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254 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28279845 54 Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Nanyang Normal University
28279561 26 Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity.EBI Persian Gulf University
27744187 42 Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.EBI South China University of Technology
28189905 35 New tacrine-derived AChE/BuChE inhibitors: Synthesis and biological evaluation of 5-amino-2-phenyl-4H-pyrano[2,3-b]quinoline-3-carboxylates.EBI University of Mazandaran
27876467 9 A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease.EBI Tehran University of Medical Sciences
27951490 72 2,4-Disubstituted quinazolines as amyloid-▀ aggregation inhibitors with dual cholinesterase inhibition and antioxidant properties: Development and structure-activity relationship (SAR) studies.EBI University of Waterloo
27936444 93 Amino derivatives of platanic acid act as selective and potent inhibitors of butyrylcholinesterase.EBI Martin-Luther-University Halle-Wittenberg
27951489 78 Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group.EBI Hu'nan University
27688184 29 New azepino[4,3-b]indole derivatives as nanomolar selective inhibitors of human butyrylcholinesterase showing protective effectsáagainst NMDA-induced neurotoxicity.EBI University of Bari"A. Moro"
27560283 58 Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HTEBI Jagiellonian University Collegium Medicum
27908752 55 N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.EBI University of Ljubljana
27923619 13 Synthesis and application of▀-carbolines as novel multi-functional anti-Alzheimer's disease agents.EBI University of Massachusetts Boston
27484515 61 Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX.EBI Tehran University of Medical Sciences
27484514 107 Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
27856236 19 Design, synthesis, biological evaluation, and molecular modeling studies of chalcone-rivastigmine hybrids as cholinesterase inhibitors.EBI South China University of Technology
27780618 7 Synthesis, structure-activity relationship and molecular docking of 3-oxoaurones and 3-thioaurones as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI University of Gujrat
26471320 50 Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.EBI Okayama University
27267007 58 New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.EBI Instituto de Qu£mica M£dica
27392529 32 Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.EBI Universidade Federal do Rio Grande do Sul
27377327 22 Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile.EBI Kazan (Volga region) Federal University
27309570 102 Fatty Acid Amide Hydrolase (FAAH), Acetylcholinesterase (AChE), and Butyrylcholinesterase (BuChE): Networked Targets for the Development of Carbamates as Potential Anti-Alzheimer's Disease Agents.EBI Alma Mater Studiorum-University of Bologna
27492195 14 Cholinesterase inhibitory activity of isoquinoline alkaloids from three Cryptocarya species (Lauraceae).EBI University of Malaya
27460699 76 Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.EBI China Pharmaceutical University
26886849 72 Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode.EBI Universit£t W£rzburg
26945113 9 Amyloid cascade in Alzheimer's disease: Recent advances in medicinal chemistry.EBI University of Waterloo
26879857 50 Application of PEG-400 as a green biodegradable polymeric medium for the catalyst-free synthesis of spiro-dihydropyridines and their use as acetyl and butyrylcholinesterase inhibitors.EBI Persian Gulf University
26917219 63 Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI China Pharmaceutical University
26632651 70 Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography.EBI China Pharmaceutical University
26503905 51 Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity.EBI University Hospital Hradec Kralove
26363866 39 New multifunctional melatonin-derived benzylpyridinium bromides with potent cholinergic, antioxidant, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI 1st Affiliated Hospital of Guangxi Medical University
26189031 52 Synthesis of novel triazoles and a tetrazole of escitalopram as cholinesterase inhibitors.EBI University of the Punjab
25260958 46 Design, synthesis and pharmacological evaluation of chalcone derivatives as acetylcholinesterase inhibitors.EBI Hu'nan University
26116179 5 Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents.EBI University of Ljubljana
26107513 172 Structure-Based Design and Optimization of Multitarget-Directed 2H-Chromen-2-one Derivatives as Potent Inhibitors of Monoamine Oxidase B and Cholinesterases.EBI Universit£ degli Studi di Bari"Aldo Moro"
26003344 48 Isolation of cholinesterase and▀-secretase 1 inhibiting compounds from Lycopodiella cernua.EBI Catholic University of Daegu
25812965 80 Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.EBI China Pharmaceutical University
25656088 32 Multifunctional tacrine-trolox hybrids for the treatment of Alzheimer's disease with cholinergic, antioxidant, neuroprotective and hepatoprotective properties.EBI China Pharmaceutical University
25418133 51 N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.EBI Laboratorio de Quimica Medica (IQOG, CSIC)
25813159 3 New septanoside and 20-hydroxyecdysone septanoside derivative from Atriplex portulacoides roots with preliminary biological activities.EBI University of Monastir
25597004 18 Iminosugars as a new class of cholinesterase inhibitors.EBI University of Strasburg
25089370 40 Synthesis and biological evaluation of novel tacrine derivatives and tacrine-coumarin hybrids as cholinesterase inhibitors.EBI P. J. Safarik University
25088549 47 Syntheses of coumarin-tacrine hybrids as dual-site acetylcholinesterase inhibitors and their activity against butylcholinesterase, A▀ aggregation, and▀-secretase.EBI Central China Normal University
25016233 14 Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting▀-amyloid, tau, and cholinesterase pathologies.EBI Universitat de Barcelona
24934993 6 Coumarin hybrids as novel therapeutic agents.EBI Punjabi University
25537270 6 Sulfonamides as multifunctional agents for Alzheimer's disease.EBI University of Massachusetts Boston
25259726 44 Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-▀ aggregation and to exert anticholinesterase and antioxidant effects.EBI Alma Mater Studiorum-University of Bologna
25257911 33 Active compounds from a diverse library of triazolothiadiazole and triazolothiadiazine scaffolds: synthesis, crystal structure determination, cytotoxicity, cholinesterase inhibitory activity, and binding mode analysis.EBI Quaid-i-Azam University
25226236 19 Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor.EBI University of Ljubljana
25189690 94 Design, synthesis and biological evaluation of novel 6H-benzo[c]chromen-6-one, and 7,8,9,10-tetrahydro-benzo[c]chromen-6-one derivatives as potential cholinesterase inhibitors.EBI Eastern Mediterranean University
25156301 8 Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with▀-amyloid and tau anti-aggregating properties.EBI Universitat de Barcelona
24980117 62 Synthesis ofa,▀-unsaturated carbonyl based compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: characterization, molecular modeling, QSAR studies and effect against amyloid▀-induced cytotoxicity.EBI Universiti Kebangsaan Malaysia
24780600 53 Dual inhibition of thea-glucosidase and butyrylcholinesterase studied by molecular field topology analysis.EBI University of Florida
24726809 72 Design, synthesis and biological evaluation of benzylisoquinoline derivatives as multifunctional agents against Alzheimer's disease.EBI China Pharmaceutical University
24568372 40 Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.EBI Universitat de Barcelona
24681981 53 Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines.EBI Quaid-i-Azam University
24675179 26 Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases.EBI Quaid-i-Azam University
24900626 15 Multifunctional cholinesterase and amyloid Beta fibrillization modulators. Synthesis and biological investigation.EBI University of Siena
24220173 37 Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.EBI Charles University in Prague
23810675 42 Synthesis, evaluation and molecular dynamics study of some new 4-aminopyridine semicarbazones as an antiamnesic and cognition enhancing agents.EBI Banaras Hindu University
23422935 29 Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors.EBI Universidade Federal do Rio Grande do Sul
23199476 36 Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.EBI Universit£ degli Studi di Bari Aldo Moro
17276075 4 Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.EBI Universit£ di Bologna
11141093 20 Hexahydrochromeno[4,3-b]pyrrole derivatives as acetylcholinesterase inhibitors.EBI University of Bologna
22795665 24 Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.EBI Universit£ de Sfax
23062825 37 Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.EBI Abo Akademi University
23164658 78 2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents.EBI University of Bologna
23041347 33 Design, synthesis, and bioevaluation of benzamides: novel acetylcholinesterase inhibitors with multi-functions on butylcholinesterase, Aß aggregation, andß-secretase.EBI Central China Normal University
22339166 14 Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.EBI University of Nebraska Medical Center
23078965 19 Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.EBI Instituto de Qu£mica Org£nica General (CSIC)
22818849 36 Synthesis, design and biological evaluation of novel highly potent tacrine congeners for the treatment of Alzheimer's disease.EBI P. J. Safarik University
24900454 43 The First Dual ChE/FAAH Inhibitors: New Perspectives for Alzheimer's Disease?EBI TBA
22503231 66 Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.EBI Laboratorio de Radicales Libres y Qu�mica Computacional (IQOG, CSIC)
22243648 112 New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties.EBI Instituto de Qu£mica M£dica
22185619 50 Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.EBI Universitat de Barcelona
21144749 55 Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.EBI University of Defence
