422 articles for thisTarget
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Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Nanyang Normal University
Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.
South China University Of Technology
New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates.
University Of Mazandaran
Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.
University Of Bologna
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-ß-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Sichuan University
Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.
Martin-Luther-University Halle-Wittenberg
Tetrahydropyranodiquinolin-8-amines as new, non hepatotoxic, antioxidant, and acetylcholinesterase inhibitors for Alzheimer's disease therapy.
University Of Sfax
3,4-Dihydroquinazoline derivatives inhibit the activities of cholinesterase enzymes.
Kyung Hee University
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.
University Of Pretoria
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases andß-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Sichuan University
Amaryllidaceae alkaloids with new framework types from Zephyranthes candida as potent acetylcholinesterase inhibitors.
Huazhong University Of Science And Technology
Design, synthesis and evaluation of some N-methylenebenzenamine derivatives as selective acetylcholinesterase (AChE) inhibitor and antioxidant to enhance learning and memory.
Indian Institute Of Technology (Banaras Hindu University)
Synthesis, anticholinesterase activity and molecular modeling study of novel carbamate-substituted thymol/carvacrol derivatives.
Bezmialem Vakif University
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
University Of Delhi
Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.
Jagiellonian University Medical College
New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effects against NMDA-induced neurotoxicity.
University Of Bari&Quot;A. Moro&Quot
Repurposing N,N'-bis-(arylamidino)-1,4-piperazinedicarboxamidines: An unexpected class of potent inhibitors of cholinesterases.
Martin-Luther-University Halle-Wittenberg
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes.
Anadolu University
New piperidine-hydrazone derivatives: Synthesis, biological evaluations and molecular docking studies as AChE and BChE inhibitors.
Gaziantep University
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Jagiellonian University Collegium Medicum
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Sichuan University
Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX.
Tehran University Of Medical Sciences
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
China Pharmaceutical University
Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease.
Istituto Di Chimica Biomolecolare (Icb)
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines.
Anadolu University
Design, synthesis and evaluation of 4-dimethylamine flavonoid derivatives as potential multifunctional anti-Alzheimer agents.
Henan University
Synthesis and biological evaluation of ranitidine analogs as multiple-target-directed cognitive enhancers for the treatment of Alzheimer's disease.
University Of South Carolina
Synthesis and anticholinesterase activity of coumarin-3-carboxamides bearing tryptamine moiety.
Islamic Azad University
Synthesis and evaluation of dihydropyrimidinone-derived selenoesters as multi-targeted directed compounds against Alzheimer's disease.
Universidade Federal De Santa Catarina
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
University Of Barcelona
Synthesis and screening of triazolopyrimidine scaffold as multi-functional agents for Alzheimer's disease therapies.
Jamia Millia Islamia (Central University)
Alkaloids from Hippeastrum argentinum and Their Cholinesterase-Inhibitory Activities: An in Vitro and in Silico Study.
Universidad Nacional De San Juan
Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).
University Of Malaya
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
China Pharmaceutical University
Potent anticholinesterasic and neuroprotective pyranotacrines as inhibitors of beta-amyloid aggregation, oxidative stress and tau-phosphorylation for Alzheimer's disease.
University Complutense Madrid (Ucm)
Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-ß-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.
University Of Delhi
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase.
Universiti Putra Malaysia
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.
Guangzhou Medical University
Design, synthesis and bioactivity of novel phthalimide derivatives as acetylcholinesterase inhibitors.
Chinese Academy Of Agricultural Sciences
Biological evaluation of synthetica,ß-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.
Wuhan University Of Technology
Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds.
Erzurum Technical University
In silico to in vitro screening of hydroxypyridinones as acetylcholinesterase inhibitors.
University Of British Columbia
Pterostilbene-O-acetamidoalkylbenzylamines derivatives as novel dual inhibitors of cholinesterase with anti-ß-amyloid aggregation and antioxidant properties for the treatment of Alzheimer's disease.
Sichuan University
Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Nanyang Normal University
Converting maslinic acid into an effective inhibitor of acylcholinesterases.
Martin-Luther-Universit£T Halle-Wittenberg
Synthesis, structural characterization, docking, lipophilicity and cytotoxicity of 1-[(1R)-1-(6-fluoro-1,3-benzothiazol-2-yl)ethyl]-3-alkyl carbamates, novel acetylcholinesterase and butyrylcholinesterase pseudo-irreversible inhibitors.
University Of Pardubice
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
China Pharmaceutical University
Design, synthesis and evaluation of novel 7-aminoalkyl-substituted flavonoid derivatives with improved cholinesterase inhibitory activities.
Henan University
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.
Linyi People'S Hospital
Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease.
University Of Bras£Lia
Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.
Ataturk University
Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents.
Lehigh University
Design, synthesis, biological evaluation and docking study of 4-isochromanone hybrids bearing N-benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors.
China Pharmaceutical University
Difluoromethyl ketones: Potent inhibitors of wild type and carbamate-insensitive G119S mutant Anopheles gambiae acetylcholinesterase.
Virginia Tech
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.
Bezmialem Vakif University
Multifunctional novel Diallyl disulfide (DADS) derivatives withß-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease.
University Of Delhi
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Jagiellonian University Medical College
Evaluation of Homobivalent Carbolines as Designed Multiple Ligands for the Treatment of Neurodegenerative Disorders.
University Of Jena
Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.
Nanjing University Of Chinese Medicine
Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
Design, synthesis and evaluation of novel tacrine-(ß-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
China Pharmaceutical University
Allobetulin derived seco-oleananedicarboxylates act as inhibitors of acetylcholinesterase.
Martin-Luther-Universit£T Halle-Wittenberg
Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.
Universit£
In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier.
Charles University
Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
Design, synthesis and anticholinesterase activity of novel benzylidenechroman-4-ones bearing cyclic amine side chain.
Tehran University Of Medicinal Sciences
Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.
China Pharmaceutical University
Blood-brain barrier permeable anticholinesterase aurones: synthesis, structure-activity relationship, and drug-like properties.
Universiti Sains Malaysia
Development of multifunctional, heterodimeric isoindoline-1,3-dione derivatives as cholinesterase andß-amyloid aggregation inhibitors with neuroprotective properties.
Jagiellonian University Medical College
Benzofuran-derived benzylpyridinium bromides as potent acetylcholinesterase inhibitors.
Islamic Azad University
Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.
China Pharmaceutical University
Potent acetylcholinesterase inhibitors: design, synthesis, biological evaluation, and docking study of acridone linked to 1,2,3-triazole derivatives.
Tehran University Of Medical Sciences
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors withß-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Jagiellonian University
Design, synthesis and evaluation of novel 5,6,7-trimethoxyflavone-6-chlorotacrine hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Wenzhou Medical University
Isoindoline-1,3-dione derivatives targeting cholinesterases: design, synthesis and biological evaluation of potential anti-Alzheimer's agents.
Jagiellonian University Medical College
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.
University Of Delhi
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
Universit£
Amine substitution of quinazolinones leads to selective nanomolar AChE inhibitors with 'inverted' binding mode.
Universit£T Regensburg
Indolinone-based acetylcholinesterase inhibitors: synthesis, biological activity and molecular modeling.
Yazd University
New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.
Tehran University Of Medical Sciences
Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.
Quaid-I-Azam University
Synthesis and anti-cholinesterase activity of new 7-hydroxycoumarin derivatives.
Tehran University Of Medical Sciences
Amino derivatives of glycyrrhetinic acid as potential inhibitors of cholinesterases.
Martin-Luther-Universit£T Halle-Wittenberg
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Okayama University
Novel aromatic-polyamine conjugates as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.
Henan University
Synthesis and properties of 2-S-(N,N-dialkylamino)ethyl)thio-1,3,2-dioxaphosphorinane 2-oxide and of the corresponding quaternary derivatives as potential nontoxic antiglaucoma agents.
TBA
Potent reversible anticholinesterase agents. Bis- and mono-N-substituted benzoquinolinium halides.
TBA
Identification of a neuroprotective and selective butyrylcholinesterase inhibitor derived from the natural alkaloid evodiamine.
University Of W£Rzburg
Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.
China Pharmaceutical University
Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidines as potent cholinesterase enzyme inhibitors.
Universiti Sains Malaysia
Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.
Quaid-I-Azam University
Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.
Quaid-I-Azam University
Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.
Universit£
Design, synthesis and biological evaluation of D-ring opened galantamine analogs as multifunctional anti-Alzheimer agents.
Southeast University
Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase.
Universidad De Buenos Aires
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Laboratorio De Quimica Medica (Iqog, Csic)
Chemical composition of the bark of Tetrapterys mucronata and identification of acetylcholinesterase inhibitory constituents.
Universidade Estadual Paulista (Unesp)
Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzheimer's disease.
Universidad Complutense De Madrid
1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies.
Universitat De Barcelona
Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer's disease.
Sun Yat-Sen University
Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria.
University Of Troms£
Cholinesterase inhibitory activity versus aromatic core multiplicity: a facile green synthesis and molecular docking study of novel piperidone embedded thiazolopyrimidines.
Universiti Sains Malaysia
Novel tacrine-ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity.
Sun Yat-Sen University
Design, synthesis and evaluation of novel 4-dimethylamine flavonoid derivatives as potential multi-functional anti-Alzheimer agents.
Henan University
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Sun Yat-Sen University
Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors.
Kerman University Of Medical Sciences
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
Sun Yat-Sen University
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection.
Punjabi University
Multifunctional tacrine-flavonoid hybrids with cholinergic,ß-amyloid-reducing, and metal chelating properties for the treatment of Alzheimer's disease.
China Pharmaceutical University
Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3',4':5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase.
Tehran University Of Medical Sciences
Design, synthesis, biological evaluation and docking study of 5-oxo-4,5-dihydropyrano[3,2-c]chromene derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.
Tehran University Of Medical Sciences
Synthesis and biological evaluation of berberine-thiophenyl hybrids as multi-functional agents: Inhibition of acetylcholinesterase, butyrylcholinesterase, and Aß aggregation and antioxidant activity.
Sun Yat-Sen University
An expedient, ionic liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes inhibitors and their molecular modeling study.
Universiti Sains Malaysia
Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors.
Ege University
Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.
Banaras Hindu University
Design, synthesis and neuroprotective evaluation of novel tacrine-benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease.
Universidade T£Cnica De Lisboa
Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease.
Sun Yat-Sen University
An atom economic synthesis and AChE inhibitory activity of novel dispiro 7-aryltetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole and 4-aryloctahydroindolizine N-methylpiperidin-4-one hybrid heterocycles.
Madurai Kamaraj University
Design, synthesis and evaluation of novel tacrine-coumarin hybrids as multifunctional cholinesterase inhibitors against Alzheimer's disease.
China Pharmaceutical University
Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.
University Of Zanjan
Investigation of the role of linker moieties in bifunctional tacrine hybrids.
University Of Michigan
Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease.
China Pharmaceutical University
Microwave assisted synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new pyridopyrimidine derivatives.
Universiti Sains Malaysia
Design, synthesis and evaluation of some new 4-aminopyridine derivatives in learning and memory.
Banaras Hindu University
NO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activity.
China Pharmaceutical University
Novel racemic tetrahydrocurcuminoid dihydropyrimidinone analogues as potent acetylcholinesterase inhibitors.
Ramkhamhaeng University
Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents.
China Pharmaceutical University
Synthesis and evaluation of 7,8-dehydrorutaecarpine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Sun Yat-Sen University
A one-pot domino synthesis and discovery of highly functionalized dihydrobenzo[b]thiophenes as AChE inhibitors.
Madurai Kamaraj University
Synthesis and in vitro evaluation of new derivatives of 2-substituted-6-fluorobenzo[d]thiazoles as cholinesterase inhibitors.
University Of Pardubice
A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease.
Sun Yat-Sen University
Synthesis and biological evaluation of 1,3,4-thiadiazole analogues as novel AChE and BuChE inhibitors.
University Of Life Sciences
Acetylcholinesterase immobilized capillary reactors-tandem mass spectrometry: an on-flow tool for ligand screening.
Universidade Federal De S£O Carlos
Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.
Jagiellonian University Medical College
Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors.
