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30 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.EBI
Gilead Sciences
Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.EBI
Biota Scientific Management
N-Acyl-phosphoramidates as potential novel form of gemcitabine prodrugs.EBI
Polish Academy Of Sciences
Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.EBI
Chulalongkorn University
4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases.EBI
Pharmacia
Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.EBI
Max-Delbr�Ck-Centrum F�R Molekulare Medizin
Isosteres of the DNA polymerase inhibitor aphidicolin as potential antiviral agents against human herpes viruses.EBI
Wellcome Research Laboratories
Synthesis and characterization of N2-(p-n-butylphenyl)-2'-deoxyguanosine and its 5'-triphosphate and their inhibition of HeLa DNA polymerase alpha.EBI
TBA
1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.EBI
Tibotec
GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.EBI
Gilead Sciences
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.EBI
Pharmasset
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.EBI
Pfizer
The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase.EBI
Pfizer
N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.EBI
Novartis Institute For Tropical Diseases
Differential Inhibition of Reverse Transcriptase and Various DNA Polymerases by Digallic Acid and Its DerivativesEBI
TBA
Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.EBI
Central Pharmaceutical Research Institute
Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.EBI
Wyeth Research
Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.EBI
The University Of Manchester
Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.EBI
Central Pharmaceutical Research Institute
3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.EBI
Glaxosmithkline
Molecular design of cholesterols as inhibitors of DNA polymerase alpha.EBI
Frontier Research Center For Genome & Drug Discovery
Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.EBI
Wyeth Research
Enhancement of nucleoside cytotoxicity through nucleotide prodrugs.EBI
Southern Research Institute
Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase.EBI
Pharmacia
Discovery of a Series of 2'-?-Fluoro,2'-?-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.EBI
Emory University School Of Medicine
Inhibition of herpes simplex virus type 1 helicase-primase by (dichloroanilino)purines and -pyrimidines.EBI
Stanford University Medical School
Synthesis, cell growth inhibition, and antitumor screening of 2-(p-n-butylanilino)purines and their nucleoside analogues.EBI
TBA
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.EBI
Bristol-Myers Squibb Research And Development
The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-?-chloro-2'-?-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.EBI
Idenix An Msd
2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.EBI
Emory University