BDBM50240419 (E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one::6-shogaol::CHEMBL25948::[(E)-1-(4-hydroxy-3-methoxyphenyl)-dec-4-en-3-one]::[6]-shogaol::trans-6-shogaol

SMILES CCCCCC=CC(=O)CCc1ccc(O)c(OC)c1

InChI Key InChIKey=OQWKEEOHDMUXEO-UHFFFAOYSA-N

Data  1 KI  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50240419   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Department Of Chemistry And Applied Biosciences

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataKi:  1.80E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  1.67E+4nMAssay Description:Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins pri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataEC50:  320nMAssay Description:Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  7.77E+4nMAssay Description:Inhibition of human CYP3A4 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  2.46E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
National Institute Of Advanced Industrial Science And Technology (Aist)

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of 5LOXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Rattus norvegicus)
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataEC50:  1.60E+4nMAssay Description:Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Mansoura University

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  2.46E+4nMAssay Description:Inhibition of recombinant C-terminal His-tagged human LTA4H epoxide hydrolase activity expressed in Escherichia coli assessed as reduction in LTB4 pr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University Of Rome

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50:  290nMAssay Description:Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Toyama Medical And Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50240419((E)-1-(4-Hydroxy-3-methoxy-phenyl)-dec-4-en-3-one ...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human CYP2D6 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed