51 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Design, synthesis and evaluation of novel indandione derivatives as multifunctional agents with cholinesterase inhibition, anti-ß-amyloid aggregation, antioxidant and neuroprotection properties against Alzheimer's disease.
University Of Delhi
Structure-Activity Relationship Studies of Isomeric 2,4-Diaminoquinazolines onß-Amyloid Aggregation Kinetics.
University Of Waterloo
Design, synthesis and evaluation of novel tacrine-multialkoxybenzene hybrids as multi-targeted compounds against Alzheimer's disease.
Guangzhou Medical University
Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.
University Of Waterloo
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.
Linyi People'S Hospital
Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.
China Pharmaceutical University
Structural insights into mechanisms for inhibiting amyloidß42 aggregation by non-catechol-type flavonoids.
Kyoto University
Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid.
Dalhousie University
Highly Efficient Synthesis of 1,3-Dihydroxy-2-carboxycarbazole and Its Neuroprotective Effects.
Virginia Commonwealth University
Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands fora-Synuclein Fibrils.
Washington University
3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease.
Sun Yat-Sen University
Naturally occurring polyphenolic inhibitors of amyloid beta aggregation.
Csiro Manufacturing Flagship (Biomedical)
Imidazo[2,1]thiazol-3-one Derivatives Useful as Diagnostic Agents for Alzheimer's Disease.
Temple University School Of Pharmacy
Oxidative stress in Alzheimer's disease: are we connecting the dots?
University Of Bologna
Polyfluorinated bis-styrylbenzenes as amyloid-ß plaque binding ligands.
Leiden University
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.
University Of Bologna
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Institute Of Science And Technology
Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.
Sungkyunkwan University School Of Medicine
F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain.
University Of Pennsylvania
Diphenylpropynone derivatives as probes for imagingß-amyloid plaques in Alzheimer's brains.
Kyoto University
Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors.
Wyeth
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Wyeth Research
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: a potent, selective, orally active dipeptidyl peptidase IV inhibitor.
Pfizer
Small conformationally restricted piperidine N-arylsulfonamides as orally active gamma-secretase inhibitors.
Schering-Plough Research Institute
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
Pharmacopeia Drug Discovery
Synthesis of biphenyltrienes as probes for beta-amyloid plaques.
University Of Pennsylvania
Novel benzofuran derivatives for PET imaging of beta-amyloid plaques in Alzheimer's disease brains.
Nagasaki University
Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging beta-amyloid in Alzheimer's disease.
Emory University
Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
Bristol-Myers Squibb Pharmaceutical Research Institute
Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.
University Of Pennsylvania
Radioiodinated flavones for in vivo imaging of beta-amyloid plaques in the brain.
Nagasaki University
Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.
Chiesi Farmaceutici
Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.
Wyeth Research
Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents.
University Of Pittsburgh
Structure-activity relationship of imidazo[1,2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain.
University Of Pennsylvania
Isomerization of (Z,Z) to (E,E)1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain.
University Of Pennsylvania
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
University Of Pennsylvania
Fenchylamine sulfonamide inhibitors of amyloid beta peptide production by the gamma-secretase proteolytic pathway: potential small-molecule therapeutic agents for the treatment of Alzheimer's disease.
Amgen
