai Hengrui Pharmaceutical
Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor.
Bioorg Med Chem 21: 2764-71 (2013)
Institute Of Organic Synthesis
Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
Bioorg Med Chem 21: 2695-702 (2013)
Kyoto University
Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators.
Bioorg Med Chem Lett 23: 2936-40 (2013)
Hoffmann-La Roche
Synthesis and antitumor activity of 1,3,4-oxadiazole possessing 1,4-benzodioxan moiety as a novel class of potent methionine aminopeptidase type II inhibitors.
Bioorg Med Chem Lett 23: 2876-9 (2013)
Nanjing University
Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.
Bioorg Med Chem Lett 23: 3438-42 (2013)
Pfizer
Design and synthesis of a tetrahydroisoquinoline-based hydroxamate derivative (ZYJ-34v), an oral active histone deacetylase inhibitor with potent antitumor activity.
Chem Biol Drug Des 82: 125-30 (2013)
Shandong University
Synthesis, evaluation and molecular docking of prolyl-fluoropyrrolidine derivatives as dipeptidyl peptidase IV inhibitors.
Chem Biol Drug Des 82: 156-66 (2013)
Delhi Institute Of Pharmaceutical Sciences And Research
In vitro evaluation of selected benzimidazole derivatives as an antioxidant and xanthine oxidase inhibitors.
Chem Biol Drug Des 82: 290-5 (2013)
Konkuk University
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors.
J Med Chem 56: 3943-58 (2013)
Universit£
5-Oxo-ETE receptor antagonists.
J Med Chem 56: 3725-32 (2013)
Florida Institute Of Technology
New multifunctional Di-tert-butylphenoloctahydro(pyrido/benz)oxazine derivatives with antioxidant, antihyperlipidemic, and antidiabetic action.
J Med Chem 56: 3330-8 (2013)
University Of Athens
Conformationally restricted homotryptamines. Part 6: indole-5-cycloalkyl methylamines as selective serotonin reuptake inhibitors.
Bioorg Med Chem Lett 23: 2948-50 (2013)
Bristol-Myers Squibb Research And Development
Design, synthesis and evaluation of 2-phenylisothiazolidin-3-one-1,1-dioxides as a new class of human protein kinase CK2 inhibitors.
J Enzyme Inhib Med Chem 29: 338-43 (2014)
Nas Of Ukraine
Triazole derivatives: a series of Darapladib analogues as orally active Lp-PLA2 inhibitors.
Bioorg Med Chem Lett 23: 2897-901 (2013)
Chinese Academy Of Sciences
Synthesis, antidepressant evaluation and docking studies of long-chain alkylnitroquipazines as serotonin transporter inhibitors.
Chem Biol Drug Des 81: 695-706 (2013)
University Of Troms£
Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase.
J Med Chem 56: 3609-19 (2013)
University Of Copenhagen
Screening and structural analysis of flavones inhibiting tankyrases.
J Med Chem 56: 3507-17 (2013)
University Of Oulu
Structure-based identification of OATP1B1/3 inhibitors.
Mol Pharmacol 83: 1257-67 (2013)
Ku Leuven
SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.
Bioorg Med Chem Lett 23: 3081-7 (2013)
Emd-Serono Research Institute
Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Bioorg Med Chem Lett 23: 3075-80 (2013)
Elan Pharmaceuticals
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Bioorg Med Chem Lett 23: 2979-83 (2013)
Universiti Sains Malaysia
Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.
J Med Chem 56: 3568-81 (2013)
The Scripps Research Institute
Design and synthesis of dual-action inhibitors targeting histone deacetylases and 3-hydroxy-3-methylglutaryl coenzyme A reductase for cancer treatment.
J Med Chem 56: 3645-55 (2013)
National Taiwan University
Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
J Med Chem 56: 3666-79 (2013)
Sirtris A Gsk
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.
Eur J Med Chem 63: 685-95 (2013)
Jishou University
Direct targeting ofß-catenin: Inhibition of protein-protein interactions for the inactivation of Wnt signaling.
Bioorg Med Chem 21: 4020-6 (2013)
Chemical Genomics Centre Of The Max Planck Society
Synthesis of new heterocyclic hybrids based on pyrazole and thiazolidinone scaffolds as potent inhibitors of tyrosinase.
Bioorg Med Chem 21: 2772-7 (2013)
Bahirji Smarak Mahavidyalaya
Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.
Bioorg Med Chem Lett 23: 2955-61 (2013)
Pfizer
Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors.
Bioorg Med Chem Lett 23: 3034-8 (2013)
Penn State University College Of Medicine
Discovery and synthesis of novel 4-aminopyrrolopyrimidine Tie-2 kinase inhibitors for the treatment of solid tumors.
Bioorg Med Chem Lett 23: 3059-63 (2013)
Pfizer
Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.
J Med Chem 56: 5219-30 (2014)
The University Of Arizona
Determination of the ?-conotoxin Vc1.1 binding site on the ?9?10 nicotinic acetylcholine receptor.
J Med Chem 56: 3557-67 (2013)
The University Of Queensland
4-Hydroxypyridazin-3(2H)-one derivatives as novel D-amino acid oxidase inhibitors.
J Med Chem 56: 3582-92 (2013)
Astellas Pharma
Synthesis and evaluation of novel (18)F-labeled spirocyclic piperidine derivatives ass1 receptor ligands for positron emission tomography imaging.
J Med Chem 56: 3478-91 (2013)
Key Laboratory Of Radiopharmaceuticals Beijing Normal University
The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.
ACS Med Chem Lett 4: 283-287 (2013)
The Scripps Research Institute
Identification of new peptide amides as selective cathepsin L inhibitors: the first step towards selective irreversible inhibitors?
Bioorg Med Chem Lett 23: 2968-73 (2013)
National Institute Of Biology
Discovery of novel Jak2-Stat pathway inhibitors with extended residence time on target.
Bioorg Med Chem Lett 23: 3105-10 (2013)
Astrazeneca
Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction.
Bioorg Med Chem Lett 23: 3039-43 (2013)
The State University Of New Jersey
Novel VEGFR-2 kinase inhibitors identified by the back-to-front approach.
Bioorg Med Chem Lett 23: 2962-7 (2013)
Mahidol University
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett 23: 3051-8 (2013)
Pfizer
Arylsulfonamide pyrimidines as VLA-4 antagonists.
Bioorg Med Chem Lett 23: 3070-4 (2013)
Elan Pharmaceuticals
Discovery of ML326: The first sub-micromolar, selective M5 PAM.
Bioorg Med Chem Lett 23: 2996-3000 (2013)
Vanderbilt University Medical Center
Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory.
Bioorg Med Chem Lett 23: 2984-9 (2013)
Banaras Hindu University
Conformational restriction approach to BACE1 inhibitors II: SAR study of the isocytosine derivatives fixed with a cis-cyclopropane ring.
Bioorg Med Chem Lett 23: 2912-5 (2013)
Shionogi
Neonicotinic analogues: selective antagonists fora4ß2 nicotinic acetylcholine receptors.
Bioorg Med Chem 21: 2687-94 (2013)
University Of Chile
Synthesis and biological evaluation of a new series of hexahydro-2H-pyrano[3,2-c]quinolines as novel selectives1 receptor ligands.
J Med Chem 56: 3656-65 (2013)
Esteve
A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787.
Bioorg Med Chem Lett 23: 2663-70 (2013)
Griffin Discoveries
Cytotoxic, antitopoisomerase II?, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata.
J Nat Prod 76: 530-7 (2013)
Mahidol University
Monocarbonyl curcumin analogues: heterocyclic pleiotropic kinase inhibitors that mediate anticancer properties.
J Med Chem 56: 3456-66 (2013)
Emory University
Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.
J Biol Chem 288: 14256-63 (2013)
University Of Washington
Neoclerodanes as atypical opioid receptor ligands.
J Med Chem 56: 3435-43 (2013)
University Of Kansas
Cytotoxicity and modulation of cancer-related signaling by (Z)- and (E)-3,4,3',5'-tetramethoxystilbene isolated from Eugenia rigida.
J Nat Prod 76: 679-84 (2013)
The University Of Mississippi
Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor.
ACS Chem Biol 8: 1291-302 (2013)
Massachusetts Institute Of Technology
Structural basis for inhibition of the fat mass and obesity associated protein (FTO).
J Med Chem 56: 3680-8 (2013)
University Of Oxford
Potent proteasome inhibitors derived from the unnatural cis-cyclopropane isomer of Belactosin A: synthesis, biological activity, and mode of action.
J Med Chem 56: 3689-700 (2013)
Hokkaido University
Oxadiazole-isopropylamides as potent and noncovalent proteasome inhibitors.
J Med Chem 56: 3783-805 (2013)
Moffitt Cancer Center
3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition.
J Med Chem 56: 3492-506 (2013)
Georgia Institute Of Technology
Biological active analogues of the opioid peptide biphalin: mixeda/ß(3)-peptides.
J Med Chem 56: 3419-23 (2013)
Universit£
(3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose.
Bioorg Med Chem 21: 4813-9 (2013)
University Of Oxford
Virtual medicinal chemistry: in silico pre-docking functional group transformation for discovery of novel inhibitors of botulinum toxin serotype A light chain.
Bioorg Med Chem Lett 23: 2505-11 (2013)
Panthera Biopharma
Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett 23: 2585-9 (2013)
Boehringer Ingelheim (Canada)
Hepatitis C replication inhibitors that target the viral NS4B protein.
J Med Chem 57: 2107-20 (2014)
Glaxosmithkline
Structure-activity relationship of 5-chloro-2-methyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole analogues as 5-HT(6) receptor agonists.
Eur J Med Chem 63: 578-88 (2013)
Neurosearch Sweden
Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.
Bioorg Med Chem 21: 2462-70 (2013)
China Pharmaceutical University
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
Bioorg Med Chem 21: 2568-76 (2013)
Institute Of Science And Technology
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.
Bioorg Med Chem 21: 2503-10 (2013)
The City University Of New York
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Bioorg Med Chem Lett 23: 2522-6 (2013)
Hoffmann-La Roche
Identification and design of a novel series of MGAT2 inhibitors.
Bioorg Med Chem Lett 23: 2721-6 (2013)
Astrazeneca
Inhibitors of the p53/hdm2 protein-protein interaction-path to the clinic.
Bioorg Med Chem Lett 23: 2480-5 (2013)
Sanofi
C1 and N5 derivatives of cerpegin: synthesis of a new series based on structure-activity relationships to optimize their inhibitory effect on 20S proteasome.
Bioorg Med Chem Lett 23: 2696-703 (2013)
Yerevan State University
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema: part 2.
Bioorg Med Chem 21: 2478-94 (2013)
Astellas Pharma
Dimerized linear mimics of a natural cyclopeptide (TMC-95A) are potent noncovalent inhibitors of the eukaryotic 20S proteasome.
J Med Chem 56: 3367-78 (2013)
University Paris 6
Novel pyridinone derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs) with high potency against NNRTI-resistant HIV-1 strains.
J Med Chem 56: 3593-608 (2013)
Peking University
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selectivea4ß2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.
J Med Chem 56: 3000-11 (2013)
Georgetown University Medical Center
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
Bioorg Med Chem Lett 23: 2793-800 (2013)
F. Hoffmann-La Roche
Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.
Bioorg Med Chem Lett 23: 2614-8 (2013)
University Of Massachusetts Boston
Discovery of thiazolobenzoxepin PI3-kinase inhibitors that spare the PI3-kinaseß isoform.
Bioorg Med Chem Lett 23: 2606-13 (2013)
Genentech
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.
Bioorg Med Chem Lett 23: 2801-7 (2013)
Baylor University
Design, synthesis and biological activities of Nilotinib derivates as antitumor agents.
Bioorg Med Chem 21: 2527-34 (2013)
Xi'An Jiaotong University
Novel pyrimidoazepine analogs as serotonin 5-HT(2A) and 5-HT(2C) receptor ligands for the treatment of obesity.
Eur J Med Chem 63: 558-69 (2013)
Korea Institute Of Science And Technology
Spirocyclicß-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloidß in a higher species.
J Med Chem 56: 3379-403 (2013)
Array Biopharma
Investigation of the role of linker moieties in bifunctional tacrine hybrids.
Bioorg Med Chem 21: 3614-23 (2013)
University Of Michigan
Structure-based design and optimization of 2-aminothiazole-4-carboxamide as a new class of CHK1 inhibitors.
Bioorg Med Chem Lett 23: 2590-4 (2013)
Merck Research Laboratories
Discovery, synthesis, selectivity modulation and DMPK characterization of 5-azaspiro[2.4]heptanes as potent orexin receptor antagonists.
Bioorg Med Chem Lett 23: 2653-8 (2013)
Rottapharm Madaus
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.
Bioorg Med Chem Lett 23: 2659-62 (2013)
Kitasato University
Novel and highly potent histamine H3 receptor ligands. Part 3: an alcohol function to improve the pharmacokinetic profile.
Bioorg Med Chem Lett 23: 2548-54 (2013)
Bioprojet-Biotech
Antileishmanial activity evaluation of bis-lawsone analogs and DNA topoisomerase-I inhibition studies.
J Enzyme Inhib Med Chem 29: 185-9 (2014)
Karunya University
De novo design of protein kinase inhibitors by in silico identification of hinge region-binding fragments.
ACS Chem Biol 8: 1044-52 (2013)
University Of Dundee
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors.
J Med Chem 56: 3191-206 (2013)
Universit£
Synthesis and biological evaluation of oleanolic acid derivatives as PTP1B inhibitors.
Eur J Med Chem 63: 511-22 (2013)
North-West University
Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.
J Med Chem 56: 3833-51 (2013)
Chinese Academy Of Sciences
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues.
J Med Chem 56: 2948-58 (2013)
University Of Alberta
Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.
Bioorg Med Chem Lett 23: 2579-84 (2013)
Aurigene Discovery Technologies
Discovery of a synthetic Aminopeptidase N inhibitor LB-4b as a potential anticancer agent.
Bioorg Med Chem Lett 23: 2512-7 (2013)
Shandong University
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.
Bioorg Med Chem Lett 23: 2601-5 (2013)
King Saud University
A thiocarbamate inhibitor of endothelial lipase raises HDL cholesterol levels in mice.
Bioorg Med Chem Lett 23: 2595-7 (2013)
Janssen Research And Development
Arylpiperazines as fatty acid transport protein 1 (FATP1) inhibitors with improved potency and pharmacokinetic properties.
Bioorg Med Chem Lett 23: 2560-5 (2013)
Daiichi Sankyo
SAR based design of nicotinamides as a novel class of androgen receptor antagonists for prostate cancer.
J Med Chem 56: 3414-8 (2013)
Chonnam National University
Discovery of highly potent microsomal prostaglandin e2 synthase 1 inhibitors using the active conformation structural model and virtual screen.
J Med Chem 56: 3296-309 (2013)
Peking University
Exploring the effect of
Medchemcomm 4: 564-568 (2013)
University Of Arkansas For Medical Sciences
Multivalent Interactions: Synthesis and Evaluation of Melanotropin Multimers - Tools for Melanoma Targeting.
ACS Med Chem Lett 4: 98-102 (2013)
Universit£
Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.
Eur J Med Chem 63: 484-500 (2013)
Medical University Of Warsaw
Design and synthesis of novel chromenone derivatives as interleukin-5 inhibitors.
Bioorg Med Chem 21: 2543-50 (2013)
Chungnam National University
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Bioorg Med Chem 21: 2651-62 (2013)
Walter Reed Army Institute Of Research
In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells.
Bioorg Med Chem Lett 23: 2642-6 (2013)
Sungkyunkwan [Corrected] University
Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Bioorg Med Chem Lett 23: 2743-9 (2013)
Elan Pharmaceuticals
Substituted thieno[2,3-d]pyrimidines as adenosine A2A receptor antagonists.
Bioorg Med Chem Lett 23: 2688-91 (2013)
Janssen Research & Development
Aminophenoxazinones as inhibitors of indoleamine 2,3-dioxygenase (IDO). Synthesis of exfoliazone and chandrananimycin A.
J Med Chem 56: 3310-7 (2013)
University Of Nottingham
Potent fibrinolysis inhibitor discovered by shape and electrostatic complementarity to the drug tranexamic acid.
J Med Chem 56: 3273-80 (2013)
Astrazeneca
Synthesis and structure-activity relationships of 5,6,7-substituted pyrazolopyrimidines: discovery of a novel TSPO PET ligand for cancer imaging.
J Med Chem 56: 3429-33 (2013)
Vanderbilt University Institute Of Imaging Science (Vuiis)
Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors.
J Med Chem 56: 3281-95 (2013)
Chinese Academy Of Sciences
Synthesis and biological activities of a new class of heat shock protein 90 inhibitors, designed by energy-based pharmacophore virtual screening.
J Med Chem 56: 3424-8 (2013)
Universit£
Improving the affinity of SL0101 for RSK using structure-based design.
ACS Med Chem Lett 4: 175-179 (2012)
Vanderbilt University
Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.
Bioorg Med Chem Lett 23: 2683-7 (2013)
The Scripps Research Institute
A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease.
Bioorg Med Chem 21: 2434-50 (2013)
R.C. Patel Institute Of Pharmaceutical Education And Research
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells.
Bioorg Med Chem 21: 2551-9 (2013)
Medical University Of South Carolina
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.
J Med Chem 57: 1790-801 (2014)
Uppsala University
Orally active opioid compounds from a non-poppy source.
J Med Chem 56: 4840-8 (2013)
Temple University School Of Pharmacy
Anti-inflammatory lanostanoids and lactone derivatives from Antrodia camphorata.
J Nat Prod 76: 489-94 (2013)
National Sun Yat-Sen University
Therapeutic agents triggering nonapoptotic cancer cell death.
J Med Chem 56: 4823-39 (2013)
Texas State University-San Marcos
Biophysical fragment screening of theß1-adrenergic receptor: identification of high affinity arylpiperazine leads using structure-based drug design.
J Med Chem 56: 3446-55 (2013)
Heptares Therapeutics
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
J Med Chem 56: 3217-27 (2013)
University Of Oxford
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).
J Med Chem 56: 3177-90 (2013)
Astrazeneca
Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt).
Eur J Med Chem 63: 378-86 (2013)
National University Of Singapore
Carbonic anhydrase inhibitors: inhibition of theß-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.
Bioorg Med Chem Lett 23: 2647-52 (2013)
Universit£
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.
Bioorg Med Chem Lett 23: 2636-41 (2013)
China Pharmaceutical University
Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists.
Bioorg Med Chem 21: 2643-50 (2013)
Gwangju Institute Of Science And Technology
Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN).
Bioorg Med Chem 21: 2663-70 (2013)
Shandong University
Development of a plate-based optical biosensor fragment screening methodology to identify phosphodiesterase 10A inhibitors.
J Med Chem 56: 3228-34 (2013)
Astrazeneca
Structure-based design of ?-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.
J Med Chem 56: 4156-80 (2013)
Vitae Pharmaceuticals
Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF.
Medchemcomm 4: 130-134 (2013)
The Johns Hopkins University School Of Medicine
Radiosynthesis and first evaluation in mice of [(18)F]NS14490 for molecular imaging ofa7 nicotinic acetylcholine receptors.
Bioorg Med Chem 21: 2635-42 (2013)
Helmholtz-Zentrum Dresden-Rossendorf
Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1.
Bioorg Med Chem 21: 2600-17 (2013)
Chinese Academy Of Sciences
Structure-based design, SAR analysis and antitumor activity of PI3K/mTOR dual inhibitors from 4-methylpyridopyrimidinone series.
Bioorg Med Chem Lett 23: 2787-92 (2013)
Pfizer
Molecular determinants for nuclear receptors selectivity: chemometric analysis, dockings and site-directed mutagenesis of dual peroxisome proliferator-activated receptors ?/? agonists.
Eur J Med Chem 63: 321-32 (2013)
Universit£
Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships.
Eur J Med Chem 63: 313-20 (2013)
University Of M£Nster
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Eur J Med Chem 63: 299-312 (2013)
Sun Yat-Sen University
Novel IKKß inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.
Eur J Med Chem 63: 269-78 (2013)
China Pharmaceutical University
New potent calcimimetics: II. Discovery of benzothiazole trisubstituted ureas.
Bioorg Med Chem Lett 23: 2455-9 (2013)
Galapagos
Identification of pyrrolo[2,3-g]indazoles as new Pim kinase inhibitors.
Bioorg Med Chem Lett 23: 2298-301 (2013)
Clermont Universit£
Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors.
Bioorg Med Chem Lett 23: 2313-8 (2013)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Exploring the UDP pocket of LpxC through amino acid analogs.
Bioorg Med Chem Lett 23: 2362-7 (2013)
Astrazeneca
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Bioorg Med Chem 21: 2623-34 (2013)
Korea Basic Science Institute
Discovery of N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor.
Bioorg Med Chem 21: 2333-45 (2013)
Takeda Pharmaceutical
VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid.
Bioorg Med Chem 21: 2241-9 (2013)
Reveragen Biopharma
Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.
Bioorg Med Chem 21: 2587-99 (2013)
St. Jude Children'S Research Hospital
Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects.
Bioorg Med Chem 21: 2271-85 (2013)
Hanyang University
Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography.
ACS Chem Biol 8: 1074-82 (2013)
Boehringer Ingelheim (Canada)
Novel 1,3,4-oxadiazole thioether derivatives targeting thymidylate synthase as dual anticancer/antimicrobial agents.
Bioorg Med Chem 21: 2286-97 (2013)
Nanjing University
Design and synthesis of a series of ?-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility.
Bioorg Med Chem 21: 2319-2332 (2013)
Okayama University
Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at¿-aminobutyric acid type A (GABA(A)) receptor.
Bioorg Med Chem 21: 2186-98 (2013)
Sintesi E Studio Di Eterocicli Biologicamente Attivi (Heterobiolab) Universit£
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.
Bioorg Med Chem 21: 2314-8 (2013)
University Of Florida
Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors.
Bioorg Med Chem 21: 2250-61 (2013)
Takeda Pharmaceutical
Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.
Bioorg Med Chem Lett 23: 2368-72 (2013)
Ge Healthcare
Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo.
Bioorg Med Chem Lett 23: 2380-3 (2013)
Shanxi Medical University
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11ß-hydroxysteroid dehydrogenase type 1: strategies to eliminate reactive metabolites.
Bioorg Med Chem Lett 23: 2344-8 (2013)
Pfizer
Identification and synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAF(V600E) inhibitors.
Bioorg Med Chem Lett 23: 2306-12 (2013)
Central South University
Synthesis and evaluation of cholecystokinin trimers: a multivalent approach to pancreatic cancer detection and treatment.
Bioorg Med Chem Lett 23: 2422-5 (2013)
Universit£
Disulfide linked pyrazole derivatives inhibit phagocytosis of opsonized blood cells.
Bioorg Med Chem Lett 23: 2324-7 (2013)
Toronto General Research Institute
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.
J Med Chem 56: 2936-47 (2013)
Universit£
Synthesis and dual D2 and 5-HT1A receptor binding affinities of 5-piperidinyl and 5-piperazinyl-1H-benzo[d]imidazol-2(3H)-ones.
J Enzyme Inhib Med Chem 29: 281-91 (2014)
King Fahd University Of Petroleum & Minerals
Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX.
J Enzyme Inhib Med Chem 29: 292-6 (2014)
S.G.S.I.T.S.
Novel inhibitor of bacterial sphingomyelinase, SMY-540, developed based on three-dimensional structure analysis.
J Enzyme Inhib Med Chem 29: 303-10 (2014)
Tokushima Bunri University
Paclitaxel is an inhibitor and its boron dipyrromethene derivative is a fluorescent recognition agent for botulinum neurotoxin subtype A.
J Med Chem 56: 2791-803 (2013)
Lakehead University And Thunder Bay Regional Research Institute
Progress and developments in tau aggregation inhibitors for Alzheimer disease.
J Med Chem 56: 4135-55 (2013)
Humboldt Universit£T Zu Berlin
N-substituted azaindoles as potent inhibitors of Cdc7 kinase.
Bioorg Med Chem Lett 23: 2056-60 (2013)
Amgen
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.
Bioorg Med Chem Lett 23: 1993-6 (2013)
China Pharmaceutical University
Novel tacrine-related drugs as potential candidates for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 23: 1916-22 (2013)
Complutense University Of Madrid
Phenylimino-2H-chromen-3-carboxamide derivatives as novel small molecule inhibitors ofß-secretase (BACE1).
Bioorg Med Chem 21: 2396-412 (2013)
Tehran University Of Medical Sciences
N-[9-(ortho-fluorobenzyl)-2-phenyl-8-azapurin-6-yl]-amides as potent and selective ligands for A1 adenosine receptors.
Chem Biol Drug Des 82: 22-38 (2013)
Universit£
Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.
Bioorg Med Chem Lett 23: 2432-5 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Discovery of SAR184841, a potent and long-lasting inhibitor of 11ß-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D.
Bioorg Med Chem Lett 23: 2414-21 (2013)
Sanofi R & D
Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase--parallel synthesis of analogs via a trimethylsilyl ylidene intermediate.
Bioorg Med Chem 21: 2229-40 (2013)
Mcgill University
Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.
Bioorg Med Chem 21: 2217-28 (2013)
Bristol-Myers Squibb
Synthesis and evaluation of an imidazole derivative-fluorescein conjugate.
Bioorg Med Chem 21: 2418-25 (2013)
University Of Texas At Houston
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists.
J Med Chem 56: 3102-14 (2013)
Lanzhou University
The development of highly potent inhibitors for porcupine.
J Med Chem 56: 2700-4 (2013)
The University Of Texas Southwestern Medical Center
Novel (coumarin-3-yl)carbamates as selective MAO-B inhibitors: synthesis, in vitro and in vivo assays, theoretical evaluation of ADME properties and docking study.
Eur J Med Chem 63: 151-61 (2013)
University Of Santiago De Compostela
Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: modulation at the N-portion and distal phenyl ring.
Eur J Med Chem 63: 118-32 (2013)
Sapienza University Of Rome
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents.
Bioorg Med Chem Lett 23: 2391-4 (2013)
Cardiff University
Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories.
Bioorg Med Chem Lett 23: 2384-90 (2013)
Bayer Healthcare
Novel 5-(benzyloxy)pyridin-2(1H)-one derivatives as potent c-Met inhibitors.
Bioorg Med Chem Lett 23: 2408-13 (2013)
Chinese Academy Of Sciences
26- and 27-Methyl groups of 2-substituted, 19-nor-1a,25-dihydroxylated vitamin D compounds are essential for calcium mobilization in vivo.
Bioorg Chem 47: 9-16 (2013)
University Of Wisconsin-Madison
Synthesis, cyclooxygenase inhibitory effects, and molecular modeling study of 4-aryl-5-(4-(methylsulfonyl)phenyl)-2-alkylthio and -2-alkylsulfonyl-1H-imidazole derivatives.
Bioorg Med Chem 21: 2355-62 (2013)
Tehran University Of Medical Sciences
Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists.
Bioorg Med Chem 21: 2413-7 (2013)
Kyoto University
BCR-ABL tyrosine kinase inhibitor pharmacophore model derived from a series of phenylaminopyrimidine-based (PAP) derivatives.
Bioorg Med Chem Lett 23: 2442-50 (2013)
The First People'S Hospital Of Hangzhou
Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.
J Med Chem 56: 3012-23 (2013)
Oslo University Hospital
Strategies to reduce HERG K+ channel blockade. Exploring heteroaromaticity and rigidity in novel pyridine analogues of dofetilide.
J Med Chem 56: 2828-40 (2013)
Leiden University
Pyrimidoaminotropanes as potent, selective, and efficacious small molecule kinase inhibitors of the mammalian target of rapamycin (mTOR).
J Med Chem 56: 3090-101 (2013)
Genentech
The impact of introducing a histidine into an apolar cavity site on docking and ligand recognition.
J Med Chem 56: 2874-84 (2013)
University Of California San Francisco
Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors.
J Med Chem 56: 2885-903 (2013)
Chinese Academy Of Sciences
Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury.
J Med Chem 56: 2568-80 (2013)
Institutes For Pharmaceutical Discovery
Design, synthesis, and biological evaluation of indenoisoquinoline rexinoids with chemopreventive potential.
J Med Chem 56: 2581-605 (2013)
Purdue University
In search of new herbicidal inhibitors of the non-mevalonate pathway.
Pest Manag Sci 69: 559-63 (2013)
Basf-Se
Design and synthesis of new bifunctional sigma-1 selective ligands with antioxidant activity.
J Med Chem 56: 2447-55 (2013)
University Of Catania
Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.
J Med Chem 56: 3068-77 (2013)
Washington University
Development and evaluation of novel phosphotyrosine mimetic inhibitors targeting the Src homology 2 domain of signaling lymphocytic activation molecule (SLAM) associated protein.
J Med Chem 56: 2841-9 (2013)
National Taiwan University
Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.
Eur J Med Chem 63: 95-103 (2013)
Chinese Academy Of Sciences
Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.
Eur J Med Chem 63: 85-94 (2013)
Universit£
Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening.
Bioorg Med Chem Lett 23: 2078-82 (2013)
East China University Of Science And Technology
Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.
Bioorg Med Chem Lett 23: 2031-4 (2013)
Veterans Affairs Medical Center
A new series of N2-substituted-5-(p-toluenesulfonylamino)phthalimide analogues asa-glucosidase inhibitors.
Bioorg Med Chem Lett 23: 2022-6 (2013)
Xi'An Jiaotong University
Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate.
Bioorg Med Chem Lett 23: 2089-92 (2013)
China Pharmaceutical University
PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Bioorg Med Chem Lett 23: 1961-6 (2013)
Pfizer
[11C]olanzapine, radiosynthesis and lipophilicity of a new potential PET 5-HT2 and D2 receptor radioligand.
Bioorg Med Chem Lett 23: 1953-6 (2013)
Indiana University School Of Medicine
Evaluation of (Z)-2-((1-benzyl-1H-indol-3-yl)methylene)-quinuclidin-3-one analogues as novel, high affinity ligands for CB1 and CB2 cannabinoid receptors.
Bioorg Med Chem Lett 23: 2019-21 (2013)
University Of Arkansas For Medical Sciences
Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer.
Bioorg Med Chem Lett 23: 1945-8 (2013)
Astrazeneca
Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study.
Bioorg Med Chem 21: 1764-74 (2013)
University Of Kentucky
Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Bioorg Med Chem Lett 23: 2181-6 (2013)
Elan Pharmaceuticals
New potent calcimimetics: I. Discovery of a series of novel trisubstituted ureas.
Bioorg Med Chem Lett 23: 2451-4 (2013)
Galapagos
Potential CRF1R PET imaging agents: 1-fluoroalkylsubstituted 5-halo-3-(arylamino)pyrazin-2(1H)-ones.
Bioorg Med Chem Lett 23: 2052-5 (2013)
Bristol-Myers Squibb Research And Development
Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography.
J Enzyme Inhib Med Chem 29: 249-55 (2014)
Bc Cancer Agency
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.
Bioorg Med Chem 21: 1735-48 (2013)
University Of Pardubice
Development of silicon-containing bis-phenol derivatives as androgen receptor antagonists: selectivity switching by C/Si exchange.
Bioorg Med Chem 21: 1643-51 (2013)
The University Of Tokyo
Improvement ofs1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones.
Bioorg Med Chem 21: 1844-56 (2013)
Wilhelms-Universit£T M£Nster
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Bioorg Med Chem 21: 1756-63 (2013)
Epichem
Microwave-assisted synthesis and tyrosinase inhibitory activity of chalcone derivatives.
Chem Biol Drug Des 82: 39-47 (2013)
Shaoyang University
(+)-Laburnamine, a natural selective ligand and partial agonist for the?4?2 nicotinic receptor subtype.
J Nat Prod 76: 727-31 (2013)
Universit£
Target- and mechanism-based therapeutics for neurodegenerative diseases: strength in numbers.
J Med Chem 56: 3121-47 (2013)
Northwestern University
Synthesis and preliminary evaluation in tumor bearing mice of new (18)F-labeled arylsulfone matrix metalloproteinase inhibitors as tracers for positron emission tomography.
J Med Chem 56: 2676-89 (2013)
Universit£
(4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Eur J Med Chem 63: 64-75 (2013)
University Of M£Nster
Fungal transformation of cedryl acetate anda-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites.
Eur J Med Chem 62: 764-70 (2013)
University Of Karachi
Structure-based drug design using GPCR homology modeling: toward the discovery of novel selective CysLT2 antagonists.
Eur J Med Chem 62: 754-63 (2013)
Zhejiang University
Nonclassical antifolates, part 3: synthesis, biological evaluation and molecular modeling study of some new 2-heteroarylthio-quinazolin-4-ones.
Eur J Med Chem 63: 33-45 (2013)
King Saud University
New quinazoline derivatives for telomeric G-quadruplex DNA: effects of an added phenyl group on quadruplex binding ability.
Eur J Med Chem 63: 1-13 (2013)
Sun Yat-Sen University
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
Eur J Med Chem 62: 745-53 (2013)
Sun Yat-Sen University
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.
Eur J Med Chem 62: 738-44 (2013)
University Of Auckland
Chemical synthesis and biological validation of immobilized protein kinase inhibitory Leucettines.
Eur J Med Chem 62: 728-37 (2013)
Universit£
Synthesis, evaluation and absolute configuration assignment of novel dihydropyrimidin-2-ones as picomolar sodium iodide symporter inhibitors.
Eur J Med Chem 62: 722-7 (2013)
Institut De Biologie Et De Technologies De Saclay (Ibitecs)
Synthesis and discovery of novel piperidone-grafted mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors.
Bioorg Med Chem 21: 1696-707 (2013)
Universiti Sains Malaysia
Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors.
Bioorg Med Chem 21: 2370-2378 (2013)
Universidad De Alcala
Triazolopyridazine LRRK2 kinase inhibitors.
Bioorg Med Chem Lett 23: 1967-73 (2013)
Elan Pharmaceuticals
Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.
Bioorg Med Chem Lett 23: 2007-13 (2013)
University Of Strasburg
Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.
Bioorg Med Chem Lett 23: 2177-80 (2013)
Boehringer Ingelheim Pharmaceuticals
2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Bioorg Med Chem Lett 23: 2027-30 (2013)
Institutes For Pharmaceutical Discovery
Synthesis and anti-acetylcholinesterase properties of novel ?- and ?-substituted alkoxy organophosphonates.
Bioorg Med Chem Lett 23: 2048-51 (2013)
The University Of Montana
Novel leucine ureido derivatives as inhibitors of aminopeptidase N (APN).
Bioorg Med Chem 21: 1621-7 (2013)
Shandong University
A series of thiazole derivatives bearing thiazolidin-4-one as non-competitive ADAMTS-5 (aggrecanase-2) inhibitors.
Bioorg Med Chem Lett 23: 2106-10 (2013)
Asahi Kasei Pharma
Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.
Bioorg Med Chem Lett 23: 2035-43 (2013)
University Of Illinois At Chicago
Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.
Bioorg Med Chem Lett 23: 1974-7 (2013)
Elan Pharmaceuticals
On dihydroorotate dehydrogenases and their inhibitors and uses.
J Med Chem 56: 3148-67 (2013)
Institut Pasteur
Structure-guided design of selective inhibitors of neuronal nitric oxide synthase.
J Med Chem 56: 3024-32 (2013)
Northwestern University
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site.
J Med Chem 56: 2415-28 (2013)
Virginia Commonwealth University
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity.
J Med Chem 56: 2779-90 (2013)
University Of Kansas Medical Center
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor.
J Med Chem 56: 3048-67 (2013)
University Of Michigan
Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity.
J Med Chem 56: 2513-26 (2013)
The University Of Queensland
Selective 3-phosphoinositide-dependent kinase 1 (PDK1) inhibitors: dissecting the function and pharmacology of PDK1.
J Med Chem 56: 2726-37 (2013)
Glaxosmithkline
Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.
J Med Chem 56: 2311-22 (2013)
University Of Southern California
Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.
J Med Chem 56: 2695-9 (2013)
Vanderbilt University Medical Center
Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
J Med Chem 56: 2110-24 (2013)
University Of North Carolina At Chapel Hill
A new target for an old drug: identifying mitoxantrone as a nanomolar inhibitor of PIM1 kinase via kinome-wide selectivity modeling.
J Med Chem 56: 2619-29 (2013)
Graduate School Of Peking Union Medical College And Chinese Academy Of Medical Sciences
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.
J Med Chem 56: 3033-47 (2013)
Cyclofluidic
Orvinols with mixed kappa/mu opioid receptor agonist activity.
J Med Chem 56: 3207-16 (2013)
University Of Bath
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.
J Med Chem 56: 2651-64 (2013)
Universit£
Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.
J Med Chem 56: 2246-55 (2013)
Mayo Clinic
Colloidal aggregation causes inhibition of G protein-coupled receptors.
J Med Chem 56: 2406-14 (2013)
University Of North Carolina At Chapel Hill
Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2).
Eur J Med Chem 62: 649-60 (2013)
University Of Toyama
Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation.
Eur J Med Chem 62: 632-48 (2013)
Xiamen University
Advances in the discovery of kinesin spindle protein (Eg5) inhibitors as antitumor agents.
Eur J Med Chem 62: 614-31 (2013)
Cairo University
Euryspongins A-C, three new unique sesquiterpenes from a marine sponge Euryspongia sp.
Bioorg Med Chem Lett 23: 2151-4 (2013)
Tohoku Pharmaceutical University
Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection.
Bioorg Med Chem Lett 23: 2197-201 (2013)
Montana State University
Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1.
Bioorg Med Chem Lett 23: 2212-6 (2013)
Actelion Pharmaceuticals
Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.
Bioorg Med Chem Lett 23: 2225-9 (2013)
Fudan University
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors.
Bioorg Med Chem Lett 23: 2128-33 (2013)
Rensselaer Polytechnic Institute
A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors.
Bioorg Med Chem Lett 23: 2101-5 (2013)
Madurai Kamaraj University
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis.
Bioorg Med Chem 21: 1724-34 (2013)
East China University Of Science And Technology
Synthesis and biological activity of 5-chloro-N4-substituted phenyl-9H-pyrimido[4,5-b]indole-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic agents.
Bioorg Med Chem 21: 1857-64 (2013)
Duquesne University
Novel antiobesity agents: synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21.
Bioorg Med Chem 21: 1708-16 (2013)
Instituto De Qu£Mica M£Dica
Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization.
Bioorg Med Chem 21: 1749-55 (2013)
Chinese Academy Of Science
Semisynthetic studies identify mitochondria poisons from botanical dietary supplements--geranyloxycoumarins from Aegle marmelos.
Bioorg Med Chem 21: 1795-803 (2013)
University Of Mississippi
Design, synthesis and SAR of novel glucokinase activators.
Bioorg Med Chem Lett 23: 2166-71 (2013)
Takeda California
Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators.
Bioorg Med Chem Lett 23: 2134-9 (2013)
Sk Biopharmaceuticals
Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
Bioorg Med Chem 21: 1787-94 (2013)
Entremed
Novel inhibitors of bacterial virulence: development of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.
Bioorg Med Chem 21: 1880-97 (2013)
University Of Michigan
Stereoselective synthesis of a new class of potent and selective inhibitors of human¿8,7-sterol isomerase.
Bioorg Med Chem 21: 1925-43 (2013)
Ludwig-Maximilians University
Cytotoxicity and topoisomerase I/II inhibition activity of novel 4-aryl/alkyl-1-(piperidin-4-yl)-carbonylthiosemicarbazides and 4-benzoylthiosemicarbazides.
J Enzyme Inhib Med Chem 29: 243-8 (2014)
Medical University
Structure-activity relationships of peptides incorporating a bioactive reverse-turn heterocycle at the melanocortin receptors: identification of a 5800-fold mouse melanocortin-3 receptor (mMC3R) selective antagonist/partial agonist versus the mouse melanocortin-4 receptor (mMC4R).
J Med Chem 56: 2747-63 (2013)
University Of Florida
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization.
J Med Chem 56: 2283-93 (2013)
Yokohama City University
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17ß-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.