20627738 32 Long-acting anticholinesterases for myasthenia gravis: synthesis and activities of quaternary phenylcarbamates of neostigmine, pyridostigmine and physostigmine.EBI National Institute on Aging
20067290 24 Isosorbide-2-benzyl carbamate-5-salicylate, a peripheral anionic site binding subnanomolar selective butyrylcholinesterase inhibitor.EBI Trinity College
19879672 16 Structural aspects of flavonoids as inhibitors of human butyrylcholinesterase.EBI Institute for Medical Research and Occupational Health
19473849 33 Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors.EBI COBRA
18954037 40 Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 4. Further investigation on the inner spacer.EBI University of Bologna
18640842 45 New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties.EBI Laboratorio de Radicales Libres (IQOG, CSIC)
18517184 47 Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI Laboratori de Qu�mica Farmac�utica (Unitat Associada al CSIC)
18479118 114 Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.EBI Universit£ di Siena
18232655 32 Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates.EBI TBA
18181565 71 Multi-target-directed ligands to combat neurodegenerative diseases.EBI University of Bologna
18023348 16 4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity.EBI Sapienza University of Rome
17850125 66 Novel class of quinone-bearing polyamines as multi-target-directed ligands to combat Alzheimer's disease.EBI University of Bologna
17328534 16 Bis-cycloSal-d4T-monophosphates: drugs that deliver two molecules of bioactive nucleotides.EBI University of Hamburg
17154513 56 Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.EBI Universitat de Barcelona
15715468 44 Novel anticholinesterases based on the molecular skeletons of furobenzofuran and methanobenzodioxepine.EBI National Institute on Aging
15887964 47 Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.EBI Universit£ di Siena
15633997 18 Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.EBI University of Bologna
15139762 133 Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship.EBI University of Hamburg
12502352 28 Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.EBI Universit£ di Siena
11741490 18 Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.EBI Universitat de Barcelona
11495583 62 Design, synthesis, and structure-activity relationships of a series of 3-[2-(1-benzylpiperidin-4-yl)ethylamino]pyridazine derivatives as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
11101357 84 New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
10052979 45 Aminopyridazines as acetylcholinesterase inhibitors.EBI Universit£ Louis Pasteur
10464010 40 Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.EBI Universitat de Barcelona
9784091 25 Acetylcholinesterase noncovalent inhibitors based on a polyamine backbone for potential use against Alzheimer's disease.EBI University of Bologna
7707311 18 Design and synthesis of 1-heteroaryl-3-(1-benzyl-4-piperidinyl)propan-1-one derivatives as potent, selective acetylcholinesterase inhibitors.EBI Pfizer Inc
1552502 74 Synthesis and cholinergic properties of bis[[(dimethylamino)methyl]furanyl] analogues of ranitidine.EBI University of South Carolina
2738887 22 Binary antidotes for organophosphate poisoning: aprophen analogues that are both antimuscarinics and carbamates.EBI Institute of Research
21438612 4 Amidine-oximes: reactivators for organophosphate exposure.EBI Human BioMolecular Research Institute
22206546 42 Nonquaternary reactivators for organophosphate-inhibited cholinesterases.EBI Human BioMolecular Research Institute
22257528 5 A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease.EBI Punjabi University
22054058 22 Synthesis of monomeric derivatives to probe memoquin's bivalent interactions.EBI University of Bologna
22023459 42 Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.EBI Universitat Aut£noma de Barcelona
22000936 33 Synthesis and biological assessment of diversely substituted furo[2,3-b]quinolin-4-amine and pyrrolo[2,3-b]quinolin-4-amine derivatives, as novel tacrine analogues.EBI University of Lisbon
21924611 38 Selective cholinesterase inhibition by lanostane triterpenes from fruiting bodies of Ganoderma lucidum.EBI Chungnam National University
21920739 14 Synthesis and in vitro evaluation of 7-methoxy-N-(pent-4-enyl)-1,2,3,4-tetrahydroacridin-9-amine-new tacrine derivate with cholinergic properties.EBI Charles University in Prague
21924801 20 Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.EBI University of Bologna
21798635 32 Multi-target strategy to address Alzheimer's disease: design, synthesis and biological evaluation of new tacrine-based dimers.EBI Institut f£r Molekulare Physiologie
21733699 121 Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.EBI St. Jude Children's Research Hospital
21570751 8 Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.EBI Medical University
21435752 76 New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation.EBI CNRS
19443217 60 Synthesis and biological evaluation of novel gamma-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists.EBI Chemical Diversity Research Institute
19423342 10 Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition.EBI Sention Inc.
