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Preparation of 5-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyloxy)-6-hydroxynap htho[2,3- f]quinoline-7,12-dione (FT-Alz), a new-type, potentially antitumor substance with various biological activities.

Institute Of Bioorganic Chemistry

Quinolino[3,4-b]quinoxalines and pyridazino[4,3-c]quinoline derivatives: Synthesis, inhibition of topoisomerase IIa, G-quadruplex binding and cytotoxic properties.

Universit£

Inhibition of human DNA topoisomerase IIa by two novel ellipticine derivatives.

Vanderbilt University School Of Medicine

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors.

Sun Yat-Sen University

Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents.

Taipei Medical University

Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-a inhibition.

Central University Of Punjab

4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIa targeting the ATP binding site.

National Institute Of Chemistry

Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: SAR and in vivo characterization.

Astrazeneca

Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIa Catalytic Inhibitors.

Department Of Pharmaceutical Technology (Biotechnology), Department Of Pharmacoinformatics, And Department Of Medicinal Chemistry, National Institute Of Pharmaceutical Education And Research (Niper

Monocyclic 4-amino-6-(phenylamino)-1,3,5-triazines as inhibitors of human DNA topoisomerase IIa.

National Institute Of Chemistry

Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure-activity relationships.

Kumamoto University

Lanostanoids from fungi: a group of potential anticancer compounds.

TBA

Synthesis and evaluation of 2-[2-(phenylthiomethyl)-1H-benzo[d] imidazol-1-yl)acetohydrazide derivatives as antitumor agents.

Sichuan University

Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides.

Stephen F. Austin State University

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.

University Of Manitoba

Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity.

Osaka University Of Pharmaceutical Sciences

Synthesis of 1-/2-substituted-[1,2,3]triazolo[4,5-g]phthalazine-4,9-diones and evaluation of their cytotoxicity and topoisomerase II inhibition.

Ewha Womans University

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

University Of Oxford

Synthesis and biological evaluation of bengacarboline derivatives.

Universit£

Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.

Purdue University

 

The antitumor activity of novel pyrazoloquinoline derivatives

TBA

Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis.

University Of Thessaly

Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases.

University Of Cagliari

N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIa and induce apoptosis in G1/S phase.

National Institute Of Pharmaceutical Education And Research (Niper)

Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors.

Sun Yat-Sen University

Role of metalation in the topoisomerase IIa inhibition and antiproliferation activity of a series ofa-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes.

Memorial Sloan-Kettering Cancer Center

A series of alpha-heterocyclic carboxaldehyde thiosemicarbazones inhibit topoisomerase IIalpha catalytic activity.

Chinese Academy Of Sciences

7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.

Universit£

The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds.

University Of Manitoba

Discovery of a new class of catalytic topoisomerase II inhibitors targeting the ATP-binding site by structure based design. Part I.

Novartis Institutes For Biomedical Research

Synthesis, cytotoxic activity, DNA topoisomerase-II inhibition, molecular modeling and structure-activity relationship of 9-anilinothiazolo[5,4-b]quinoline derivatives.

Universidad Nacional AutóNoma De MéXico

The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.

University Of Manitoba

Triterpenoid constituents isolated from the bark of Abies sachalinensis.

Osaka University Of Pharmaceutical Sciences

Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica.

University Of Arizona

Isoaurostatin, a novel topoisomerase inhibitor produced by Thermomonospora alba.

Kumamoto University

Three new triterpenoids from Peganum nigellastrum.

Toho University

DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia.

Ohio State University

Critical structural motif for the catalytic inhibition of human topoisomerase II by UK-1 and analogs.

University Of Maryland

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

Banyu Tsukuba Research Institute

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

Banyu Tsukuba Research Institute