PMID

Data

Article Title

Organization

Design and synthesis of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

Abbott Laboratories

Lead optimization of antimalarial propafenone analogues.

St. Jude Children'S Research Hospital

Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

Universite De Liege

Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

Abbott Laboratories

Optimization of propafenone analogues as antimalarial leads.

St. Jude Children'S Research Hospital

Virtual screening for novel openers of pancreatic K(ATP) channels.

University Of Perugia

New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

Novo Nordisk Research And Development

3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists.

Glaxosmithkline

Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.

Abbott Laboratories

Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as K(ATP) channel agonists.

Glaxosmithkline

6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.

Novo Nordisk Research And Development

Binding of ATP-sensitive potassium channel (KATP) openers to cardiac membranes: correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies.

Bristol-Myers Squibb Pharmaceutical Research Institute

Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder.

Abbott Laboratories

Effects of substitution on 9-(3-bromo-4-fluorophenyl)-5,9-dihydro-3H,4H-2,6-dioxa-4- azacyclopenta[b]naphthalene-1,8-dione, a dihydropyridine ATP-sensitive potassium channel opener.

Abbott Laboratories