BDBM50240945 (E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxyphenyl)prop-2-en-1-one::1-(5-Hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(4-hydroxy-phenyl)-propenone::4-hydroxyisolonchocarpin::4-hydroxylonchocarpin::CHEMBL362378

SMILES CC1(C)Oc2ccc(C(=O)\C=C\c3ccc(O)cc3)c(O)c2C=C1

InChI Key InChIKey=IQHPDUUSMBMDGN-WEVVVXLNSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50240945   

TargetCholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataKi:  3.48E+3nMAssay Description:Mixed type inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by Ellman's method based Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataKi:  7.39E+3nMAssay Description:Competitive type inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's method based Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  1.71E+4nMAssay Description:Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  2.57E+3nMAssay Description:Binding affinity to BChE (unknown origin) assessed as reduction in intrinsic protein fluorescence at 25 degC by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  2.96E+4nMAssay Description:Binding affinity to AChE (unknown origin) assessed as reduction in intrinsic protein fluorescence at 25 degC by fluorescence spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  5.68E+3nMAssay Description:Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  7.41E+4nMAssay Description:Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrnithine decarboxylase(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of phorbol ester-induced ornithine decraboxylase in human MCF7 cells after 6 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50240945((E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-(...)
Affinity DataIC50:  9.80E+3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in baculovirus-expression system using Rh-EVNLDAEFK-Quencher substrate by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed