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18 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).EBI
Astrazeneca
Biliary excretion of pravastatin in rats: contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter.EBI
Toho University School Of Pharmaceutical Sciences
Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.EBI
Toho University School Of Pharmaceutical Sciences
Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent ATP-dependent transport across the canalicular membrane.EBI
Deutsches Krebsforschungszentrum
ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2.EBI
Deutsches Krebsforschungszentrum
Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.EBI
University Of Tokyo
Reduced folate derivatives are endogenous substrates for cMOAT in rats.EBI
University Of Tokyo
Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR).EBI
Sankyo
Primary active transport of peptidic endothelin antagonists by rat hepatic canalicular membrane.EBI
University Of Tokyo
Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.EBI
TBA
Kinetic analysis of the primary active transport of conjugated metabolites across the bile canalicular membrane: comparative study of S-(2,4-dinitrophenyl)-glutathione and 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)benzothiazole glucuronide.EBI
University Of Tokyo
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.EBI
The University Of Tokyo
Inhibition of transport across the hepatocyte canalicular membrane by the antibiotic fusidate.EBI
Deutsches Krebsforschungszentrum
The potential for an interaction between MRP2 (ABCC2) and various therapeutic agents: probenecid as a candidate inhibitor of the biliary excretion of irinotecan metabolites.EBI
University Of Tokyo
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2).EBI
University Of Tokyo
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.EBI
University Of Tokyo
Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.EBI
University Of Tokyo
Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2.EBI
Deutsches Krebsforschungszentrum