31 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
Organization
Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.
The Scripps Research Institute
Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase.
Northwestern University
Discovery of a nanomolar inhibitor of the human murine double minute 2 (MDM2)-p53 interaction through an integrated, virtual database screening strategy.
University Of Michigan
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction.
University Of Michigan
Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Medical University Of South Carolina
Benzopyrans as selective estrogen receptor beta agonists (SERBAs). Part 3: synthesis of cyclopentanone and cyclohexanone intermediates for C-ring modification.
Eli Lilly
Crystal structure of Staphylococcus aureus tyrosyl-tRNA synthetase in complex with a class of potent and specific inhibitors.
Gsk
Synthesis of beta-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases.
Crefsip
Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
Schering-Plough Research Institute
Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
The Procter & Gamble Pharmaceuticals
Design and Synthesis of HIV-1 Protease Inhibitors Incorporating Oxazolidinones as P2/P2' Ligands in Pseudosymmetric Dipeptide Isosteres.
University Of Massachusetts Medical School
Selection of a 2-azabicyclo[2.2.2]octane-based alpha4beta1 integrin antagonist as an inhaled anti-asthmatic agent.
Johnson & Johnson Pharmaceutical
Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors.
Glaxosmithkline
Synthesis, molecular modeling studies, and selective inhibitory activity against monoamine oxidase of 1-thiocarbamoyl-3,5-diaryl-4,5-dihydro-(1H)- pyrazole derivatives.
Sapienza University Of Rome
Bis-huperzine B: highly potent and selective acetylcholinesterase inhibitors.
Shanghai Institute Of Materia Medica
Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives.
Chinese Academy Of Sciences
Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.
University Of Dundee
Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.
Merck Frosst Canada
Synthesis and structure-activity relationships of 6-substituted androst-4-ene analogs as aromatase inhibitors.
Tohoku College Of Pharmacy