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Synthesis and anti-influenza evaluation of orally active bicyclic ether derivatives related to zanamivir.

Sankyo

Synthesis and anti-influenza virus activity of 7-O-alkylated derivatives related to zanamivir.

Sankyo

Synthesis and anti-influenza virus activity of 4-guanidino-7-substituted Neu5Ac2en derivatives.

Sankyo

Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity.

University Of Alabama At Birmingham

Limited inhibitory effects of oseltamivir and zanamivir on human sialidases.

Miyagi Cancer Center Research Institute

Fragment-based drug discovery.

Sunesis Pharmaceuticals

BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

Biocryst Pharmaceuticals

Binding constants of neuraminidase inhibitors: An investigation of the linear interaction energy method.

University Of Southampton

Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.

Glaxo Wellcome Research And Development

Molecular modeling studies on ligand binding to sialidase from influenza virus and the mechanism of catalysis.

Monash University

Sialidase inhibitors related to zanamivir. Further SAR studies of 4-amino-4H-pyran-2-carboxylic acid-6-propylamides.

Glaxowellcome Medicines Research Centre

 

Novel inhibitors of influenza sialidases related to zanamivir. Heterocyclic replacements of the glycerol sidechain

TBA

 

Novel inhibitors of influenza sialidases related to GG167 structure-activity, crystallographic and Molecular dynamics studies with 4H-pyran-2-carboxylic acid 6-carboxamides

TBA

 

Novel inhibitors of influenza sialidase related to GG167 Synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza a virus sialidase

TBA

Synthesis and biological evaluation of sialic acid derivatives containing a long hydrophobic chain at the anomeric position and their C-5 linked polymers as potent influenza virus inhibitors.

Saitama University

3D QSAR and docking study of flavone derivatives as potent inhibitors of influenza H1N1 virus neuraminidase.

Chinese Academy Of Medical Sciences

Antiviral potential and molecular insight into neuraminidase inhibiting diarylheptanoids from Alpinia katsumadai.

University Of Innsbruck

Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza.

Glaxosmithkline

Design, synthesis, and structural analysis of inhibitors of influenza neuraminidase containing a 2,3-disubstituted tetrahydrofuran-5-carboxylic acid core.

Abbott Laboratories

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Abbott Laboratories

Boronate, trifluoroborate, sulfone, sulfinate and sulfonate congeners of oseltamivir carboxylic acid: Synthesis and anti-influenza activity.

National Taiwan University

Discovery of novel 1,2,3-triazole oseltamivir derivatives as potent influenza neuraminidase inhibitors targeting the 430-cavity.

Shandong University

Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent.

University Of Alabama At Birmingham

Total synthesis of dryocrassin ABBA and its analogues with potential inhibitory activity against drug-resistant neuraminidases.

Chinese Academy Of Sciences

Design, synthesis and biological evaluation of "Multi-Site"-binding influenza virus neuraminidase inhibitors.

Shandong University

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

Charles University

Discovery of Novel Neuraminidase Inhibitors by Structure-Based Virtual Screening, Structural Optimization, and Bioassay.

Shanghai Institute Of Technology

Design, synthesis and biological evaluation of oseltamivir derivatives containing pyridyl group as potent inhibitors of neuraminidase for influenza A.

Wuyi University

Aspulvinones from a mangrove rhizosphere soil-derived fungus Aspergillus terreus Gwq-48 with anti-influenza A viral (H1N1) activity.

Ocean University Of China

QSAR study of flavonoids and biflavonoids as influenza H1N1 virus neuraminidase inhibitors.

Universidad De Buenos Aires

Synthesis and biological evaluation of NH

Shenyang Pharmaceutical University

Synthesis and anti-influenza virus evaluation of triterpene-sialic acid conjugates.

Meiji Pharmaceutical University

Discovery of berberine based derivatives as anti-influenza agent through blocking of neuraminidase.

Konkuk University

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Shandong University

C-Methylated Flavonoid Glycosides from Pentarhizidium orientale Rhizomes and Their Inhibitory Effects on the H1N1 Influenza Virus.

Seoul National University

Novel 5-azaindole factor VIIa inhibitors.

Celera

Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).

Boehringer Ingelheim Pharmaceuticals

Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.

Boehringer Ingelheim Pharmaceuticals

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Abbott Laboratories

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.

Wyeth Research

Thermodynamics of substrate binding to the chaperone SecB.

Indian Institute Of Science