The first public molecular recognition database, BindingDB supports research, education and practice in drug discovery, pharmacology and related fields.

BindingDB contains 2.8M data for 1.2M Compounds and 9.2K Targets. Of those, 1,346K data for 622K Compounds and 4.5K Targets were curated by BindingDB curators. BindingDB is a FAIRsharing resource.

If BindingDB was of value to your research, please take a moment to donate to this nonprofit project. Your donation will let us provide you with more data and improved service.

Advanced Search

86 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review

PMID
Data
Article Title
Organization
Pyridopyrimidinone inhibitors of HIV-1 RNase H.EBI
Glaxosmithkline
Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.EBI
Boehringer Ingelheim (Canada)
4-amino-1-hydroxy-2-oxo-1,8-naphthyridine-containing compounds having high potency against raltegravir-resistant integrase mutants of HIV-1.EBI
National Institutes Of Health
Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75.EBI
South China Normal University
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.EBI
University Of Lille
Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.EBI
Boehringer Ingelheim (Canada)
A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.EBI
Universit£
Basic quinolinonyl diketo acid derivatives as inhibitors of HIV integrase and their activity against RNase H function of reverse transcriptase.EBI
Sapienza University Of Rome
Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors.EBI
University Of Southern California
CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.EBI
University Of Tennessee Health Science Center
Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.EBI
Bristol-Myers Squibb
Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.EBI
National Cancer Institute/Nih
Active site binding modes of HIV-1 integrase inhibitors.EBI
University Of California
Developing a dynamic pharmacophore model for HIV-1 integrase.EBI
University Of California
Modeling of the inhibition of retroviral integrases by styrylquinoline derivatives.EBI
Cnrs Umr 8532
Structure-activity relationships: analogues of the dicaffeoylquinic and dicaffeoyltartaric acids as potent inhibitors of human immunodeficiency virus type 1 integrase and replication.EBI
University Of California
Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.EBI
Sapienza University Of Rome
Depsides and depsidones as inhibitors of HIV-1 integrase: discovery of novel inhibitors through 3D database searching.EBI
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore: discovery of inhibitors through three-dimensional database searching.EBI
National Cancer Institute-Bethesda
Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action.EBI
National Cancer Institute-Bethesda
Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.EBI
National Cancer Institute-Bethesda
Three-dimensional quantitative structure-activity relationship (QSAR) of HIV integrase inhibitors: a comparative molecular field analysis (CoMFA) study.EBI
National Cancer Institute-Bethesda
HIV-1 integrase pharmacophore model derived from diverse classes of inhibitors.EBI
University Of Houston
Binding modes of two novel dinucleotide inhibitors of HIV-1 integrase.EBI
The University Of Iowa
Synthesis and HIV-1 integrase inhibitory activities of caffeoylglucosides.EBI
Institute Of Science And Technology
Ring substituent effects on biological activity of vinyl sulfones as inhibitors of HIV-1.EBI
University Of California
Inhibition of HIV-1 integrase activity by synthetic peptides derived from the HIV-1 HXB2 Pol region of the viral genome.EBI
University Of Southern California
Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: insight into the binding mode of the enzyme.EBI
Graduate School Of The Chinese Academy Of Sciences
From ligand to complexes: inhibition of human immunodeficiency virus type 1 integrase by beta-diketo acid metal complexes.EBI
Università
Design, synthesis, and biological evaluation of novel tricyclic HIV-1 integrase inhibitors by modification of its pyridine ring.EBI
Gilead Sciences
Design, synthesis, and SAR studies of novel and highly active tri-cyclic HIV integrase inhibitors.EBI
Gilead Sciences
Effect of substitution on novel tricyclic HIV-1 integrase inhibitors.EBI
Gilead Sciences
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors.EBI
Merck Research Laboratories
Novel bifunctional quinolonyl diketo acid derivatives as HIV-1 integrase inhibitors: design, synthesis, biological activities, and mechanism of action.EBI
Sapienza University Of Rome
Dynamic pharmacophore model optimization: identification of novel HIV-1 integrase inhibitors.EBI
University Of Houston
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics.EBI
Central Pharmaceutical Research Institute
Beta-diketo acids with purine nucleobase scaffolds: novel, selective inhibitors of the strand transfer step of HIV integrase.EBI
University Of Georgia
HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent.EBI
University Of Georgia
Diketo acid pharmacophore. 2. Discovery of structurally diverse inhibitors of HIV-1 integrase.EBI
