PMID

Data

Article Title

Organization

Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake.

Warner-Lambert

Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models.

University Of Alabama

Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel.

University Of Alabama

2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators.

Institut Henri Beaufour

Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety.

Pharmacia & Upjohn

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications.

Merck Research Laboratories

Ion channels as therapeutic targets: a drug discovery perspective.

Pfizer

A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects.

Institute For Bio-Medical Research

Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants.

Pharmacia & Upjohn

 

Batrachotoxin binding site antagonists

TBA

Lactam-stabilized helical analogues of the analgesicµ-conotoxin KIIIA.

Monash University

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

University Of Utah

The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers.

Arqule

Isolation and Biological Activity of 8- Epitetrodotoxin and the Structure of a Possible Biosynthetic Shunt Product of Tetrodotoxin, Cep-226A, from the Newt Cynops ensicauda popei.

Tohoku University

Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

Boehringer Ingelheim Pharma

Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel.

University Of Alabama At Birmingham

Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.

Bial

Effects of log P and phenyl ring conformation on the binding of 5-phenylhydantoins to the voltage-dependent sodium channel.

University Of Alabama At Birmingham

Synthesis and anticonvulsant activity of enaminones. 3. Investigations on 4'-, 3'-, and 2'-substituted and polysubstituted anilino compounds, sodium channel binding studies, and toxicity evaluations.

Howard University

Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel.

University Of Alabama At Birmingham