J Med Chem 56: 2429-46 (2013)
Vanderbilt University School Of Medicine
Optimization of heterocyclic substituted benzenesulfonamides as novel carbonic anhydrase IX inhibitors and their structure activity relationship.
Eur J Med Chem 62: 597-604 (2013)
East China University Of Science And Technology
Discovery of dopamine D4 receptor antagonists with planar chirality.
Bioorg Med Chem 21: 1680-4 (2013)
Friedrich-Alexander University
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy.
Bioorg Med Chem 21: 2135-44 (2013)
Universit£
Solubility-driven optimization of (pyridin-3-yl) benzoxazinyl-oxazolidinones leading to a promising antibacterial agent.
J Med Chem 56: 2642-50 (2013)
Chinese Academy Of Sciences
Evaluation of difluoromethyl ketones as agonists of the¿-aminobutyric acid type B (GABAB) receptor.
J Med Chem 56: 2456-65 (2013)
Purdue University
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation.
J Med Chem 56: 2256-69 (2013)
Universit£
The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
J Med Chem 56: 2207-17 (2013)
Novartis Pharma
Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.
Eur J Med Chem 62: 556-63 (2013)
Universidade Federal Do Rio Grande Do Sul
Farnesyl diphosphate synthase inhibitors from in silico screening.
Chem Biol Drug Des 81: 742-8 (2013)
University Of California San Diego
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.
J Med Chem 56: 1715-22 (2013)
University Health Network
Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors.
Eur J Med Chem 62: 515-25 (2013)
Dongguk University-Seoul
Opioid peptidomimetics: leads for the design of bioavailable mixed efficacyµ opioid receptor (MOR) agonist/d opioid receptor (DOR) antagonist ligands.
J Med Chem 56: 2139-49 (2013)
University Of Michigan
Incorporation of rapid thermodynamic data in fragment-based drug discovery.
J Med Chem 56: 2155-9 (2013)
The University Of Tokyo
3D-QSAR studies of 1,2-diaryl-1H-benzimidazole derivatives as JNK3 inhibitors with protective effects in neuronal cells.
Bioorg Med Chem Lett 23: 1639-42 (2013)
Hanyang University
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett 23: 1622-5 (2013)
Bristol-Myers Squibb Research And Development
Design and synthesis of bicyclic pyrazinone and pyrimidinone amides as potent TF-FVIIa inhibitors.
Bioorg Med Chem Lett 23: 1604-7 (2013)
Bristol-Myers Squibb R & D
Amino acid derived quinazolines as Rock/PKA inhibitors.
Bioorg Med Chem Lett 23: 1592-9 (2013)
Translational Research Institute
Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: the continued optimization of an MLPCN probe molecule.
Bioorg Med Chem Lett 23: 1860-4 (2013)
Vanderbilt University Medical Center
Synthesis and biological evaluation of pyridazine derivatives as novel HIV-1 NNRTIs.
Bioorg Med Chem 21: 2128-34 (2013)
Shandong University
Novel imidazophenoxazine-4-sulfonamides: their synthesis and evaluation as potential inhibitors of PDE4.
Bioorg Med Chem 21: 1952-63 (2013)
Ckm Arts And Science College
Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches.
Bioorg Med Chem 21: 1944-51 (2013)
Centro De Investigaci�N Pr�Ncipe Felipe
Synthesis and evaluation of coumarin derivatives as potential dual-action HIV-1 protease and reverse transcriptase inhibitors.
Bioorg Med Chem 21: 1964-71 (2013)
Rhodes University
Synthesis, characterization and Akt phosphorylation inhibitory activity of cyclopentanecarboxylate-substituted alkylphosphocholines.
Bioorg Med Chem 21: 2018-24 (2013)
Kyung Hee University
Investigation ofs receptors agonist/antagonist activity through N-(6-methoxytetralin-1-yl)- and N-(6-methoxynaphthalen-1-yl)alkyl derivatives of polymethylpiperidines.
Bioorg Med Chem 21: 1865-9 (2013)
Universit£
Structure-based discovery of cellular-active allosteric inhibitors of FAK.
Bioorg Med Chem Lett 23: 1779-85 (2013)
Takeda Pharmaceutical
Spirocyclic compounds, potent CCR1 antagonists.
Bioorg Med Chem Lett 23: 1883-6 (2013)
Astrazeneca
Synthesis and evaluation of methylsulfonylnitrobenzamides (MSNBAs) as inhibitors of the thyroid hormone receptor-coactivator interaction.
Bioorg Med Chem Lett 23: 1891-5 (2013)
St. Jude Children'S Research Hospital
3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (s1) receptor.
Bioorg Med Chem Lett 23: 1707-11 (2013)
Northeast Ohio Medical University
Discovery of a novel series of quinolonea7 nicotinic acetylcholine receptor agonists.
Bioorg Med Chem Lett 23: 1684-8 (2013)
Bristol-Myers Squibb Pharmaceutical Research Institute
Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.
Bioorg Med Chem Lett 23: 1743-7 (2013)
Bristol-Myers Squibb
Anion inhibition studies of thea-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
Bioorg Med Chem Lett 23: 1636-8 (2013)
Universit£
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase.
Bioorg Med Chem Lett 23: 1588-91 (2013)
Celgene
Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors.
Bioorg Med Chem Lett 23: 1748-51 (2013)
Korea Research Institute Of Bioscience And Biotechnology
Kinetic and anion inhibition studies of aß-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.
Bioorg Med Chem Lett 23: 1626-30 (2013)
Istituto Di Biostrutture E Bioimmagini
Discovery of novel 7-membered cyclic amide derivatives that inhibit 11beta-hydroxysteroid dehydrogenase type 1.
Bioorg Med Chem Lett 23: 1617-21 (2013)
Toray Industries
Vegfrecine, an inhibitor of VEGF receptor tyrosine kinases isolated from the culture broth of Streptomyces sp.
J Nat Prod 76: 715-9 (2013)
Institute Of Microbial Chemistry (Bikaken)
Psoralen derivatives as inhibitors of NF-¿B/DNA interaction: synthesis, molecular modeling, 3D-QSAR, and biological evaluation.
J Med Chem 56: 1830-42 (2013)
Universit£
Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.
J Med Chem 56: 1614-28 (2013)
University Of Copenhagen
Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor that Affords Robust CNS Aß Reduction.
ACS Med Chem Lett 3: 897-902 (2012)
TBA
Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.
Bioorg Med Chem 21: 2025-36 (2013)
Westf£Lische Wilhelms-Universit£T M£Nster
Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors.
Bioorg Med Chem 21: 2088-92 (2013)
Payame Noor University
Synthesis and SAR study of pyrrolo[3,4-b]pyridin-7(6H)-one derivatives as melanin concentrating hormone receptor 1 (MCH-R1) antagonists.
Bioorg Med Chem Lett 23: 1736-9 (2013)
Korea Research Institute Of Chemical Technology
Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bioorg Med Chem Lett 23: 2234-7 (2013)
Janssen Research And Development
Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.
Bioorg Med Chem Lett 23: 1776-8 (2013)
Ocean University Of China
Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
Bioorg Med Chem Lett 23: 1768-70 (2013)
Dongguk University-Seoul
Spiro heterocycles as potential inhibitors of SIRT1: Pd/C-mediated synthesis of novel N-indolylmethyl spiroindoline-3,2'-quinazolines.
Bioorg Med Chem Lett 23: 1351-7 (2013)
University Of Hyderabad Campus
Synthesis and cancer stem cell-based activity of substituted 5-morpholino-7H-thieno[3,2-b]pyran-7-ones designed as next generation PI3K inhibitors.
J Med Chem 56: 1922-39 (2013)
The University Of Arizona
Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.
J Med Chem 56: 2087-96 (2013)
Vu University Amsterdam
Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists.
J Med Chem 56: 1946-60 (2013)
Glaxosmithkline
New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.
J Enzyme Inhib Med Chem 29: 198-204 (2014)
Universidad De La Republica
A nonionic inhibitor with high specificity for the UDP-Gal donor binding site of human blood group B galactosyltransferase: design, synthesis, and characterization.
J Med Chem 56: 2150-4 (2013)
University Of Hamburg
Novel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.
J Med Chem 56: 2045-58 (2013)
University Of Pittsburgh
Olive secoiridoids and semisynthetic bioisostere analogues for the control of metastatic breast cancer.
Bioorg Med Chem 21: 2117-27 (2013)
University Of Louisiana At Monroe
Synthesis of tetrahydroxybiphenyls and tetrahydroxyterphenyls and their evaluation as amyloid-? aggregation inhibitors.
Bioorg Med Chem Lett 23: 1703-6 (2013)
Winthrop University
Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells.
Bioorg Med Chem Lett 23: 1834-8 (2013)
Broad Institute Of Mit And Harvard
Design, synthesis and aromatase inhibitory activities of novel indole-imidazole derivatives.
Bioorg Med Chem Lett 23: 1760-2 (2013)
Key Laboratory Of Medicinal Chemistry For Natural Resource (Yunnan University)
The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
Bioorg Med Chem Lett 23: 1870-3 (2013)
Bristol-Myers Squibb Research & Development
Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line.
Bioorg Med Chem Lett 23: 1631-5 (2013)
Universidade De Vigo
Discovery of new HER2/EGFR dual kinase inhibitors based on the anilinoquinazoline scaffold as potential anti-cancer agents.
J Enzyme Inhib Med Chem 29: 215-22 (2014)
Msa University
Interaction of silymarin flavonolignans with organic anion-transporting polypeptides.
Drug Metab Dispos 41: 958-65 (2013)
University Of North Carolina At Chapel Hill
Synthesis and biological evaluation of guanidino analogues of roscovitine.
Eur J Med Chem 62: 443-52 (2013)
Palack£
Design, Synthesis, Structural Characterization by IR, (1) H, (13) C, (15) N, 2D-NMR, X-Ray Diffraction and Evaluation of a New Class of Phenylaminoacetic Acid Benzylidene Hydrazines as pfENR Inhibitors.
Chem Biol Drug Des 81: 715-29 (2013)
Bombay College Of Pharmacy
Mexican antidiabetic herbs: valuable sources of inhibitors ofa-glucosidases.
J Nat Prod 76: 468-83 (2013)
Universidad Nacional Aut£Noma De M£Xico
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
J Med Chem 56: 2160-4 (2013)
University Of Copenhagen
Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
J Med Chem 56: 1996-2015 (2013)
Astrazeneca
Design and optimization of selective protein kinase C¿ (PKC¿) inhibitors for the treatment of autoimmune diseases.
J Med Chem 56: 1799-810 (2013)
Vertex Pharmaceuticals
?-(Substituted-phenoxyacetoxy)-?-heterocyclylmethylphosphonates: synthesis, herbicidal activity, inhibition on pyruvate dehydrogenase complex (PDHc), and application as postemergent herbicide against broadleaf weeds.
J Agric Food Chem 61: 2479-88 (2013)
Central China Normal University
Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans.
Drug Metab Dispos 41: 994-1003 (2013)
Dalian Medical University
In vitro activity of scorpiand-like azamacrocycle derivatives in promastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis.
Eur J Med Chem 62: 466-77 (2013)
Universidad De Granada
Characterization of a selective CaMKII peptide inhibitor.
Eur J Med Chem 62: 425-34 (2013)
University Of Naples Federico Ii
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): metabolically stabilized LPA receptor agonists.
Bioorg Med Chem Lett 23: 1865-9 (2013)
The University Of Utah
Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors.
Bioorg Med Chem Lett 23: 1789-92 (2013)
University Of Debrecen
Benzimidazole-carboxamides as potent and bioavailable stearoyl-CoA desaturase (SCD1) inhibitors from ligand-based virtual screening and chemical optimization.
Bioorg Med Chem Lett 23: 1817-22 (2013)
Sanofi-Aventis Deutschland
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers.
Bioorg Med Chem Lett 23: 1887-90 (2013)
Korea Institute Of Science And Technology
Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.
Bioorg Med Chem Lett 23: 1662-6 (2013)
Okayama University 1-1-1
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Bioorg Med Chem Lett 23: 1544-7 (2013)
University Of Illinois At Chicago
Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis.
Bioorg Med Chem 21: 1972-7 (2013)
St. Jude Children'S Research Hospital
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists.
Bioorg Med Chem 21: 2045-55 (2013)
Shionogi Pharmaceutical Research Center
Novel pseudopeptides incorporating a benzodiazepine-based turn mimetic--targeting Mycobacterium tuberculosis ribonucleotide reductase.
Bioorg Med Chem 21: 1992-2000 (2013)
Uppsala University
Novel symmetrical ureas as modulators of protein arginine methyl transferases.
Bioorg Med Chem 21: 2056-67 (2013)
Universidade De Vigo
Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors.
Bioorg Med Chem 21: 1379-85 (2013)
Atat£Rk University
Synthesis and biological evaluation of substituted imidazoquinoline derivatives as mPGES-1 inhibitors.
Bioorg Med Chem 21: 2068-78 (2013)
Dainippon Sumitomo Pharma
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Bioorg Med Chem 21: 2093-106 (2013)
Vilnius University Institute Of Biotechnology
Antidepressant abietane diterpenoids from Chinese eaglewood.
J Nat Prod 76: 216-22 (2013)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.
J Med Chem 56: 2059-73 (2013)
Astrazeneca
Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity.
J Med Chem 56: 2125-38 (2013)
Astrazeneca
Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.
J Med Chem 56: 1878-93 (2013)
The Beatson Institute For Cancer Research
1,2,3,4,6-Penta-O-galloyl-?-D-glucopyranose inhibits angiogenesis via inhibition of capillary morphogenesis gene 2.
J Med Chem 56: 1940-5 (2013)
Harvard Medical School
Discovery of a novel class of highly potent, selective, ATP-competitive, and orally bioavailable inhibitors of the mammalian target of rapamycin (mTOR).
J Med Chem 56: 2218-34 (2013)
Exelixis
Discovery of novel inhibitors targeting the Mycobacterium tuberculosis O-acetylserine sulfhydrylase (CysK1) using virtual high-throughput screening.
Bioorg Med Chem Lett 23: 1182-6 (2013)
Birla Institute Of Technology
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.
Bioorg Med Chem 21: 2156-62 (2013)
Sun Yat-Sen University
Design, modification and 3D QSAR studies of novel naphthalin-containing pyrazoline derivatives with/without thiourea skeleton as anticancer agents.
Bioorg Med Chem 21: 1050-63 (2013)
Nanjing University
Cloning, characterization, and sulfonamide and thiol inhibition studies of ana-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
J Med Chem 56: 1761-71 (2013)
University Of Tampere And Tampere University Hospital
Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.
J Med Chem 56: 1894-907 (2013)
Kitasato University
Mechanism of retinoid X receptor partial agonistic action of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)-1H-benzotriazole-5-carboxylic acid and structural development to increase potency.
J Med Chem 56: 1865-77 (2013)
Okayama University Graduate School Of Medicine
Synthesis and carbonic anhydrase isoenzymes I and II inhibitory effects of novel benzylamine derivatives.
J Enzyme Inhib Med Chem 29: 168-74 (2014)
Atatürk University
Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1.
Drug Metab Dispos 41: 916-22 (2013)
Gilead Sciences
Sesquiterpenes from the rhizomes of Curcuma heyneana.
J Nat Prod 76: 223-9 (2013)
University Of Toyama
Reversible inhibition of human carboxylesterases by acyl glucuronides.
Drug Metab Dispos 41: 698-703 (2013)
Eisai
Synthesis and antibacterial activities of new piperidine substituted (5R)-[1,2,3]triazolylmethyl and (5R)-[(4-F-[1,2,3]triazolyl)methyl] oxazolidinones.
Bioorg Med Chem Lett 23: 1193-6 (2013)
Korea Institute Science And Technology
Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma.
Bioorg Med Chem Lett 23: 1220-4 (2013)
Trinity College
Novel acylethanolamide derivatives that modulate body weight through enhancement of hypothalamic pro-opiomelanocortin (POMC) and/or decreased neuropeptide Y (NPY).
J Med Chem 56: 1811-29 (2013)
Hebrew University Of Jerusalem
Synthesis, biological evaluation and molecular modeling of aloe-emodin derivatives as new acetylcholinesterase inhibitors.
Bioorg Med Chem 21: 1064-73 (2013)
Hainan University
Highly potent and selective cannabinoid receptor 2 agonists: initial hit optimization of an adamantyl hit series identified from high-through-put screening.
Bioorg Med Chem Lett 23: 1177-81 (2013)
F. Hoffmann-La Roche
Cinnamic acid derivatives as inhibitors for chorismatases and isochorismatases.
Bioorg Med Chem Lett 23: 1477-81 (2013)
University Of Freiburg
Design, synthesis, and SAR of N-((1-(4-(propylsulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide inhibitors of glycine transporter-1.
Bioorg Med Chem Lett 23: 1257-61 (2013)
Amri
Montmorillonite K-10 catalyzed green synthesis of 2,6-unsubstituted dihydropyridines as potential inhibitors of PDE4.
Eur J Med Chem 62: 395-404 (2013)
Dr. Reddy'S Laboratories
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J Med Chem 56: 2294-310 (2013)
Merck
Torsion angle preferences in druglike chemical space: a comprehensive guide.
J Med Chem 56: 2016-28 (2013)
University Of Hamburg
Structural modifications to tetrahydropyridine-3-carboxylate esters en route to the discovery of M5-preferring muscarinic receptor orthosteric antagonists.
J Med Chem 56: 1693-703 (2013)
University Of Arkansas For Medical Sciences
Absorption, elimination, and metabolism of CS-1036, a novela-amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption.
Drug Metab Dispos 41: 878-87 (2013)
Daiichi Sankyo
Arylsulfonamide inhibitors of aggrecanases as potential therapeutic agents for osteoarthritis: synthesis and biological evaluation.
Eur J Med Chem 62: 379-94 (2013)
Universit£
Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.
Eur J Med Chem 62: 352-70 (2013)
University Of Patras
Towards dual antithrombotic compounds - balancing thrombin inhibitory and fibrinogen GPIIb/IIIa binding inhibitory activities of 2,3-dihydro-1,4-benzodioxine derivatives through regio- and stereoisomerism.
Eur J Med Chem 62: 329-40 (2013)
University Of Ljubljana
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.
Eur J Med Chem 62: 311-9 (2013)
University Of Life Sciences
Discovery of novel inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening.
Eur J Med Chem 62: 301-10 (2013)
Fudan University
Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents.
Bioorg Med Chem 21: 1284-304 (2013)
The Institute Of Cancer Research
Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
Bioorg Med Chem Lett 23: 1206-11 (2013)
Nanjing University Of Chinese Medicine
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.
Bioorg Med Chem Lett 23: 1212-6 (2013)
Astrazeneca
Critical role of a methyl group on the¿-lactone ring of annonaceous acetogenins in the potent inhibition of mitochondrial complex I.
Bioorg Med Chem Lett 23: 1217-9 (2013)
Kyoto Pharmaceutical University
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species.
Bioorg Med Chem Lett 23: 1279-84 (2013)
University Of Connecticut
Hybrids consisting of the pharmacophores of salmeterol and roflumilast or phthalazinone: dualß2-adrenoceptor agonists-PDE4 inhibitors for the treatment of COPD.
Bioorg Med Chem Lett 23: 1548-52 (2013)
Sun Yat-Sen University
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
Bioorg Med Chem 21: 1109-15 (2013)
The University Of Tokyo
The effect of absolute configuration on activity, subtype selectivity (M3/M2) of 3a-acyloxy-6ß-acetoxyltropane derivatives as muscarinic M3 receptor antagonists.
Bioorg Med Chem 21: 1234-9 (2013)
Shanghai Jiao Tong University
Selective inhibition of glycosyltransferases by bivalent imidazolium salts.
Bioorg Med Chem 21: 1305-11 (2013)
Queen'S University
N2-Trimethylacetyl substituted and unsubstituted-N4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines: design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents.
Bioorg Med Chem 21: 1312-23 (2013)
Duquesne University
Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp.
Bioorg Med Chem Lett 23: 1370-4 (2013)
Universit£
Inhibition of monoamine oxidase by phthalide analogues.
Bioorg Med Chem Lett 23: 1269-73 (2013)
North-West University
1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists.
