PMID

Article Title

Citation

Organization

Download

View Data

N-(alpha-Hydroxyalkanoyl) derivatives of Leu-Val-Phe-OCH3 as inhibitors of renin.

J Med Chem 23: 666-9 (1980)

TBA

2D 3D TSV

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 4. 6-Substituted trimethoprim derivatives from phenolic Mannich intermediates. Application to the synthesis of trimethoprim and 3,5-dialkylbenzyl analogues.

J Med Chem 23: 535-41 (1980)

TBA

2D 3D TSV

Absolute stereochemistry and dopaminergic activity of enantiomers of 2,3,4,5-tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine.

J Med Chem 25: 697-703 (1982)

TBA

2D 3D TSV

Binding specificities of adenosine aminohydrolase from calf intestinal mucosa with dialdehydes derived from hexofuranosyladenine nucleosides.

J Med Chem 23: 39-42 (1980)

TBA

2D 3D TSV

Basic antiinflammatory compounds. N,N',N''-Trisubstituted guanidines.

J Med Chem 23: 13-20 (1980)

TBA

2D 3D TSV

Resolution and absolute configuration of an ergoline-related dopamine agonist, trans-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H(or 2H)-pyrazolo[3,4-g]quinoline.

J Med Chem 26: 1112-6 (1983)

TBA

2D 3D TSV

Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.

J Med Chem 26: 1036-42 (1983)

TBA

2D 3D TSV

Preparation of 2-amino-4(3H)-oxopyrimido[5,4-b] [1,4]thiazines (5-thiapterins) and their evaluation as cofactors for phenylalanine hydroxylase.

J Med Chem 26: 559-63 (1983)

TBA

2D 3D TSV

Synthesis and central dopaminergic activities of (+/-)-hexahydro-7H-indolo[3,4-gh][1,4]benzoxazine derivatives [(+/-)-9-oxaergolines].

J Med Chem 26: 522-7 (1983)

TBA

2D 3D TSV

Some adenine and adenosine methylene-bridged estrogens.

J Med Chem 26: 162-6 (1983)

TBA

2D 3D TSV

In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.

J Med Chem 26: 145-52 (1983)

TBA

2D 3D TSV

Analogues of aminoglutethimide: selective inhibition of cholesterol side-chain cleavage.

J Med Chem 26: 50-4 (1983)

TBA

2D 3D TSV

Spiro oxazolidinedione aldose reductase inhibitors.

J Med Chem 25: 1451-4 (1983)

TBA

2D 3D TSV

Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure in subsite P3 on inhibition of pepsin.

J Med Chem 25: 791-5 (1982)

TBA

2D 3D TSV

Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis.

J Med Chem 25: 777-84 (1982)

TBA

2D 3D TSV

Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: A possible relationship with cromolyn-like antiallergy activity.

J Med Chem 25: 742-5 (1982)

TBA

2D 3D TSV

Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.

J Med Chem 25: 446-51 (1982)

TBA

2D 3D TSV

Interaction of 5-ethynyl-2'-deoxyuridylate with thymidylate synthetase.

J Med Chem 24: 1537-40 (1982)

TBA

2D 3D TSV

Comparison of the inhibition of methotrexate-sensitive and -resistant Lactobacillus casei cell cultures with purified Lactobacillus casei dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(3-substituted-phenyl)-s-triazines. Use of quantitative structure-activity relationships in maki

J Med Chem 24: 1422-9 (1981)

TBA

2D 3D TSV

Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates.

J Med Chem 24: 1385-8 (1982)

TBA

2D 3D TSV

Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.

J Med Chem 24: 1068-73 (1981)

TBA

2D 3D TSV

Synthesis and aldose reductase inhibitory activity of 7-sulfamoylxanthone-2-carboxylic acids.

J Med Chem 23: 1264-7 (1981)

TBA

2D 3D TSV

Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.

J Med Chem 23: 899-903 (1980)

TBA

2D 3D TSV

Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.

J Med Chem 23: 734-8 (1980)

TBA

2D 3D TSV

Inhibitors of Bacillus subtilis DNA polymerase III. 6-Anilinouracils and 6-(alkylamino)uracils.

J Med Chem 23: 34-8 (1980)

TBA

2D 3D TSV

Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.

J Med Chem 23: 27-33 (1980)

TBA

2D 3D TSV

Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.

J Med Chem 25: 1120-2 (1983)

TBA

2D 3D TSV

cis-1,3,4,6,7,11b-Hexahydro-2-methyl-7-phenyl-2H-pyrazino[2,1-a] isoquinoline: a new atypical antidepressant.

J Med Chem 27: 995-1003 (1984)

TBA

2D 3D TSV

Pyrroloisoquinoline antidepressants. Potent, enantioselective inhibition of tetrabenazine-induced ptosis and neuronal uptake of norepinephrine, dopamine, and serotonin.

J Med Chem 27: 943-6 (1984)

TBA

2D 3D TSV

Methotrexate analogues. 23. Synthesis, dihydrofolate reductase affinity, cytotoxicity, and in vivo antitumor activity of some putative degradation products of methotrexate-poly(L-lysine) conjugates.

J Med Chem 27: 888-93 (1984)

TBA

2D 3D TSV

Aporphines. 58. N-(2-chloroethyl) [8,9-2H]norapomorphine, an irreversible ligand for dopamine receptors: synthesis and application.

J Med Chem 27: 806-10 (1984)

TBA

2D 3D TSV

Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines.

J Med Chem 27: 616-27 (1984)

TBA

2D 3D TSV

Adenosine deaminase inhibitors. Synthesis of deaza analogues of erythro-9-(2-hydroxy-3-nonyl)adenine.

J Med Chem 27: 274-8 (1984)

TBA

2D 3D TSV

Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase alpha.

J Med Chem 27: 175-81 (1984)

TBA

2D 3D TSV

Inhibition of human dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. A quantitative structure-activity relationship analysis.

J Med Chem 27: 144-9 (1984)

TBA

2D 3D TSV

Aporphines. 48. Enantioselectivity of (R)-(-)- and (S)-(+)-N-n-propylnorapomorphine on dopamine receptors.

J Med Chem 26: 516-21 (1983)

TBA

2D 3D TSV

Comparison of dopamine receptor sites labeled by [3H]-S-sulpiride and [3H]-spiperone in striatum.

J Pharmacol Exp Ther 227: 592-9 (1983)

University Of California

2D 3D TSV

pH-dependent modulation of agonist interactions with [3H]-ketanserin-labelled S2 serotonin receptors.

Life Sci 33: 2011-6 (1983)

University Of Toronto

2D 3D TSV

S-carbobenzoxyglutathione: a competitive inhibitor of mammalian glyoxalase II.

J Med Chem 26: 1784-5 (1984)

TBA

2D 3D TSV

alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase.

J Med Chem 26: 1551-6 (1983)

TBA

2D 3D TSV

Optical resolution, absolute configuration, and activity of the enantiomers of proxyphylline.

J Med Chem 26: 1514-8 (1983)

TBA

2D 3D TSV

Multisubstrate adducts as potential inhibitors of S-adenosylmethionine dependent methylases: inhibition of indole N-methyltransferase by (5'-deoxyadenosyl)[3-(3-indolyl)prop-1-yl]methylsulfonium and (5'-deoxyadenosyl)[4-(3-indolyl)but-1-yl]methylsulfonium salts.

J Med Chem 26: 1470-7 (1983)

TBA

2D 3D TSV

Structure-activity relationship study of the inhibition of adrenal cortical 11 beta-hydroxylase by new metyrapone analogues.

J Med Chem 27: 15-9 (1984)

TBA

2D 3D TSV

Adenosine deaminase inhibitors. Synthesis and biological evaluation of (+/-)-3,6,7,8-tetrahydro-3-[(2-hydroxyethoxy)methyl]imidazo[4,5-d] [1,3]diazepin-8-ol and some selected C-5 homologues of pentostatin.

J Med Chem 26: 1478-82 (1983)

TBA

2D 3D TSV

Synthesis and pharmacological studies of 4,4-disubstituted piperidines: a new class of compounds with potent analgesic properties.

J Med Chem 26: 42-50 (1983)

TBA

2D 3D TSV

Methotrexate analogues. 21. Divergent influence of alkyl chain length on the dihydrofolate reductase affinity and cytotoxicity of methotrexate monoesters.

J Med Chem 27: 605-9 (1984)

TBA

2D 3D TSV

Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.

J Med Chem 27: 41-5 (1984)

TBA

2D 3D TSV

Isomeric N-methyl-7-deazaguanines: synthesis, structural assignment, and inhibitory activity on xanthine oxidase.

J Med Chem 27: 981-5 (1984)

TBA

2D 3D TSV

Vinylogous amino acid esters: a new class of inactivators for thiol proteases.

J Med Chem 27: 711-2 (1984)

TBA

2D 3D TSV

Methotrexate analogues. 19. Replacement of the glutamate side chain in classical antifolates by L-homocysteic acid and L-cysteic acid: effect on enzyme inhibition and antitumor activity.

J Med Chem 27: 600-4 (1984)

TBA

2D 3D TSV

A potent multisubstrate analogue inhibitor of human thymidylate synthetase.

J Med Chem 27: 1710-7 (1985)

TBA

2D 3D TSV

Bulky amine analogues of ketoprofen: potent antiinflammatory agents.

J Med Chem 27: 1682-90 (1984)

TBA

2D 3D TSV

Nontricyclic antidepressant agents derived from cis- and trans-1-amino-4-aryltetralins.

J Med Chem 27: 1508-15 (1984)

TBA

2D 3D TSV

Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.

J Med Chem 27: 1431-8 (1984)

TBA

2D 3D TSV

Carbocyclic analogues of xylofuranosylpurine nucleosides. Synthesis and antitumor activity.

J Med Chem 27: 1358-60 (1984)

TBA

2D 3D TSV

Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.

J Med Chem 27: 1317-21 (1984)

TBA

2D 3D TSV

N-allyl analogues of phencyclidine: chemical synthesis and pharmacological properties.

J Med Chem 27: 1267-71 (1984)

TBA

2D 3D TSV

Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro.

J Med Chem 27: 1201-11 (1984)

TBA

2D 3D TSV

Steroids. 2. Synthesis of C-18 functionalized steroids via the Smith-Hughes route.

J Med Chem 27: 1131-7 (1984)

TBA

2D 3D TSV

Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.

J Med Chem 27: 1099-101 (1984)

TBA

2D 3D TSV

Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.

J Med Chem 24: 1499-507 (1982)

TBA

2D 3D TSV

A 1H NMR study of the interactions and conformations of rationally designed brodimoprim analogues in complexes with Lactobacillus casei dihydrofolate reductase.

J Med Chem 27: 1672-6 (1985)

TBA

2D 3D TSV

Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.

J Med Chem 27: 1379-88 (1984)

TBA

2D 3D TSV

Interaction of N4-hydroxy-2'-deoxycytidylic acid with thymidylate synthetase.

J Med Chem 27: 1259-62 (1984)

TBA

2D 3D TSV

Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis.

J Med Chem 27: 717-26 (1984)

TBA

2D 3D TSV

N-[5-(trifluoromethyl)-6-methoxy-1-naphthalenyl]thioxomethyl]- N-methylglycine (Tolrestat), a potent, orally active aldose reductase inhibitor.

J Med Chem 27: 255-6 (1984)

TBA

2D 3D TSV

Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III.

J Med Chem 27: 181-5 (1984)

TBA

2D 3D TSV

Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s.

J Med Chem 27: 129-43 (1984)

TBA

2D 3D TSV

5-p-benzoquinonyl-2'-deoxyuridine 5'-phosphate: a possible mechanism-based inhibitor of thymidylate synthetase.

J Med Chem 26: 1028-36 (1983)

TBA

2D 3D TSV

Synthesis of analogues of pepstatin. Effect of structure in subsites P1', P2', and P2 on inhibition of porcine pepsin.

J Med Chem 26: 904-10 (1983)

TBA

2D 3D TSV

Folate analogues. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid.

J Med Chem 26: 605-7 (1983)

TBA

2D 3D TSV

Characterization of the binding of 3H-SCH 23390, a selective D-1 receptor antagonist ligand, in rat striatum.