University Of Southern California
Intermolecular interactions in the crystal structures of potential HIV-1 integrase inhibitors.EBI
Jagiellonian University
Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.EBI
Università
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis.EBI
Université
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells.EBI
Merck Research Laboratories
Synthesis and biological evaluation of geminal disulfones as HIV-1 integrase inhibitors.EBI
University Of California
Design and optimization of tricyclic phtalimide analogues as novel inhibitors of HIV-1 integrase.EBI
Tibotec
Dynamic receptor-based pharmacophore model development and its application in designing novel HIV-1 integrase inhibitors.EBI
University Of Houston
New approaches toward anti-HIV chemotherapy.EBI
Katholieke Universiteit Leuven
Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.EBI
National Cancer Institute-Frederick
HCV NS5b RNA-dependent RNA polymerase inhibitors: from alpha,gamma-diketoacids to 4,5-dihydroxypyrimidine- or 3-methyl-5-hydroxypyrimidinonecarboxylic acids. Design and synthesis.EBI
Italy. Vinc
Design and synthesis of novel indole beta-diketo acid derivatives as HIV-1 integrase inhibitors.EBI
Università
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: implication for binding to two metal ions on the active site of integrase.EBI
Institute Of Materia Medica
Linker-modified quinoline derivatives targeting HIV-1 integrase: synthesis and biological activity.EBI
Cnrs Umr 8076
6-aryl-2,4-dioxo-5-hexenoic acids, novel integrase inhibitors active against HIV-1 multiplication in cell-based assays.EBI
Sapienza University Of Rome
Design and synthesis of photoactivatable aryl diketo acid-containing HIV-1 integrase inhibitors as potential affinity probes.EBI
Nci-Frederick
Catechol-substituted L-chicoric acid analogues as HIV integrase inhibitors.EBI
Institute Of Science & Technology
Design and synthesis of dimeric HIV-1 integrase inhibitory peptides.EBI
Nih
Azido-containing aryl beta-diketo acid HIV-1 integrase inhibitors.EBI
National Cancer Institute-Bethesda
Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization.EBI
Purdue University
Four novel bis-(naphtho-gamma-pyrones) isolated from Fusarium species as inhibitors of HIV-1 integrase.EBI
Merck Research Laboratories
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.EBI
Merck Research Laboratories
Metal-dependent inhibition of HIV-1 integrase.EBI
University Of Southern California
Synthesis and HIV-1 integrase inhibitory activities of catechol and bis-catechol derivatives.EBI
Université
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n).EBI
Russian Academy Of Sciences
Synthesis and biological evaluation of bis-NEBI
Rhodes University
Discovery of a nuclease-resistant, non-natural dinucleotide that inhibits HIV-1 integrase.EBI
The University Of Iowa
Pyrrolyl Pyrazoles as Non-Diketo Acid Inhibitors of the HIV-1 Ribonuclease H Function of Reverse Transcriptase.EBI
"Sapienza" Universit£
5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein.EBI
Irbm
4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.EBI
Merck Research Laboratories
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.EBI
Bristol-Myers Squibb Research & Development
Design, synthesis and biological evaluation of imidazole and oxazole fragments as HIV-1 integrase-LEDGF/p75 disruptors and inhibitors of microbial pathogens.EBI
University Of The Witwatersrand
Structure-activity relationships and binding mode of styrylquinolines as potent inhibitors of HIV-1 integrase and replication of HIV-1 in cell culture.EBI
Université
Chemical and enzymatic modifications of integric acid and HIV-1 integrase inhibitory activity.EBI
Merck Research Laboratories
Thiazolothiazepine inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Lamellarin alpha 20-sulfate, an inhibitor of HIV-1 integrase active against HIV-1 virus in cell culture.EBI
Institute Of Chemical Technology
Chicoric acid analogues as HIV-1 integrase inhibitors.EBI
National Cancer Institute-Bethesda
Inhibition of HIV integrase by novel nucleotides bearing tricyclic bases.EBI
University Of Iowa
Salicylhydrazine-containing inhibitors of HIV-1 integrase: implication for a selective chelation in the integrase active site.EBI
National Cancer Institute-Bethesda
Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.EBI
Paris-Sud University
Arylamide inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Hydrazide-containing inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Discovery of HIV-1 integrase inhibitors by pharmacophore searching.EBI
National Cancer Institute-Bethesda
Coumarin-based inhibitors of HIV integrase.EBI
National Cancer Institute-Bethesda
(-)-Arctigenin as a lead structure for inhibitors of human immunodeficiency virus type-1 integrase.EBI
Freie UniversitäT Berlin
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase.EBI
Purdue University
Hydroxylated aromatic inhibitors of HIV-1 integrase.EBI
National Cancer Institute-Bethesda
Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.BDB
Daiichi Pharmaceutical