Bioorg Med Chem Lett 23: 1228-31 (2013)
Chemocentryx
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Bioorg Med Chem Lett 23: 1249-52 (2013)
Eli Lilly
Inhibiting NF-¿B-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.
Bioorg Med Chem Lett 23: 1238-44 (2013)
Amgen
Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists.
Bioorg Med Chem Lett 23: 1519-21 (2013)
College Of Pharmacy Of Kangwon National University
Discovery of biphenylacetamide-derived inhibitors of BACE1 using de novo structure-based molecular design.
J Med Chem 56: 1843-52 (2013)
University Of Leeds
Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics.
Drug Metab Dispos 41: 870-7 (2013)
University Of Arkansas For Medical Sciences
The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation.
Drug Metab Dispos 41: 858-69 (2013)
University Of Michigan Medical School
Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.
Bioorg Med Chem Lett 23: 1285-7 (2013)
Kitasato University
Biological profile of the less lipophilic and synthetically more accessible bryostatin 7 closely resembles that of bryostatin 1.
ACS Chem Biol 8: 767-77 (2013)
National Cancer Institute-Bethesda
Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.
J Med Chem 56: 1704-14 (2013)
Bristol-Myers Squibb Research And Development
Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.
J Med Chem 56: 1772-6 (2013)
Broad Institute Of Mit And Harvard
The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition.
Biochemistry 52: 1776-1787 (2013)
University Of Auckland
Fluorinated N,N-dialkylaminostilbenes repress colon cancer by targeting methionine S-adenosyltransferase 2A.
ACS Chem Biol 8: 796-803 (2013)
University Of Kentucky
Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11ß-hydroxylase inhibition.
J Med Chem 56: 1723-9 (2013)
University Of Bologna
Pharmacological chaperones as therapeutics for lysosomal storage diseases.
J Med Chem 56: 2705-25 (2013)
Amicus Therapeutics
Development of inhibitors of the PAS-B domain of the HIF-2a transcription factor.
J Med Chem 56: 1739-47 (2013)
University Of Texas Southwestern Medical Center
Structure-activity relationship studies of pyrazolo[3,4-d]pyrimidine derivatives leading to the discovery of a novel multikinase inhibitor that potently inhibits FLT3 and VEGFR2 and evaluation of its activity against acute myeloid leukemia in vitro and in vivo.
J Med Chem 56: 1641-55 (2013)
Sichuan University
Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J Med Chem 56: 1748-60 (2013)
Trius Therapeutics
Biselectivity of isoDGR peptides for fibronectin binding integrin subtypesa5ß1 andavß6: conformational control through flanking amino acids.
J Med Chem 56: 1509-19 (2013)
Technische Universit£T M£Nchen
A chemical-biological study reveals C9-type iridoids as novel heat shock protein 90 (Hsp90) inhibitors.
J Med Chem 56: 1583-95 (2013)
Universit£
Development of¿ opioid receptor antagonists.
J Med Chem 56: 2178-95 (2013)
Research Triangle Institute
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Ka.
J Med Chem 56: 712-21 (2013)
Celgene Avilomics Research
A novel class of oral direct renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
J Med Chem 56: 2196-206 (2013)
Novartis Pharma
Exploring a new frontier in cancer treatment: targeting the ubiquitin and ubiquitin-like activating enzymes.
J Med Chem 56: 2165-77 (2013)
University Of Toronto Mississauga
Bioactive polyhydroxylated steroids from the Hainan soft coral Sinularia depressa Tixier-Durivault.
Bioorg Med Chem Lett 23: 1334-7 (2013)
Chinese Academy Of Sciences
Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.
Bioorg Med Chem Lett 23: 1398-406 (2013)
Lundbeck Research Usa
Phosphonic analogues of glutamic acid as irreversible inhibitors of Staphylococcus aureus endoproteinase GluC: an efficient synthesis and inhibition of the human IgG degradation.
Bioorg Med Chem Lett 23: 1412-5 (2013)
Wroclaw University Of Technology
Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake.
Eur J Med Chem 62: 256-69 (2013)
Neuroscienze Pharmaness S.C.A R.L.
N1,N3-disubstituted uracils as nonnucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg Med Chem 21: 1150-8 (2013)
Volgograd State Medical University
Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists.
Bioorg Med Chem 21: 1349-56 (2013)
Kangwon National University
Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.
J Med Chem 56: 1777-81 (2013)
Goethe-University Frankfurt
Synthesis and carbonic anhydrase inhibitory properties of 1,3-dicarbonyl derivatives of methylaminobenzene-sulfonamide.
J Enzyme Inhib Med Chem 29: 132-6 (2014)
Sakarya University
Benzenesulfonamides with benzimidazole moieties as inhibitors of carbonic anhydrases I, II, VII, XII and XIII.
J Enzyme Inhib Med Chem 29: 124-31 (2014)
Vilnius University
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
Drug Metab Dispos 41: 814-26 (2013)
Glaxosmithkline
Evidence for a new binding mode to GSK-3: allosteric regulation by the marine compound palinurin.
Eur J Med Chem 60: 479-89 (2013)
Universitat De Barcelona
Synthesis, pharmacological evaluation and QSAR modeling of mono-substituted 4-phenylpiperidines and 4-phenylpiperazines.
Eur J Med Chem 62: 241-55 (2013)
Neurosearch Sweden
2,3-diarylpropenoic acids as selective non-steroidal inhibitors of type-5 17ß-hydroxysteroid dehydrogenase (AKR1C3).
Eur J Med Chem 62: 89-97 (2013)
University Of Ljubljana
Design, synthesis and SAR of piperidyl-oxadiazoles as 11ß-hydroxysteroid dehydrogenase 1 inhibitors.
Eur J Med Chem 62: 1-10 (2013)
Chinese Academy Of Sciences
Synthesis and biological evaluation of some novel resveratrol amide derivatives as potential anti-tumor agents.
Eur J Med Chem 62: 222-31 (2013)
Hefei University Of Technology
Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound.
Eur J Med Chem 62: 214-21 (2013)
Universidade Federal De Goi£S
Synthesis of derivatives of methyl rosmarinate and their inhibitory activities against matrix metalloproteinase-1 (MMP-1).
Eur J Med Chem 62: 148-57 (2013)
Second Military Medical University
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.
Bioorg Med Chem 21: 1333-43 (2013)
University Of California
o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.
Bioorg Med Chem 21: 1386-91 (2013)
Istanbul University
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg Med Chem Lett 23: 1486-92 (2013)
Roche Palo Alto
Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the ?3?4 nicotinic acetylcholine receptor (nAChR).
Bioorg Med Chem Lett 23: 1450-5 (2013)
Targacept
Design, synthesis and structure-activity relationship of novel tricyclic benzimidazolone derivatives as potent 18 kDa translocator protein (TSPO) ligands.
Bioorg Med Chem 21: 1257-67 (2013)
Dainippon Sumitomo Pharma
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
J Med Chem 56: 1677-92 (2013)
Hoffmann-La Roche
Docking-based virtual screening of covalently binding ligands: an orthogonal lead discovery approach.
J Med Chem 56: 1478-90 (2013)
Msd Animal Health Innovation
Design, synthesis, and pharmacological properties of new heteroarylpyridine/heteroarylpyrimidine derivatives as CB(2) cannabinoid receptor partial agonists.
J Med Chem 56: 1098-112 (2013)
Universit£
Synthesis, fungicidal activity, and sterol 14?-demethylase binding interaction of 2-azolyl-3,4-dihydroquinazolines on Penicillium digitatum.
J Agric Food Chem 61: 1419-26 (2013)
Central China Normal University
Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.
J Med Chem 56: 1276-90 (2013)
University Of Florida
Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters.
Bioorg Med Chem 21: 1324-32 (2013)
Universit£
A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships.
Bioorg Med Chem Lett 23: 1456-61 (2013)
Theravance
Using a fragment-based approach to target protein-protein interactions.
Chembiochem 14: 332-42 (2013)
University Of Cambridge
Organic anion transporter 3 interacts selectively with lipophilicß-lactam antibiotics.
Drug Metab Dispos 41: 791-800 (2013)
Wilkes University
Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of A? plaques.
Eur J Med Chem 60: 469-78 (2013)
Nagasaki University
Molecular determinants of a selective matrix metalloprotease-12 inhibitor: insights from crystallography and thermodynamic studies.
J Med Chem 56: 1149-59 (2013)
Cea
Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening.
J Med Chem 56: 2738-46 (2013)
Rutgers University
Effect of helical conformation and side chain structure on ?-secretase inhibition by ?-peptide foldamers: insight into substrate recognition.
J Med Chem 56: 1443-54 (2013)
Nagoya City University
Structure-activity relationships and molecular modeling of 1,2,4-triazoles as adenosine receptor antagonists.
ACS Med Chem Lett 3: 715-720 (2012)
TBA
Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.
Bioorg Med Chem 21: 1344-8 (2013)
The Scripps Research Institute
Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.
J Med Chem 56: 735-47 (2013)
Ikerchem
In vitro inhibition effect and structure-activity relationships of some saccharin derivatives on erythrocyte carbonic anhydrase I and II.
J Enzyme Inhib Med Chem 29: 118-23 (2014)
Sakarya University
Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors.
Bioorg Med Chem 21: 1159-65 (2013)
Toho University
Synthesis and SAR study of new thiazole derivatives as vascular adhesion protein-1 (VAP-1) inhibitors for the treatment of diabetic macular edema.
Bioorg Med Chem 21: 1219-33 (2013)
Astellas Pharma
Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries.
Bioorg Med Chem Lett 23: 1407-11 (2013)
Pfizer
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.
Bioorg Med Chem Lett 23: 1433-7 (2013)
Guru Nanak Dev University
Focused pseudostatic hydrazone libraries screened by mass spectrometry binding assay: optimizing affinities toward¿-aminobutyric acid transporter 1.
J Med Chem 56: 1323-40 (2013)
Ludwig Maximilians University At Munich
Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases.
ACS Med Chem Lett 4: 22-26 (2013)
University Of Athens
Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2.
Bioorg Med Chem Lett 23: 1553-6 (2013)
Activx Biosciences
Design and synthesis of D1 agonist/D2 antagonist for treatment of schizophrenia.
Bioorg Med Chem Lett 23: 1498-501 (2013)
Sanofi Us
Synthesis and biological evaluation of 2-(arylethynyl)quinoline derivatives as mGluR5 antagonists for the treatment of neuropathic pain.
Bioorg Med Chem Lett 23: 1472-6 (2013)
Brain Science Institute
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Bioorg Med Chem 21: 891-902 (2013)
Duquesne University
Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.
Bioorg Med Chem 21: 856-68 (2013)
Chinese Academy Of Sciences
Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
J Med Chem 56: 671-84 (2013)
Chinese Academy Of Sciences
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.
J Med Chem 56: 2038-44 (2013)
Universidade Federal De S£O Carlos
Selective inhibition of extracellular thioredoxin by asymmetric disulfides.
J Med Chem 56: 1301-10 (2013)
Stanford University
Phenolic compounds with pancreatic lipase inhibitory activity from Korean yam (Dioscorea opposita).
J Enzyme Inhib Med Chem 29: 1-6 (2014)
Seoul National University
Selective inhibition of E. coli 1-deoxy-D-xylulose-5-phosphate synthase by acetylphosphonates().
Medchemcomm 3: 65-67 (2012)
The Johns Hopkins University School Of Medicine
Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum.
Bioorg Med Chem Lett 23: 1004-7 (2013)
Brandeis University
Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold.
Bioorg Med Chem Lett 23: 944-8 (2013)
Actelion Pharmaceuticals
Synthesis and carbonic anhydrase inhibitory properties of novel 1,4-dihydropyrimidinone substituted diarylureas.
J Enzyme Inhib Med Chem 29: 18-22 (2014)
Sakarya University
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
J Enzyme Inhib Med Chem 29: 59-63 (2014)
Gyeongsang National University
Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.
J Med Chem 56: 1573-82 (2013)
University Of South Carolina
Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites.
J Med Chem 56: 1262-75 (2013)
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors.
J Med Chem 56: 1171-81 (2013)
University Of Copenhagen
Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: binding mode, inhibitory mechanism and biological action.
Eur J Med Chem 60: 441-50 (2013)
Chinese Academy Of Sciences
Design, synthesis and biological evaluation of sulfur-containing 1,1-bisphosphonic acids as antiparasitic agents.
Eur J Med Chem 60: 431-40 (2013)
Universidad De Buenos Aires
Radiolytic transformation of rotenone with potential anti-adipogenic activity.
Bioorg Med Chem Lett 23: 1099-103 (2013)
Korea Atomic Energy Research Institute
A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma.
Bioorg Med Chem Lett 23: 939-43 (2013)
Theravance
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors.
Bioorg Med Chem Lett 23: 985-8 (2013)
Merck Research Laboratories
Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.
Bioorg Med Chem Lett 23: 979-84 (2013)
Osi Pharmaceuticals
Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.
J Med Chem 56: 1341-5 (2013)
Amgen
Sulfated pentagalloylglucoside is a potent, allosteric, and selective inhibitor of factor XIa.
J Med Chem 56: 867-78 (2013)
Virginia Commonwealth University
Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate.
J Med Chem 56: 761-80 (2013)
Chinese Academy Of Sciences
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.
Eur J Med Chem 60: 410-20 (2013)
Dalian University Of Technology
Identification of novel antimycobacterial chemical agents through the in silico multi-conformational structure-based drug screening of a large-scale chemical library.
Eur J Med Chem 60: 333-9 (2013)
Kyushu Institute Of Technology
Inhibition of protein glycation by urea and thiourea derivatives of glycine/proline conjugated benzisoxazole analogue - synthesis and structure-activity studies.
Eur J Med Chem 60: 325-32 (2013)
University Of Mysore
Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities.
Eur J Med Chem 60: 295-304 (2013)
Tohoku Pharmaceutical University
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Eur J Med Chem 60: 285-94 (2013)
Columbia University
Pyrazole-based arylalkyne cathepsin S inhibitors. Part III: modification of P4 region.
Bioorg Med Chem Lett 23: 1070-4 (2013)
Janssen Research And Development
Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors.
Bioorg Med Chem Lett 23: 1091-5 (2013)
Nanjing University
Synthesis and evaluation of 4,5-dihydro-5-methylisoxazolin-5-carboxamide derivatives as VLA-4 antagonists.
Bioorg Med Chem Lett 23: 1482-5 (2013)
Ranbaxy Research Laboratories
Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious ?-secretase inhibitors.
Bioorg Med Chem Lett 23: 996-1000 (2013)
Elan Pharmaceuticals
Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Bioorg Med Chem Lett 23: 1051-5 (2013)
Pfizer
Synthesis of derivatives of the keto-pyrrolyl-difluorophenol scaffold: some structural aspects for aldose reductase inhibitory activity and selectivity.
Bioorg Med Chem 21: 869-73 (2013)
Aristotle University Of Thessaloniki
Effective inhibition of acid and neutral ceramidases by novel B-13 and LCL-464 analogues.
Bioorg Med Chem 21: 874-82 (2013)
Humboldt Universit£T Zu Berlin
Identification of N-acyl 4-(5-pyrimidine-2,4-dionyl)phenylalanine derivatives and their orally active prodrug esters as dual-acting alpha4-beta1 and alpha4-beta7 receptor antagonists.
Bioorg Med Chem Lett 23: 1026-31 (2013)
Hoffmann-La Roche
Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase.
Bioorg Med Chem Lett 23: 1046-50 (2013)
Pfizer
Identification of N-acyl 4-(3-pyridonyl)phenylalanine derivatives and their orally active prodrug esters as dual actinga4ß1 anda4ß7 receptor antagonists.
Bioorg Med Chem Lett 23: 1036-40 (2013)
Hoffmann-La Roche
A comparative protease stability study of synthetic macrocyclic peptides that mimic two endocrine hormones.
Bioorg Med Chem Lett 23: 989-95 (2013)
The College Of New Jersey
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Chem Biol Drug Des 81: 607-14 (2013)
Umdnj-New Jersey Medical School
Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins.
J Enzyme Inhib Med Chem 29: 35-42 (2014)
Atatürk University
The 2.5Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J Med Chem 56: 963-9 (2013)
Eli Lilly
Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Predictive of Anti-Psychotic Activity.
ACS Med Chem Lett 1: 433-438 (2010)
TBA
Thiolactomycin-based ß-Ketoacyl-AcpM Synthase A (KasA) Inhibitors: FRAGMENT-BASED INHIBITOR DISCOVERY USING TRANSIENT ONE-DIMENSIONAL NUCLEAR OVERHAUSER EFFECT NMR SPECTROSCOPY.
J Biol Chem 288: 6045-52 (2013)
Institute For Chemical Biology & Drug Discovery
Probing the steric requirements of the¿-aminobutyric acid aminotransferase active site with fluorinated analogues of vigabatrin.
Bioorg Med Chem 21: 903-11 (2013)
Northwestern University
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
Bioorg Med Chem 21: 957-63 (2013)
University Of Southern California
Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.
Bioorg Med Chem Lett 23: 1132-5 (2013)
Drexel University College Of Medicine
Synthesis and dual biological effects of hydroxycinnamoyl phenylalanyl/prolyl hydroxamic acid derivatives as tyrosinase inhibitor and antioxidant.
Bioorg Med Chem Lett 23: 1136-42 (2013)
Seoul National University
Pharmacokinetics, metabolism, and excretion of the glycogen synthase kinase-3 inhibitor LY2090314 in rats, dogs, and humans: a case study in rapid clearance by extensive metabolism with low circulating metabolite exposure.
Drug Metab Dispos 41: 714-26 (2013)
Eli Lilly
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
J Med Chem 56: 832-42 (2013)
Indiana University School Of Medicine
A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic Applications.
ACS Chem Biol 8: 691-9 (2013)
University Of Washington
Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors.
J Med Chem 56: 1023-40 (2013)
Ariad Pharmaceuticals
Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).
J Nat Prod 76: 382-7 (2013)
University Of North Carolina At Greensboro
Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities.
J Med Chem 56: 640-59 (2013)
University Of Nottingham
Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutation-induced resistance against imatinib.
J Med Chem 56: 879-94 (2013)
Chinese Academy Of Sciences
Targeting the binding function 3 (BF3) site of the androgen receptor through virtual screening. 2. development of 2-((2-phenoxyethyl) thio)-1H-benzimidazole derivatives.
J Med Chem 56: 1136-48 (2013)
University Of British Columbia
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.
J Med Chem 56: 1211-27 (2013)
University Of Copenhagen
Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.
Bioorg Med Chem Lett 23: 1120-6 (2013)
Pfizer
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
J Med Chem 56: 1228-46 (2013)
Takeda Pharmaceutical
Novel P2 tris-tetrahydrofuran group in antiviral compound 1 (GRL-0519) fills the S2 binding pocket of selected mutants of HIV-1 protease.
J Med Chem 56: 1074-83 (2013)
Georgia State University
Discovery of INT131: a selective PPAR¿ modulator that enhances insulin sensitivity.
Bioorg Med Chem 21: 979-92 (2013)
Amgen
Synthesis of gatifloxacin derivatives and their biological activities against Mycobacterium leprae and Mycobacterium tuberculosis.
Bioorg Med Chem 21: 948-56 (2013)
Universit£
Structure-activity relationship of benzodiazepine derivatives as LXXLL peptide mimetics that inhibit the interaction of vitamin D receptor with coactivators.
Bioorg Med Chem 21: 993-1005 (2013)
The University Of Tokyo
Further characterization of a putative serine protease contributing to the¿-secretase cleavage ofß-amyloid precursor protein.
Bioorg Med Chem 21: 1018-29 (2013)
University Of Montpellier
Synthesis and biological evaluation of 1-(6-methylpyridin-2-yl)-5-(quinoxalin-6-yl)-1,2,3-triazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.
Bioorg Med Chem Lett 23: 1083-6 (2013)
Ewha Womans University
A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists.
Bioorg Med Chem Lett 23: 1063-9 (2013)
Janssen Research And Development
Discovery of novel 1,4-dihydropyridine-based PDE4 inhibitors.
Bioorg Med Chem Lett 23: 1104-9 (2013)
University Of Hyderabad Campus
Fragment-based discovery of new highly substituted 1H-pyrrolo[2,3-b]- and 3H-imidazolo[4,5-b]-pyridines as focal adhesion kinase inhibitors.
J Med Chem 56: 1160-70 (2013)
Merck Serono
Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability.
J Med Chem 56: 982-92 (2013)
University Of Southern Denmark
Development of new cyclic plasmin inhibitors with excellent potency and selectivity.
J Med Chem 56: 820-31 (2013)
Philipps University Marburg
Attenuating Staphylococcus aureus virulence gene regulation: a medicinal chemistry perspective.
J Med Chem 56: 1389-404 (2013)
University Of Nottingham
Synthesis and biological evaluation of 4-(aminomethyl)-1-hydroxypyrazole analogues of muscimol as¿-aminobutyric acid(a) receptor agonists.
J Med Chem 56: 993-1006 (2013)
University Of Copenhagen
Polyamine-based small molecule epigenetic modulators.
Medchemcomm 3: 14-21 (2012)
Wayne State University
Synthesis and biological evaluation of novel coumarin-pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents.
Eur J Med Chem 60: 187-98 (2013)
Cairo University
Carbonic anhydrase inhibitors: benzenesulfonamides incorporating cyanoacrylamide moieties are low nanomolar/subnanomolar inhibitors of the tumor-associated isoforms IX and XII.
Bioorg Med Chem 21: 1396-403 (2013)
Salman Bin Abdulaziz University
Regiospecificity and stereospecificity of human UDP-glucuronosyltransferases in the glucuronidation of estriol, 16-epiestriol, 17-epiestriol, and 13-epiestradiol.
Drug Metab Dispos 41: 582-91 (2013)
University Of Helsinki
SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists.
Bioorg Med Chem Lett 23: 614-9 (2013)
The Scripps Research Institute
Discovery of coumarin-monastrol hybrid as potential antibreast tumor-specific agent.
Eur J Med Chem 60: 120-7 (2013)
Csir-Central Drug Research Institute
An unprecedented reversible mode of action ofß-lactams for the inhibition of human fatty acid amide hydrolase (hFAAH).
Eur J Med Chem 60: 101-11 (2013)
Universit£
Sulphonamides: Deserving class as MMP inhibitors?
Eur J Med Chem 60: 89-100 (2013)
Indian Institute Of Technology (Bhu)
Identification and characterization of small molecules as potent and specific EPAC2 antagonists.
J Med Chem 56: 952-62 (2013)
University Of Texas Medical Branch
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor¿.
J Med Chem 56: 1535-43 (2013)
Helmholtz Centre For Infection Research
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
J Nat Prod 76: 36-44 (2013)
St. Jude Children'S Research Hospital
Discovery of 5-benzyl-3-phenyl-4,5-dihydroisoxazoles and 5-benzyl-3-phenyl-1,4,2-dioxazoles as potent firefly luciferase inhibitors.
J Med Chem 56: 1064-73 (2013)
University Of Eastern Finland
Amide hydrolysis of a novel chemical series of microsomal prostaglandin E synthase-1 inhibitors induces kidney toxicity in the rat.
Drug Metab Dispos 41: 634-41 (2013)
Astrazeneca
Systematic exploration of dual-acting modulators from a combined medicinal chemistry and biology perspective.
J Med Chem 56: 1197-210 (2013)
Astrazeneca
Tuning the preference of thiodigalactoside- and lactosamine-based ligands to galectin-3 over galectin-1.
J Med Chem 56: 1350-4 (2013)
Utrecht University
Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.
J Med Chem 56: 1247-61 (2013)
Universit£
Tetrahydropyrroloquinolinone type dual inhibitors of aromatase/aldosterone synthase as a novel strategy for breast cancer patients with elevated cardiovascular risks.
J Med Chem 56: 460-70 (2013)
Saarland University & Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT1A/5-HT2A/5-HT7 and dopamine D2/D3 receptors.
Eur J Med Chem 60: 42-50 (2013)
Jagiellonian University Medical College
Structure-based design, synthesis and evaluation of novel anthra[1,2-d]imidazole-6,11-dione derivatives as telomerase inhibitors and potential for cancer polypharmacology.
Eur J Med Chem 60: 29-41 (2013)
National Defense Medical Center
Synthesis, molecular modeling and biological evaluation of 2-aminomethyl-5-(quinolin-2-yl)-1,3,4-oxadiazole-2(3H)-thione quinolone derivatives as novel anticancer agent.
Eur J Med Chem 60: 23-8 (2013)
Shandong University Of Technology
Microwave-assisted synthesis of pyrimido[4,5-b][1,6]naphthyridin-4(3H)-ones with potential antitumor activity.
Eur J Med Chem 60: 1-9 (2013)
Universidad Del Valle
Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors.
Chem Biol Drug Des 81: 399-407 (2013)
Southeast University
Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives.
Bioorg Med Chem Lett 23: 702-5 (2013)
Birla Institute Of Technology
Small-molecular, non-peptide, non-ATP-competitive polo-like kinase 1 (Plk1) inhibitors with a terphenyl skeleton.
Bioorg Med Chem 21: 608-17 (2013)
The University Of Tokyo
Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists.
Bioorg Med Chem 21: 693-702 (2013)
Arizona State University
Design, synthesis, and structure-activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptorß (TRß) selective agonists.
Bioorg Med Chem 21: 592-607 (2013)
Kissei Pharmaceutical
A formyl peptide substituted with a conformationally constrained phenylalanine residue evokes a selective immune response in human neutrophils.
Bioorg Med Chem 21: 668-75 (2013)
Saga University
Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2).
Medchemcomm 3: 699-709 (2012)
Moffitt Cancer Center
Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency.
ACS Med Chem Lett 3: 991-996 (2012)
TBA
The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.
J Biol Chem 288: 5149-56 (2013)
John Innes Centre
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Bioorg Med Chem 21: 676-83 (2013)
The Hong Kong University Of Science And Technology
Recent development of potent analogues of oxazolidinone antibacterial agents.
Bioorg Med Chem 21: 577-91 (2013)
National Medicines Institute
Design, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-ylß-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1).
Bioorg Med Chem 21: 748-65 (2013)
Kissei Pharmaceutical
Ligand-based discovery of N-(1,3-dioxo-1H,3H-benzo[de]isochromen-5-yl)-carboxamide and sulfonamide derivatives as thymidylate synthase A inhibitors.
Bioorg Med Chem Lett 23: 663-8 (2013)
Universit£
Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.
Bioorg Med Chem Lett 23: 682-6 (2013)
National Center For Advancing Translational Sciences
Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aß aggregation.
Bioorg Med Chem Lett 23: 440-3 (2012)
Baskent University
Carbon-11 N-methyl alkylation of L-368,899 and in vivo PET imaging investigations for neural oxytocin receptors.
Bioorg Med Chem Lett 23: 902-6 (2013)
Yerkes National Primate Research Center
Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity.
J Med Chem 56: 241-53 (2013)
University Of T£Bingen
Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
J Nat Prod 76: 29-35 (2013)
Universit£
Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymeraseß.
Bioorg Med Chem 21: 403-11 (2012)
Kobe Gakuin University
Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV.
Bioorg Med Chem 21: 1410-8 (2013)
National University Of La Plata
Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity.
Bioorg Med Chem 21: 795-804 (2013)
Heidelberg University
Novel benzoxazole inhibitors of mPGES-1.
Bioorg Med Chem Lett 23: 907-11 (2013)
Pfizer
Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold.
Bioorg Med Chem Lett 23: 728-32 (2013)
Daiichi Sankyo
Epidithiodiketopiperazine as a pharmacophore for protein lysine methyltransferase G9a inhibitors: reducing cytotoxicity by structural simplification.
Bioorg Med Chem Lett 23: 733-6 (2013)
Riken Advanced Science Institute
Design and synthesis of novel 2-methyl-4,5-substitutedbenzo[f]-3,3a,4,5-tetrahydro-pyrazolo[1,5-d][1,4]oxazepin-8(7H)-one derivatives as telomerase inhibitors.
Bioorg Med Chem Lett 23: 720-3 (2013)
Guizhou University
Discovery of liver-targeted inhibitors of stearoyl-CoA desaturase (SCD1).
Bioorg Med Chem Lett 23: 791-6 (2013)
Merck Research Laboratories
Inhibition of theß-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: identification of the first inhibitor with anti-mycobacterial activity.
Bioorg Med Chem Lett 23: 740-3 (2013)
Universidad Nacional De Rosario
A-ring modification of SCH 900229 and related chromene sulfone ?-secretase inhibitors.
Bioorg Med Chem Lett 23: 850-3 (2013)
Merck Research Laboratories
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.
Bioorg Med Chem Lett 23: 669-72 (2013)
Dainippon Sumitomo Pharma
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors.
Bioorg Med Chem Lett 23: 715-9 (2013)
Universit£
Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.
Bioorg Med Chem Lett 23: 802-5 (2013)
Monash Institute Of Pharmaceutical Sciences
Cis-amide isosteric replacement in thienobenzoxepin inhibitors of PI3-kinase.
Bioorg Med Chem Lett 23: 897-901 (2013)
Genentech
Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.
Bioorg Med Chem Lett 23: 687-92 (2013)
The Ohio State University
Structure activity relationship studies of tricyclic bispyran sulfone ?-secretase inhibitors.
Bioorg Med Chem Lett 23: 844-9 (2013)
Merck Research Laboratories
Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation.
Bioorg Med Chem Lett 23: 673-8 (2013)
Chugai Pharmaceutical
Synthesis of new N-(arylcyclopropyl)acetamides and N-(arylvinyl)acetamides as conformationally-restricted ligands for melatonin receptors.
Bioorg Med Chem Lett 23: 430-4 (2012)
Paris-Sud University
Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-¿.
Bioorg Med Chem Lett 23: 767-72 (2013)
Pfizer
A new single-photon emission computed tomography (SPECT) imaging agent for serotonin transporters: [(125)I]Flip-IDAM, (2-((2-((dimethylamino)methyl)-4-iodophenyl)thio)phenyl)methanol.
Bioorg Med Chem Lett 23: 869-72 (2013)
University Of Pennsylvania
Lead optimization of isocytosine-derived xanthine oxidase inhibitors.
Bioorg Med Chem Lett 23: 834-8 (2013)
Piramal Healthcare
Design and synthesis of tricyclic cores for kinase inhibition.
Bioorg Med Chem Lett 23: 693-8 (2013)
Abbott Bioresearch Center
Near native binding of a fluorescent serotonin conjugate to serotonin type 3 receptors.
Bioorg Med Chem Lett 23: 773-5 (2013)
Washington State University
The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.
Bioorg Med Chem 21: 766-78 (2013)
The University Of Sydney
Synthesis, crystal structure and antidiabetic activity of substituted (E)-3-(Benzo [d]thiazol-2-ylamino) phenylprop-2-en-1-one.
Eur J Med Chem 59: 304-9 (2013)
North Maharashtra University
Enhanced bioactivity of silybin B methylation products.
Bioorg Med Chem 21: 742-7 (2013)
University Of North Carolina At Greensboro
Identification of benzofuran central cores for the inhibition of leukotriene A(4) hydrolase.
Bioorg Med Chem Lett 23: 811-5 (2013)
Janssen Research And Development
Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
Bioorg Med Chem Lett 23: 1114-9 (2013)
Pfizer
Discovery of a new series of [1,2,4]triazolo[4,3-a]quinoxalines as dual phosphodiesterase 2/phosphodiesterase 10 (PDE2/PDE10) inhibitors.
Bioorg Med Chem Lett 23: 785-90 (2013)
Janssen-Cilag
Synthesis and evaluation of diphenylphosphinic amides and diphenylphosphine oxides as inhibitors of Kv1.5.
Bioorg Med Chem Lett 23: 706-10 (2013)
Astrazeneca
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1).
J Med Chem 56: 182-200 (2013)
Purdue University
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm.
ACS Med Chem Lett 3: 745-748 (2012)
University Of Minnesota
Synthesis, pharmacology, and biostructural characterization of novela4ß2 nicotinic acetylcholine receptor agonists.
J Med Chem 56: 940-51 (2013)
University Of Copenhagen
Structural-functional studies of Burkholderia cenocepacia D-glycero-ß-D-manno-heptose 7-phosphate kinase (HldA) and characterization of inhibitors with antibiotic adjuvant and antivirulence properties.
J Med Chem 56: 1405-17 (2013)
Mcmaster University
A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells.
ACS Med Chem Lett 3: 1034-1038 (2012)
TBA
Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression.
Bioorg Med Chem Lett 23: 407-11 (2012)
Bristol-Myers Squibb Research And Development
The discovery of fused oxadiazepines as gamma secretase modulators for treatment of Alzheimer's disease.
Bioorg Med Chem Lett 23: 466-71 (2012)
Merck Research Laboratory
Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography.
J Med Chem 56: 84-96 (2013)
University Of Zurich
Structure-activity relationships in 1,4-benzodioxan-related compounds. 11. (1) reversed enantioselectivity of 1,4-dioxane derivatives ina1-adrenergic and 5-HT1A receptor binding sites recognition.
J Med Chem 56: 584-8 (2013)
University Of Camerino
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives.
J Med Chem 56: 521-33 (2013)
University Of Ljubljana
Comparative structural and functional studies of 4-(thiazol-5-yl)-2-(phenylamino)pyrimidine-5-carbonitrile CDK9 inhibitors suggest the basis for isotype selectivity.
J Med Chem 56: 660-70 (2013)
University Of Oxford
Histone deacetylase (HDAC) inhibitors with a novel connecting unit linker region reveal a selectivity profile for HDAC4 and HDAC5 with improved activity against chemoresistant cancer cells.
J Med Chem 56: 427-36 (2013)
Heinrich Heine Universit£T
Trimeric hemibastadin congener from the marine sponge Ianthella basta.
J Nat Prod 76: 121-5 (2013)
Heinrich-Heine University
MMP inhibition by barbiturate homodimers.
Bioorg Med Chem Lett 23: 444-7 (2012)
Trinity College
Induction of ABCA1 and ABCG1 expression by the liver X receptor modulator cineole in macrophages.
Bioorg Med Chem Lett 23: 579-83 (2012)
Korea University
Synthesis and preliminary evaluation of pharmacological properties of some piperazine derivatives of xanthone.
Bioorg Med Chem 21: 514-22 (2013)
Jagiellonian University Medical College
Synthesis and structure-activity relationships of 2-hydrazinyladenosine derivatives as A(2A) adenosine receptor ligands.
Bioorg Med Chem 21: 436-47 (2012)
University Of Bonn
Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents.
Bioorg Med Chem 21: 448-55 (2012)
Nanjing University
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR).
Bioorg Med Chem 21: 456-65 (2013)
Universit£
Design, synthesis and molecular docking ofa,ß-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferative activity.
Bioorg Med Chem 21: 388-94 (2012)
Soochow University
Naphthyridinone (NTD) integrase inhibitors: N1 protio and methyl combination substituent effects with C3 amide groups.
Bioorg Med Chem Lett 23: 422-5 (2013)
Glaxosmithkline Research & Development
Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1.
Bioorg Med Chem Lett 23: 472-5 (2012)
Praecis Pharmaceuticals Incorporated (Currently Glaxosmithkline)
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships.
J Med Chem 56: 437-50 (2013)
TBA
Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.
J Med Chem 56: 568-83 (2013)
Xenon Pharmaceuticals
Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
J Med Chem 56: 1113-23 (2013)
University Of Michigan
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
J Med Chem 56: 15-30 (2013)
Vanderbilt University School Of Medicine
Synthesis and SAR of 1-hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of D-Amino Acid Oxidase.
ACS Med Chem Lett 3: 839-843 (2012)
TBA
Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.
J Med Chem 56: 293-300 (2013)
Latvian Association Of Human Genetics
Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling.
J Med Chem 56: 781-95 (2013)
University Of California
Synthesis and evaluation ofa-thymidine analogues as novel antimalarials.
J Med Chem 55: 10948-57 (2012)
University Of Dundee
Boron-based inhibitors of acyl protein thioesterases 1 and 2.
Chembiochem 14: 115-22 (2013)
Technical University Of Dortmund
Synthesis and biological evaluation of N-aryl-7-methoxybenzo[b]furo[3,2-d]pyrimidin-4-amines and their N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amine analogues as dual inhibitors of CLK1 and DYRK1A kinases.
Eur J Med Chem 59: 283-95 (2013)
Universit£
Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: continued optimization of an MLPCN probe molecule.
Bioorg Med Chem Lett 23: 412-6 (2012)
Vanderbilt University Medical Center
Synthesis and biological activity of aminophthalazines and aminopyridazines as novel inhibitors of PGE2 production in cells.
Bioorg Med Chem Lett 23: 528-31 (2012)
The University Of Arizona
Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.
Bioorg Med Chem Lett 23: 492-5 (2012)
Universit£
Synthesis and SAR of aminothiazole fused benzazepines as selective dopamine D2 partial agonists.
Bioorg Med Chem Lett 23: 543-7 (2012)
Astrazeneca
Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Bioorg Med Chem Lett 23: 417-21 (2012)
Columbia University
Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.
J Med Chem 56: 210-9 (2013)
The University Of Queensland
Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.
J Med Chem 56: 547-55 (2013)
University Of Oxford
Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
J Med Chem 56: 301-19 (2013)
Pfizer
Discovery of 4-phenyl-2-phenylaminopyridine based TNIK inhibitors.
Bioorg Med Chem Lett 23: 569-73 (2012)
Astex Pharmaceuticals
Small molecule amides as potent ROR-¿ selective modulators.
Bioorg Med Chem Lett 23: 532-6 (2012)
The Scripps Research Institute
Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.
Eur J Med Chem 59: 235-42 (2013)
University Of Santiago De Compostela
An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
J Med Chem 56: 254-63 (2013)
University Of Chicago
Coumarin-based inhibitors of Bacillus anthracis and Staphylococcus aureus replicative DNA helicase: chemical optimization, biological evaluation, and antibacterial activities.
J Med Chem 55: 10896-908 (2012)
Microbiotix
Synthesis and biological evaluation of novel series of aminopyrimidine derivatives as urease inhibitors and antimicrobial agents.
J Enzyme Inhib Med Chem 28: 1316-23 (2013)
Solapur University
Development of substituted N-[3-(3-methoxylphenyl)propyl] amides as MT(2)-selective melatonin agonists: improving metabolic stability.
Bioorg Med Chem 21: 547-52 (2012)
Hong Kong University Of Science And Technology
Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease.
J Med Chem 56: 220-40 (2013)
Astrazeneca
Design and synthesis of novel benzoheterocyclic derivatives as human acrosin inhibitors by scaffold hopping.
Eur J Med Chem 59: 176-82 (2013)
Second Military Medical University
Optimization of 5-hydroxytryptamines as dual function inhibitors targeting phospholipase A2 and leukotriene A4 hydrolase.
Eur J Med Chem 59: 160-7 (2013)
Peking University
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.
Eur J Med Chem 59: 141-9 (2013)
Dalian University Of Technology
Sirtuins as emerging anti-parasitic targets.
Eur J Med Chem 59: 132-40 (2013)
Jiangsu University
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.
Bioorg Med Chem 21: 532-9 (2012)
Department Of Pharmaceutical Chemistry Of Aristotle University Of Thessaloniki
Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease.
Bioorg Med Chem Lett 23: 426-9 (2012)
Universidad Complutense
Novel cinnoline-based inhibitors of LRRK2 kinase activity.
Bioorg Med Chem Lett 23: 71-4 (2012)
Elan Pharmaceuticals
Inhibitory effects of metachromins L-Q and its related analogs against receptor tyrosine kinases EGFR and HER2.
Bioorg Med Chem Lett 23: 117-8 (2013)
Hokkaido University
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Bioorg Med Chem 21: 28-41 (2012)
Takeda Pharmaceutical
Discovery of novela1-adrenoceptor ligands based on the antipsychotic sertindole suitable for labeling as PET ligands.
Bioorg Med Chem 21: 196-204 (2012)
H. Lundbeck
A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.
Bioorg Med Chem 21: 42-61 (2012)
Daiichi Sankyo
Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.
Bioorg Med Chem Lett 23: 47-54 (2012)
University Of Namur
The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors.
Bioorg Med Chem Lett 23: 66-70 (2012)
Glaxosmithkline
Development of an in vivo active, dual EP1 and EP3 selective antagonist based on a novel acyl sulfonamide bioisostere.
Bioorg Med Chem Lett 23: 37-41 (2012)
Vanderbilt University School Of Medicine
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett 23: 537-42 (2012)
Yuhan Research Institute
Novel peptidomimetics as BACE-1 inhibitors: synthesis, molecular modeling, and biological studies.
Bioorg Med Chem Lett 23: 85-9 (2012)
Universit£
Synthesis and evaluation of novel ligands for the histamine H4 receptor based on a pyrrolo[2,3-d]pyrimidine scaffold.
Bioorg Med Chem Lett 23: 132-7 (2012)
Ku Leuven
Fragment-based discovery of novel and selective mPGES-1 inhibitors Part 1: identification of sulfonamido-1,2,3-triazole-4,5-dicarboxylic acid.
Bioorg Med Chem Lett 23: 75-80 (2012)
Kyung Hee University
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.
Bioorg Med Chem Lett 23: 125-31 (2012)
University Of Paris
Facile synthesis and characterization of novel pyrazole-sulfonamides and their inhibition effects on human carbonic anhydrase isoenzymes.
Bioorg Med Chem 21: 21-7 (2012)
Dumlupinar University
Structure-activity relationship study on benzoic acid part of diphenylamine-based retinoids.
Bioorg Med Chem Lett 23: 81-4 (2013)
Tohoku Pharmaceutical University
Virtual Screening of CB2 Receptor Agonists from Bayesian Network and High-Throughput Docking: Structural Insights into Agonist-Modulated GPCR Features.
Chem Biol Drug Des 81: 442-454 (2013)
Universite Lille-Nord de France
3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.
J Med Chem 56: 345-56 (2013)
F. Hoffmann-La Roche
Peptide-conjugated pterins as inhibitors of ricin toxin A.
J Med Chem 56: 320-9 (2013)
Toho University
Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.
J Med Chem 56: 201-9 (2013)
Centre For Addiction And Mental Health
3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3.
J Med Chem 56: 264-75 (2013)
Technische Universit£T Braunschweig
Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
J Med Chem 55: 10972-94 (2012)
Glaxosmithkline
Synthesis and biological evaluation of novel propargyl amines as potential fluorine-18 labeled radioligands for detection of MAO-B activity.
Bioorg Med Chem 21: 186-95 (2012)
Karolinska Institutet
Identification of new potent GPR119 agonists by combining virtual screening and combinatorial chemistry.
J Med Chem 55: 11031-41 (2012)
Boehringer Ingelheim Pharma
Synthesis and biological evaluation of a new series of phenothiazine-containing protein farnesyltransferase inhibitors.
Eur J Med Chem 59: 101-10 (2013)
Al. I. Cuza University Of Iasi
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.
Eur J Med Chem 59: 91-100 (2013)
Sapienza University Of Rome
Combining QSAR classification models for predictive modeling of human monoamine oxidase inhibitors.
Eur J Med Chem 59: 75-90 (2013)
Universidade Do Porto
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.
Bioorg Med Chem 21: 11-20 (2012)
Dalian University Of Technology
QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII.
Bioorg Med Chem 21: 1404-9 (2013)
Romanian Academy
Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors.
Bioorg Med Chem Lett 23: 179-82 (2012)
The General Hospital Of Chinese People'S Liberation Army
Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK).
Bioorg Med Chem Lett 23: 169-73 (2012)
Astrazeneca
Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile.
Bioorg Med Chem Lett 23: 90-5 (2012)
Shionogi
Tetrahydro-ß-carboline derivatives targeting fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channels.
Bioorg Med Chem Lett 23: 138-42 (2012)
Sapienza University Of Rome
Identification of novel chromenone derivatives as interleukin-5 inhibitors.
Eur J Med Chem 59: 31-8 (2013)
Chungnam National University
Design, synthesis and crystallographic analysis of nitrile-based broad-spectrum peptidomimetic inhibitors for coronavirus 3C-like proteases.
Eur J Med Chem 59: 1-6 (2013)
The Chinese University Of Hong Kong
Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.
Bioorg Med Chem Lett 23: 119-24 (2012)
Astrazeneca
Phosphodiesterase inhibitors. Part 5: hybrid PDE3/4 inhibitors as dual bronchorelaxant/anti-inflammatory agents for inhaled administration.
Bioorg Med Chem Lett 23: 375-81 (2012)
Kyorin Pharmaceutical
Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.
Bioorg Med Chem Lett 23: 223-7 (2012)
Vanderbilt University Medical Center
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
Bioorg Med Chem Lett 23: 256-60 (2012)
Kochi Medical School
The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.
Bioorg Med Chem Lett 23: 268-72 (2012)
Kitasato University
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.
Bioorg Med Chem Lett 23: 163-8 (2012)
University Of Alberta
Fluorescent ligands for adenosine receptors.
Bioorg Med Chem Lett 23: 26-36 (2012)
National Institute Of Diabetes And Digestive And Kidney Diseases
Macrolactonolides: a novel class of anti-inflammatory compounds.
Bioorg Med Chem 21: 321-32 (2012)
Glaxosmithkline
Glycosidic carbonic anhydrase IX inhibitors: a sweet approach against cancer.
Bioorg Med Chem 21: 1419-26 (2013)
Ecole Nationale Sup£Rieure De Chimie De Montpellier
Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.
Bioorg Med Chem 21: 311-20 (2012)
Tokyo University Of Science
Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.
Bioorg Med Chem 21: 257-68 (2012)
Ghent University
Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity.
Bioorg Med Chem 21: 62-9 (2012)
China Pharmaceutical University
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists.
Bioorg Med Chem 21: 70-83 (2012)
Takeda Pharmaceutical
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Bioorg Med Chem 21: 146-52 (2012)
Universit£
Synthesis and biological evaluation of¹8F labeled fluoro-oligo-ethoxylated 4-benzylpiperazine derivatives for sigma-1 receptor imaging.
Bioorg Med Chem 21: 215-22 (2012)
Key Laboratory Of Radiopharmaceuticals (Beijing Normal University)
Potent, selective, and orally bioavailable inhibitors of the mammalian target of rapamycin kinase domain exhibiting single agent antiproliferative activity.
J Med Chem 55: 10958-71 (2012)
Genentech
Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo.
J Med Chem 56: 97-108 (2013)
Chinese Academy Of Medical Sciences And Peking Union Medical College
Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.
Bioorg Med Chem Lett 23: 143-6 (2012)
University Of Bayreuth
Development of N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-N-methyl-4-[11C]methylbenzamide for positron emission tomography imaging of metabotropic glutamate 1 receptor in monkey brain.
J Med Chem 55: 11042-51 (2012)
National Institute Of Radiological Sciences
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
J Med Chem 55: 10937-47 (2012)
Sapienza University Of Rome
Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines.
J Med Chem 55: 11022-30 (2012)
University Of Cape Town
PPAR¿ agonist from Chromolaena odorata.
J Nat Prod 75: 2076-81 (2012)
Hebei Medical University
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
J Med Chem 55: 10863-84 (2012)
Seoul National University
Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.
Bioorg Med Chem 21: 4027-33 (2013)
University Of Oxford
Novel 2-aminooctahydrocyclopentalene-3a-carboxamides as potent CCR2 antagonists.
Bioorg Med Chem Lett 23: 351-4 (2012)
Janssen Research And Development
DNA cloning, characterization, and inhibition studies of ana-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
J Med Chem 55: 10742-8 (2012)
Istituto Di Biochimica Delle Proteine-Cnr
Cyanobacterial peptides as a prototype for the design of potentß-secretase inhibitors and the development of selective chemical probes for other aspartic proteases.
J Med Chem 55: 10749-65 (2012)
University Of Florida
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
ACS Med Chem Lett 3: 668-672 (2012)
The Scripps Research Institute
Protein tyrosine phosphatase 1B inhibitory effect by dammarane-type triterpenes from hydrolyzate of total Gynostemma pentaphyllum saponins.
Bioorg Med Chem Lett 23: 297-300 (2012)
Shenyang Pharmaceutical University
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Bioorg Med Chem Lett 23: 194-7 (2012)
Pfizer
Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.
Bioorg Med Chem Lett 23: 346-50 (2012)
Vanderbilt University Medical Center
QSAR investigation of NaV1.7 active compounds using the SVM/Signature approach and the Bioclipse Modeling platform.
Bioorg Med Chem Lett 23: 261-3 (2013)
Astrazeneca
Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
Bioorg Med Chem Lett 23: 330-5 (2012)
Bristol-Myers Squibb Research And Development
Trisubstituted thiophene analogues of 1-thiazolyl-2-pyrazoline, super oxidase inhibitors and free radical scavengers.
Bioorg Med Chem 21: 365-72 (2012)
Swami Ramanand Teerth Marathwada University
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Bioorg Med Chem Lett 23: 370-4 (2012)
University Of Maryland
Cyclic analogs of galanin and neuropeptide Y by hydrocarbon stapling.
Bioorg Med Chem 21: 303-10 (2012)
University Of Utah
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.
J Med Chem 55: 11062-6 (2012)
University Of Bradford
Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors.
J Med Chem 55: 10909-17 (2012)
University Of Lille
Kinetic and in silico analysis of thiazolidin-based inhibitors of a-carbonic anhydrase isoenzymes.
J Enzyme Inhib Med Chem 28: 370-4 (2013)
Ondokuz Mayis University
Pyrazolo[1,5-c]quinazoline derivatives and their simplified analogues as adenosine receptor antagonists: synthesis, structure-affinity relationships and molecular modeling studies.
Bioorg Med Chem 21: 283-94 (2012)
Universita' Di Firenze
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptora/¿ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
J Med Chem 56: 60-72 (2013)
Universit�
Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase.
J Med Chem 56: 371-5 (2013)
Imperial College
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides.
Bioorg Med Chem 21: 1451-64 (2013)
University Of Lille
A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.
Bioorg Med Chem Lett 23: 323-6 (2012)
National Institute On Drug Abuse-Intramural Research Program
Creation of an HDAC-based yeast screening method for evaluation of marine-derived actinomycetes: discovery of streptosetin A.
J Nat Prod 75: 2193-9 (2012)
San Francisco State University
Development of second-generation indole-based dynamin GTPase inhibitors.
J Med Chem 56: 46-59 (2013)
The University Of Newcastle
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
J Med Chem 55: 10918-36 (2012)
Universidade Federal De Pernambuco
An anthraquinone scaffold for putative, two-face Bim BH3a-helix mimic.
J Med Chem 55: 10735-41 (2012)
Dalian University Of Technology
Inhibition of HIV-1 integrase dimerization and activity with crosslinked interfacial peptides.
Bioorg Med Chem 21: 4041-4 (2013)
Purdue University
On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.
Bioorg Med Chem Lett 23: 355-9 (2012)
Virginia Commonwealth University
Identification of inhibitors against interaction between pro-inflammatory sPLA2-IIA protein and integrinavß3.
Bioorg Med Chem Lett 23: 340-5 (2012)
University Of California
2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.
Eur J Med Chem 58: 519-32 (2012)
University Of Bologna
Synthesis, structure-activity relationships, and docking studies of N-phenylarylformamide derivatives (PAFAs) as non-nucleoside HIV reverse transcriptase inhibitors.
Eur J Med Chem 58: 504-12 (2012)
Fudan University
Non-proteinogenic amino acids in the pThr-2 position of a pentamer peptide that confer high binding affinity for the polo box domain (PBD) of polo-like kinase 1 (Plk1).
Bioorg Med Chem Lett 22: 7306-8 (2012)
Frederick National Laboratory For Cancer Research
Characterization of human carbonic anhydrase XII stability and inhibitor binding.
Bioorg Med Chem 21: 1431-6 (2013)
Vilnius University Institute Of Biotechnology
HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship.
J Med Chem 55: 10405-13 (2012)
University Of Osnabr£Ck
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.
Eur J Med Chem 58: 405-17 (2012)
Sapienza University Of Rome
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett 22: 7523-9 (2012)
Pfizer
Free-Wilson and structural approaches to co-optimizing human and rodent isoform potency for 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitors.
J Med Chem 55: 10652-61 (2012)
Astrazeneca
Conjugation of quinones with natural polyamines: toward an expanded antitrypanosomatid profile.
J Med Chem 55: 10490-500 (2012)
University Of Bologna
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.
J Med Chem 55: 10424-36 (2012)
National Research Center
Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine.
J Med Chem 55: 10644-51 (2012)
Bristol-Myers Squibb Research & Development
Synthesis and structure-activity relationship of (E)-phenoxyacrylic amide derivatives as hypoxia-inducible factor (HIF) 1a inhibitors.
J Med Chem 55: 10564-71 (2012)
Dongguk University-Seoul
Virtual screening and QSAR study of some pyrrolidine derivatives asa-mannosidase inhibitors for binding feature analysis.
Bioorg Med Chem 20: 6945-59 (2012)
Universidade Do Porto 687
Scaffold hopping strategy toward original pyrazolines as selective CB2 receptor ligands.
Eur J Med Chem 58: 396-404 (2012)
Avenue De L'Universit£
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
J Med Chem 55: 10551-63 (2012)
Johns Hopkins University
Rational design of highly selective spleen tyrosine kinase inhibitors.
J Med Chem 55: 10414-23 (2012)
Hoffmann-La Roche
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
J Med Chem 55: 10700-15 (2012)
Bar-Ilan University
Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands.
J Med Chem 55: 10572-83 (2012)
Vu University Amsterdam
Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9.
Eur J Med Chem 58: 368-76 (2012)
Universit£
The discovery of a novel series of glucokinase activators based on a pyrazolopyrimidine scaffold.
Bioorg Med Chem Lett 22: 7302-5 (2012)
Astrazeneca
6,7-Dihydroxy-1-oxoisoindoline-4-sulfonamide-containing HIV-1 integrase inhibitors.
Bioorg Med Chem Lett 22: 7309-13 (2012)
Frederick National Laboratory For Cancer Research
Discovery of selective biaryl ethers as PDE10A inhibitors: improvement in potency and mitigation of Pgp-mediated efflux.
Bioorg Med Chem Lett 22: 7371-5 (2012)
Amgen
Phenyltetrahydroisoquinoline-pyridinaldoxime conjugates as efficient uncharged reactivators for the dephosphylation of inhibited human acetylcholinesterase.
J Med Chem 55: 10791-5 (2012)
Universit£
Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.
J Med Chem 55: 10475-89 (2012)
Chinese Academy Of Sciences
Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.
Bioorg Med Chem Lett 22: 7326-9 (2012)
Takeda Pharmaceutical
Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.
Bioorg Med Chem Lett 22: 7314-21 (2012)
Nycomed Pharma
Identification of novel mPGES-1 inhibitors through screening of a chemical library.
Bioorg Med Chem Lett 22: 7335-9 (2012)
Kookmin University
Analogue-based design, synthesis and docking of non-steroidal anti-inflammatory agents. Part 2: methyl sulfanyl/methyl sulfonyl substituted 2,3-diaryl-2,3-dihydro-1H-quinazolin-4-ones.
Bioorg Med Chem 20: 7119-27 (2012)
Devi Ahilya Vishwavidyalaya
Brominated aromatic furanones and related esters from the ascidian Synoicum sp.
J Nat Prod 75: 2055-61 (2012)
Seoul National University
Principles and applications of halogen bonding in medicinal chemistry and chemical biology.
J Med Chem 56: 1363-88 (2013)
Eberhard-Karls University
Mimicking the intramolecular hydrogen bond: synthesis, biological evaluation, and molecular modeling of benzoxazines and quinazolines as potential antimalarial agents.
J Med Chem 55: 10387-404 (2012)
University Of Siena
Structural optimization of 2,5-thiophene amides as highly potent and selective 17ß-hydroxysteroid dehydrogenase type 2 inhibitors for the treatment of osteoporosis.
J Med Chem 56: 167-81 (2013)
Saarland University
Truncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane Substitutions.
ACS Med Chem Lett 3: 596-601 (2012)
TBA
Discovery of a novel series of 4-quinolone JNK inhibitors.
Bioorg Med Chem Lett 22: 7381-7 (2012)
Roche Palo Alto
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part I.
Bioorg Med Chem Lett 22: 7702-6 (2012)
Astrazeneca
Discovery and SAR of a novel series of non-MPEP site mGlu5 PAMs based on an aryl glycine sulfonamide scaffold.
Bioorg Med Chem Lett 22: 7388-92 (2012)
Vanderbilt University Medical Center
Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC.
Bioorg Med Chem Lett 22: 7340-4 (2012)
Rensselaer Polytechnic Institute
Synthesis of novel azo-resveratrol, azo-oxyresveratrol and their derivatives as potent tyrosinase inhibitors.
Bioorg Med Chem Lett 22: 7451-5 (2012)
Pusan National University
Optimization of thiazole analogues of resveratrol for induction of NAD(P)H:quinone reductase 1 (QR1).
Bioorg Med Chem 20: 7030-9 (2012)
Purdue University
Design, synthesis and in vitro anti-proliferative activity of 4,6-quinazolinediamines as potent EGFR-TK inhibitors.
Eur J Med Chem 61: 132-45 (2013)
Misr International University
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.
Bioorg Med Chem Lett 22: 7456-60 (2012)
Dongguk University-Seoul
Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists.
Bioorg Med Chem Lett 22: 7672-6 (2012)
RhôNe-Poulenc Rorer
Design, synthesis and pharmacological evaluation of 4-(piperazin-1-yl methyl)-N1-arylsulfonyl indole derivatives as 5-HT6 receptor ligands.
Bioorg Med Chem Lett 22: 7431-5 (2012)
Suven Life Sciences
Heteroaryl urea inhibitors of fatty acid amide hydrolase: structure-mutagenicity relationships for arylamine metabolites.
Bioorg Med Chem Lett 22: 7357-62 (2012)
Janssen Research And Development
New diterpene furanoids from the Antarctic lichen Huea sp.
Bioorg Med Chem Lett 22: 7393-6 (2012)
Silla University
Design and synthesis of novel bis-thiazolone derivatives as micromolar CDC25 phosphatase inhibitors: effect of dimerisation on phosphatase inhibition.
Bioorg Med Chem Lett 22: 7345-50 (2012)
University Of Paris
Optimization and structure-activity relationships of a series of potent inhibitors of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as novel antimicrobial agents.
Bioorg Med Chem 20: 7069-82 (2012)
Simon Fraser University
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.
Bioorg Med Chem 20: 7214-22 (2012)
University College Of Science
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett 22: 7555-61 (2012)
Korea Institute Of Science And Technology
Synthesis and biological characterization of 3-substituted 1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Part 2.
J Med Chem 55: 10532-9 (2012)
Universit£
Synthesis and biological evaluation (in vitro and in vivo) of cyclic arginine-glycine-aspartate (RGD) peptidomimetic-paclitaxel conjugates targeting integrinaVß3.
J Med Chem 55: 10460-74 (2012)
Universit£
Allosteric competitive inhibitors of the glucose-1-phosphate thymidylyltransferase (RmlA) from Pseudomonas aeruginosa.
ACS Chem Biol 8: 387-96 (2013)
University Of St. Andrews
Fibrate-derived N-(methylsulfonyl)amides with antagonistic properties on PPARa.
Eur J Med Chem 58: 317-22 (2012)
Universit£
Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.
J Med Chem 55: 10540-50 (2012)
Chinese Academy Of Sciences
Design and synthesis of procollagen C-proteinase inhibitors.
Bioorg Med Chem Lett 22: 7397-401 (2012)
Fibrogen
Acetylcholinesterase inhibitors from the leaves of Macaranga kurzii.
J Nat Prod 75: 2012-2015 (2012)
TBA
Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.
J Med Chem 55: 10523-31 (2012)
Universit£
Discovery and pharmacological evaluation of a diphenethylamine derivative (HS665), a highly potent and selective¿ opioid receptor agonist.
J Med Chem 55: 10302-6 (2012)
University Of Innsbruck
In vitro investigations into the roles of drug transporters and metabolizing enzymes in the disposition and drug interactions of dolutegravir, a HIV integrase inhibitor.