Life Sci 35: 1885-93 (1984)

Schering-Plough

2D 3D TSV

Inhibition of renin by substrate analogue inhibitors containing the olefinic amino acid 5(S)-amino-7-methyl-3(E)-octenoic acid.

J Med Chem 27: 1351-4 (1984)

TBA

2D 3D TSV

Inhibition of renin by angiotensinogen peptide fragments containing the hydroxy amino acid residue 5-amino-3-hydroxy-7-methyloctanoic acid.

J Med Chem 26: 1457-62 (1983)

TBA

2D 3D TSV

Inhibitors of glycolic acid oxidase. 4-substituted 2,4-dioxobutanoic acid derivatives.

J Med Chem 26: 1196-200 (1983)

TBA

2D 3D TSV

Inhibition by carboxamides and sulfoxides of liver alcohol dehydrogenase and ethanol metabolism.

J Med Chem 26: 916-22 (1983)

TBA

2D 3D TSV

Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.

J Med Chem 27: 918-21 (1984)

TBA

2D 3D TSV

The 3,4-catechol derivative of propranolol, a minor dihydroxylated metabolite.

J Med Chem 27: 857-61 (1984)

TBA

2D 3D TSV

Bicyclic lactam inhibitors of angiotensin converting enzyme.

J Med Chem 27: 816-8 (1984)

TBA

2D 3D TSV

Cholecystokinin receptors: biochemical demonstration and autoradiographical localization in rat brain and pancreas using [3H] cholecystokinin8 as radioligand.

J Neurosci 4: 1021-33 (1984)

F. Hoffmann-La Roche

2D 3D TSV

Replacement of the peptide-backbone amides connecting Tyr-Gly and Gly-Gly in leucine-enkephalin with ketomethylene groups: synthesis and biological activity.

J Med Chem 27: 115-20 (1984)

TBA

2D 3D TSV

Synthesis, resolution, absolute stereochemistry, and enantioselectivity of 3',4'-dihydroxynomifensine.

J Med Chem 27: 28-35 (1984)

TBA

2D 3D TSV

Parasite enzymes as potential targets for antiparasitic chemotherapy.

J Med Chem 27: 1-9 (1984)

TBA

2D 3D TSV

Ligand binding to thromboxane receptors on human platelets: correlation with biological activity.

Br J Pharmacol 79: 953-64 (1983)

University Of Edinburgh

2D 3D TSV

14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone.

J Med Chem 26: 1775-7 (1983)

TBA

2D 3D TSV

Neurotransmitter receptor binding and drug discovery.

J Med Chem 26: 1667-72 (1984)

TBA

2D 3D TSV

Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.

J Med Chem 26: 1643-5 (1983)

TBA

2D 3D TSV

C4-substituted 1-beta-D-ribofuranosylpyrazolo[3,4-d]pyrimidines as adenosine agonist analogues.

J Med Chem 26: 1601-6 (1983)

TBA

2D 3D TSV

Different receptor sites mediate opioid agonism and antagonism.

J Med Chem 26: 1341-3 (1983)

TBA

2D 3D TSV

Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.

J Med Chem 26: 1277-82 (1983)

TBA

2D 3D TSV

Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.

J Med Chem 26: 1267-77 (1983)

TBA

2D 3D TSV

Sertraline, 1S,4S-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthylamine, a new uptake inhibitor with selectivity for serotonin.

J Pharmacol Exp Ther 226: 686-700 (1983)

Pfizer

2D 3D TSV

4-(Aminoalkyl)-7-hydroxy-2(3H)-indolones, a novel class of potent presynaptic dopamine receptor agonists.

J Med Chem 26: 933-5 (1983)

TBA

2D 3D TSV

4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.

J Med Chem 26: 895-900 (1983)

TBA

2D 3D TSV

(Mercaptopropanoyl)indoline-2-carboxylic acids and related compounds as potent angiotensin converting enzyme inhibitors and antihypertensive agents.

J Med Chem 26: 394-403 (1983)

TBA

2D 3D TSV

Antihypertensive agents: angiotensin converting enzyme inhibitors. 1-[3-(Acylthio)-3-aroylpropionyl]-L-prolines.

