PMID

Data

Article Title

Organization

Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.

Pfizer

The discovery of diazepinone-based 5-HT3 receptor partial agonists.

Amri

Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.

Merrell Dow Research Institute

 

Design and synthesis of novel ligands for the 5-HT3 and the 5-HT4 receptor

TBA

A comprehensive study on the 5-hydroxytryptamine(3A) receptor binding of agonists serotonin and m-chlorophenylbiguanidine.

Virtua Drug

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.

Pfizer

An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.

Predix Pharmaceuticals

Dopamine D3 and D4 receptor antagonists: synthesis and structure--activity relationships of (S)-(+)-N-(1-Benzyl-3-pyrrolidinyl)-5-chloro-4- [(cyclopropylcarbonyl) amino]-2-methoxybenzamide (YM-43611) and related compounds.

Yamanouchi Pharmaceutical

FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.

Avanti Polar Lipids

Synthesis and anti-acetylcholinesterase activity of scopoletin derivatives.

Chulabhorn Research Institute

Triazinoindole analogs as potent inhibitors of a-glucosidase: synthesis, biological evaluation and molecular docking studies.

Hazara University