BDBM50315537 CHEMBL1089316::chaetocin
SMILES CN1C(=O)[C@@]23C[C@]4([C@H](Nc5ccccc45)N2C(=O)[C@]1(CO)SS3)[C@]12C[C@]34SS[C@](CO)(N(C)C3=O)C(=O)N4[C@H]1Nc1ccccc21
InChI Key InChIKey=PZPPOCZWRGNKIR-PNVYSBBASA-N
Data 27 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 50315537
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of G9a (unknown origin) using SAM/biotinylated H3 as substrate preincubated for 1 hr followed by substrate addition measured after 2 hrs b...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of GST-tagged EHMT2 (unknown origin) using biotinylated-H3 peptide as substrate preincubated for 1 hr followed by substrate addition and m...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of GST-tagged G9a after 1 hr by radioactive filter-binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: >9.00E+4nMAssay Description:Inhibition of Drosophila melanogaster PRSET7More data for this Ligand-Target Pair
Affinity DataIC50: >9.00E+4nMAssay Description:Inhibition of Drosophila melanogaster E(Z)More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse G9aMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human SUV39H1More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant Drosophila melanogaster SUV39 by radioactive filter-binding assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.57E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human Histone-lysine N-methyltransferase G9a using S-(5'-adenosyl)-L-methionine chloride as substrate...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human Histone-lysine N-methyltransferase G9a using S-(5'-adenosyl)-L-methionine chloride as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse Histone-lysine N-methyltransferase G9aMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of human Histone-lysine N-methyltransferase SUV39H1More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of Drosophila melanogaster Histone-lysine N-methyltransferase Su(var)3-9More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of protein lysine methyltransferase G9a (unknown origin) by ELISA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of protein lysine methyltransferase G9a (unknown origin) by modified ELISA assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul
Curated by ChEMBL
Dongguk University-Seoul
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF secretion in human Hep3b cells by ELISAMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul
Curated by ChEMBL
Dongguk University-Seoul
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of HIF-1alpha-mediated VEGF expression in human Hep3b cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Dongguk University-Seoul
Curated by ChEMBL
Dongguk University-Seoul
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of HIF-1alpha transcriptional co-activator p300 interactionMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-9 specific dim-5(Neurospora crassa)
Ludwig-Maximillians University Of Munich
Curated by ChEMBL
Ludwig-Maximillians University Of Munich
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Neurospora crassa DIM5More data for this Ligand-Target Pair
Affinity DataIC50: >9.00E+4nMAssay Description:Inhibition of Drosophila melanogaster histone-lysine N-methyl-transferase E(z)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of Drosophila melanogaster SU(VAR)3-9More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of mouse G9aMore data for this Ligand-Target Pair
Affinity DataIC50: >1.80E+5nMAssay Description:Inhibition of Drosophila melanogaster PRSET2More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of N-terminal biotinylated HIF-1alpha (786 to 826 residues) (unknown origin)/GST-tagged p300-CH1 domain (unknown origin) protein-protein i...More data for this Ligand-Target Pair
TargetHistone acetyltransferase p300/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of HIF-1alpha (unknown origin)/p300 (unknown origin) protein-protein interactionMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Icahn School Of Medicine At Mount Sinai
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition human G9a catalytic domainMore data for this Ligand-Target Pair
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
University Of California Santa Cruz
Curated by ChEMBL
University Of California Santa Cruz
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of thioredoxin reductase 1More data for this Ligand-Target Pair