J Med Chem 26: 381-93 (1983)

TBA

2D 3D TSV

Synthesis of (7R)-7H-indolo[3,4-gh][1,4]benzoxazines, a new class of D-heteroergolines with dopamine agonist activity.

J Med Chem 26: 363-7 (1983)

TBA

2D 3D TSV

Synthesis of esters of phosphonoformic acid and their antiherpes activity.

J Med Chem 26: 264-70 (1983)

TBA

2D 3D TSV

Synthesis and 5-lipoxygenase inhibitory activities of eicosanoid compounds.

J Med Chem 26: 72-8 (1983)

TBA

2D 3D TSV

New carboxyalkyl inhibitors of brain enkephalinase: synthesis, biological activity, and analgesic properties.

J Med Chem 26: 60-5 (1983)

TBA

2D 3D TSV

Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity.

J Med Chem 25: 1432-8 (1983)

TBA

2D 3D TSV

alpha 2 adrenoceptors: classification, localization, mechanisms, and targets for drugs.

J Med Chem 25: 1389-401 (1982)

TBA

2D 3D TSV

N-Methylnalorphine: definition of N-allyl conformation for antagonism at the opiate receptor.

J Med Chem 25: 1278-80 (1982)

TBA

2D 3D TSV

Synthesis and pharmacology of metabolically stable tert-butyl ethers of morphine and levorphanol.

J Med Chem 25: 1264-6 (1982)

TBA

2D 3D TSV

Pentasubstituted quercetin analogues as selective inhibitors of particulate 3':5'-cyclic-AMP phosphodiesterase from rat brain.

J Med Chem 25: 1192-8 (1983)

TBA

2D 3D TSV

Species- or isozyme-specific enzyme inhibitors. 8. Synthesis of disubstituted two-substrate condensation products as inhibitors of rat adenylate kinases.

J Med Chem 25: 1179-84 (1983)

TBA

2D 3D TSV

Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.

J Med Chem 25: 1157-62 (1982)

TBA

2D 3D TSV

Specific binding of prostaglandin D2 to rat brain synaptic membrane. Occurrence, properties, and distribution.

J Biol Chem 257: 13570-5 (1982)

Kyoto University

2D 3D TSV

Angiotensin converting enzyme inhibitors: modifications of a tripeptide analogue.

J Med Chem 25: 996-9 (1982)

TBA

2D 3D TSV

Potential affinity labels for the opiate receptor based on fentanyl and related compounds.

J Med Chem 25: 913-9 (1982)

TBA

2D 3D TSV

Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives.

J Med Chem 25: 806-12 (1982)

TBA

2D 3D TSV

Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.

J Med Chem 25: 638-44 (1982)

TBA

2D 3D TSV

1-beta-D-arabinofuranosyl-1H-imidazo[4,5-c]pyridine (ara-3-deazaadenine).

J Med Chem 25: 96-8 (1982)

TBA

2D 3D TSV

Stereochemical studies on medicinal agents. 25. Absolute configuration and analgetic potency of beta-1,2-dimethyl-2-phenyl-4-(propionyloxy)piperidine enantiomers.

J Med Chem 25: 9-12 (1982)

TBA

2D 3D TSV

2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents.

J Med Chem 25: 420-6 (1982)

TBA

2D 3D TSV

Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues.

J Med Chem 25: 382-6 (1982)

TBA

2D 3D TSV

Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 3. Synthesis of adenosine 5'-triphosphate derivatives with N6- or 8-substituents bearing iodoacetyl groups.

J Med Chem 25: 373-81 (1982)

TBA

2D 3D TSV

Adenosine receptors: targets for future drugs.

J Med Chem 25: 197-207 (1982)

TBA

2D 3D TSV

Common anionic receptor site hypothesis: its relevance to the antagonist action of naloxone.

J Med Chem 25: 116-20 (1982)

TBA

2D 3D TSV

Evidence of the preferential involvement of mu receptors in analgesia using enkephalins highly selective for peripheral mu or delta receptors.

J Med Chem 24: 1119-24 (1982)

TBA

2D 3D TSV

Preparation and analgesic properties of amino acid derivatives of (-)-5,9 alpha-diethyl-2'-hydroxybenzomorphan.

