18 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
Astrazeneca
Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.
Toho University School Of Pharmaceutical Sciences
Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.
Toho University School Of Pharmaceutical Sciences
Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.
Deutsches Krebsforschungszentrum
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.
Deutsches Krebsforschungszentrum
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.
University Of Tokyo
Reduced folate derivatives are endogenous substrates for cMOAT in rats.
University Of Tokyo
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).
Sankyo
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.
University Of Tokyo
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.
TBA
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.
University Of Tokyo
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.
The University Of Tokyo
Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.
Deutsches Krebsforschungszentrum
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.
University Of Tokyo
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).
University Of Tokyo
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
University Of Tokyo
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.
University Of Tokyo