BDBM50058759 CHEMBL436559::CHEMBL462831::Cariporide::N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine (Cariporide)::N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine(Cariporide)::N-(4-isopropyl-3-methanesulfonyl-benzoyl)-guanidine::N-(diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide
SMILES CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)NC(N)=N
InChI Key InChIKey=IWXNYAIICFKCTM-UHFFFAOYSA-N
Data 17 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50058759
Affinity DataIC50: 560nMAssay Description:In vitro concentration required to inhibit NHE-1 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat platelet-rich plasma by optical swelling assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Screened in AP1 cells expressing human NHE-1 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 5(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-5 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 3(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: >3.00E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-3 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Compound is screened in AP1 cells expressing human NHE-2 for sodium hydrogen exchange activityMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory activity against Na+/H+ exchanger 1 (NHE-1) expressed in PS120 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 680nMAssay Description:Inhibitory concentration against human sodium/hydrogen exchanger (NHE-1) in PS120 variant cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of human NHE1 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of human NHE2 expressed in Ap1 cell lineMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human NHE1 expressed in PS120 cellsMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1 in rat platelets by Platelet swelling assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human NHE1 expressed in PS120 cells assessed as imposed acidosisMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of NHE1-mediated rat platelet swellingMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 30.7nMAssay Description:Inhibition of NHE1 in Sprague-Dawley rat assessed as inhibition of acid-induced platelet swelling by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 1(Rattus norvegicus)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:In vitro inhibition of acid induced swelling in rat platelets by 50% as a measure of NHE-1 inhibitionMore data for this Ligand-Target Pair
TargetSodium/hydrogen exchanger 2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 2.87E+4nMAssay Description:In vitro concentration of compound required to inhibit NHE-2 mediated intracellular maximal pH recovery by 50%More data for this Ligand-Target Pair