60 articles for thisTarget
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Article Title
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Synthesis and biological evaluation of potential inhibitors of the cysteine proteases cruzain and rhodesain designed by molecular simplification.
Universidade Federal De Minas Gerais
Dipeptidyl Nitroalkenes as Potent Reversible Inhibitors of Cysteine Proteases Rhodesain and Cruzain.
Universitat Jaume I
Design, synthesis, molecular docking and biological evaluation of thiophen-2-iminothiazolidine derivatives for use against Trypanosoma cruzi.
Federal University Of Alagoas
Structural design, synthesis and pharmacological evaluation of 4-thiazolidinones against Trypanosoma cruzi.
Universidade Federal De Pernambuco
Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.
University Of California
Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain.
Universidade Federal De Pernambuco
Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir.
National University Of La Plata (Unlp)
2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation.
Universidade Federal De Pernambuco
Trends in research of antitrypanosomal agents among synthetic heterocycles.
Danylo Halytsky Lviv National Medical University
Structures and bioactivities of dihydrochalcones from Metrodorea stipularis.
Universidade Federal De S£O Carlos
Design, synthesis and biological evaluation of hybrid bioisoster derivatives of N-acylhydrazone and furoxan groups with potential and selective anti-Trypanosoma cruzi activity.
Universidade De S£O Paulo (Usp)
Synthesis, biological evaluation, and structure-activity relationships of potent noncovalent and nonpeptidic cruzain inhibitors as anti-Trypanosoma cruzi agents.
Universidade De S£O Paulo
Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.
Universit£
Colloidal aggregation causes inhibition of G protein-coupled receptors.
University Of North Carolina At Chapel Hill
CoMFA and HQSAR of acylhydrazide cruzain inhibitors.
Universidade Federal Do Rio De Janeiro
Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.
Universidade Federal De Pernambuco
Optimization of anti-Trypanosoma cruzi oxadiazoles leads to identification of compounds with efficacy in infected mice.
Universidade Federal De Pernambuco
Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents.
Instituto De Tecnologia Em F£Rmacos - Farmanguinhos
Colloid formation by drugs in simulated intestinal fluid.
University Of California San Francisco
2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L.
Universidade De S£O Paulo
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
University Of California San Francisco
Dipeptidyl-alpha,beta-epoxyesters as potent irreversible inhibitors of the cysteine proteases cruzain and rhodesain.
Universitat Jaume I
cis-6-oxo-hexahydro-2-oxa-1,4-diazapentalene and cis-6-oxo-hexahydropyrrolo[3,2-c]pyrazole based scaffolds: design rationale, synthesis and cysteinyl proteinase inhibition.
Amura Therapeutics
Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease.
Merck Research Laboratories
Studies toward the structural optimization of novel thiazolylhydrazone-based potent antitrypanosomal agents.
Federal University Of Pernambuco
Design, synthesis, crystal structures, and antimicrobial activity of sulfonamide boronic acids asß-lactamase inhibitors.
University Of California San Francisco
Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors.
University Of California San Francisco
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
University Of California
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.
University Of California
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
National Human Genome Research Institute
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
National Human Genome Research Institute
Neglected tropical diseases: multi-target-directed ligands in the search for novel lead candidates against Trypanosoma and Leishmania.
University Of Bologna
Divergent modes of enzyme inhibition in a homologous structure-activity series.
University Of California
Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines.
Universidade Federal De Santa Maria
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.
Unviersidad De La RepÚBlica
Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.
University Of California
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
Universidad De La RepúBlica
Design, synthesis, and biochemical evaluation of novel cruzain inhibitors with potential application in the treatment of Chagas' disease.
Baylor University
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain.
University Of California San Francisco
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
University Of California San Francisco
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain.
University Of Cape Town
General solid-phase method to prepare novel cyclic ketone inhibitors of the cysteine protease cruzain.
University Of California
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
University Of California San Francisco
Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis.
University Of California
2-(phenylthio)ethylidene derivatives as anti-Trypanosoma cruzi compounds: Structural design, synthesis and antiparasitic activity.
Universidade De Pernambuco
Synthesis, structure-activity relationship and trypanocidal activity of pyrazole-imidazoline and new pyrazole-tetrahydropyrimidine hybrids as promising chemotherapeutic agents for Chagas disease.
Instituto Oswaldo Cruz
Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.
Texas A&M University
Potential Anticancer Agents Characterized from Selected Tropical Plants.
The Ohio State University
Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and
The University Of Jordan
Can Cysteine Protease Cross-Class Inhibitors Achieve Selectivity?
University Of S£O Paulo
Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement.
Universidade De S£O Paulo
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2.8.
Johannes Gutenberg-Universit£T Mainz
Antiprotozoal and cysteine proteases inhibitory activity of dipeptidyl enoates.
Universitat Jaume I
A comparative study of warheads for design of cysteine protease inhibitors.
Universidade De S£O Paulo
Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi.
Universidade Federal De Pernambuco - Ufpe