China Pharmaceutical University
Nonquaternary cholinesterase reactivators. 2. Alpha-heteroaromatic aldoximes and thiohydroximates as reactivators of ethyl methylphosphonyl-acetylcholinesterase in vitro.
TBA
Novel coumarin derivatives bearing N-benzyl pyridinium moiety: potent and dual binding site acetylcholinesterase inhibitors.
University College Of Science
Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.
Universit£
Tacrine-silibinin codrug shows neuro- and hepatoprotective effects in vitro and pro-cognitive and hepatoprotective effects in vivo.
Universit£T Regensburg
Tacrine-ferulic acid-nitric oxide (NO) donor trihybrids as potent, multifunctional acetyl- and butyrylcholinesterase inhibitors.
China Pharmaceutical University
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Abo Akademi University
Novel multipotent phenylthiazole-tacrine hybrids for the inhibition of cholinesterase activity,ß-amyloid aggregation and Ca²¿ overload.
Huazhong University Of Science And Technology
Neuroprotective Tri- and Tetracyclic BChE Inhibitors Releasing Reversible Inhibitors upon Carbamate Transfer.
TBA
Design, synthesis and biological evaluation of benzo[e][1,2,4]triazin-7(1H)-one and [1,2,4]-triazino[5,6,1-jk]carbazol-6-one derivatives as dual inhibitors of beta-amyloid aggregation and acetyl/butyryl cholinesterase.
Universit£
Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease.
Sun Yat-Sen University
O-Hydroxyl- or o-amino benzylamine-tacrine hybrids: multifunctional biometals chelators, antioxidants, and inhibitors of cholinesterase activity and amyloid-ß aggregation.
Sun Yat-Sen University
Design, synthesis, and evaluation of indanone derivatives as acetylcholinesterase inhibitors and metal-chelating agents.
Sun Yat-Sen University
Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
Huazhong University Of Science And Technology
Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives.
University Of Lisbon
Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids.
Sun Yat-Sen University
Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques.
China Pharmaceutical University
Prospective acetylcholinesterase inhibitory activity of indole and its analogs.
Naresuan University
Design, synthesis and evaluation of isaindigotone derivatives as dual inhibitors for acetylcholinesterase and amyloid beta aggregation.
Sun Yat-Sen University
Azaphilones and p-terphenyls from the mangrove endophytic fungus Penicillium chermesinum (ZH4-E2) isolated from the South China Sea.
Sun Yat-Sen University
Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities.
Zhejiang University
Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation.
National Taiwan University
Morphinans and isoquinolines: acetylcholinesterase inhibition, pharmacophore modeling, and interaction with opioid receptors.
University Of Innsbruck And Center For Molecular Biosciences Innsbruck-Cmbi
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Universidad Autonoma De Madrid
Bivalent 5,8,9,13b-tetrahydro-6H-isoquino[1,2-a]isoquinolines and -isoquinolinium salts: novel heterocyclic templates for butyrylcholinesterase inhibitors.
Friedrich-Schiller-Universit£T Jena
Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.
Trinity College
New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.
Laboratorio De Radicales Libres (Iqog, Csic)
Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana.
Leopold-Franzens-Universit£T
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Universit£
Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors.
Sun Yat-Sen University
Design and synthesis of tacrine-ferulic acid hybrids as multi-potent anti-Alzheimer drug candidates.
Friedrich-Schiller-Universit£T Jena
Derivatives of oxoisoaporphine alkaloids: a novel class of selective acetylcholinesterase inhibitors.
Sun Yat-Sen University
First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor.
University Of Bonn
Synthesis and screening for acetylcholinesterase inhibitor activity of some novel 2-butyl-1,3-diaza-spiro[4,4]non-1-en-4-ones: derivatives of irbesartan key intermediate.
University Of Mysore
Selective optimization of side activities: another way for drug discovery.
Prestwick Chemical
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.
University Of Hamburg
Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.
Universit£
Structure-based alignment and comparative molecular field analysis of acetylcholinesterase inhibitors.
University Of North Carolina
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Sri International
Synthesis and anticholinesterase activity of (-)-N1-norphysostigmine, (-)-eseramine, and other N(1)-substituted analogues of (-)-physostigmine.
Niddk
Synthesis of 1-(2-Indolyl)pyridinium salts: a prodrug approach to acetylcholinesterase inhibition
TBA
Novel oxoisoaporphine-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
School Of Chemistry & Chemical Engineering Of Guangxi Normal University
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3¿]-2,3-dihydro-1H-inden-1¿-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Universiti Sains Malaysia
New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.
The University Of Adelaide
Benzenediol-berberine hybrids: multifunctional agents for Alzheimer's disease.
Guangzhou Institute Of Biomedicine And Health
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Universitat Aut£Noma De Barcelona
Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.
The Scripps Research Institute
Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-ß aggregation.
Sun Yat-Sen University
Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.
University Of Lisbon
Benzofurans from Styrax agrestis as acetylcholinesterase inhibitors: structure-activity relationships and molecular modeling studies.
Guangzhou University Of Chinese Medicine
HLE-inhibitory alkaloids with a polyketide skeleton from the marine-derived fungus Coniothyrium cereale.
University Of Bonn
Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-inducedß-amyloid aggregation inhibitors.
Guangxi Normal University
New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights.
University Putra Malaysia
Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase.
Universiti Sains Malaysia
Mycobacterium tuberculosis and cholinesterase inhibitors from Voacanga globosa.
University Of Santo Tomas
New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.
Cnrs
Synthesis and evaluation of heterobivalent tacrine derivatives as potential multi-functional anti-Alzheimer agents.
Sun Yat-Sen University
Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation.
Sun Yat-Sen University
Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors.
Sun Yat-Sen University
Synthesis, biological assessment and molecular modeling of 14-aryl-10,11,12,14-tetrahydro-9H-benzo[5,6]chromeno[2,3-b]quinolin-13-amines.
Universit£
Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques.
National Institute Of Pharmaceutical Education And Research (Niper)
Probing the mid-gorge of cholinesterases with spacer-modified bivalent quinazolinimines leads to highly potent and selective butyrylcholinesterase inhibitors.
Queen'S University Belfast
Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists.
UniversitÉ
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as dual inhibitors for cholinesterases and amyloid beta aggregation.
Sun Yat-Sen University
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic)
4-Phenylcoumarins from Mesua elegans with acetylcholinesterase inhibitory activity.
University Of Malaya
Berberine derivatives, with substituted amino groups linked at the 9-position, as inhibitors of acetylcholinesterase/butyrylcholinesterase.
Sun Yat-Sen University
Design, synthesis and anticholinesterase activity of a novel series of 1-benzyl-4-((6-alkoxy-3-oxobenzofuran-2(3H)-ylidene) methyl) pyridinium derivatives.
Tehran University Of Medical Sciences
Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.
Laboratorio De Radicales Libres Y QuíMica Computacional (Iqog, Csic)
Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.
Sun Yat-Sen University
Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors.
University Of Waterloo
Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase.
Sun Yat-Sen University
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.
Friedrich-Schiller-Universitat Jena
Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate.
Laboratorio De Radicales Libres Y QuÍMica Computacional (Iqog, Csic)
Peripheral site acetylcholinesterase inhibitors targeting both inflammation and cholinergic dysfunction.
Lehigh University
Synthesis and evaluation of novel rutaecarpine derivatives and related alkaloids derivatives as selective acetylcholinesterase inhibitors.
Sun Yat-Sen University
Design, synthesis and evaluation of novel 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-2-indenyl-3,4-substituted phenyl methanone analogues.
Alwar Pharmacy College
Synthesis, biological evaluation, and molecular modeling of berberine derivatives as potent acetylcholinesterase inhibitors.
Sun Yat-Sen University
Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases.
Ege University
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.
Trinity College
4-Aryl-4-oxo-N-phenyl-2-aminylbutyramides as acetyl- and butyrylcholinesterase inhibitors. Preparation, anticholinesterase activity, docking study, and 3D structure-activity relationship based on molecular interaction fields.
Institute
Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase.
University Of Mysore
Synthesis, biological evaluation and molecular modeling of oxoisoaporphine and oxoaporphine derivatives as new dual inhibitors of acetylcholinesterase/butyrylcholinesterase.
Sun Yat-Sen University
Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B.
National Taiwan University
The synthesis and in vitro acetylcholinesterase and butyrylcholinesterase inhibitory activity of tacrine (Cognex®) derivaties
TBA
Serratezomines D and E, new Lycopodium alkaloids from Lycopodium serratum var. serratum.
Hokkaido University
NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity.
Friedrich-Schiller-University Jena
Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.
Trinity College
Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues.
China Pharmaceutical University
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.
Sun Yat-Sen University
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.
Friedrich-Schiller-UniversitäT Jena
Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.
Università
New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.
University Of Karachi
Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
Tribhuvan University
Litebamine N-homologues: preparation and anti-acetylcholinesterase activity.
National Taiwan University
N-Alkylated galanthamine derivatives: Potent acetylcholinesterase inhibitors from Leucojum aestivum.
Universitat De Barcelona
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Woosuk University
Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
Laboratorio De Radicales Libres (Iqog, Csic)
Homobivalent quinazolinimines as novel nanomolar inhibitors of cholinesterases with dirigible selectivity toward butyrylcholinesterase.
Friedrich-Schiller-UniversitäT Jena
Synthesis and efficacy of 1-[bis(4-fluorophenyl)-methyl]piperazine derivatives for acetylcholinesterase inhibition, as a stimulant of central cholinergic neurotransmission in Alzheimer's disease.
University Of Mysore
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and acetylcholinesterase inhibition.
University Of Bonn
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum.
University Of Karachi
Cage amines as the stopper inhibitors of cholinesterases.
National Chung-Hsing University
Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.
Cnrs
Design, synthesis, and structure-activity relationships of alkylcarbamic acid aryl esters, a new class of fatty acid amide hydrolase inhibitors.
Università
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.
University Of Jinan
Galanthamine, Plicamine, and Secoplicamine Alkaloids from Zephyranthes candida and Their Anti-acetylcholinesterase and Anti-inflammatory Activities.
Huazhong University Of Science And Technology
Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.
The University Of Queensland
Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors.
Seoul National University
Cholinesterase inhibitory activity of chlorophenoxy derivatives-Histamine H3 receptor ligands.
Jagiellonian University Medical College
Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents.
Universit£
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Sichuan University
Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity.
Sunchon National University
Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.
Cnrs
Cholinesterase Inhibitory Arisugacins L-Q from a
Institute For Natural Products Applications And Research Technologies
Labdanes, Withanolides, and Other Constituents from
Universidad Nacional Aut£Noma De M£Xico
Discovery of novel series of 2-substituted benzo[d]oxazol-5-amine derivatives as multi-target directed ligands for the treatment of Alzheimer's disease.
Indian Institute Of Technology (Banaras Hindu University)
Discovery of ?-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies.
Anhui Medical University
Ellagic acid a multi-target bioactive compound for drug discovery in CNS? A narrative review.
University Of Genoa
Sulfamates in drug design and discovery: Pre-clinical and clinical investigations.
University Of Sharjah
Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease.
University Of Bari Aldo Moro
Caffeic acid phenethyl ester (CAPE)-derivatives act as selective inhibitors of acetylcholinesterase.
Martin-Luther-University Halle-Wittenberg
A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer's disease.
Jamia Millia Islamia (Central University)
Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents.
University Of Porto
Design, synthesis, evaluation and molecular modeling study of 4-N-phenylaminoquinolines for Alzheimer disease treatment.
Tianjin University Of Technology
Dispiropyrrolidinyl-piperidone embedded indeno[1,2-b]quinoxaline heterocyclic hybrids: Synthesis, cholinesterase inhibitory activity and their molecular docking simulation.
King Saud University
Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.
University Of Hradec Kralove
Efficient click chemistry towards novel 1H-1,2,3-triazole-tethered 4H-chromene-d-glucose conjugates: Design, synthesis and evaluation of in vitro antibacterial, MRSA and antifungal activities.
Vnu University Of Science (Vietnam National University)
Dual functional cholinesterase and PDE4D inhibitors for the treatment of Alzheimer's disease: Design, synthesis and evaluation of tacrine-pyrazolo[3,4-b]pyridine hybrids.
