PMID

Data

Article Title

Organization

Enhancement of kinase selectivity in a potent class of arylamide FMS inhibitors.

Janssen Research And Development

Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.

TBA

Optimization of a potent class of arylamide colony-stimulating factor-1 receptor inhibitors leading to anti-inflammatory clinical candidate 4-cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

Johnson & Johnson Pharmaceutical Research & Development

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.

TBA

Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952.

Japan Tobacco

Design, synthesis and SAR study of hydroxychalcone inhibitors of human ß-secretase (BACE1).

Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

Inhibitory effects of thioethers on fatty acid synthase and 3T3-L1 cells.

Graduate University Of Chinese Academy Of Sciences

Role of the two structural domains from the periplasmic Escherichia coli histidine-binding protein HisJ.

University Of Calgary