BDBM50378582 APIGETRIN::Apigenin 7-O-β-D-glucoside (8)::NSC-407303

SMILES OC[C@H]1O[C@@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O

InChI Key InChIKey=KMOUJOKENFFTPU-QNDFHXLGSA-N

Data  6 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50378582   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Catholic University Of Daegu

LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50:  1.00E+5nMpH: 6.0Assay Description:PTP1B activity was measured by adding 2mM p-NPP and PTP1B in a 50 mM citrate buffer (pH 6.0, 0.1 M NaCl, 1 mMEDTA, and 1 mM dithiothreitol), with or ...More data for this Ligand-Target Pair
In DepthDetails
TargetAcetylcholinesterase(Homo sapiens (Human))
Catholic University Of Daegu

LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50:  1.00E+5nMpH: 8.0 T: 2°CAssay Description:Briefly, 140 μL of sodium phosphate buffer (pH 8.0), 20 μL of each tested compound with different concentrations (4, 20, and 100 μM) a...More data for this Ligand-Target Pair
In DepthDetails
TargetTumor necrosis factor(Homo sapiens (Human))
The Second People'S Hospital Of Fujian Provinc

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataKd:  200nMAssay Description:Binding affinity to TNF-alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))
Hiroshima University

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (fumarate)(Leishmania major)
University Of S£O Paulo

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50:  1.05E+5nMAssay Description:Inhibition of recombinant oligo-histidine-tagged Leishmania major DHODH expressed in Escherichia coli BL21(DE3) cells using DHO as substrate measured...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
Korea Research Institute Of Bioscience And Biotechnology

Curated by ChEMBL
LigandPNGBDBM50378582(APIGETRIN | Apigenin 7-O-β-D-glucoside (8) | ...)
Affinity DataIC50:  3.93E+4nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed