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103 articles for thisTarget


The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
1548679 20 Development of high-affinity 5-HT3 receptor antagonists. 2. Two novel tricyclic benzamides.EBI Rh£ne-Poulenc Rorer Central Research
8410977 43 2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists.EBI Syntex Research
1578478 30 Novel antagonists of the 5-HT3 receptor. Synthesis and structure-activity relationships of (2-alkoxybenzoyl)ureas.EBI Wyeth Research
1552497 38 Novel 5-HT3 antagonists: indol-3-ylspiro(azabicycloalkane-3,5'(4'H)-oxazoles).EBI Merck Sharp and Dohme Research Laboratories
1992112 53 Novel 5-HT3 antagonists. Indole oxadiazoles.EBI Merck Sharp and Dohme Research Laboratories
 18 Synthesis and serotonergic activity of benzofuran and dihydrogenzofuran analogues of 5-carboxamidotryptamine.EBI TBA
8642566 277 Novel selective and partial agonists of 5-HT3 receptors. Part 1. Synthesis and biological evaluation of piperazinopyrrolothienopyrazines.EBI Universit£ de Caen
7752204 98 Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.EBI Merck Sharp& Dohme Research Laboratories
8496922 92 Synthesis and serotonergic activity of 5-(oxadiazolyl)tryptamines: potent agonists for 5-HT1D receptors.EBI Merck Sharp and Dohme Research Laboratories
2342053 20 Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site.EBI Merrell Dow Research Institute
 12 Quaternised renzapride as a potent and selective 5-HT4 receptor agonistEBI TBA
21486038 177 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder.EBI H. Lundbeck A/S
24900351 19 Bivalent Ligands for the Serotonin 5-HT3 Receptor.EBI TBA
19831400 47 Novel, potent, and selective quinoxaline-based 5-HT(3) receptor ligands. 1. Further structure-activity relationships and pharmacological characterization.EBI European Research Centre for Drug Discovery and Development
18490160 13 Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.EBI Pfizer Inc.
16451077 86 Pyrrolizidine esters and amides as 5-HT4 receptor agonists and antagonists.EBI Pfizer Inc.
15801844 25 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI Universidad Complutense
15715459 3 Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors.EBI Pfizer Inc.
15887964 47 Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties.EBI Universit£ di Siena
15482914 25 Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI Pfizer Inc.
12593651 107 Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.EBI Dainippon Pharmaceutical Co. Ltd.
10229626 66 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 2. Molecular basis of the intrinsic efficacy of arylpiperazine derivatives at the central 5-HT3 receptors.EBI Universit£ di Siena
10585211 62 Benzimidazole derivatives. 2. Synthesis and structure-activity relationships of new azabicyclic benzimidazole-4-carboxylic acid derivatives with affinity for serotoninergic 5-HT(3) receptors.EBI Universidad Complutense
10425096 80 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives.EBI FAES, S.A.
9513601 53 Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.EBI Universit£ di Siena
9464362 19 5-HT3 antagonists derived from aminopyridazine-type muscarinic M1 agonists.EBI Universit£ Louis Pasteur
9685241 2 Benzoxazole derivatives as novel 5-HT3 receptor partial agonists in the gut.EBI Pharmaceutical Research Center
9046352 86 New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors.EBI CNRS-BIOCIS
9357534 49 Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.EBI Universit£ di Siena
9341912 43 Phenylimidazolidin-2-one derivatives as selective 5-HT3 receptor antagonists and refinement of the pharmacophore model for 5-HT3 receptor binding.EBI Pharmacia& Upjohn
7629808 64 Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.EBI Universit£ di Siena
8176710 24 Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.EBI CIFA Universidad de Navarra
8496941 23 5-HT3 receptor antagonists. 2. 4-Hydroxy-3-quinolinecarboxylic acid derivatives.EBI Kyowa Hakko Kogyo Company, Ltd.
8410988 12 Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives.EBI Universidad de Navarra
1573641 60 SC-53116: the first selective agonist at the newly identified serotonin 5-HT4 receptor subtype.EBI Searle Research and Development
1312602 18 Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.EBI Rh£ne-Poulenc Rorer Central Research
1479589 36 5-HT3 receptor antagonists. 1. New quinoline derivatives.EBI Kyowa Hakko Kogyo Co.
1695682 41 Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.EBI Istituto De Angeli
2362270 3 5-Hydroxytryptamine (5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives.EBI Beecham Pharmaceuticals Research Division
2258903 23 Synthesis and biochemical evaluation of tritium-labeled 1-methyl-N-(8-methyl-8-azabicyclo[3.2.1]oct-3-yl)-1H-indazole-3-carboxa mide, a useful radioligand for 5HT3 receptors.EBI Lilly Research Laboratories
2296012 10 Aromatic thiazole derivatives: structurally novel and selective serotonin-3 receptor antagonists.EBI Pfizer Central Research
2874226 27 Buspirone analogues. 2. Structure-activity relationships of aromatic imide derivatives.EBI TBA
15050614 10 Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.EBI University of Florida
11755351 24 Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.EBI Universidad de Alcal£
9871571 44 A novel series of N-(hexahydro-1,4-diazepin-6-yl) and N-(hexahydroazepin- 3-yl)benzamides with high affinity for 5-HT3 and dopamine D2 receptors.EBI Dainippon Pharmaceutical Co., Ltd.
