BDBM17662 (2S)-2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid::2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid::AMPA::CHEMBL276815
SMILES Cc1o[nH]c(=O)c1C[C@H](N)C(O)=O
InChI Key InChIKey=UUDAMDVQRQNNHZ-YFKPBYRVSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 24 hits for monomerid = 17662
TargetGlutamate receptor 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 16.8nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA2(R)o expressed in sS9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 3(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 20.6nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA3o expressed in sS9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 21.9nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 22nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA1o expressed in sS9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Displacement of [3H[AMPA from rat recombinant GluA4o expressed in sS9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 4(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Binding affinity for ionotropic Glutamate receptor AMPA 4 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 103nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 107nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 2 expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor 4(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 155nMAssay Description:Displacement of [3H]AMPA from human Ionotropic glutamate receptor AMPA 4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.15E+3nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK1(Q)1b expressed in sS9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 1(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: 1.15E+3nMAssay Description:Binding affinity for kainate Glutamate receptor GluR5 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 5(Homo sapiens (Human))
University Of Bristol
Curated by ChEMBL
University Of Bristol
Curated by ChEMBL
Affinity DataKi: 2.14E+3nMAssay Description:Displacement of [3H]kainate from human Ionotropic glutamate receptor ionotropic kainate 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.27E+4nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK3a expressed in sS9 cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+6nMAssay Description:Displacement of [3H[SYM2081 from rat recombinant GluK2(VCR)a expressed in sS9 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, kainate 2(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
The Danish University Of Pharmaceutical Sciences
Curated by ChEMBL
Affinity DataKi: >1.00E+6nMAssay Description:Binding affinity for kainate Glutamate receptor GluR6 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: >1.00E+6nMAssay Description:Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu1-alphaMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 4(Homo sapiens (Human))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: >3.00E+6nMAssay Description:Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu4aMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:The compound was evaluated for agonist to competitive inhibition of radioligand ([3H]- CPP ) at Ionotropic Excitatory Amino acid receptorsMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 6(Homo sapiens (Human))
Royal Danish School Of Pharmacy
Curated by ChEMBL
Royal Danish School Of Pharmacy
Curated by ChEMBL
Affinity DataEC50: 2.20E+5nMAssay Description:Agonist activityof the compound at Metabotropic Excitatory Amino acid Receptors Expressed in CHO cells. mGlu6More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+7nMpH: 7.4 T: 2°CAssay Description:The inhibition concentration values of GCPII were determined using the radioenzymatic assay with [3H] NAAG (radiolabeled on the terminal glutamate). ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.80E+3nMAssay Description:In vitro activity of the compound at Ionotropic glutamate receptor using cortical wedge assays in rat brain synaptosomaMore data for this Ligand-Target Pair