Drug Metab Dispos 41: 353-61 (2013)
Glaxosmithkline
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Eur J Med Chem 58: 287-98 (2012)
Sapienza University Of Rome
Synthesis, in silico, in vitro, and in vivo investigation of 5-[¹¹C]methoxy-substituted sunitinib, a tyrosine kinase inhibitor of VEGFR-2.
Eur J Med Chem 58: 272-80 (2012)
Universidad De Talca
Purpuroines A-J, halogenated alkaloids from the sponge Iotrochota purpurea with antibiotic activity and regulation of tyrosine kinases.
Bioorg Med Chem 20: 6924-8 (2012)
Peking University
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.
Bioorg Med Chem Lett 22: 7376-80 (2012)
Corcept Therapeutics
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).
Bioorg Med Chem Lett 22: 7551-4 (2012)
Kitasato University
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.
Bioorg Med Chem Lett 22: 7471-4 (2012)
University Of Strasbourg
Synthesis of novel¿¿3 receptor ligands via an unusual Knoevenagel condensation.
Bioorg Med Chem Lett 22: 7578-81 (2012)
Moscow State University
Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors.
J Med Chem 55: 10771-5 (2012)
Zafes/Liff/Osf Goethe-University Frankfurt
Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFß signaling.
J Med Chem 55: 9946-57 (2012)
Human Biomolecular Research Institute
Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1.
Chembiochem 13: 2527-36 (2012)
Mcgill University
Molecular cloning and pharmacological characterisation of a tyramine receptor from the rice stem borer, Chilo suppressalis (Walker).
Pest Manag Sci 69: 126-34 (2013)
Zhejiang University
SAR and in vivo evaluation of 4-aryl-2-aminoalkylpyrimidines as potent and selective Janus kinase 2 (JAK2) inhibitors.
Bioorg Med Chem Lett 22: 7653-8 (2012)
Exelixis
2-Styrylindolium based fluorescent probes visualize neurofibrillary tangles in Alzheimer's disease.
Bioorg Med Chem Lett 22: 7667-71 (2012)
Technische Universit£T Darmstadt
Azabenzthiazole inhibitors of leukotriene A4 hydrolase.
Bioorg Med Chem Lett 22: 7504-11 (2012)
Janssen Research And Development
3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
Bioorg Med Chem 20: 7012-29 (2012)
The State University Of New Jersey
Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.
J Med Chem 55: 9793-809 (2012)
Targacept
Core refinement toward permeable ?-secretase (BACE-1) inhibitors with low hERG activity.
J Med Chem 56: 4181-205 (2013)
Astrazeneca
The Multi-Leu peptide inhibitor discriminates between PACE4 and furin and exhibits antiproliferative effects on prostate cancer cells.
J Med Chem 55: 10501-11 (2012)
Universit£
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogs as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents.
Eur J Med Chem 58: 228-36 (2012)
Peking University
Affinity and activity profiling of unichiral 8-substituted 1,4-benzodioxane analogues of WB4101 reveals a potent and selectivea1B-adrenoceptor antagonist.
Eur J Med Chem 58: 184-91 (2012)
Universit£
Synthesis and biological evaluation of N-arylbenzo[b]thieno[3,2-d]pyrimidin-4-amines and their pyrido and pyrazino analogues as Ser/Thr kinase inhibitors.
Eur J Med Chem 58: 171-83 (2012)
Universit£
Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis.
Eur J Med Chem 58: 160-70 (2012)
University Of Ljubljana
Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.
Eur J Med Chem 58: 136-52 (2012)
Zydus Research Centre
Synthesis, biological evaluation and molecular docking studies of 3-(triazolyl)-coumarin derivatives: effect on inducible nitric oxide synthase.
Eur J Med Chem 58: 117-27 (2012)
Universidade De S£O Paulo
Synthesis and docking studies of novel antitumor benzimidazoles.
Bioorg Med Chem 20: 6989-7001 (2012)
National Research Center
Bicyclic peptidomimetics targeting secreted aspartic protease 2 (SAP2) from Candida albicans reveal a constrained inhibitory chemotype.
Bioorg Med Chem 20: 7206-13 (2012)
University Of Florence
Design, synthesis, and evaluation of imidazo[1,2-b]pyridazine derivatives having a benzamide unit as novel VEGFR2 kinase inhibitors.
Bioorg Med Chem 20: 7051-8 (2012)
Takeda Pharmaceutical
Triazole pyrimidine nucleosides as inhibitors of Ribonuclease A. Synthesis, biochemical, and structural evaluation.
Bioorg Med Chem 20: 7184-93 (2012)
University Of Thessaly
Inhibition of monoamine oxidase by 8-[(phenylethyl)sulfanyl]caffeine analogues.
Bioorg Med Chem 20: 7040-50 (2012)
North-West University
7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors.
Bioorg Med Chem Lett 22: 7518-22 (2012)
Roche Research Center
Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.
Bioorg Med Chem Lett 22: 7641-6 (2012)
The University Of Sydney
Isocytosine-based inhibitors of xanthine oxidase: design, synthesis, SAR, PK and in vivo efficacy in rat model of hyperuricemia.
Bioorg Med Chem Lett 22: 7543-6 (2012)
Piramal Healthcare
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase¿ inhibitors.
Bioorg Med Chem Lett 22: 7534-8 (2012)
Taisho Pharmaceutical
Sulfanylphthalonitrile analogues as selective and potent inhibitors of monoamine oxidase B.
Bioorg Med Chem Lett 22: 7367-70 (2012)
North-West University
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Bioorg Med Chem Lett 22: 7677-82 (2012)
Daiichi Sankyo
Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.
Bioorg Med Chem Lett 22: 7512-7 (2012)
Boehringer Ingelheim (Canada)
Synthesis and biological evaluation of a water-soluble derivative of the potent V-ATPase inhibitor archazolid.
Bioorg Med Chem Lett 22: 7735-8 (2012)
Ruprecht-Karls-Universit£T Heidelberg
Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors.
Bioorg Med Chem Lett 22: 7486-9 (2012)
Chugai Pharmaceutical
Fluorescent nitrile-based inhibitors of cysteine cathepsins.
Bioorg Med Chem Lett 22: 7715-8 (2012)
University Of Bonn
Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.
Bioorg Med Chem Lett 22: 7440-3 (2012)
East China University Of Science And Technology
Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure-activity relationships for the interaction of human carbonic anhydrase isoforms I and II.
Bioorg Med Chem 21: 1477-82 (2013)
Karamanoglu Mehmetbey University
Ion channels as therapeutic targets: a drug discovery perspective.
J Med Chem 56: 593-624 (2013)
Pfizer
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.
J Med Chem 55: 9856-67 (2012)
University Of Antwerp
The Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol.
ACS Med Chem Lett 3: 818-822 (2012)
TBA
Clinical pharmacokinetics, metabolism, and drug-drug interaction of carfilzomib.
Drug Metab Dispos 41: 230-7 (2012)
Onyx Pharmaceuticals
5-(1,3-Benzothiazol-6-yl)-4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazole derivatives as potent and selective transforming growth factor-ß type I receptor inhibitors.
Bioorg Med Chem 20: 7128-38 (2012)
Taisho Pharmaceutical
Microwave assisted synthesis and anti-influenza virus activity of 1-adamantyl substituted N-(1-thia-4-azaspiro[4.5]decan-4-yl)carboxamide derivatives.
Bioorg Med Chem 20: 7155-9 (2012)
Istanbul University
Structural modifications of a 3-methoxy-2-aminopyridine compound to reduce potential for mutagenicity and time-dependent drug-drug interaction.
Bioorg Med Chem Lett 22: 7605-9 (2012)
Pfizer
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.
Bioorg Med Chem Lett 22: 7697-701 (2012)
Kitasato University
Synthesis and evaluation of 3-¹²³I-iodo-5-[2-(S)-3-pyrrolinylmethoxy]-pyridine (niodene) as a potential nicotinic ?4?2 receptor imaging agent.
Bioorg Med Chem Lett 22: 7610-4 (2012)
University Of California - Irvine
Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: optimising in vivo clearance.
Bioorg Med Chem Lett 22: 7707-10 (2012)
Astrazeneca
Design and optimization of pyrazinecarboxamide-based inhibitors of diacylglycerol acyltransferase 1 (DGAT1) leading to a clinical candidate dimethylpyrazinecarboxamide phenylcyclohexylacetic acid (AZD7687).
J Med Chem 55: 10610-29 (2012)
Astrazeneca
Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations.
J Med Chem 55: 10685-99 (2012)
Sichuan University
Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries.
J Med Chem 55: 9562-75 (2012)
Kyoto Prefectural University Of Medicine
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6ß-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selectiveµ opioid receptor Agents.
J Med Chem 55: 10118-29 (2012)
Virginia Commonwealth University
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.
Eur J Med Chem 58: 84-97 (2012)
Universit£
Peptidomimetic modification improves cell permeation of bivalent farnesyltransferase inhibitors.
Bioorg Med Chem 21: 4004-10 (2013)
Osaka University
Fluorescence study for selecting specific ligands toward HER2 receptor: an example of receptor fragment approach.
Eur J Med Chem 61: 116-21 (2013)
Institute Of Biostructures And Bioimages
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Bioorg Med Chem Lett 22: 7627-33 (2012)
Genentech
Modification of a promiscuous inhibitor shifts the inhibition from¿-secretase to FLT-3.
Bioorg Med Chem Lett 22: 7634-40 (2012)
Technische Universit£T Darmstadt
Structural basis for the potent and selective inhibition of casein kinase 1 epsilon.
J Med Chem 55: 10307-11 (2012)
Amgen
a-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based orala-glucosidase inhibitor for improving postprandial hyperglycemia.
J Med Chem 55: 10347-62 (2012)
University Of Toyama
2-(3-Oxo-1,3-diphenylpropyl)malonic acids as potent allosteric ligands of the PIF pocket of phosphoinositide-dependent kinase-1: development and prodrug concept.
J Med Chem 55: 9817-30 (2012)
Saarland University
Hit to Lead optimization of a novel class of squarate-containing polo-like kinases inhibitors.
Bioorg Med Chem Lett 22: 7615-22 (2012)
Abbott Laboratories
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.
Bioorg Med Chem Lett 22: 7711-4 (2012)
Kitasato University
Synthesis and structure-activity relationships of fibrate-based analogues inside PPARs.
Bioorg Med Chem Lett 22: 7662-6 (2012)
Universit£
Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.
Bioorg Med Chem Lett 22: 7183-8 (2012)
Northeast Ohio Medical University
Synthesis and glycosidase inhibitory activity of novel (2-phenyl-4H-benzopyrimedo[2,1-b]-thiazol-4-yliden)acetonitrile derivatives.
Bioorg Med Chem Lett 22: 7011-4 (2012)
North Maharashtra University
Variation of the net charge, lipophilicity, and side chain flexibility in Dmt(1)-DALDA: Effect on Opioid Activity and Biodistribution.
J Med Chem 55: 9549-61 (2012)
Vrije Universiteit Brussel
Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers.
J Med Chem 55: 9693-707 (2012)
Universit£
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3ß inhibitors through virtual screening.
Bioorg Med Chem Lett 22: 7232-6 (2012)
Fudan University
Novel azulene derivatives for the treatment of erectile dysfunction.
Bioorg Med Chem Lett 22: 7151-4 (2012)
Friedrich-Alexander University
Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases.
Bioorg Med Chem Lett 22: 7169-73 (2012)
Mrc Technology
Tyrosine urea muscarinic acetylcholine receptor antagonists: achiral quaternary ammonium groups.
Bioorg Med Chem Lett 22: 7087-91 (2012)
Glaxosmithkline
Discovery of novel 2-(3-(2-chlorophenyl)pyrazin-2-ylthio)-N-arylacetamides as potent HIV-1 inhibitors using a structure-based bioisosterism approach.
Bioorg Med Chem 20: 6795-802 (2012)
Shandong University
Carbonic anhydrase IX as a target for metastatic disease.
Bioorg Med Chem 21: 1470-6 (2013)
University Of Manchester
O-Aryla,ß-d-ribofuranosides: synthesis& highly efficient biocatalytic separation of anomers and evaluation of their Src kinase inhibitory activity.
Bioorg Med Chem 20: 6821-30 (2012)
University Of Delhi
Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
J Med Chem 55: 9654-68 (2012)
Universit£
Aminopiperidine sulfonamide Cav2.2 channel inhibitors for the treatment of chronic pain.
J Med Chem 55: 9847-55 (2012)
Merck Research Laboratories
Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.
J Med Chem 55: 10797-822 (2012)
University Of Genoa
Repositioning HIV-1 integrase inhibitors for cancer therapeutics: 1,6-naphthyridine-7-carboxamide as a promising scaffold with drug-like properties.
J Med Chem 55: 9492-509 (2012)
Chinese Academy Of Sciences
Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.
J Med Chem 55: 10022-32 (2012)
Research Triangle Institute
Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.
J Med Chem 55: 10047-63 (2012)
Pfizer
Novel toll-like receptor 2 ligands for targeted pancreatic cancer imaging and immunotherapy.
J Med Chem 55: 9751-62 (2012)
H. Lee Moffitt Cancer Center And Research Institute
Identification of small molecule inhibitors of amyloidß-induced neuronal apoptosis acting through the imidazoline I(2) receptor.
J Med Chem 55: 9838-46 (2012)
Imim-Hospital Del Mar Research Institute And University Pompeu Fabra
Identification of a chemical probe for bromo and extra C-terminal bromodomain inhibition through optimization of a fragment-derived hit.
J Med Chem 55: 9831-7 (2012)
Pfizer
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1.
J Med Chem 55: 9875-90 (2012)
Universit£
New adamantane phenylalkylamines withs-receptor binding affinity and anticancer activity, associated with putative antagonism of neuropathic pain.
J Med Chem 55: 10241-61 (2012)
National And Kapodistrian University Of Athens
Lanostanoids from fungi: a group of potential anticancer compounds.
J Nat Prod 75: 2016-2044 (2012)
TBA
General synthesis ofß-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors.
J Med Chem 55: 10297-301 (2012)
University Of Copenhagen
Discovery of highly potent and selectivea4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
J Med Chem 55: 9998-10009 (2012)
University Of Illinois At Chicago
From triclosan toward the clinic: discovery of nonbiocidal, potent FabI inhibitors for the treatment of resistant bacteria.
J Med Chem 55: 9914-28 (2012)
Mutabilis
The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.
Bioorg Med Chem Lett 22: 7084-6 (2012)
Wayne State University
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett 22: 7100-5 (2012)
Pfizer
Design, synthesis, and biological evaluation of 3-(1H-1,2,3-triazol-1-yl)benzamide derivatives as Potent Pan Bcr-Abl inhibitors including the threonine(315)¿isoleucine(315) mutant.
J Med Chem 55: 10033-46 (2012)
Chinese Academy Of Sciences
Target Selectivity of FimH Antagonists.
J Med Chem 55: 9810-6 (2012)
University Of Basel
Novel acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329).
J Med Chem 55: 10136-47 (2012)
Astrazeneca
Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity.
J Med Chem 55: 9531-40 (2012)
Johannes Gutenberg University Of Mainz
Bicyclization and tethering to albumin yields long-acting peptide antagonists.
J Med Chem 55: 10187-97 (2012)
Ecole Polytechnique F�D�Rale De Lausanne
Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors.
Eur J Med Chem 58: 30-43 (2012)
Universit£
Synthesis and biological evaluation of imidazo[4,5-b]pyridine and 4-heteroaryl-pyrimidine derivatives as anti-cancer agents.
Eur J Med Chem 57: 311-22 (2012)
University Of Nottingham
Development of macrocyclic inhibitors of HCV NS3/4A protease with cyclic constrained P2-P4 linkers.
Bioorg Med Chem Lett 22: 7207-13 (2012)
Merck Research Laboratories
Investigations into specificity of azepinomycin for inhibition of guanase: discrimination between the natural heterocyclic inhibitor and its synthetic nucleoside analogues.
Bioorg Med Chem Lett 22: 7214-8 (2012)
University Of Maryland
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.
Bioorg Med Chem Lett 22: 7189-93 (2012)
Boehringer Ingelheim Pharmaceuticals
Prohormone-substrate peptide sequence recognition by peptidylglycinea-amidating monooxygenase and its reflection in increased glycolate inhibitor potency.
Bioorg Med Chem Lett 22: 7015-8 (2012)
Australian National University
4-Phenyl tetrahydroisoquinolines as dual norepinephrine and dopamine reuptake inhibitors.
Bioorg Med Chem Lett 22: 7219-22 (2012)
Amri
Structure-based bioisosterism design, synthesis and biological evaluation of novel 1,2,4-triazin-6-ylthioacetamides as potent HIV-1 NNRTIs.
Bioorg Med Chem Lett 22: 7155-62 (2012)
Shandong University
Synthesis and SAR development of novel mGluR1 antagonists for the treatment of chronic pain.
Bioorg Med Chem Lett 22: 7223-6 (2012)
Merck Research Laboratories
Specific interactions between adenosine and streptavidin/avidin.
Bioorg Med Chem Lett 22: 7052-5 (2012)
Chinese Academy Of Sciences
Synthesis of N-phenyl-N-(3-(piperidin-1-yl)propyl)benzofuran-2-carboxamides as new selective ligands for sigma receptors.
Bioorg Med Chem 20: 6856-61 (2012)
Savannah State University
Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.
Bioorg Med Chem Lett 22: 7106-9 (2012)
Monash University (Parkville Campus)
Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.
Bioorg Med Chem Lett 22: 7127-30 (2012)
Merck Research Laboratories
Design, synthesis and evaluation of novel zwitterionic compounds as PPARa/¿ dual agonists (1).
Bioorg Med Chem Lett 22: 7075-9 (2012)
Daiichi Sankyo
Novel tetrahydropyrido[1,2-a]isoindolone derivatives (valmerins): potent cyclin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and antitumor effects in human tumor xenografts.
J Med Chem 55: 9589-606 (2012)
Universit£
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward ana7 nicotinic acetylcholine receptor agonist preclinical candidate.
J Med Chem 55: 10277-81 (2012)
Siena Biotech
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase.
J Med Chem 55: 10074-89 (2012)
Northeastern University
Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors.
J Med Chem 55: 10229-40 (2012)
The Institute Of Cancer Research
Novel progesterone receptor modulators: 4-aryl-phenylsulfonamides.
Bioorg Med Chem Lett 22: 7119-22 (2012)
Pfizer
Synthesis of enantiomerically pure perhydro-1,4-diazepine-2,5-dione and 1,4-piperazine-2,5-dione derivatives exhibiting potent activity as apoptosis inhibitors.
Bioorg Med Chem Lett 22: 7097-9 (2012)
Instituto De Qu£Mica Avanzada De Catalu£A
Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7).
Bioorg Med Chem Lett 22: 7135-41 (2012)
The Scripps Research Institute
In vivo activity of an azole series of CCR2 antagonists.
Bioorg Med Chem Lett 22: 7252-5 (2012)
Glaxosmithkline
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
Eur J Med Chem 57: 296-301 (2012)
Instituto De Qu£Mica Org£Nica General (Csic)
Ana-carbonic anhydrase from the thermophilic bacterium Sulphurihydrogenibium azorense is the fastest enzyme known for the CO2 hydration reaction.
Bioorg Med Chem 21: 1465-9 (2013)
Istituto Di Biochimica Delle Proteine (Ibp)
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase.
J Med Chem 55: 10272-6 (2012)
Universit£
Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis.
J Med Chem 55: 9643-53 (2012)
Bristol-Myers Squibb
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists.
J Med Chem 55: 9576-88 (2012)
University Of Bonn
Small molecules that target protein misfolding.
J Med Chem 55: 10823-43 (2012)
Pfizer
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.
ACS Med Chem Lett 3: 808-813 (2012)
TBA
Evaluation and prediction of potential drug-drug interactions of linagliptin using in vitro cell culture methods.
Drug Metab Dispos 41: 149-58 (2012)
Nippon Boehringer Ingelheim
Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102.
Bioorg Med Chem 20: 6831-9 (2012)
University Of Copenhagen
Anion inhibition studies of the fastest carbonic anhydrase (CA) known, the extremo-CA from the bacterium Sulfurihydrogenibium azorense.
Bioorg Med Chem Lett 22: 7142-5 (2012)
Universit£
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett 22: 7036-40 (2012)
Toray Industries
Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors.
J Med Chem 55: 9973-87 (2012)
University Of Pittsburgh
Discovery of 3-cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl[1,2,4]triazolo[4,3-a]pyridine (JNJ-42153605): a positive allosteric modulator of the metabotropic glutamate 2 receptor.
J Med Chem 55: 8770-89 (2012)
Janssen-Cilag
Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.
Bioorg Med Chem Lett 22: 7237-42 (2012)
East China Normal University
Synthetic bicyclic iminosugar derivatives fused thiazolidin-4-one as new potential HIV-RT inhibitors.
Bioorg Med Chem Lett 22: 7041-4 (2012)
Hebei University
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibita- andß-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
J Med Chem 55: 9619-29 (2012)
Universit£
Virtual screening and optimization yield low-nanomolar inhibitors of the tautomerase activity of Plasmodium falciparum macrophage migration inhibitory factor.
J Med Chem 55: 10148-59 (2012)
Yale University
An oral sphingosine 1-phosphate receptor 1 (S1P(1)) antagonist prodrug with efficacy in vivo: discovery, synthesis, and evaluation.
J Med Chem 55: 9722-34 (2012)
Novartis Pharma
Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate.
ACS Med Chem Lett 3: 378-382 (2012)
TBA
Selected C7-substituted chromone derivatives as monoamine oxidase inhibitors.
Bioorg Chem 1-11 (2012)
North-West University
Synthesis and biological evaluation of new 5-benzylated 4-oxo-3,4-dihydro-5H-pyridazino[4,5-b]indoles as PI3Ka inhibitors.
Eur J Med Chem 57: 225-33 (2012)
Universit£
Identification of a novel Smoothened antagonist that potently suppresses Hedgehog signaling.
Bioorg Med Chem 20: 6751-7 (2012)
Duke University Medical Center
Recent results in protein kinase inhibition for tropical diseases.
Bioorg Med Chem Lett 22: 6788-93 (2012)
Montclair State University
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Bioorg Med Chem 20: 6669-79 (2012)
Abo Akademi University
Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-ylß-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia.
Bioorg Med Chem 20: 6598-612 (2012)
Kissei Pharmaceutical
Dimeric Smac mimetics/IAP inhibitors as in vivo-active pro-apoptotic agents. Part II: Structural and biological characterization.
Bioorg Med Chem 20: 6709-23 (2012)
Fondazione Irccs Istituto Nazionale Dei Tumori
Synthesis and structure-activity relationships of 8-substituted-2-aryl-5-alkylaminoquinolines: Potent, orally active corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem 20: 6559-78 (2012)
Eisai
Synthesis, biological evaluation and molecular modeling of dihydro-pyrazolyl-thiazolinone derivatives as potential COX-2 inhibitors.
Bioorg Med Chem 20: 6648-54 (2012)
Nanjing University
Development of anti-coxsackievirus agents targeting 3C protease.
Bioorg Med Chem Lett 22: 6952-6 (2012)
Gwangju Institute Of School Of Life Sciences
Synthesis and biological characterization of a series of novel diaryl amide M1 antagonists.
Bioorg Med Chem Lett 22: 6923-8 (2012)
Vanderbilt University Medical Center
Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors.
J Med Chem 55: 10090-107 (2012)
Genentech
Organosilicon molecules with medicinal applications.
J Med Chem 56: 388-405 (2013)
University Of California Davis
Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.
J Med Chem 55: 8903-25 (2012)
Roche R & D Center China
Synthesis and pharmacological evaluation of pyrazolo[4,3-c]cinnoline derivatives as potential anti-inflammatory and antibacterial agents.
Eur J Med Chem 57: 176-84 (2012)
Jamia Hamdard (Hamdard University)
Synthesis, DNA-PK inhibition, anti-platelet activity studies of 2-(N-substituted-3-aminopyridine)-substituted-1,3-benzoxazines and DNA-PK and PI3K inhibition, homology modelling studies of 2-morpholino-(7,8-di and 8-substituted)-1,3-benzoxazines.
Eur J Med Chem 57: 85-101 (2012)
La Trobe University
Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer.
Eur J Med Chem 57: 41-50 (2012)
Universit£
Discovery of novel pyrrolopyridazine scaffolds as transient receptor potential vanilloid (TRPV1) antagonists.
Bioorg Med Chem Lett 22: 6888-95 (2012)
Astrazeneca
Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.
Bioorg Med Chem Lett 22: 6854-7 (2012)
Nankai University
In vivo and in vitro effect of androstene derivatives as 5a-reductase type 1 enzyme inhibitors.
J Enzyme Inhib Med Chem 28: 1247-54 (2013)
National University Of Mexico City
Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.
J Med Chem 55: 10130-5 (2012)
Academy Of Sciences Of The Czech Republic
A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
J Med Chem 55: 10160-76 (2012)
University Of Medicine And Dentistry Of New Jersey
Optimized 5-membered heterocycle-linked pterins for the inhibition of Ricin Toxin A.
ACS Med Chem Lett 3: 588-591 (2012)
TBA
Serotonin transporter activity of imidazolidine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives in aspect of their acid-base properties.
Med Chem Res 21: 3455-3459 (2012)
Jagiellonian University Medical College
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors.
Eur J Med Chem 57: 134-42 (2012)
Mashhad University Of Medical Sciences
Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.
Eur J Med Chem 57: 112-25 (2012)
Clermont Universit£
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-ß type 1 receptor kinase inhibitors.
Eur J Med Chem 57: 74-84 (2012)
Ewha Womans University
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.
Eur J Med Chem 57: 59-64 (2012)
Hacettepe University
Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3ß (GSK-3ß).
Eur J Med Chem 61: 95-103 (2013)
Fudan University
Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development.
Bioorg Med Chem Lett 22: 6974-9 (2012)
Astrazeneca
Pyrrolidinyl phenylurea derivatives as novel CCR3 antagonists.
Bioorg Med Chem Lett 22: 6876-81 (2012)
Toray Industries
Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.
Bioorg Med Chem Lett 22: 6832-8 (2012)
Pfizer
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ?-secretase inhibitors.
Bioorg Med Chem Lett 22: 6828-31 (2012)
Bristol-Myers Squibb R&D
Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays.
J Med Chem 55: 10108-17 (2012)
East China University Of Science And Technology
2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation.
Bioorg Med Chem Lett 22: 6867-70 (2012)
Shanghai Jiao Tong University
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity.
Eur J Med Chem 57: 21-8 (2012)
China Pharmaceutical University
Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.
Eur J Med Chem 57: 10-20 (2012)
Shanghai Jiao Tong University
Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.
J Med Chem 55: 8721-34 (2012)
The Institute Of Cancer Research
Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4).
J Med Chem 55: 10287-91 (2012)
University Of Troms£
Pyrimidine-fused heterocycle derivatives as a novel class of inhibitors for a-glucosidase.
J Enzyme Inhib Med Chem 28: 1228-35 (2013)
Shiraz University
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.
J Med Chem 55: 9446-66 (2012)
Angelini Santa Palomba Research Center
Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).
J Med Chem 55: 10010-21 (2012)
Astrazeneca
Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.
J Med Chem 55: 9735-50 (2012)
Neurosearch Sweden
Phthalazine derivatives containing imidazole rings behave as Fe-SOD inhibitors and show remarkable anti-T. cruzi activity in immunodeficient-mouse mode of infection.
J Med Chem 55: 9900-13 (2012)
Universidad De Granada
Fumaroylamino-4,5-epoxymorphinans and related opioids with irreversibleµ opioid receptor antagonist effects.
J Med Chem 55: 9868-74 (2012)
University Of Bristol
Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles.
J Med Chem 55: 9607-18 (2012)
Freie Universit£T Berlin
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.
J Med Chem 55: 8807-26 (2012)
Istituto Italiano Di Tecnologia
The Substrate-Activity-Screening methodology applied to receptor tyrosine kinases: a proof-of-concept study.
Eur J Med Chem 57: 1-9 (2012)
Novartis Institutes For Biomedical Research
Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.
Bioorg Med Chem 20: 6739-50 (2012)
Central China Normal University
Rational design of apoptosis signal-regulating kinase 1 inhibitors: discovering novel structural scaffold.
Eur J Med Chem 61: 104-15 (2013)
Nas Of Ukraine
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.
Bioorg Med Chem 20: 6758-69 (2012)
University Of Warsaw
Adamantyl carboxamides and acetamides as potent human 11ß-hydroxysteroid dehydrogenase type 1 inhibitors.
Bioorg Med Chem 20: 6394-402 (2012)
University Of Bath
Synthesis of 1,5-diarylhaloimidazole analogs and their inhibitory activities against PGE2 production from LPS-treated RAW 264.7 cells.
Bioorg Med Chem 20: 6256-9 (2012)
College Of Pharmacy
Discovery of new non-steroidal FXR ligands via a virtual screening workflow based on Phase shape and induced fit docking.
Bioorg Med Chem Lett 22: 6848-53 (2012)
East China University Of Science And Technology
Viridin analogs derived from steroidal building blocks.
Bioorg Med Chem Lett 22: 6919-22 (2012)
University Of Connecticut
Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases.
Bioorg Med Chem Lett 22: 6914-8 (2012)
Martin-Luther-University Halle-Wittenberg
N,N-Dimethyl-[9-(arylsulfonyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]amines as novel, potent and selective 5-HT6 receptor antagonists.
Bioorg Med Chem Lett 22: 6980-5 (2012)
Suven Life Sciences
Design, synthesis, and structure-activity-relationship of phenyl imidazoles as potent Smoothened antagonists.
Bioorg Med Chem Lett 22: 6573-6 (2012)
Genomics Institute Of The Novartis Research Foundation
Synthesis and biological evaluation of new phenothiazine derivatives bearing a pyrazole unit as protein farnesyltransferase inhibitors.
Bioorg Med Chem Lett 22: 6896-902 (2012)
'Al. I. Cuza' University Of Iasi
Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold.
Bioorg Med Chem 20: 6260-75 (2012)
Sapienza University Of Rome
Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery.
J Med Chem 55: 8879-90 (2012)
Imperial College
The story of a new insecticidal chemistry class: the diamides.
Pest Manag Sci 69: 7-14 (2013)
Syngenta Crop Protection M£Nchwilen
Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease.
J Med Chem 55: 9708-21 (2012)
Istituto Italiano Di Tecnologia
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Drug Metab Dispos 41: 60-71 (2012)
Tongji University
The therapeutic journey of benzimidazoles: a review.
Bioorg Med Chem 20: 6208-36 (2012)
Punjabi University
Role of the side chain stereochemistry in thea-glucosidase inhibitory activity of kotalanol, a potent naturala-glucosidase inhibitor. Part 2.
Bioorg Med Chem 20: 6321-34 (2012)
Kinki University
Diarylheptanoid glycosides from Tacca plantaginea and their effects on NF-¿B activation and PPAR transcriptional activity.
Bioorg Med Chem Lett 22: 6681-7 (2012)
Chungnam National University
Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.
Bioorg Med Chem Lett 22: 6661-4 (2012)
Research Triangle Institute
The discovery of CCR3/H1 dual antagonists with reduced hERG risk.
Bioorg Med Chem Lett 22: 6688-93 (2012)
Astrazeneca
Identification of a glutathione peroxidase inhibitor that reverses resistance to anticancer drugs in human B-cell lymphoma cell lines.
Bioorg Med Chem Lett 22: 6712-5 (2012)
Ernst-Moritz-Arndt University Greifswald
Optimization of a direct spectrophotometric method to investigate the kinetics and inhibition of sialidases.
BMC Biochem 13: 19 (2012)
Universit?? Degli Studi Di Siena
Acyl guanidine inhibitors ofß-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.
J Med Chem 55: 9208-23 (2012)
Bristol-Myers Squibb Research
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression.
J Med Chem 55: 8502-14 (2012)
University Of Michigan
Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease.
Bioorg Med Chem 20: 6313-20 (2012)
Csir-Central Drug Research Institute
The antitumor agent doxorubicin binds to Fanconi anemia group F protein.
Bioorg Med Chem 20: 6248-55 (2012)
Tokyo University Of Science
Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines.
Bioorg Med Chem 20: 6489-505 (2012)
University Of Bonn
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors.
Bioorg Med Chem Lett 22: 6628-31 (2012)
Takeda California
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy.
Bioorg Med Chem Lett 22: 6554-8 (2012)
Shionogi
Identification of novel 3,5-diarylpyrazoline derivatives containing salicylamide moiety as potential anti-melanoma agents.
Bioorg Med Chem Lett 22: 6596-601 (2012)
Nanjing University
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.
J Med Chem 55: 9929-45 (2012)
Targacept
Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloidß (Aß) oligomers-induced neuronal cell death by tricyclic pyrone molecules.
J Med Chem 55: 8969-73 (2012)
Kansas State University
Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors.
J Med Chem 55: 8859-78 (2012)
Infinity Pharmaceuticals
Radiofluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid as inhibitors of prostate specific membrane antigen (PSMA) for the imaging of prostate cancer.
J Med Chem 55: 9510-20 (2012)
Bayer Healthcare
Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors.
J Med Chem 55: 9055-68 (2012)
Pfizer
Discovery of an allosteric mechanism for the regulation of HCV NS3 protein function.
Nat Chem Biol 8: 920-5 (2012)
Astex Pharmaceuticals
New prenylated isoflavonoids as protein tyrosine phosphatase 1B (PTP1B) inhibitors from Erythrina addisoniae.
Bioorg Med Chem 20: 6459-64 (2012)
Chosun University
Design, synthesis and in vitro evaluation of a series ofa-substituted phenylpropanoic acid PPAR¿ agonists to further investigate the stereochemistry-activity relationship.
Bioorg Med Chem 20: 6375-83 (2012)
Okayama University
Synthesis, biological activity and structure-activity relationship of endomorphin-1/substance P derivatives.
Bioorg Med Chem 20: 6335-43 (2012)
The University Of Queensland
A novel spirocyclic tropanyl-¿²-isoxazoline derivative enhances citalopram and paroxetine binding to serotonin transporters as well as serotonin uptake.
Bioorg Med Chem 20: 6344-55 (2012)
Universit£
Identification of pyrimidine derivatives as hSMG-1 inhibitors.
Bioorg Med Chem Lett 22: 6636-41 (2012)
Pfizer
Scaffold-hopping with zwitterionic CCR3 antagonists: identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092.
Bioorg Med Chem Lett 22: 6694-9 (2012)
Astrazeneca
Improving the affinity of naphthalene diimide ligand to telomeric DNA by incorporating Zn²¿ ions into its dipicolylamine groups.
Bioorg Med Chem 20: 6416-22 (2012)
Research Center For Bio-Microsensing Technology
Cyclic tetrapeptides with thioacetate tails or intramolecular disulfide bridge as potent inhibitors of histone deacetylases.
Bioorg Med Chem Lett 22: 6770-2 (2012)
Graduate School Of Life Science And Systems Engineering
Design, synthesis and biological evaluation of heterocyclic azoles derivatives containing pyrazine moiety as potential telomerase inhibitors.
Bioorg Med Chem 20: 6356-65 (2012)
Nanjing University
Salicylaldoxime derivatives as new leads for the development of carbonic anhydrase inhibitors.
Bioorg Med Chem 21: 1511-5 (2013)
Universit£
Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D3 receptor-selective full agonist ligand.
Bioorg Med Chem 20: 6366-74 (2012)
Purdue University
Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorg Med Chem 20: 6770-89 (2012)
Vernalis
4-Substituted-2-phenylquinazolines as inhibitors of BCRP.
Bioorg Med Chem Lett 22: 6766-9 (2012)
University Of Bonn
Formylated polyamines as peptidomimetics.
Bioorg Med Chem Lett 22: 6580-2 (2012)
The Scripps Research Institute
Evaluation of structure-derived pharmacophore of soluble epoxide hydrolase inhibitors by virtual screening.
Bioorg Med Chem Lett 22: 6762-5 (2012)
Johann Wolfgang Goethe University
4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
J Med Chem 55: 8948-52 (2012)
University Of Lille
New aminoimidazoles asß-secretase (BACE-1) inhibitors showing amyloid-ß (Aß) lowering in brain.
J Med Chem 55: 9297-311 (2012)
Astrazeneca
14-Alkoxy- and 14-acyloxypyridomorphinans:µ agonist/d antagonist opioid analgesics with diminished tolerance and dependence side effects.
J Med Chem 55: 8350-63 (2012)
Southern Research Institute
Optimisation of pharmacokinetic properties in a neutral series of 11ß-HSD1 inhibitors.
Bioorg Med Chem Lett 22: 6756-61 (2012)
Astrazeneca
Effect of phospholipid-based formulations of Boswellia serrata extract on the solubility, permeability, and absorption of the individual boswellic acid constituents present.
J Nat Prod 75: 1675-82 (2012)
Central Laboratory Of German Pharmacists
Enantiomerically pure 1,3-dioxanes as highly selective NMDA ands1 receptor ligands.
J Med Chem 55: 8953-7 (2012)
Westf£Lische Wilhelms-Universit£T M£Nster
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.
Bioorg Med Chem 21: 1489-94 (2013)
Universidad Nacional De La Plata
Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110ß isoform inhibitors through structure-based fragment optimisation.
Bioorg Med Chem Lett 22: 6665-70 (2012)
Astrazeneca
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.
Bioorg Med Chem Lett 22: 6731-4 (2012)
University Of Salford
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.
Bioorg Med Chem Lett 22: 6745-9 (2012)
University Of Hyderabad Campus
Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.
Bioorg Med Chem Lett 22: 6656-60 (2012)
Sanford-Burnham Medical Research Institute
Design and synthesis of potent hydroxyethylamine (HEA) BACE-1 inhibitors carrying prime side 4,5,6,7-tetrahydrobenzazole and 4,5,6,7-tetrahydropyridinoazole templates.
Bioorg Med Chem Lett 22: 6721-7 (2012)
Medivir
Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B.
Bioorg Med Chem Lett 22: 6632-5 (2012)
North-West University
Novel histone deacetylase 8 ligands without a zinc chelating group: exploring an 'upside-down' binding pose.
Bioorg Med Chem Lett 22: 6621-7 (2012)
University Of Illinois At Chicago
[18F](R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4-(2-fluoroethoxy)-2,5-dimethyl phenylamino)pyrazin-2(1H)-one: introduction of N3-phenylpyrazinones as potential CRF-R1 PET imaging agents.
Bioorg Med Chem Lett 22: 6651-5 (2012)
Bristol-Myers Squibb
Discovery of phosphoinositide 3-kinases (PI3K) p110ß isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance.
Bioorg Med Chem Lett 22: 6671-6 (2012)
Astrazeneca
Structure-activity relationships of bergenin derivatives effect on a-glucosidase inhibition.
J Enzyme Inhib Med Chem 28: 1162-70 (2013)
Kinki University
Synthesis and characterization of 5,7-dihydroxyflavanone derivatives as novel protein tyrosine phosphatase 1B inhibitors.
J Enzyme Inhib Med Chem 28: 1199-204 (2013)
Yanbian University College Of Pharmacy
Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.
J Med Chem 55: 9434-45 (2012)
Sanford-Burnham Medical Research Institute
Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.
J Med Chem 55: 9891-9 (2012)
University Of Illinois At Chicago
Development of oseltamivir phosphonate congeners as anti-influenza agents.
J Med Chem 55: 8657-70 (2012)
The Genomics Research Center
Discovery of novel inhibitors of amyloid ?-peptide 1-42 aggregation.
J Med Chem 55: 9521-30 (2012)
Universidad De Zaragoza
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.
Bioorg Med Chem 20: 6423-33 (2012)
Universidade Federal De Pernambuco
Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Bioorg Med Chem Lett 22: 6705-11 (2012)
Actelion Pharmaceuticals
5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I.
J Med Chem 55: 8671-84 (2012)
University Of Minnesota
Design, synthesis, and structure-activity relationships of highly potent 5-HT3 receptor ligands.
J Med Chem 55: 8603-14 (2012)
Vu University Amsterdam
Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT6 receptor antagonists.
J Med Chem 55: 9255-69 (2012)
Suven Life Sciences
From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.
ACS Med Chem Lett 3: 721-725 (2012)
TBA
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