21397996 36 Benzophenone-based derivatives: a novel series of potent and selective dual inhibitors of acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.EBI University of Bologna
21417225 116 Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity.EBI Universidad de Granada
21236667 16 Multitargeted drugs discovery: balancing anti-amyloid and anticholinesterase capacity in a single chemical entity.EBI Department of Pharmaceutical Sciences-Alma Mater Studiorum-Bologna University
21216144 13 (+)-Arisugacin A--computational evidence of a dual binding site covalent inhibitor of acetylcholinesterase.EBI Alchemical Research, LLC
21397501 54 Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.EBI Charles University
21236521 58 Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.EBI University of Defence
21105730 30 Structure-activity relationships of substituted 1-pyridyl-2-phenyl-1,2-ethanediones: potent, selective carboxylesterase inhibitors.EBI St. Jude Children's Research Hospital
20801550 9 Synthesis, characterization, oxidative degradation, antibacterial activity and acetylcholinesterase/butyrylcholinesterase inhibitory effects of some new phosphorus(V) hydrazides.EBI Tarbiat Modares University
20817518 23 Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.EBI Charles University
20545360 38 Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.EBI Instituto de Quimica Medica
20138518 40 Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.EBI Military Health Sciences
19856923 40 Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.EBI Instituto de Quimica Medica (CSIC)
20181484 46 Differential binding of phenothiazine urea derivatives to wild-type human cholinesterases and butyrylcholinesterase mutants.EBI Dalhousie University
20171894 49 Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.EBI University of Bologna
20093035 9 Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability.EBI Trinity College
19813747 12 Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.EBI University of Bologna
19520578 11 Synthesis of novel purine nucleosides towards a selective inhibition of human butyrylcholinesterase.EBI Faculdade de Ci£ncias da Universidade de Lisboa
19505825 12 Structure-activity relationships of memoquin: Influence of the chain chirality in the multi-target mechanism of action.EBI Alma Mater Studiorum-Bologna University
19215141 8 Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.EBI Istanbul University
 11 Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibitorEBI TBA
18817366 43 Isosorbide-2-carbamate esters: potent and selective butyrylcholinesterase inhibitors.EBI Trinity College
18786825 30 Tacrine based human cholinesterase inhibitors: synthesis of peptidic-tethered derivatives and their effect on potency and selectivity.EBI European Research Centre for Drug Discovery and Development (NatSynDrugs)
18686941 11 Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors.EBI Instituto Politécnico Nacional
18681480 14 Bioactive 5alpha-pregnane-type steroidal alkaloids from Sarcococca hookeriana.EBI Bielefeld University
18650096 17 Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.EBI Quaid-i-Azam University
18605718 17 Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush.EBI University of Bologna
18570368 27 Carbamates with differential mechanism of inhibition toward acetylcholinesterase and butyrylcholinesterase.EBI Dalhousie University
18524585 20 Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors.EBI Sun Yat-sen University
18419109 18 Benzofuran-based hybrid compounds for the inhibition of cholinesterase activity, beta amyloid aggregation, and abeta neurotoxicity.EBI University of Bologna
18396354 29 Design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors.EBI University of Bologna
12828454 8 New triterpenoid alkaloid cholinesterase inhibitors from Buxus hyrcana.EBI University of Karachi
18047264 10 Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease.EBI Bologna University
17918819 114 Synthesis and structure-activity relationship for a novel class of potent and selective carbamate-based inhibitors of hormone selective lipase with acute in vivo antilipolytic effects.EBI Novo Nordisk A/S
17681794 43 Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.EBI Woosuk University
17681768 23 Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.EBI Dalhousie University
17655212 56 Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.EBI University of Bologna
17399985 136 Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.EBI St. Jude Children's Research Hospital
17181144 30 Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.EBI Laboratorio de Radicales Libres (IQOG, CSIC)
17008100 54 Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.EBI University of Bologna
16945529 42 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.EBI Friedrich-Schiller-Universität Jena
16335932 7 cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.EBI University of Hamburg
15603953 13 Isoterreulactone A, a novel meroterpenoid with anti-acetylcholinesterase activity produced by Aspergillus terreus.EBI Korea Research Institute of Bioscience and Biotechnology
14711311 104 Synthesis and structure-activity relationship for a novel class of potent and selective carbamoyl-triazole based inhibitors of hormone sensitive lipase.EBI Novo Nordisk A/S
14584959 55 Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.EBI University of Innsbruck
12824041 14 Synthesis and structure-activity relationships of open D-Ring galanthamine analogues.EBI CNRS
10346939 30 Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.EBI National Institute on Aging Intramural Research Program
10230623 10 Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: unique structural analogs of tacrine based on the BCD-ring of arisugacin.EBI University of Minnesota
9357518 74 Novel tacrine analogues for potential use against Alzheimer's disease: potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors.EBI University of Strathclyde
9288171 28 Total syntheses and anticholinesterase activities of (3aS)-N(8)-norphysostigmine, (3aS)-N(8)-norphenserine, their antipodal isomers, and other N(8)-substituted analogues.EBI National Institute on Aging
26827140 83 Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.EBI Institute of Physiologically Active Compounds Russian Academy of Sciences
26795115 34 Ferulic acid-carbazole hybrid compounds: Combination of cholinesterase inhibition, antioxidant and neuroprotection as multifunctional anti-Alzheimer agents.EBI Southeast University
26599534 22 Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.EBI Anadolu University
24508831 7 Synthesis, biological evaluation and molecular modeling study of novel tacrine-carbazole hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.EBI Khon Kaen University
24140444 30 Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer's disease.EBI Alma Mater Studiorum University of Bologna
23838422 22 Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease.EBI Instituto de Qu£mica Org£nica General (CSIC)
23791077 12 Selective inhibition of human acetylcholinesterase by xanthine derivatives: in vitro inhibition and molecular modeling investigations.EBI University of Waterloo
23719283 32 Synthesis, biological evaluation and molecular modeling of substituted 2-aminobenzimidazoles as novel inhibitors of acetylcholinesterase and butyrylcholinesterase.EBI Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
23540646 14 Design, synthesis and biological activity of multifunctional ?,?-unsaturated carbonyl scaffolds for Alzheimer's disease.EBI University of Massachusetts Boston
7636841 16 5,7-dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H- pyrrolo[3,2-f]-1,2-benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety.EBI Pfizer Inc
30096650 102 Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.EBI China Pharmaceutical University
30031971 30 Multi-target-directed ligands for treating Alzheimer's disease: Butyrylcholinesterase inhibitors displaying antioxidant and neuroprotective activities.EBI University of Ljubljana
30025348 149 Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.EBI Consejo Superior de Investigaciones Cient�ficas (IQM-CSIC)
30351923 12 Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza ("Danshen").EBI St. Jude Children's Research Hospital
30245401 61 Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors.EBI University of Porto
30383374 20 Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents.EBI Institute for Medical Research and Occupational Health
29541355 35 Dual GSK-3?/AChE Inhibitors as a New Strategy for Multitargeting Anti-Alzheimer's Disease Drug Discovery.EBI China Pharmaceutical University
29335209 16 Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors.EBI University of S£o Paulo
29533874 76 The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.EBI University of Defence
29466774 78 Synthesis and activity towards Alzheimer's disease inávitro: Tacrine, phenolic acid and ligustrazine hybrids.EBI Chinese Academy of Medical Sciences & Peking Union Medical College
28923380 44 Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.EBI Xinyang Normal University
28800459 68 Novel cinnamamide-dibenzylamine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.EBI China Pharmaceutical University
28797883 56 Design, synthesis and biological evaluation of novel coumarin-N-benzyl pyridinium hybrids as multi-target agents for the treatment of Alzheimer's disease.EBI Shanghai University of Traditional Chinese Medicine
29958119 28 Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.EBI Laboratory of Medicinal Chemistry (IQOG, CSIC)
30040425 3 A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera.EBI University of Colombo
29407958 15 Design, synthesis and biological evaluation of new coumarin-dithiocarbamate hybrids as multifunctional agents for the treatment of Alzheimer's disease.EBI Jiangxi University of Traditional Chinese Medicine
29126732 19 2-Arylbenzofurans from Artocarpus lakoocha and methyl ether analogs with potent cholinesterase inhibitory activity.EBI Srinakharinwirot University
29969030 24 Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.EBI IQOG, CSIC
29031070 8 Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.EBI University of Pisa
29031067 30 New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation.EBI Sapienza University of Rome
28863358 21 From dual binding site acetylcholinesterase inhibitors to allosteric modulators: A new avenue for disease-modifying drugs in Alzheimer's disease.EBI University of S£o Paulo
28759875 30 An overview of benzo[b]thiophene-based medicinal chemistry.EBI Jain University
30017112 36 Developing hybrid molecule therapeutics for diverse enzyme inhibitory action: Active role of coumarin-based structural leads in drug discovery.EBI Abbottabad University of Science and Technology
2202827 55 Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.EBI NIDDK
28242552 30 Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.EBI Instituto de Qu£mica M£dica
28242549 86 Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.EBI Sun Yat-sen University
29033232 164 Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.EBI Nanyang Normal University
1507203 96 Synthesis and cholinergic properties of N-aryl-2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethylamino analogs of ranitidine.EBI University of South Carolina
29227101 30 The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity.EBI University of Ljubljana
28371641 32 Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease.EBI China Pharmaceutical University
29400965 83 Structure-Activity Relationships and Computational Investigations into the Development of Potent and Balanced Dual-Acting Butyrylcholinesterase Inhibitors and Human Cannabinoid Receptor 2 Ligands with Pro-Cognitive in Vivo Profiles.EBI Julius Maximilian University of W£rzburg
28404526 23 Stereospecific cholinesterase inhibition by O,S-diethylphenylphosphonothioate.EBI University of Missouri St. Louis
28400237 19 Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.EBI University of Waterloo
27603793 12 Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes.BDB The University of Texas at Arlington
10411562 36 Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.BDB Merck Frosst Centre for Therapeutic Research
8996189 24 Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.BDB Pfizer Inc
18849971 56 Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.BDB University of California San Francisco
19167885 24 Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.BDB GSK
18541433 45 Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer.BDB Abbott Laboratories
19143567 49 Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity.BDB Astex
19022670 8 Potent inhibitors of HCV-NS3 protease derived from boronic acids.BDB Schering-Plough Research Institute
19193158 77 Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.BDB University of Tampere
18973287 87 Structural Requirements for Eszopiclone and Zolpidem Binding to the gamma-Aminobutyric Acid Type-A (GABAA) Receptor Are Different.BDB University of Wisconsin at Madison
18947224 54 Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson's Disease.BDB Neurocrine Bioscience
18983139 12 cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia.BDB Abbott Laboratories
18973288 34 Indazole-Based Liver X Receptor (LXR) Modulators with Maintained Atherosclerotic Lesion Reduction Activity but Diminished Stimulation of Hepatic Triglyceride SynthesisBDB Wyeth Research
18922779 15 Identification of a new JNK inhibitor targeting the JNK-JIP interaction site.BDB Burnham Institute for Medical Research
18942827 66 Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors.BDB Novartis
18834108 22 Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.BDB University of Connecticut at Storrs
10639181 68 Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.BDB Vanderbilt University School of Medicine
15239652 22 Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.BDB Fujisawa Pharmaceutical Co., Ltd
14709046 4 A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.BDB Fujisawa Pharmaceutical Co., Ltd
17941623 72 Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.BDB St. Jude Research Hospital
17154493 13 4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species.BDB IRBM-MRL
17567119 7 Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.BDB NCI-FCRDC
16750629 28 p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones.BDB Merck Research Laboratories