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34 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28274633 2 Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties.EBI Gilead Sciences Inc
28124907 3 Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.EBI Gilead Sciences Inc
24944743 3 Discovery and Synthesis of C-Nucleosides as Potential New Anti-HCV Agents.EBI Biota Scientific Management Pty Ltd
23968551 55 New nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase: discovery, characterization, and crystal structure in complex with the target.EBI Sapienza University of Rome
23713606 116 8-Benzamidochromen-4-one-2-carboxylic acids: potent and selective agonists for the orphan G protein-coupled receptor GPR35.EBI University of Bonn
21561086 21 Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.EBI Gifu Pharmaceutical University
18811136 4 Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.EBI University of Rhode Island
14640519 5 A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.EBI Virginia Polytechnic Institute and State University
8864237 4 Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.EBI Chulalongkorn University
18343122 8 Inhibitors of DNA polymerase beta: activity and mechanism.EBI University of Virginia
9622545 41 Newly synthesized L-enantiomers of 3'-fluoro-modified beta-2'-deoxyribonucleoside 5'-triphosphates inhibit hepatitis B DNA polymerases but not the five cellular DNA polymerases alpha, beta, gamma, delta, and epsilon nor HIV-1 reverse transcriptase.EBI Max-Delbr�ck-Centrum f�r Molekulare Medizin
18852280 8 1,5-benzodiazepines, a novel class of hepatitis C virus polymerase nonnucleoside inhibitors.EBI Tibotec BVBA
19398642 10 GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.EBI Gilead Sciences
20516278 10 PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.EBI Pharmasset Inc
20014868 6 N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase.EBI Novartis Institute for Tropical Diseases
1705574 2 Differential Inhibition of Reverse Transcriptase and Various DNA Polymerases by Digallic Acid and Its DerivativesEBI TBA
7561895 4 Mechanistic Evaluation of New Plant-Derived Compounds That Inhibit HIV-1 Reverse TranscriptaseEBI TBA
18364258 1 Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp.EBI Kobe Gakuin University
16038535 5 Acylphloroglucinol derivatives from Mahurea palustris.EBI National Center for Scientific Research (CNRS)-Pierre Fabre
15497946 2 Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta.EBI Virginia Polytechnic Institute and State University
15217274 13 New neolignans that inhibit DNA polymerase beta lyase.EBI Virginia Polytechnic Institute and State University
15165161 5 A new ursane triterpene from Monochaetum vulcanicum that inhibits DNA polymerase beta lyase.EBI Virginia Polytechnic Institute and State University
16854079 57 Benzimidazole derivatives bearing substituted biphenyls as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors: structure-activity relationship studies and identification of a potent and highly selective inhibitor JTK-109.EBI Central Pharmaceutical Research Institute
16722622 24 Discovery of proline sulfonamides as potent and selective hepatitis C virus NS5b polymerase inhibitors. Evidence for a new NS5b polymerase binding site.EBI Wyeth Research
16563761 48 Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase.EBI The University of Manchester
16455252 72 Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.EBI Central Pharmaceutical Research Institute
16451063 139 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.EBI GlaxoSmithKline
15588095 1 Discovery of pyrano[3,4-b]indoles as potent and selective HCV NS5B polymerase inhibitors.EBI Wyeth Research
15261274 28 Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase.EBI Wyeth Research
30653317 104 Discovery of a Series of 2'-?-Fluoro,2'-?-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.EBI Emory University School of Medicine
28633899 8 Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.EBI Bristol-Myers Squibb Research and Development
28835346 3 The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-?-chloro-2'-?-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.EBI IDENIX an MSD Company
28595015 14 2'-Chloro,2'-fluoro Ribonucleotide Prodrugs with Potent Pan-genotypic Activity against Hepatitis C Virus Replication in Culture.EBI Emory University