PMID

Data

Article Title

Organization

Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit.

Kezar Life Sciences

Structure-based design of฿1i or฿5i specific inhibitors of human immunoproteasomes.

Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Structurally novel highly potent proteasome inhibitors created by the structure-based hybridization of nonpeptidic belactosin derivatives and peptide boronates.

Hokkaido University

LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.

University Of Kentucky

Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.

Roche Pharma Research And Early Development

Covalent docking modelling-based discovery of tripeptidyl epoxyketone proteasome inhibitors composed of aliphatic-heterocycles.

Hangzhou Institute Of Innovative Medicine

Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.

Zhejiang University

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2 S,3 R)- N-(( S)-3-(Cyclopent-1-en-1-yl)-1-(( R)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-(( S)-2-(2-morpholinoacetamido)propanamido)propenamide).

Kezar Life Sciences

Immunoproteasome-selective inhibitors: An overview of recent developments as potential drugs for hematologic malignancies and autoimmune diseases.

Hangzhou Xixi Hospital

Development of Novel Epoxyketone-Based Proteasome Inhibitors as a Strategy To Overcome Cancer Resistance to Carfilzomib and Bortezomib.

University Of Kentucky

Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators.

Purdue University

Structure-Based Design of Inhibitors Selective for Human Proteasome ?2c or ?2i Subunits.

Leiden Institute Of Chemistry And Netherlands Proteomics Centre

Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations.

University Of Auckland

Tetradehydrohalicyclamine B, a new proteasome inhibitor from the marine sponge Acanthostrongylophora ingens.

Kumamoto University

Cinnabaramides A-G: analogues of lactacystin and salinosporamide from a terrestrial streptomycete.

Intermed Discovery Gmbh (Imd)

Structure-based design of derivatives of tyropeptin A as the potent and selective inhibitors of mammalian 20S proteasome.

Numazu Bio-Medical Research Institute

Potent inhibitors of proteasome.

Cephalon

Structure-based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Novartis Pharma

Structure-based design of human immuno- and constitutive proteasomes inhibitors.

Universit£

Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example.

Monash University