BDBM16649 2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide::4-Pivaloylamido-benzenesulfonamide::CHEMBL23285::aromatic sulfonamide compound 14

SMILES CC(C)(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O

InChI Key InChIKey=KGBTVIQRHXYTRQ-UHFFFAOYSA-N

Data  12 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 16649   

TargetCarbonic anhydrase 5A, mitochondrial(Mus musculus (mouse))
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  96nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  136nMAssay Description:Inhibitiory activity against human Carbonic anhydrase IX (hCA IX)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  230nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  230nMAssay Description:Inhibitiory activity against human Carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Università

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  249nMAssay Description:Inhibitiory activity against human Carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  730nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi Di Firenze

LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  2.55E+3nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  7.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  2.06E+4nM ΔG°:  -6.39kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM16649(2,2-dimethyl-N-(4-sulfamoylphenyl)propanamide | 4-...)
Affinity DataKi:  2.06E+4nMAssay Description:Inhibitiory activity against human Carbonic anhydrase I (hCA I)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed