86 articles for thisTarget
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Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.
Boehringer Ingelheim (Canada)
4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.
National Institutes Of Health
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.
South China Normal University
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
University Of Lille
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.
Boehringer Ingelheim (Canada)
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.
Universit£
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.
Sapienza University Of Rome
Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors.
University Of Southern California
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.
University Of Tennessee Health Science Center
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.
Bristol-Myers Squibb
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.
National Cancer Institute/Nih
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.
Cnrs Umr 8532
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.
University Of California
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
Sapienza University Of Rome
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.
National Cancer Institute-Bethesda
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.
National Cancer Institute-Bethesda
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
National Cancer Institute-Bethesda
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.
University Of Houston
Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.
The University Of Iowa
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.
Institute Of Science And Technology
Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.
University Of California
Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.
University Of Southern California
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.
Graduate School Of The Chinese Academy Of Sciences
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.
Università
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.
Gilead Sciences
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.
Gilead Sciences
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.
Merck Research Laboratories
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.
Sapienza University Of Rome
Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.
University Of Houston
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.
Central Pharmaceutical Research Institute
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.
University Of Georgia
HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.
University Of Georgia
Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.
University Of Southern California
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.
Jagiellonian University
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.
Université
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.
Merck Research Laboratories
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.
University Of California
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.
Tibotec
Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.
University Of Houston
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.
National Cancer Institute-Frederick
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.
Italy. Vinc
Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.
Università
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.
Institute Of Materia Medica
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.
Cnrs Umr 8076
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.
Sapienza University Of Rome
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.
Nci-Frederick
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.
Institute Of Science & Technology
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.
National Cancer Institute-Bethesda
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.
Purdue University
Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.
Merck Research Laboratories
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
Merck Research Laboratories
Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.
Université
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).
Russian Academy Of Sciences
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.
The University Of Iowa
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.
"Sapienza" Universit£
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.
Merck Research Laboratories
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bristol-Myers Squibb Research & Development
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.
University Of The Witwatersrand
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.
Université
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.
Merck Research Laboratories
Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.
Institute Of Chemical Technology
Chicoric acid analogues as HIV-1 integrase inhibitors.
National Cancer Institute-Bethesda
Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.
University Of Iowa
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.
National Cancer Institute-Bethesda
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.
Paris-Sud University
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.
National Cancer Institute-Bethesda
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.
Freie UniversitäT Berlin
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.
Purdue University