J Med Chem 24: 1297-9 (1981)

TBA

2D 3D TSV

Prostacyclin receptors of a neuronal hybrid cell line. Divalent citations and ligand-receptor coupling.

Biochem Pharmacol 30: 2041-4 (1981)

Royal Postgraduate Medical School

2D 3D TSV

Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists.

J Med Chem 24: 903-6 (1981)

TBA

2D 3D TSV

Opiate receptor interaction of compounds derived from or structurally related to fentanyl.

J Med Chem 24: 777-82 (1981)

TBA

2D 3D TSV

Inhibition of the renin-angiotensin system. A new approach to the therapy of hypertension.

J Med Chem 24: 355-61 (1981)

TBA

2D 3D TSV

The binding of [3H]-prostacyclin to membranes of a neuronal somatic hybrid.

Br J Pharmacol 72: 435-41 (1981)

Royal Postgraduate Medical School

2D 3D TSV

Synthesis and antiviral activity of 1-(2-deoxy-beta-D-ribofuranosyl)-5-(methylmercapto)-2-pyrimidinone.

J Med Chem 24: 109-12 (1981)

TBA

2D 3D TSV

Synthesis and angiotensin-converting enzyme inhibitory activity of 3-(Mercaptomethyl)-2-oxo-1-pyrrolidineacetic acids and 3-(Mercaptomethyl)-2-oxo-1-piperidineacetic acids.

J Med Chem 24: 104-9 (1981)

TBA

2D 3D TSV

Conformationally restricted tricyclic antidepressants. 1. Octahydrodibenzazepinonaphthyridines as rigid imipramine analogues.

J Med Chem 23: 865-73 (1980)

TBA

2D 3D TSV

Synthesis and analgesic activity of some 5-(4-hydroxyphenyl)-2-azabicyclo[3.2.1]octanes.

J Med Chem 23: 726-9 (1980)

TBA

2D 3D TSV

Some spiro analogues of the potent analgesic ketobemidone.

J Med Chem 23: 688-90 (1980)

TBA

2D 3D TSV

Mammalian alkaloids. 8. Synthesis and biological effects of tetrahydropapaveroline related 1-benzyltetrahydroisoquinolines.

J Med Chem 23: 648-52 (1980)

TBA

2D 3D TSV

Opioid binding properties of brain and peripheral tissues: evidence for heterogeneity in opioid ligand binding sites.

J Pharmacol Exp Ther 214: 395-402 (1980)

Stanford University

2D 3D TSV

Synthesis and biological activity of 5-fluoro-2',3'-dideoxy-3'-fluorouridine and its 5'-phosphate.

J Med Chem 27: 11-4 (1984)

TBA

2D 3D TSV

Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT.

Nature 305: 140-2 (1983)

College Of France

2D 3D TSV

Aromatic amidines: comparison of their ability to block respiratory syncytial virus induced cell fusion and to inhibit plasmin, urokinase, thrombin, and trypsin.

J Med Chem 26: 294-8 (1983)

TBA

2D 3D TSV

Diastereomeric 6-desoxy-6-spiro-alpha-methylene-gamma-butyrolactone derivatives of naltrexone and oxymorphone. Selective irreversible inhibition of naltrexone binding in an opioid receptor preparation by a conformationally restricted michael acceptor ligand.

J Med Chem 27: 1718-23 (1984)

TBA

2D 3D TSV

Design, synthesis, and X-ray data of novel potential antipsychotic agents. Substituted 7-phenylquinolizidines: stereospecific, neuroleptic, and antinociceptive properties.

J Med Chem 27: 165-75 (1984)

TBA

2D 3D TSV

Synthesis and biological properties of thiophene ring analogues of mianserin.

J Med Chem 26: 1116-22 (1983)

TBA

2D 3D TSV

Novel synthesis of (S)-1-[5-(benzoylamino)-1,4-dioxo-6-phenylhexyl]-L-proline and analogues: potent angiotensin converting enzyme inhibitors.

J Med Chem 24: 964-9 (1982)

TBA

2D 3D TSV

Substituted 6,7-dihydroimidazo[1,2-a]purin-9(4H)-ones.

J Med Chem 23: 1188-98 (1980)

TBA

2D 3D TSV

Quantitative structure--activity correlations of rifamycins as inhibitors of viral RNA-directed DNA polymerase and mammalian alpha and beta DNA polymerases.

J Med Chem 23: 256-61 (1980)

TBA

2D 3D TSV

Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors.

J Med Chem 27: 1570-4 (1985)

TBA

2D 3D TSV

Antagonism by neuroleptics of neurotransmitter receptors of normal human brain in vitro.

Eur J Pharmacol 103: 197-204 (1984)

Mayo Clinic

2D 3D TSV

Synthesis and beta-adrenergic blocking activity of new aliphatic and alicyclic oxime ethers.

J Med Chem 27: 1291-4 (1984)

TBA

2D 3D TSV

Histamine H1 receptors in human brain labelled with [3H]doxepin.

Brain Res 304: 1-7 (1984)

Mayo Foundation

2D 3D TSV

Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.

Naunyn Schmiedebergs Arch Pharmacol 325: 136-44 (1984)

TBA

2D 3D TSV

Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.

J Med Chem 27: 495-503 (1984)

TBA

2D 3D TSV

Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids.

J Med Chem 27: 429-32 (1984)

TBA

2D 3D TSV

Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes.

J Med Chem 27: 417-22 (1984)

TBA

2D 3D TSV

Design and synthesis of tetrahedral intermediate analogues as potential dihydroorotase inhibitors.

J Med Chem 27: 228-32 (1984)

TBA

2D 3D TSV

alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.

J Med Chem 26: 1769-72 (1984)

TBA

2D 3D TSV

Pyridinylpiperazines, a new class of selective alpha 2-adrenoceptor antagonists.

J Med Chem 26: 1696-701 (1984)

TBA

2D 3D TSV

Specific binding of 3H-tiotidine to histamine H2 receptors in guinea pig cerebral cortex.

Nature 304: 65-7 (1983)

Hoechst Pharmaceutical Research Laboratories

2D 3D TSV

Synthesis and receptor binding studies relevant to the neuroleptic activities of some 1-methyl-4-piperidylidene-9-substituted-pyrrolo[2,1-b][3]benzazepine derivatives.

J Med Chem 26: 974-80 (1983)

TBA

2D 3D TSV

Beta 1-selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class.

J Med Chem 26: 950-7 (1983)

TBA

2D 3D TSV

Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans.

J Med Chem 26: 935-47 (1983)

TBA

2D 3D TSV

Antihypertensive 9-substituted 1-oxa-4,9-diazaspiro[5.5]undecan-3-ones.

J Med Chem 26: 855-61 (1983)

TBA

2D 3D TSV

alpha-adrenoreceptor reagents. 1. Synthesis of some 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists and potential antidepressants.

J Med Chem 26: 823-31 (1983)

TBA

2D 3D TSV

Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.

J Med Chem 26: 564-9 (1983)

TBA

2D 3D TSV

Buspirone analogues. 1. Structure-activity relationships in a series of N-aryl- and heteroarylpiperazine derivatives.

J Med Chem 26: 194-203 (1983)

TBA

2D 3D TSV

Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogues related to cimetidine and tiotidine.

J Med Chem 26: 140-4 (1983)

TBA

2D 3D TSV

Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.

J Med Chem 25: 1408-12 (1983)

TBA

2D 3D TSV

Ultra-short-acting beta-adrenergic receptor blocking agents. 1. (Aryloxy)propanolamines containing esters in the nitrogen substituent.

J Med Chem 25: 1402-7 (1983)

TBA

2D 3D TSV

Effects of conformationally restricted 4-piperazinyl-10H-thienobenzodiazepine neuroleptics on central dopaminergic and cholinergic systems.

J Med Chem 25: 1133-40 (1982)

TBA

2D 3D TSV

Use of (S)-(trifloxymethyl)oxirane in the synthesis of a chiral beta-adrenoceptor antagonist, (R)- and (S)-9-[[3-(tert-butylamino)-2-hydroxypropyl]oximino]fluorene.

J Med Chem 25: 931-6 (1982)

TBA

2D 3D TSV

Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.

J Med Chem 25: 680-4 (1982)

TBA

2D 3D TSV

1-(alkylamino)isochromans: hypotensives with peripheral and central activities.

J Med Chem 25: 75-81 (1982)

TBA

2D 3D TSV

Synthesis and pharmacological evaluation of conformationally restricted phenothiazine analogues.

J Med Chem 25: 5-9 (1982)

TBA

2D 3D TSV

A new inhibitor of norepinephrine uptake devoid of affinity for receptors in rat brain.

J Pharmacol Exp Ther 222: 61-5 (1982)

Eli Lilly

2D 3D TSV

Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2-receptor antagonists.

J Med Chem 25: 207-10 (1982)

TBA

2D 3D TSV

2-Benzodioxinylaminoethanols: a new class of beta-adrenergic blocking and antihypertensive agents.

J Med Chem 24: 994-8 (1982)

TBA

2D 3D TSV

beta-Adrenergic blocking agents. alpha- and gamma-methyl(aryloxy)propanolamines.

J Med Chem 24: 1211-4 (1981)

TBA

2D 3D TSV

Inhibition of inosinic acid dehydrogenase by 8-substituted purine nucleotides.

J Med Chem 24: 1155-61 (1982)

TBA

2D 3D TSV

Alpha-adrenergic agents. 1. Direct-acting alpha 1 agonists related to methoxamine.

J Med Chem 24: 1432-7 (1982)

TBA

2D 3D TSV

Synthesis and biological activity of fluoroalkylamine derivatives of narcotic analgesics.

J Med Chem 23: 985-90 (1980)

TBA

2D 3D TSV

Synthesis of 8-aryltetrahydroisoquinolines as dopamine antagonists and evaluation for potential neuroleptic activity.

J Med Chem 23: 977-80 (1980)

TBA

2D 3D TSV

6-(Phenylthio)-substituted 2,3,4,5-tetrahydro-1H-3-benzazepines, a novel class of dopamine receptor antagonists and neuroleptics.

J Med Chem 23: 975-6 (1980)

TBA

2D 3D TSV

Synthesis and anxiolytic activity of a series of pyrazino[1,2-a][1,4]benzodiazepine derivatives.

J Med Chem 23: 952-5 (1980)

TBA

2D 3D TSV

4a,9b-trans-8-Fluoro-5-(4-fluorophenyl)-2-[4-(4-fluorophenyl)-4-hydroxybutyl]-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole hydrochloride, a new potent neuroleptic.

J Med Chem 23: 949-52 (1980)

TBA

2D 3D TSV

Conformationally restricted phenothiazine neuroleptics. 1. 3-(Dimethylamino)-1,2,3,4-tetrahydroazepino[3,2,1-kl]phenothiazine.

J Med Chem 23: 938-41 (1980)

TBA

2D 3D TSV

Neuroleptic activity in 5-aryltetrahydro-gamma-carbolines.

J Med Chem 23: 635-43 (1980)

TBA

2D 3D TSV

Synthesis and beta-adrenergic blocking activity of new aliphatic oxime ethers.

J Med Chem 23: 620-4 (1980)

TBA

2D 3D TSV

Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists.

J Med Chem 27: 1607-13 (1984)

TBA

2D 3D TSV

Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property.

J Med Chem 27: 1597-601 (1985)

TBA

2D 3D TSV

Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones.

J Med Chem 27: 1575-9 (1984)

TBA

2D 3D TSV

Cyclopentenyluridine and cyclopentenylcytidine analogues as inhibitors of uridine-cytidine kinase.

J Med Chem 27: 1536-8 (1985)

TBA

2D 3D TSV

Mesoionic xanthine analogues: antagonists of adenosine receptors.

J Med Chem 27: 1364-7 (1984)

TBA

2D 3D TSV

Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues.

J Med Chem 27: 1325-35 (1984)

TBA

2D 3D TSV

Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.

J Med Chem 27: 1182-5 (1984)

TBA

2D 3D TSV

Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.

Proc Natl Acad Sci U S A 81: 4983-7 (1984)

TBA

2D 3D TSV