Compile Data Set for Download or QSAR
maximum 50k data
Found 407 of affinity data for UniProtKB/TrEMBL: O14492
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484440(US10934285, Example 24)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484457(US10934285, Example 43)
Affinity DataIC50:  1.5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504308((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  2nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479344((3-((3S,4)S-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  2.30nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479347((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...)
Affinity DataIC50:  2.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484469(US10934285, Example 55)
Affinity DataIC50:  2.80nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484421(US10934285, Example 5)
Affinity DataIC50:  3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484461(US10934285, Example 47)
Affinity DataIC50:  3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484466(US10934285, Example 52)
Affinity DataIC50:  3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484472(US10934285, Example 59)
Affinity DataIC50: <3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504292((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479327((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479359((3-((S)-5-amino-5,7-dihydro- spiro[cyclopenta[b]py...)
Affinity DataIC50:  3.30nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479361((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...)
Affinity DataIC50:  3.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479340((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3.60nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504343((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...)
Affinity DataIC50:  3.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479341((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3.80nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50:  3.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504293((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  4nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504323((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50:  4nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479342((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  4.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479348((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...)
Affinity DataIC50:  4.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484467(US10934285, Example 53)
Affinity DataIC50:  4.40nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479354((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...)
Affinity DataIC50:  4.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484429(US10934285, Example 13)
Affinity DataIC50:  4.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504342((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...)
Affinity DataIC50:  4.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484422(US10934285, Example 6)
Affinity DataIC50:  5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484439(US10934285, Example 23)
Affinity DataIC50:  5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504295((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479325((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479352((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479349((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...)
Affinity DataIC50:  5.70nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479355((3S,4S)-8-(6-amino-5-(((6aS,8S)-8-((methoxymeth- o...)
Affinity DataIC50:  5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479353((3S,4S)-8-(5-(((6aS,8S)-8-((methoxymethoxy)methyl)...)
Affinity DataIC50:  5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484430(US10934285, Example 14)
Affinity DataIC50:  5.90nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479351((3-((3S,4S)-4-amino-3-methyl- 2-oxa-8-azaspiro[4.5...)
Affinity DataIC50:  5.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484419(US10934285, Example 3)
Affinity DataIC50:  6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484423(US10934285, Example 7)
Affinity DataIC50:  6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484426(US10934285, Example 10)
Affinity DataIC50:  6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484451(US10934285, Example 37)
Affinity DataIC50:  6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504297((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM504298((6aS,8S)-4-((5-((3S,4S)-4-amino-3- methyl-2-oxa-8-...)
Affinity DataIC50:  6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479333((6aS,8S)-4-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- ...)
Affinity DataIC50:  6nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479345((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  6.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484470(US10934285, Example 56)
Affinity DataIC50:  6.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484418(US10934285, Example 2)
Affinity DataIC50:  7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484425(US10934285, Example 9)
Affinity DataIC50:  7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484459(US10934285, Example 45)
Affinity DataIC50:  7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM479350((3-((S)-5-amino-13-oxa-9- azadispiro[3.1.56.24]tri...)
Affinity DataIC50:  7nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484468(US10934285, Example 54)
Affinity DataIC50:  7.30nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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