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27 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery of a Potent and Selective Sphingosine Kinase 1 Inhibitor through the Molecular Combination of Chemotype-Distinct Screening Hits.EBI
Pfizer
Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice.EBI
Peking Union Medical College And Chinese Academy Of Medical Sciences
Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.EBI
Virginia Tech
Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles.EBI
University Of Virginia
From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).EBI
Monash University (Parkville Campus)
Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.EBI
Virginia Tech
Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.EBI
Virginia Tech
Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors.EBI
Goethe University
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors.EBI
Penn State Hershey Cancer Institute
Structure-activity relationships and molecular modeling of sphingosine kinase inhibitors.EBI
The City University Of New York
Structure guided design of a series of sphingosine kinase (SphK) inhibitors.EBI
Amgen
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Ka.EBI
Celgene Avilomics Research
Effect of alkyl chain length on sphingosine kinase 2 selectivity.EBI
Virginia Tech
Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.EBI
Virginia Tech
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.EBI
University Of Virginia
Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation.EBI
University Of Pennsylvania
Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases.EBI
National University Of Singapore
Discovery and optimization of heteroaryl piperazines as potent and selective PI3K? inhibitors.EBI
Merck
Evolution of a Novel, Orally Bioavailable Series of PI3K? Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.EBI
Glaxosmithkline R&D
Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2.EBI
Heriot-Watt University
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity.EBI
Virginia Tech
Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.EBI
The City University Of New York
Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction.EBI
Universitaire Vaudois
Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.EBI
University Of Virginia
Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B.EBI
Kyoto University
Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3K?/? inhibitors for the treatment of PTEN-deficient tumours.EBI
Astrazeneca
Crystal structures of multidrug binding protein TtgR in complex with antibiotics and plant antimicrobials.BDB
Imperial College