 63 Serotoninergic 5-HT3 and 5-HT4 receptor activities of dihydrobenzofuran carboxylic acid derivativesEBI TBA
 26 Novel benzimidazole-4-carboxylic acid derivatives as potent and selective 5-HT3 receptor ligandsEBI TBA
 24 Synthesis and pharmacological activity of a macrocyclic benzamideEBI TBA
 8 N-chloromethyl quinuclidinium derivatives: A new class of irreversible ligands for 5-HT3 receptors.EBI TBA
 25 Pyrazolo[1,5-a]pyridines and pyrazolo[1,5-b]pyridazines as 5ht3-antagonistsEBI TBA
 7 Azaheteroaromatic ethers as carbonyl bioisosteres. Synthesis and evaluation of a novel class of 5-HT3 receptor antagonistsEBI TBA
 14 New aza(nor)adamantanes are agonists at the newly identified serotonin 5-HT4 receptor and antagonists at the 5-HT3 receptorEBI TBA
22107017 47 Optimization of 5-pyridazin-3-one phenoxypropylamines as potent, selective histamine H3 receptor antagonists with potent cognition enhancing activity.EBI Cephalon, Inc.
22029386 156 New serotonin 5-HT(1A) receptor agonists with neuroprotective effect against ischemic cell damage.EBI Universidad Complutense de Madrid
19726200 37 Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors.EBI Hungarian Academy of Sciences
 49 Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.EBI TBA
 21 Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamidesEBI TBA
 8 (S)-4-amino-5-chloro-3-iodo-2-methoxy-N-(1-azabicyclo[2.2.2]oct-3-yl)benzamide (TRIZAC), a high-affinity ligand for the 5-HT-3 receptorEBI TBA
 35 Design of a potent 5-HT4 receptor agonist with nanomolar affinityEBI TBA
 18 Derivatives of quinuclidine as 5-HT3 receptor antagonists: influence of an additional carbonyl group on the recognition of chirality by the receptor.EBI TBA
 18 Derivatives of naphthalimide: new potent conformationally restricted antagonists of 5-HT3 receptors.EBI TBA
19425598 61 Specific targeting of peripheral serotonin 5-HT(3) receptors. Synthesis, biological investigation, and structure-activity relationships.EBI European Research Centre for Drug Discovery and Development
17328523 36 Novel sigma receptor ligands: synthesis and biological profile.EBI University of Catania
15341484 159 Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors.EBI Merck KGaA
15084129 52 4-(tetralin-1-yl)- and 4-(naphthalen-1-yl)alkyl derivatives of 1-cyclohexylpiperazine as sigma receptor ligands with agonist sigma2 activity.EBI Università di Bari
12951088 22 Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.EBI Universidad Complutense
12109911 47 Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.EBI University Center for Pharmacy
11934576 85 Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands.EBI Université de Lille 2
11462981 184 New 1-aryl-3-(4-arylpiperazin-1-yl)propane derivatives, with dual action at 5-HT1A serotonin receptors and serotonin transporter, as a new class of antidepressants.EBI Universidad de Navarra
10543880 63 Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.EBI Universita' degli Studi di Salerno
9873388 24 Synthesis of N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)nicotinamides and their affinities for 5-HT3 and dopamine D2 receptors.EBI Dainippon Pharmaceutical Co., Ltd.
9046348 45 [[(Arylpiperazinyl)alkyl]thio]thieno[2,3-d]pyrimidinone derivatives as high-affinity, selective 5-HT1A receptor ligands.EBI Università di Catania
8246239 84 Development of high-affinity 5-HT3 receptor antagonists. Structure-affinity relationships of novel 1,7-annelated indole derivatives.EBI Solvay Duphar B.V.
8071931 20 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist.EBI Medical College of Virginia/Virginia Commonwealth University
8064797 118 Binding of 5H-dibenzo[b,e][1,4]diazepine and chiral 5H-dibenzo[a,d]cycloheptene analogues of clozapine to dopamine and serotonin receptors.EBI Vanderbilt University
6581313 2 Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines.EBI TBA
26119990 19 Synthesis, biological evaluation and molecular docking of N-phenyl thiosemicarbazones as urease inhibitors.BDB University of Karachi
26042530 40 Discovery of isoalloxazine derivatives as a new class of potential anti-Alzheimer agents and their synthesis.BDB The M. S. University of Baroda