Sun Yat-Sen University
Naphthalene-triazolopyrimidine hybrid compounds as potential multifunctional anti-Alzheimer's agents.
Jamia Millia Islamia (Central University)
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview.
Chinese Academy Of Sciences
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
Jagiellonian University Medical College
Search for new multi-target compounds against Alzheimer's disease among histamine H
Jagiellonian University Medical College
Triazole derivatives as inhibitors of Alzheimer's disease: Current developments and structure-activity relationships.
Wuhan Institute Of Technology
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Nanyang Normal University
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Nanyang Normal University
Tacrine-O-protected phenolics heterodimers as multitarget-directed ligands against Alzheimer's disease: Selective subnanomolar BuChE inhibitors.
Universidad De Sevilla
Inhibition of electric eel acetylcholinesterase by porphin compounds.
Taejon National University Of Technology
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Istituto Di Strutturistica Chimica G. Giacomello
Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors.
Sun Yat-Sen University
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Guizhou Medical University
Novel N-benzylpiperidine carboxamide derivatives as potential cholinesterase inhibitors for the treatment of Alzheimer's disease.
University Of Pretoria
Dipropargyl substituted diphenylpyrimidines as dual inhibitors of monoamine oxidase and acetylcholinesterase.
Central University Of Punjab
Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease.
Anhui Medical University
Multi-target design strategies for the improved treatment of Alzheimer's disease.
China Pharmaceutical University
Microwave-Assisted Organic Synthesis, structure-activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors.
University Of Karachi
Comparative analysis of stilbene and benzofuran neolignan derivatives as acetylcholinesterase inhibitors with neuroprotective and anti-inflammatory activities.
Gifu University
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Csir-Central Drug Research Institute
Design, synthesis, and biological evaluation of novel 4-oxobenzo[d]1,2,3-triazin-benzylpyridinum derivatives as potent anti-Alzheimer agents.
University Of Zanjan
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Alexandria University
Glucoconjugated Monoterpene Indole Alkaloids from
Peking University Health Science Center
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.
Julius Maximilian University Of W£Rzburg
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory.
Indian Institute Of Technology (Banaras Hindu University)
Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors.
Universit£
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Chinese Academy Of Sciences
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.
Universidade De £Vora
Synthesis and biological evaluation of calycanthaceous alkaloid analogs.
Jiangsu University Of Science And Technology
Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.
Southeast University
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.
Anadolu University
Synthesis, pharmacological assessment, molecular modeling and in silico studies of fused tricyclic coumarin derivatives as a new family of multifunctional anti-Alzheimer agents.
Yogi Vemana University
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Universitat De Barcelona
Cyclic acyl guanidines bearing carbamate moieties allow potent and dirigible cholinesterase inhibition of either acetyl- or butyrylcholinesterase.
Universit£T Regensburg
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Sun Yat-Sen University
Synthesis and anti-acetylcholinesterase properties of novel ?- and ?-substituted alkoxy organophosphonates.
The University Of Montana
Synthesis of novel phosphorothioates and phosphorodithioates and their differential inhibition of cholinesterases.
Institute For Advanced Studies In Basic Sciences (Iasbs)
In vitro and in vivo protection of acetylcholinesterase against organophosphate poisoning by pretreatment with a novel derivative of 1,3,2-dioxaphosphorinane 2-oxide.
TBA
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
China Pharmaceutical University
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.
China Pharmaceutical University
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.
University Of Pavia
Unexpected AChE inhibitory activity of (2E)?,?-unsaturated fatty acids.
Martin-Luther-University Halle-Wittenberg
Nonquaternary cholinesterase reactivators. 3. 3(5)-Substituted 1,2,4-oxadiazol-5(3)-aldoximes and 1,2,4-oxadiazole-5(3)-thiocarbohydroximates as reactivators of organophosphonate-inhibited eel and human acetylcholinesterase in vitro.
TBA
Demonstration of In Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents.
The Ohio State University-Marion
Design, synthesis, and biological evaluation of selective and potent Carbazole-based butyrylcholinesterase inhibitors.
Tehran University Of Medical Sciences
Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.
University Of Groningen
Success stories of natural product-based hybrid molecules for multi-factorial diseases.
Punjabi University
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and ?-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Sichuan University
Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.
China Pharmaceutical University
In silico studies, synthesis and pharmacological evaluation to explore multi-targeted approach for imidazole analogues as potential cholinesterase inhibitors with neuroprotective role for Alzheimer's disease.
Prin. K. M. Kundnani College Of Pharmacy
Development of Piperazinediones as dual inhibitor for treatment of Alzheimer's disease.
Banaras Hindu University
Novel Tacrine-Hydroxyphenylbenzimidazole hybrids as potential multitarget drug candidates for Alzheimer's disease.
Universidade De Lisboa
Synthesis and activity towards Alzheimer's disease in vitro: Tacrine, phenolic acid and ligustrazine hybrids.
Chinese Academy Of Medical Sciences & Peking Union Medical College
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation.
Technology And Research University-Vfstru (Vignan's University)
New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.
Tehran University Of Medical Sciences
Piperlongumine B and analogs are promising and selective inhibitors for acetylcholinesterase.
Martin-Luther University Halle-Wittenberg
Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
China Pharmaceutical University
Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.
Shanghai University Of Traditional Chinese Medicine
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents.
Universidad De Sevilla
Synthesis of novel 5-(aroylhydrazinocarbonyl)escitalopram as cholinesterase inhibitors.
University Of The Punjab
Novel tetrahydrocarbazole benzyl pyridine hybrids as potent and selective butryl cholinesterase inhibitors with neuroprotective and ?-secretase inhibition activities.
Tehran University Of Medical Sciences
Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.
Tehran University Of Medical Sciences
Tricyclic pyrazolo[1,5-d][1,4]benzoxazepin-5(6H)-one scaffold derivatives: Synthesis and biological evaluation as selective BuChE inhibitors.
Anhui Medical University
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Federal University Of Alfenas
Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.
Medical University Of Lodz
Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity.
Henan University
2-Arylbenzofurans from Artocarpus lakoocha and methyl ether analogs with potent cholinesterase inhibitory activity.
Srinakharinwirot University
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
University Of Maribor
Rational design, synthesis and biological screening of triazine-triazolopyrimidine hybrids as multitarget anti-Alzheimer agents.
Jamia Millia Islamia (Central University)
Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis.
Universidade Federal Do Rio Grande Do Sul-Ufrgs
New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.
Sapienza University Of Rome
A novel class of thiosemicarbazones show multi-functional activity for the treatment of Alzheimer's disease.
The University Of Sydney
Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.
Abbottabad University Of Science And Technology
Design, synthesis and evaluation of novel bivalent ?-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease.
China Pharmaceutical University
A cascade synthesis, in vitro cholinesterases inhibitory activity and docking studies of novel Tacrine-pyranopyrazole derivatives.
Fr£Res Mentouri-Constantine University
Synthesis, structure-activity relationship and molecular docking studies of 3-O-flavonol glycosides as cholinesterase inhibitors.
University Of Gujrat
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.
Niddk
Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.
Tianjin University Of Technology
Synthesis, docking study and neuroprotective effects of some novel pyrano[3,2-c]chromene derivatives bearing morpholine/phenylpiperazine moiety.
Tehran University Of Medical Sciences
BACE1 inhibitory activity and molecular docking analysis of meroterpenoids from Sargassum serratifolium.
Pukyong National University
Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.
Sichuan University
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Nanyang Normal University
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Nanyang Normal University
Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors.
Tehran University Of Medical Sciences
Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.
University Of The Western Cape
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Federal University Of Alfenas
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Nanyang Normal University
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
Shanghai University Of Traditional Chinese Medicine
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.
China Pharmaceutical University
Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.
Julius Maximilian University Of W£Rzburg
Antioxidant and anticholinesterase potential of diterpenoid alkaloids from Aconitum heterophyllum.
University Of Malakand
Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.
Sun Yat-Sen University
Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.
University Of Missouri St. Louis
Chromone as a Privileged Scaffold in Drug Discovery: Recent Advances.
University Of Porto
Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.
Pfizer
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
University Of California San Francisco